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A1DH89 (CREA_NEOFI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable DNA-binding protein creA
Alternative name(s):
Carbon catabolite repressor A
Gene names
Name:creA
ORF Names:NFIA_087020
OrganismNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus) [Complete proteome]
Taxonomic identifier331117 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya

Protein attributes

Sequence length416 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC-rich region in their promoter. Plays also a role in response to carbon starvation and the control of extracellular proteases activity By similarity.

Subunit structure

Interacts with creB By similarity.

Subcellular location

Nucleus By similarity.

Post-translational modification

Ubiquitinated. Deubiquitinated by creB, probably to control its activity or amount By similarity.

Sequence similarities

Belongs to the creA/MIG C2H2-type zinc-finger protein family.

Contains 2 C2H2-type zinc fingers.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionRepressor
   PTMUbl conjugation
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 416416Probable DNA-binding protein creA
PRO_0000395725

Regions

Zinc finger66 – 8823C2H2-type 1
Zinc finger94 – 11825C2H2-type 2
Compositional bias133 – 1419Poly-Ala
Compositional bias280 – 384105Pro-rich

Sequences

Sequence LengthMass (Da)Tools
A1DH89 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 7063E4850EE2288B

FASTA41644,999
        10         20         30         40         50         60 
MGFSDLLNPQ NPESTPSTPA NKSSAPSTPS TGQSNSNMTS VSLLPPLMKG ARPANEEPRQ 

        70         80         90        100        110        120 
DLPRPYKCPL CDRAFHRLEH QTRHIRTHTG EKPHACQFPG CTKRFSRSDE LTRHSRIHNN 

       130        140        150        160        170        180 
PNSRRNNKAQ HLAAAAAAAA ANQDNALASN AASMMPPPSK PITRSAPVSQ VGSPDISPPH 

       190        200        210        220        230        240 
SFSNYAGHMR SNLGPYARNS DRASSGMDIN LLATAASQVE RDEHYGFHNG PRGHHIFGSR 

       250        260        270        280        290        300 
HHNSNRLPSL SAYAISQNMS RSHSHDEDDM YSHRVKRSRP NSPNSTAPSS PTFSHDSLSP 

       310        320        330        340        350        360 
TPDHTPLATP AHSPRLRPLG TSELQLPSIR HLSLHHTPAL APMEPQPEGP NYYSPTQPHV 

       370        380        390        400        410 
GPSISDIMSK PDGTQRKLPV PQVPKVAVQD LLSPGFTSVS SSASNSVAGG DLADRF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS027696 Genomic DNA. Translation: EAW18746.1.
RefSeqXP_001260643.1. XM_001260642.1.

3D structure databases

ProteinModelPortalA1DH89.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING36630.CADNFIAP00007056.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADNFIAT00007223; CADNFIAP00007056; CADNFIAG00007223.
GeneID4587201.
KEGGnfi:NFIA_087020.

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000164217.
KOK09467.
OMARIHSNPN.
OrthoDBEOG7K0ZMS.

Family and domain databases

Gene3D3.30.160.60. 2 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCREA_NEOFI
AccessionPrimary (citable) accession number: A1DH89
Entry history
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: January 23, 2007
Last modified: February 19, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families