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A1DES4 (MPKC_NEOFI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitogen-activated protein kinase mpkC

Short name=MAP kinase C
EC=2.7.11.24
Gene names
Name:mpkc
ORF Names:NFIA_078210
OrganismNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus) [Complete proteome]
Taxonomic identifier331117 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Mitogen-activated protein kinase required for growth on media where sorbitol or mannitol is the sole carbon source By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Cofactor

Magnesium By similarity.

Enzyme regulation

Activated by tyrosine and threonine phosphorylation By similarity.

Domain

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Post-translational modification

Dually phosphorylated on Thr-171 and Tyr-173, which activates the enzyme By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.

Contains 1 protein kinase domain.

Sequence caution

The sequence EAW17881.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase
Transferase
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

MAP kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 377377Mitogen-activated protein kinase mpkC
PRO_0000289718

Regions

Domain20 – 299280Protein kinase
Nucleotide binding26 – 349ATP By similarity
Motif171 – 1733TXY

Sites

Active site1411Proton acceptor By similarity
Binding site491ATP By similarity

Amino acid modifications

Modified residue1711Phosphothreonine By similarity
Modified residue1731Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
A1DES4 [UniParc].

Last modified May 29, 2007. Version 2.
Checksum: 9799CB428A4F547C

FASTA37742,913
        10         20         30         40         50         60 
MAEFVRAEIL GTKFEYTTRY VNPQPIGMGS FGLVCSAFDQ ITQQPVALKK IMKPFDSSSL 

        70         80         90        100        110        120 
AKRTYREIRL LKYLRHENLI CLRDIFISPL EDIYIATELL GTDLGRLLSI KPLDSKFSQY 

       130        140        150        160        170        180 
FIYQILRGLK YIHSANVIHR DLKPTNILIN ENCDLKICDF GLARLQEPQM TGYVATRYYR 

       190        200        210        220        230        240 
APEIMLTWQR YGVQVDVWSA GCILAEMLRG KPLFPGKDHV HQFHLITNVL GNPPDAVIEK 

       250        260        270        280        290        300 
ITSKNTVNFV KSLPSREPRD LSTVIMTHTS IAIDLLKKML VIDPDTRISA QDALRHPYLA 

       310        320        330        340        350        360 
PYHDPTDEPA ASGPFDWSFD SADFPKETWK IMIYSEVLDY LNVGNPADPA PFDPSTPFDP 

       370 
SALEREFSEF LSDSGQI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS027696 Genomic DNA. Translation: EAW17881.1. Sequence problems.
RefSeqXP_001259778.1. XM_001259777.1.

3D structure databases

ProteinModelPortalA1DES4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING36630.CADNFIAP00006731.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4586381.
KEGGnfi:NFIA_078210.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
OrthoDBEOG7K3TWD.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMPKC_NEOFI
AccessionPrimary (citable) accession number: A1DES4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: April 16, 2014
This is version 42 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families