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A1DH89

- CREA_NEOFI

UniProt

A1DH89 - CREA_NEOFI

Protein

Probable DNA-binding protein creA

Gene

creA

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC-rich region in their promoter. Plays also a role in response to carbon starvation and the control of extracellular proteases activity By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri66 – 8823C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri94 – 11825C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable DNA-binding protein creA
    Alternative name(s):
    Carbon catabolite repressor A
    Gene namesi
    Name:creA
    ORF Names:NFIA_087020
    OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
    Taxonomic identifieri331117 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
    ProteomesiUP000006702: Unassembled WGS sequence

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 416416Probable DNA-binding protein creAPRO_0000395725Add
    BLAST

    Post-translational modificationi

    Ubiquitinated. Deubiquitinated by creB, probably to control its activity or amount By similarity.By similarity

    Keywords - PTMi

    Ubl conjugation

    Interactioni

    Subunit structurei

    Interacts with creB.By similarity

    Protein-protein interaction databases

    STRINGi36630.CADNFIAP00007056.

    Structurei

    3D structure databases

    ProteinModelPortaliA1DH89.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi133 – 1419Poly-Ala
    Compositional biasi280 – 384105Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri66 – 8823C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri94 – 11825C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000164217.
    KOiK09467.
    OMAiRIHSNPN.
    OrthoDBiEOG7K0ZMS.

    Family and domain databases

    Gene3Di3.30.160.60. 2 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 2 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
    PS50157. ZINC_FINGER_C2H2_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1DH89-1 [UniParc]FASTAAdd to Basket

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    MGFSDLLNPQ NPESTPSTPA NKSSAPSTPS TGQSNSNMTS VSLLPPLMKG    50
    ARPANEEPRQ DLPRPYKCPL CDRAFHRLEH QTRHIRTHTG EKPHACQFPG 100
    CTKRFSRSDE LTRHSRIHNN PNSRRNNKAQ HLAAAAAAAA ANQDNALASN 150
    AASMMPPPSK PITRSAPVSQ VGSPDISPPH SFSNYAGHMR SNLGPYARNS 200
    DRASSGMDIN LLATAASQVE RDEHYGFHNG PRGHHIFGSR HHNSNRLPSL 250
    SAYAISQNMS RSHSHDEDDM YSHRVKRSRP NSPNSTAPSS PTFSHDSLSP 300
    TPDHTPLATP AHSPRLRPLG TSELQLPSIR HLSLHHTPAL APMEPQPEGP 350
    NYYSPTQPHV GPSISDIMSK PDGTQRKLPV PQVPKVAVQD LLSPGFTSVS 400
    SSASNSVAGG DLADRF 416
    Length:416
    Mass (Da):44,999
    Last modified:January 23, 2007 - v1
    Checksum:i7063E4850EE2288B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027696 Genomic DNA. Translation: EAW18746.1.
    RefSeqiXP_001260643.1. XM_001260642.1.

    Genome annotation databases

    EnsemblFungiiCADNFIAT00007223; CADNFIAP00007056; CADNFIAG00007223.
    GeneIDi4587201.
    KEGGinfi:NFIA_087020.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027696 Genomic DNA. Translation: EAW18746.1 .
    RefSeqi XP_001260643.1. XM_001260642.1.

    3D structure databases

    ProteinModelPortali A1DH89.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 36630.CADNFIAP00007056.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADNFIAT00007223 ; CADNFIAP00007056 ; CADNFIAG00007223 .
    GeneIDi 4587201.
    KEGGi nfi:NFIA_087020.

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000164217.
    KOi K09467.
    OMAi RIHSNPN.
    OrthoDBi EOG7K0ZMS.

    Family and domain databases

    Gene3Di 3.30.160.60. 2 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 2 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 2 hits.
    PS50157. ZINC_FINGER_C2H2_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

    Entry informationi

    Entry nameiCREA_NEOFI
    AccessioniPrimary (citable) accession number: A1DH89
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 13, 2010
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3