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Reviewed, UniProtKB/Swiss-Prot A1DGY9 (MTLD_NEOFI)

Last modified June 16, 2009. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Mannitol-1-phosphate 5-dehydrogenase
      Short name=M1PDH
      Short name=MPDH
      Short name=MPD
    EC=1.1.1.17
Gene names
Name: mpdA
ORF Names: NFIA_086010
OrganismNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus) [Complete proteome]
Taxonomic identifier331117 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeNeosartorya

Protein attributes

Sequence length388 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the NAD(H)-dependent interconversion of D-fructose 6-phosphate and D-mannitol 1-phosphate in the mannitol metabolic pathway By similarity.

Catalytic activity

D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

mannitol-1-phosphate 5-dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 388388Mannitol-1-phosphate 5-dehydrogenase
PRO_0000371529

Regions

Nucleotide binding5 – 1612NAD By similarity

Sites

Active site2131 By similarity

Sequences

Sequence LengthMass (Da)Tools
A1DGY9-1 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: AECBA22D7475D657

FASTA38842,891
        10         20         30         40         50         60 
MGKKAIQFGG GNIGRGFVAE FLHEAGYEVV FIDVVDKIID ALKSTPSYEV SEVSEEGEKT 

        70         80         90        100        110        120 
KTITNYRAIN SKTNEEDVVK EIGTADVVTC AVGPNVLKFI APVIAKGIDA RTASKPVAVI 

       130        140        150        160        170        180 
ACENAIGATD TLRGFIEQHT DKDRLSSMSE RARFANSAID RIVPNQPPNA GLNVRIEKFY 

       190        200        210        220        230        240 
EWTVEQTPFG EFGHPDIPAI HWVDDLKPYI ERKLFTVNTG HATTAYYGHV RGKKMIADAL 

       250        260        270        280        290        300 
ADAEIRKIVH NVLEQTAMLI TTKHEITEQE QNEYVDTIVK RMSNPFLEDN VERVGRAPLR 

       310        320        330        340        350        360 
KLSRNERFIG PASQLAEKGL PFDALLGSIE MALRFQNVPG DEESAELAKI LKEMSADEAT 

       370        380 
GKLTGLEKSH PLYKPVQNVV AKVQKDSK 

« Hide

Cross-references

Sequence databases

DS027696 Genomic DNA. Translation: EAW18646.1.
RefSeqXP_001260543.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID4587101.
KEGGnfi:NFIA_086010.

Family and domain databases

InterProIPR013328. DH_multihelical.
IPR013118. Mannitol_DH_C.
IPR000669. Mannitol_DH_core.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
PfamPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSPR00084. MTLDHDRGNASE.
PROSITEPS00974. MANNITOL_DHGENASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTLD_NEOFI
AccessionPrimary (citable) accession number: A1DGY9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: January 23, 2007
Last modified: June 16, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents