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Protein

Class E vacuolar protein-sorting machinery protein hse1

Gene

hse1

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).By similarity

GO - Biological processi

  1. ascospore-type prospore assembly Source: EnsemblFungi
  2. protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: EnsemblFungi
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Class E vacuolar protein-sorting machinery protein hse1
Gene namesi
Name:hse1
ORF Names:NFIA_081360
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
ProteomesiUP000006702 Componenti: Unassembled WGS sequence

Subcellular locationi

Endosome membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity

GO - Cellular componenti

  1. cytosol Source: EnsemblFungi
  2. endosome membrane Source: UniProtKB-SubCell
  3. ESCRT-0 complex Source: EnsemblFungi
  4. Golgi apparatus Source: EnsemblFungi
  5. nucleus Source: EnsemblFungi
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 603603Class E vacuolar protein-sorting machinery protein hse1PRO_0000292499Add
BLAST

Interactioni

Subunit structurei

Component of the ESCRT-0 complex composed of HSE1 and VPS27.By similarity

Protein-protein interaction databases

STRINGi36630.CADNFIAP00008420.

Structurei

3D structure databases

ProteinModelPortaliA1DFN5.
SMRiA1DFN5. Positions 220-269.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 145130VHSPROSITE-ProRule annotationAdd
BLAST
Domaini162 – 18120UIMCuratedAdd
BLAST
Domaini215 – 27460SH3PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi372 – 578207Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the STAM family.Curated
Contains 1 SH3 domain.PROSITE-ProRule annotation
Contains 1 VHS domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiNOG309509.
HOGENOMiHOG000048362.
KOiK04705.
OMAiYMSPQHQ.
OrthoDBiEOG75MW70.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiIPR008942. ENTH_VHS.
IPR001452. SH3_domain.
IPR013315. Spectrin_alpha_SH3.
IPR002014. VHS.
IPR018205. VHS_subgr.
[Graphical view]
PfamiPF00018. SH3_1. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
PR01887. SPECTRNALPHA.
SMARTiSM00326. SH3. 1 hit.
SM00288. VHS. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
PS50179. VHS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1DFN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRAQQNAFD DAVAKATDEN LTSENWEYIL DVCDKVAAEE SGAKDAVAAM
60 70 80 90 100
IKRLAHRNAN VQLYTLELAN ALAQNCGPKI HRELASRSFT DALLRLANDR
110 120 130 140 150
NTHQQVKPKI LERMQEWAQM FANNPDFGIM EQAYMKLKTQ NPNLQPPSKP
160 170 180 190 200
GKREITEADR QKEEEELQMA LALSIREKPS AAPEPKAEPS TSASVPASQT
210 220 230 240 250
QAATSQAVPP GTSAATVSRV RALFDFQPSE PGELQFRKGD IIAVLESVYK
260 270 280 290 300
DWWKGSLRGQ TGIFPLNYVE KLPDPTVEEL QREAQMEAEV FGQIKNVEKL
310 320 330 340 350
LTLLSTRSSE LNVQDNEEIT ALYHSTLSIR PKLIELIGKY SQKKDEFTQL
360 370 380 390 400
NEKFIKARRD YESLLEASMS HPAQPQYGRP GQTPYGYPGP AAPLGYPQGP
410 420 430 440 450
PQSDPQRYFS PRPQDQTHMY PPTSHSPDPR GRTPPAGPSF PQHQQPPPDS
460 470 480 490 500
YQPVHHRPES TYDNPQELGT SVYDSPVEHP SSSQRLPYPP SGAPVPPGVH
510 520 530 540 550
QQFQHQQQEY PPSGYPPEDA SKPPTAGFAS QPPQQTLQQP PYPTAPVAHQ
560 570 580 590 600
PPPSHQPPPV PSTASKPTPY PSLTPGTPSG GEYQAYNPSQ AGAANSNPNS

YYR
Length:603
Mass (Da):66,746
Last modified:January 22, 2007 - v1
Checksum:i5BA8AC0B82ECC513
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027696 Genomic DNA. Translation: EAW18192.1.
RefSeqiXP_001260089.1. XM_001260088.1.

Genome annotation databases

EnsemblFungiiCADNFIAT00008587; CADNFIAP00008420; CADNFIAG00008587.
GeneIDi4586645.
KEGGinfi:NFIA_081360.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027696 Genomic DNA. Translation: EAW18192.1.
RefSeqiXP_001260089.1. XM_001260088.1.

3D structure databases

ProteinModelPortaliA1DFN5.
SMRiA1DFN5. Positions 220-269.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi36630.CADNFIAP00008420.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADNFIAT00008587; CADNFIAP00008420; CADNFIAG00008587.
GeneIDi4586645.
KEGGinfi:NFIA_081360.

Phylogenomic databases

eggNOGiNOG309509.
HOGENOMiHOG000048362.
KOiK04705.
OMAiYMSPQHQ.
OrthoDBiEOG75MW70.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiIPR008942. ENTH_VHS.
IPR001452. SH3_domain.
IPR013315. Spectrin_alpha_SH3.
IPR002014. VHS.
IPR018205. VHS_subgr.
[Graphical view]
PfamiPF00018. SH3_1. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
PR01887. SPECTRNALPHA.
SMARTiSM00326. SH3. 1 hit.
SM00288. VHS. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
PS50179. VHS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

Entry informationi

Entry nameiHSE1_NEOFI
AccessioniPrimary (citable) accession number: A1DFN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 25, 2007
Last sequence update: January 22, 2007
Last modified: March 31, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.