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Protein

High osmolarity signaling protein sho1

Gene

sho1

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity.By similarity

Keywordsi

Biological processStress response

Names & Taxonomyi

Protein namesi
Recommended name:
High osmolarity signaling protein sho1
Alternative name(s):
Osmosensor sho1
Gene namesi
Name:sho1
ORF Names:NFIA_078870
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006702 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:NFIA_078870.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 14CytoplasmicSequence analysisAdd BLAST14
Transmembranei15 – 35HelicalSequence analysisAdd BLAST21
Topological domaini36 – 44ExtracellularSequence analysis9
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Topological domaini66 – 70CytoplasmicSequence analysis5
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Topological domaini92 – 103ExtracellularSequence analysisAdd BLAST12
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Topological domaini125 – 288CytoplasmicSequence analysisAdd BLAST164

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004103851 – 288High osmolarity signaling protein sho1Add BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi44N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Forms homooligomers.By similarity

Structurei

3D structure databases

ProteinModelPortaliA1DEZ0.
SMRiA1DEZ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini229 – 288SH3PROSITE-ProRule annotationAdd BLAST60

Sequence similaritiesi

Belongs to the SHO1 family.Curated

Keywords - Domaini

SH3 domain, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000174182.
KOiK11246.
OMAiDAYEISF.
OrthoDBiEOG092C3BG5.

Family and domain databases

InterProiView protein in InterPro
IPR001452. SH3_domain.
PfamiView protein in Pfam
PF00018. SH3_1. 1 hit.
PRINTSiPR00452. SH3DOMAIN.
SMARTiView protein in SMART
SM00326. SH3. 1 hit.
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiView protein in PROSITE
PS50002. SH3. 1 hit.

Sequencei

Sequence statusi: Complete.

A1DEZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKFRASNIL GDPFALATVS ISILAWLIAC IASIISDIKT DYPNYSWWAV
60 70 80 90 100
AYMFCCIIGV TIVFGSDTGL VYGVAVVGYL STGLVLTTLA VNTLVYADES
110 120 130 140 150
SSQAAAAGFI LLSMVIVVWI FYFGSSPQAT HRGFIDSFAL NKESSGAYGN
160 170 180 190 200
RPMSTAFGPR PDTMSTSAPQ MYTSAQLNGF ETSSPVSGYP GGAPGSENRS
210 220 230 240 250
SSQARFGNPS ASNVTGNNNG QDEVPQPTEY PYKAKAIYSY DANPEDANEI
260 270 280
SFSKHEILEV SDVSGRWWQA RKSNGETGIA PSNYLILL
Length:288
Mass (Da):30,802
Last modified:January 23, 2007 - v1
Checksum:iEA78E63B915E092F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027696 Genomic DNA. Translation: EAW17947.1.
RefSeqiXP_001259844.1. XM_001259843.1.

Genome annotation databases

EnsemblFungiiCADNFIAT00006953; CADNFIAP00006786; CADNFIAG00006953.
GeneIDi4585757.
KEGGinfi:NFIA_078870.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027696 Genomic DNA. Translation: EAW17947.1.
RefSeqiXP_001259844.1. XM_001259843.1.

3D structure databases

ProteinModelPortaliA1DEZ0.
SMRiA1DEZ0.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADNFIAT00006953; CADNFIAP00006786; CADNFIAG00006953.
GeneIDi4585757.
KEGGinfi:NFIA_078870.

Organism-specific databases

EuPathDBiFungiDB:NFIA_078870.

Phylogenomic databases

HOGENOMiHOG000174182.
KOiK11246.
OMAiDAYEISF.
OrthoDBiEOG092C3BG5.

Family and domain databases

InterProiView protein in InterPro
IPR001452. SH3_domain.
PfamiView protein in Pfam
PF00018. SH3_1. 1 hit.
PRINTSiPR00452. SH3DOMAIN.
SMARTiView protein in SMART
SM00326. SH3. 1 hit.
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiView protein in PROSITE
PS50002. SH3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSHO1_NEOFI
AccessioniPrimary (citable) accession number: A1DEZ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: January 23, 2007
Last modified: March 15, 2017
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.