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A1DH89

- CREA_NEOFI

UniProt

A1DH89 - CREA_NEOFI

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Protein

Probable DNA-binding protein creA

Gene

creA

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC-rich region in their promoter. Plays also a role in response to carbon starvation and the control of extracellular proteases activity By similarity.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri66 – 8823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri94 – 11825C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA-binding protein creA
Alternative name(s):
Carbon catabolite repressor A
Gene namesi
Name:creA
ORF Names:NFIA_087020
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
ProteomesiUP000006702: Unassembled WGS sequence

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416Probable DNA-binding protein creAPRO_0000395725Add
BLAST

Post-translational modificationi

Ubiquitinated. Deubiquitinated by creB, probably to control its activity or amount By similarity.By similarity

Keywords - PTMi

Ubl conjugation

Interactioni

Subunit structurei

Interacts with creB.By similarity

Protein-protein interaction databases

STRINGi36630.CADNFIAP00007056.

Structurei

3D structure databases

ProteinModelPortaliA1DH89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi133 – 1419Poly-Ala
Compositional biasi280 – 384105Pro-richAdd
BLAST

Sequence similaritiesi

Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri66 – 8823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri94 – 11825C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000164217.
KOiK09467.
OMAiRIHSNPN.
OrthoDBiEOG7K0ZMS.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1DH89-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGFSDLLNPQ NPESTPSTPA NKSSAPSTPS TGQSNSNMTS VSLLPPLMKG
60 70 80 90 100
ARPANEEPRQ DLPRPYKCPL CDRAFHRLEH QTRHIRTHTG EKPHACQFPG
110 120 130 140 150
CTKRFSRSDE LTRHSRIHNN PNSRRNNKAQ HLAAAAAAAA ANQDNALASN
160 170 180 190 200
AASMMPPPSK PITRSAPVSQ VGSPDISPPH SFSNYAGHMR SNLGPYARNS
210 220 230 240 250
DRASSGMDIN LLATAASQVE RDEHYGFHNG PRGHHIFGSR HHNSNRLPSL
260 270 280 290 300
SAYAISQNMS RSHSHDEDDM YSHRVKRSRP NSPNSTAPSS PTFSHDSLSP
310 320 330 340 350
TPDHTPLATP AHSPRLRPLG TSELQLPSIR HLSLHHTPAL APMEPQPEGP
360 370 380 390 400
NYYSPTQPHV GPSISDIMSK PDGTQRKLPV PQVPKVAVQD LLSPGFTSVS
410
SSASNSVAGG DLADRF
Length:416
Mass (Da):44,999
Last modified:January 23, 2007 - v1
Checksum:i7063E4850EE2288B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027696 Genomic DNA. Translation: EAW18746.1.
RefSeqiXP_001260643.1. XM_001260642.1.

Genome annotation databases

EnsemblFungiiCADNFIAT00007223; CADNFIAP00007056; CADNFIAG00007223.
GeneIDi4587201.
KEGGinfi:NFIA_087020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027696 Genomic DNA. Translation: EAW18746.1 .
RefSeqi XP_001260643.1. XM_001260642.1.

3D structure databases

ProteinModelPortali A1DH89.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 36630.CADNFIAP00007056.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADNFIAT00007223 ; CADNFIAP00007056 ; CADNFIAG00007223 .
GeneIDi 4587201.
KEGGi nfi:NFIA_087020.

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000164217.
KOi K09467.
OMAi RIHSNPN.
OrthoDBi EOG7K0ZMS.

Family and domain databases

Gene3Di 3.30.160.60. 2 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 2 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

Entry informationi

Entry nameiCREA_NEOFI
AccessioniPrimary (citable) accession number: A1DH89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3