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A1DEK3

- XKS1_NEOFI

UniProt

A1DEK3 - XKS1_NEOFI

Protein

Probable D-xylulose kinase A

Gene

xkiA

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway By similarity.By similarity

    Catalytic activityi

    ATP + D-xylulose = ADP + D-xylulose 5-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei97 – 971SubstrateBy similarity
    Binding sitei168 – 1681SubstrateBy similarity
    Binding sitei284 – 2841SubstrateBy similarity
    Binding sitei285 – 2851SubstrateBy similarity
    Binding sitei366 – 3661ATPBy similarity
    Binding sitei475 – 4751ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi471 – 4722ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. xylulokinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. D-xylose metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Carbohydrate metabolism, Xylose metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable D-xylulose kinase A (EC:2.7.1.17)
    Short name:
    Xylulokinase A
    Gene namesi
    Name:xkiA
    ORF Names:NFIA_077470
    OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
    Taxonomic identifieri331117 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
    ProteomesiUP000006702: Unassembled WGS sequence

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 573573Probable D-xylulose kinase APRO_0000393526Add
    BLAST

    Expressioni

    Inductioni

    By D-xylose, L-arabinose or L-arabitol.

    Interactioni

    Protein-protein interaction databases

    STRINGi36630.CADNFIAP00007712.

    Structurei

    3D structure databases

    ProteinModelPortaliA1DEK3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FGGY kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG1070.
    HOGENOMiHOG000174850.
    KOiK00854.
    OMAiGSYSPID.
    OrthoDBiEOG7CRTZN.

    Family and domain databases

    InterProiIPR018485. Carb_kinase_FGGY_C.
    IPR018484. Carb_kinase_FGGY_N.
    [Graphical view]
    PfamiPF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1DEK3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSQGPLYIG FDLSTQQLKG LVVNSELKVV HVSKFDFDAD SHGFSIKKGV    50
    LTNEAEHEVF APVALWLQAL DGVLDGLRKQ GLDFSRVKGI SGAGQQHGSV 100
    YWGENAESLL KSLDSSKSLE EQLSGAFSHP FSPNWQDAST QKECDEFDAF 150
    LGGPEQLAEA TGSKAHHRFT GPQILRMQRK YPEVYRKTAR ISLVSSFLAS 200
    LLLGYIAPMD ISDVCGMNLW DIKKGAYNEK LLGLCAGPFG AEDLKRKLGD 250
    VPEDGGLRLG KINRYFVERY GFSSNCEILP STGDNPATIL ALPLRPSDAM 300
    VSLGTSTTFL MSTPSYKPDP ATHFFNHPTT PGLYMFMLCY KNGGLAREHV 350
    RDAINEKSGS GASQSWESFD KIMLETPPMG QKTESGPMKM GLFFPRPEIV 400
    PNVRSGQWRF TYDPASDTLT ETEDGWNKPS DEARAIVESQ MLSLRLRSRG 450
    LTQSPGDGLP PQPRRVYLVG GGSKNKAIAK VAGEILGGSD GVYKLDVGDN 500
    ACALGAAYKA VWAIERKPGQ TFEDLIGQRW REEEFIEKIA DGYQKGVFEK 550
    YGKAVEGFER MEQQVLKQEA ARK 573
    Length:573
    Mass (Da):63,054
    Last modified:January 23, 2007 - v1
    Checksum:i487BF898987F5640
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027696 Genomic DNA. Translation: EAW17810.1.
    RefSeqiXP_001259707.1. XM_001259706.1.

    Genome annotation databases

    EnsemblFungiiCADNFIAT00007879; CADNFIAP00007712; CADNFIAG00007879.
    GeneIDi4586369.
    KEGGinfi:NFIA_077470.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027696 Genomic DNA. Translation: EAW17810.1 .
    RefSeqi XP_001259707.1. XM_001259706.1.

    3D structure databases

    ProteinModelPortali A1DEK3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 36630.CADNFIAP00007712.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADNFIAT00007879 ; CADNFIAP00007712 ; CADNFIAG00007879 .
    GeneIDi 4586369.
    KEGGi nfi:NFIA_077470.

    Phylogenomic databases

    eggNOGi COG1070.
    HOGENOMi HOG000174850.
    KOi K00854.
    OMAi GSYSPID.
    OrthoDBi EOG7CRTZN.

    Family and domain databases

    InterProi IPR018485. Carb_kinase_FGGY_C.
    IPR018484. Carb_kinase_FGGY_N.
    [Graphical view ]
    Pfami PF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

    Entry informationi

    Entry nameiXKS1_NEOFI
    AccessioniPrimary (citable) accession number: A1DEK3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 20, 2010
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3