A1DEZ0 (SHO1_NEOFI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
High osmolarity signaling protein sho1

Alternative name(s):
Osmosensor sho1

Gene names

Name:	sho1
ORF Names:	NFIA_078870

Organism

Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus) [Complete proteome]

Taxonomic identifier

331117 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › Neosartorya › Neosartorya fischeri group › Neosartorya fischeri

Protein attributes

Sequence length	288 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity By similarity.
Subunit structure	Forms homooligomers By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the SHO1 family. Contains 1 SH3 domain.

Ontologies

Keywords
Biological process	Stress response
Cellular component	Cell membrane Membrane
Domain	SH3 domain Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 288	288	High osmolarity signaling protein sho1		PRO_0000410385
Regions
	Topological domain	1 – 14	14	Cytoplasmic Potential
	Transmembrane	15 – 35	21	Helical; Potential
	Topological domain	36 – 44	9	Extracellular Potential
	Transmembrane	45 – 65	21	Helical; Potential
	Topological domain	66 – 70	5	Cytoplasmic Potential
	Transmembrane	71 – 91	21	Helical; Potential
	Topological domain	92 – 103	12	Extracellular Potential
	Transmembrane	104 – 124	21	Helical; Potential
	Topological domain	125 – 288	164	Cytoplasmic Potential
	Domain	229 – 288	60	SH3
Amino acid modifications
	Glycosylation	44	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	A1DEZ0 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: EA78E63B915E092F	FASTA	288	30,802
	10 20 30 40 50 60 MAKFRASNIL GDPFALATVS ISILAWLIAC IASIISDIKT DYPNYSWWAV AYMFCCIIGV 70 80 90 100 110 120 TIVFGSDTGL VYGVAVVGYL STGLVLTTLA VNTLVYADES SSQAAAAGFI LLSMVIVVWI 130 140 150 160 170 180 FYFGSSPQAT HRGFIDSFAL NKESSGAYGN RPMSTAFGPR PDTMSTSAPQ MYTSAQLNGF 190 200 210 220 230 240 ETSSPVSGYP GGAPGSENRS SSQARFGNPS ASNVTGNNNG QDEVPQPTEY PYKAKAIYSY 250 260 270 280 DANPEDANEI SFSKHEILEV SDVSGRWWQA RKSNGETGIA PSNYLILL

References

[1]

"Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus." Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J., Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H., Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M. , Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J., Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C., White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H., Wortman J.R., Jiang B., Denning D.W., Nierman W.C. PLoS Genet. 4:E1000046-E1000046(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS027696 Genomic DNA. Translation: EAW17947.1.
RefSeq	XP_001259844.1. XM_001259843.1.
3D structure databases
ProteinModelPortal	A1DEZ0.
SMR	A1DEZ0. Positions 230-288.
ModBase	Search...
Protein-protein interaction databases
STRING	36630.CADNFIAP00006786.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADNFIAT00006953; CADNFIAP00006786; CADNFIAG00006953.
GeneID	4585757.
KEGG	nfi:NFIA_078870.
Phylogenomic databases
HOGENOM	HOG000174182.
KO	K11246.
OrthoDB	EOG42VCRD.
Family and domain databases
InterPro	IPR001452. SH3_domain. [Graphical view]
Pfam	PF00018. SH3_1. 1 hit. [Graphical view]
PRINTS	PR00452. SH3DOMAIN.
SMART	SM00326. SH3. 1 hit. [Graphical view]
SUPFAM	SSF50044. SH3. 1 hit.
PROSITE	PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SHO1_NEOFI

Accession

Primary (citable) accession number: A1DEZ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 28, 2011
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program