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A1DEK3

- XKS1_NEOFI

UniProt

A1DEK3 - XKS1_NEOFI

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Protein
Probable D-xylulose kinase A
Gene
xkiA, NFIA_077470
Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway By similarity.

Catalytic activityi

ATP + D-xylulose = ADP + D-xylulose 5-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei97 – 971Substrate By similarity
Binding sitei168 – 1681Substrate By similarity
Binding sitei284 – 2841Substrate By similarity
Binding sitei285 – 2851Substrate By similarity
Binding sitei366 – 3661ATP By similarity
Binding sitei475 – 4751ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi471 – 4722ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. xylulokinase activity Source: UniProtKB-EC

GO - Biological processi

  1. D-xylose metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism, Xylose metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable D-xylulose kinase A (EC:2.7.1.17)
Short name:
Xylulokinase A
Gene namesi
Name:xkiA
ORF Names:NFIA_077470
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
ProteomesiUP000006702: Unassembled WGS sequence

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 573573Probable D-xylulose kinase A
PRO_0000393526Add
BLAST

Expressioni

Inductioni

By D-xylose, L-arabinose or L-arabitol.

Interactioni

Protein-protein interaction databases

STRINGi36630.CADNFIAP00007712.

Structurei

3D structure databases

ProteinModelPortaliA1DEK3.

Family & Domainsi

Sequence similaritiesi

Belongs to the FGGY kinase family.

Phylogenomic databases

eggNOGiCOG1070.
HOGENOMiHOG000174850.
KOiK00854.
OMAiGSYSPID.
OrthoDBiEOG7CRTZN.

Family and domain databases

InterProiIPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1DEK3-1 [UniParc]FASTAAdd to Basket

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MTSQGPLYIG FDLSTQQLKG LVVNSELKVV HVSKFDFDAD SHGFSIKKGV    50
LTNEAEHEVF APVALWLQAL DGVLDGLRKQ GLDFSRVKGI SGAGQQHGSV 100
YWGENAESLL KSLDSSKSLE EQLSGAFSHP FSPNWQDAST QKECDEFDAF 150
LGGPEQLAEA TGSKAHHRFT GPQILRMQRK YPEVYRKTAR ISLVSSFLAS 200
LLLGYIAPMD ISDVCGMNLW DIKKGAYNEK LLGLCAGPFG AEDLKRKLGD 250
VPEDGGLRLG KINRYFVERY GFSSNCEILP STGDNPATIL ALPLRPSDAM 300
VSLGTSTTFL MSTPSYKPDP ATHFFNHPTT PGLYMFMLCY KNGGLAREHV 350
RDAINEKSGS GASQSWESFD KIMLETPPMG QKTESGPMKM GLFFPRPEIV 400
PNVRSGQWRF TYDPASDTLT ETEDGWNKPS DEARAIVESQ MLSLRLRSRG 450
LTQSPGDGLP PQPRRVYLVG GGSKNKAIAK VAGEILGGSD GVYKLDVGDN 500
ACALGAAYKA VWAIERKPGQ TFEDLIGQRW REEEFIEKIA DGYQKGVFEK 550
YGKAVEGFER MEQQVLKQEA ARK 573
Length:573
Mass (Da):63,054
Last modified:January 23, 2007 - v1
Checksum:i487BF898987F5640
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027696 Genomic DNA. Translation: EAW17810.1.
RefSeqiXP_001259707.1. XM_001259706.1.

Genome annotation databases

EnsemblFungiiCADNFIAT00007879; CADNFIAP00007712; CADNFIAG00007879.
GeneIDi4586369.
KEGGinfi:NFIA_077470.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027696 Genomic DNA. Translation: EAW17810.1 .
RefSeqi XP_001259707.1. XM_001259706.1.

3D structure databases

ProteinModelPortali A1DEK3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 36630.CADNFIAP00007712.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADNFIAT00007879 ; CADNFIAP00007712 ; CADNFIAG00007879 .
GeneIDi 4586369.
KEGGi nfi:NFIA_077470.

Phylogenomic databases

eggNOGi COG1070.
HOGENOMi HOG000174850.
KOi K00854.
OMAi GSYSPID.
OrthoDBi EOG7CRTZN.

Family and domain databases

InterProi IPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view ]
Pfami PF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

Entry informationi

Entry nameiXKS1_NEOFI
AccessioniPrimary (citable) accession number: A1DEK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi