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A1DFN5

- HSE1_NEOFI

UniProt

A1DFN5 - HSE1_NEOFI

Protein

Class E vacuolar protein-sorting machinery protein hse1

Gene

hse1

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).By similarity

    GO - Biological processi

    1. intracellular protein transport Source: InterPro

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Class E vacuolar protein-sorting machinery protein hse1
    Gene namesi
    Name:hse1
    ORF Names:NFIA_081360
    OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
    Taxonomic identifieri331117 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
    ProteomesiUP000006702: Unassembled WGS sequence

    Subcellular locationi

    Endosome membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity

    GO - Cellular componenti

    1. endosome membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 603603Class E vacuolar protein-sorting machinery protein hse1PRO_0000292499Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the ESCRT-0 complex composed of HSE1 and VPS27.By similarity

    Protein-protein interaction databases

    STRINGi36630.CADNFIAP00008420.

    Structurei

    3D structure databases

    ProteinModelPortaliA1DFN5.
    SMRiA1DFN5. Positions 220-269.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini16 – 145130VHSPROSITE-ProRule annotationAdd
    BLAST
    Repeati162 – 18120UIMAdd
    BLAST
    Domaini215 – 27460SH3PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi372 – 578207Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the STAM family.Curated
    Contains 1 SH3 domain.PROSITE-ProRule annotation
    Contains 1 VHS domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3 domain

    Phylogenomic databases

    eggNOGiNOG309509.
    HOGENOMiHOG000048362.
    KOiK04705.
    OMAiGEYQAYN.
    OrthoDBiEOG75MW70.

    Family and domain databases

    Gene3Di1.25.40.90. 1 hit.
    InterProiIPR008942. ENTH_VHS.
    IPR001452. SH3_domain.
    IPR013315. Spectrin_alpha_SH3.
    IPR002014. VHS.
    IPR018205. VHS_subgr.
    [Graphical view]
    PfamiPF00018. SH3_1. 1 hit.
    PF00790. VHS. 1 hit.
    [Graphical view]
    PRINTSiPR00452. SH3DOMAIN.
    PR01887. SPECTRNALPHA.
    SMARTiSM00326. SH3. 1 hit.
    SM00288. VHS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48464. SSF48464. 1 hit.
    SSF50044. SSF50044. 1 hit.
    PROSITEiPS50002. SH3. 1 hit.
    PS50179. VHS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1DFN5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFRAQQNAFD DAVAKATDEN LTSENWEYIL DVCDKVAAEE SGAKDAVAAM    50
    IKRLAHRNAN VQLYTLELAN ALAQNCGPKI HRELASRSFT DALLRLANDR 100
    NTHQQVKPKI LERMQEWAQM FANNPDFGIM EQAYMKLKTQ NPNLQPPSKP 150
    GKREITEADR QKEEEELQMA LALSIREKPS AAPEPKAEPS TSASVPASQT 200
    QAATSQAVPP GTSAATVSRV RALFDFQPSE PGELQFRKGD IIAVLESVYK 250
    DWWKGSLRGQ TGIFPLNYVE KLPDPTVEEL QREAQMEAEV FGQIKNVEKL 300
    LTLLSTRSSE LNVQDNEEIT ALYHSTLSIR PKLIELIGKY SQKKDEFTQL 350
    NEKFIKARRD YESLLEASMS HPAQPQYGRP GQTPYGYPGP AAPLGYPQGP 400
    PQSDPQRYFS PRPQDQTHMY PPTSHSPDPR GRTPPAGPSF PQHQQPPPDS 450
    YQPVHHRPES TYDNPQELGT SVYDSPVEHP SSSQRLPYPP SGAPVPPGVH 500
    QQFQHQQQEY PPSGYPPEDA SKPPTAGFAS QPPQQTLQQP PYPTAPVAHQ 550
    PPPSHQPPPV PSTASKPTPY PSLTPGTPSG GEYQAYNPSQ AGAANSNPNS 600
    YYR 603
    Length:603
    Mass (Da):66,746
    Last modified:January 23, 2007 - v1
    Checksum:i5BA8AC0B82ECC513
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027696 Genomic DNA. Translation: EAW18192.1.
    RefSeqiXP_001260089.1. XM_001260088.1.

    Genome annotation databases

    EnsemblFungiiCADNFIAT00008587; CADNFIAP00008420; CADNFIAG00008587.
    GeneIDi4586645.
    KEGGinfi:NFIA_081360.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027696 Genomic DNA. Translation: EAW18192.1 .
    RefSeqi XP_001260089.1. XM_001260088.1.

    3D structure databases

    ProteinModelPortali A1DFN5.
    SMRi A1DFN5. Positions 220-269.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 36630.CADNFIAP00008420.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADNFIAT00008587 ; CADNFIAP00008420 ; CADNFIAG00008587 .
    GeneIDi 4586645.
    KEGGi nfi:NFIA_081360.

    Phylogenomic databases

    eggNOGi NOG309509.
    HOGENOMi HOG000048362.
    KOi K04705.
    OMAi GEYQAYN.
    OrthoDBi EOG75MW70.

    Family and domain databases

    Gene3Di 1.25.40.90. 1 hit.
    InterProi IPR008942. ENTH_VHS.
    IPR001452. SH3_domain.
    IPR013315. Spectrin_alpha_SH3.
    IPR002014. VHS.
    IPR018205. VHS_subgr.
    [Graphical view ]
    Pfami PF00018. SH3_1. 1 hit.
    PF00790. VHS. 1 hit.
    [Graphical view ]
    PRINTSi PR00452. SH3DOMAIN.
    PR01887. SPECTRNALPHA.
    SMARTi SM00326. SH3. 1 hit.
    SM00288. VHS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48464. SSF48464. 1 hit.
    SSF50044. SSF50044. 1 hit.
    PROSITEi PS50002. SH3. 1 hit.
    PS50179. VHS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

    Entry informationi

    Entry nameiHSE1_NEOFI
    AccessioniPrimary (citable) accession number: A1DFN5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3