A1DG00 (RIFK_NEOFI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Riboflavin kinase
EC=2.7.1.26

Alternative name(s):
Flavin mononucleotide kinase 1

Gene names

Name:	fmn1
ORF Names:	NFIA_082540

Organism

Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus) [Complete proteome]

Taxonomic identifier

331117 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › Neosartorya › Neosartorya fischeri group › Neosartorya fischeri

Protein attributes

Sequence length	218 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme By similarity.
Catalytic activity	ATP + riboflavin = ADP + FMN.
Cofactor	Zinc or magnesium By similarity.
Pathway	Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.
Sequence similarities	Belongs to the flavokinase family.

Ontologies

Keywords
Ligand	ATP-binding FMN Magnesium Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	FMN biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway riboflavin biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW riboflavin kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 218	218	Riboflavin kinase		PRO_0000301845
Sites
	Active site	120	1	Nucleophile By similarity
	Metal binding	44	1	Magnesium or zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1DG00 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: F670445E67236D81	FASTA	218	23,563
	10 20 30 40 50 60 MRPDGPRDPV AGPDSGPEPP YPVRLSGPVI KGFGRGSKEL GIPTANIPAE GLAEYPDLQV 70 80 90 100 110 120 GVYYGVVALD PAKFQYQEDQ GEGSTSSTGG AGAGAGAAIL PAVLSIGYNP FYKNKTKSIE 130 140 150 160 170 180 IHIMPPLSSP SPTAEGAGEV KFHKLPDFYG TQLKLLILGY IRPEYDYVSL EALIEDIRVD 190 200 210 CEVARKSLQR PAYACYIDGD EKECSDAVRE QRRWLVNF

References

[1]

"Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus." Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J., Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H., Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M. , Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J., Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C., White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H., Wortman J.R., Jiang B., Denning D.W., Nierman W.C. PLoS Genet. 4:E1000046-E1000046(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS027696 Genomic DNA. Translation: EAW18307.1.
RefSeq	XP_001260204.1. XM_001260203.1.
3D structure databases
ProteinModelPortal	A1DG00.
ModBase	Search...
Protein-protein interaction databases
STRING	36630.CADNFIAP00006812.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADNFIAT00006979; CADNFIAP00006812; CADNFIAG00006979.
GeneID	4586761.
KEGG	nfi:NFIA_082540.
Phylogenomic databases
eggNOG	COG0196.
HOGENOM	HOG000260803.
KO	K00861.
OrthoDB	EOG4BCHXC.
Enzyme and pathway databases
UniPathway	UPA00276; UER00406.
Family and domain databases
Gene3D	2.40.30.30. 1 hit.
InterPro	IPR023468. Riboflavin_kinase. IPR015865. Riboflavin_kinase_bac/euk. IPR023465. Riboflavin_kinase_domain. [Graphical view]
PANTHER	PTHR22749. PTHR22749. 1 hit.
Pfam	PF01687. Flavokinase. 1 hit. [Graphical view]
SMART	SM00904. Flavokinase. 1 hit. [Graphical view]
SUPFAM	SSF82114. Riboflavin_kinase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RIFK_NEOFI

Accession

Primary (citable) accession number: A1DG00

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program