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A1DFN5 (HSE1_NEOFI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Class E vacuolar protein-sorting machinery protein hse1
Gene names
Name:hse1
ORF Names:NFIA_081360
OrganismNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus) [Complete proteome]
Taxonomic identifier331117 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › Neosartorya ›

Protein attributes

Sequence length603 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) By similarity.

Subunit structure

Component of the ESCRT-0 complex composed of HSE1 and VPS27 By similarity.

Subcellular location

Endosome membrane; Peripheral membrane protein; Cytoplasmic side By similarity.

Sequence similarities

Belongs to the STAM family.

Contains 1 SH3 domain.

Contains 1 UIM (ubiquitin-interacting motif) repeat.

Contains 1 VHS domain.

Ontologies

Keywords
   Biological processProtein transport
Transport
   Cellular componentEndosome
Membrane
   DomainSH3 domain
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processintracellular protein transport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentendosome membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 603603Class E vacuolar protein-sorting machinery protein hse1
PRO_0000292499

Regions

Domain16 – 145130VHS
Repeat162 – 18120UIM
Domain215 – 27460SH3
Compositional bias372 – 578207Pro-rich

Sequences

Sequence LengthMass (Da)Tools
A1DFN5 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 5BA8AC0B82ECC513

FASTA60366,746
        10         20         30         40         50         60 
MFRAQQNAFD DAVAKATDEN LTSENWEYIL DVCDKVAAEE SGAKDAVAAM IKRLAHRNAN 

        70         80         90        100        110        120 
VQLYTLELAN ALAQNCGPKI HRELASRSFT DALLRLANDR NTHQQVKPKI LERMQEWAQM 

       130        140        150        160        170        180 
FANNPDFGIM EQAYMKLKTQ NPNLQPPSKP GKREITEADR QKEEEELQMA LALSIREKPS 

       190        200        210        220        230        240 
AAPEPKAEPS TSASVPASQT QAATSQAVPP GTSAATVSRV RALFDFQPSE PGELQFRKGD 

       250        260        270        280        290        300 
IIAVLESVYK DWWKGSLRGQ TGIFPLNYVE KLPDPTVEEL QREAQMEAEV FGQIKNVEKL 

       310        320        330        340        350        360 
LTLLSTRSSE LNVQDNEEIT ALYHSTLSIR PKLIELIGKY SQKKDEFTQL NEKFIKARRD 

       370        380        390        400        410        420 
YESLLEASMS HPAQPQYGRP GQTPYGYPGP AAPLGYPQGP PQSDPQRYFS PRPQDQTHMY 

       430        440        450        460        470        480 
PPTSHSPDPR GRTPPAGPSF PQHQQPPPDS YQPVHHRPES TYDNPQELGT SVYDSPVEHP 

       490        500        510        520        530        540 
SSSQRLPYPP SGAPVPPGVH QQFQHQQQEY PPSGYPPEDA SKPPTAGFAS QPPQQTLQQP 

       550        560        570        580        590        600 
PYPTAPVAHQ PPPSHQPPPV PSTASKPTPY PSLTPGTPSG GEYQAYNPSQ AGAANSNPNS 


YYR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		DS027696 Genomic DNA. Translation: EAW18192.1.
RefSeqXP_001260089.1. XM_001260088.1.

3D structure databases

ProteinModelPortalA1DFN5.
SMRA1DFN5. Positions 220-269.
ModBaseSearch...

Protein-protein interaction databases

STRING36630.CADNFIAP00008420.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADNFIAT00008587; CADNFIAP00008420; CADNFIAG00008587.
GeneID4586645.
KEGGnfi:NFIA_081360.

Phylogenomic databases

eggNOGNOG309509.
HOGENOMHOG000048362.
KOK04705.
OrthoDBEOG4KM2BT.

Family and domain databases

Gene3D1.25.40.90. 1 hit.
InterProIPR008942. ENTH_VHS.
IPR001452. SH3_domain.
IPR013315. Spectrin_alpha_SH3.
IPR002014. VHS.
IPR018205. VHS_subgr.
[Graphical view]
PfamPF00018. SH3_1. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view]
PRINTSPR00452. SH3DOMAIN.
PR01887. SPECTRNALPHA.
SMARTSM00326. SH3. 1 hit.
SM00288. VHS. 1 hit.
[Graphical view]
SUPFAMSSF48464. ENTH_VHS. 1 hit.
SSF50044. SH3. 1 hit.
PROSITEPS50002. SH3. 1 hit.
PS50330. UIM. False negative.
PS50179. VHS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHSE1_NEOFI
AccessionPrimary (citable) accession number: A1DFN5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: January 23, 2007
Last modified: April 3, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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