A1DG66 (AMPP3_NEOFI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase pepP
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

Name:	pepP
ORF Names:	NFIA_083240

Organism

Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus) [Complete proteome]

Taxonomic identifier

331117 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › Neosartorya › Neosartorya fischeri group › Neosartorya fischeri

Protein attributes

Sequence length	467 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: InterPro metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 467	467	Probable Xaa-Pro aminopeptidase pepP		PRO_0000411878
Sites
	Metal binding	264	1	Manganese 2 By similarity
	Metal binding	275	1	Manganese 1 By similarity
	Metal binding	275	1	Manganese 2 By similarity
	Metal binding	398	1	Manganese 1 By similarity
	Metal binding	438	1	Manganese 1 By similarity
	Metal binding	438	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1DG66 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: EB791F98387A7570	FASTA	467	51,850
	10 20 30 40 50 60 MAAVDAILAG KYPAKAHARR VAESLQSHRN GCPGIVYLEA QKTRLIEDND EPVPFRQRRP 70 80 90 100 110 120 FFYLSGCPLS DSCLVYDLSE DQLTLFIPPV DPEDVIWSGL PMSTEQAQNQ YDVDRVLVTT 130 140 150 160 170 180 ELNSTLASIA SSHGGKAIAF TIADQVSEST QFHGFSEVNQ SVLKGVIEQS RVVKDEYEVA 190 200 210 220 230 240 LLRKANDISA KAHIAAIKAS QTAVNEREIE GAFIATCIAN GAREQSYHPI VACGENGAIL 250 260 270 280 290 300 HYGKNDDTLI DPVTNQKKRN VLIDAGGEYR TYCADITRVI PVGGKFTAET RQIYDIVLQM 310 320 330 340 350 360 QTECIAMLKE GVQWEDVHAH AHRVAIRGLL RLGILRGAED EIFEKRVSVA FFPHGLGHYL 370 380 390 400 410 420 GMDTHDTGGN PNYTDKDTMF RYLRVRGRLP AGSVITVEPG VYFCRFIIEP YIKSPESNKY 430 440 450 460 IDTNVLDRYW RVGGVRIEDN VVVTKNGYDN LTTAPKAVDE IERLAVS

References

[1]

"Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus." Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J., Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H., Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M. , Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J., Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C., White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H., Wortman J.R., Jiang B., Denning D.W., Nierman W.C. PLoS Genet. 4:E1000046-E1000046(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS027696 Genomic DNA. Translation: EAW18373.1.
RefSeq	XP_001260270.1. XM_001260269.1.
3D structure databases
ProteinModelPortal	A1DG66.
ModBase	Search...
Protein-protein interaction databases
STRING	36630.CADNFIAP00007184.
Protein family/group databases
MEROPS	M24.A09.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADNFIAT00007351; CADNFIAP00007184; CADNFIAG00007351.
GeneID	4586827.
KEGG	nfi:NFIA_083240.
Phylogenomic databases
HOGENOM	HOG000008763.
KO	K14213.
OrthoDB	EOG4J40RD.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR007865. Aminopep_P_N. IPR000994. Pept_M24_structural-domain. [Graphical view]
Pfam	PF05195. AMP_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SMART	SM01011. AMP_N. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP3_NEOFI

Accession

Primary (citable) accession number: A1DG66

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program