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A1DE13

- DCL1_NEOFI

UniProt

A1DE13 - DCL1_NEOFI

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Protein

Dicer-like protein 1

Gene

dcl1

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons By similarity.By similarity

Cofactori

Magnesium or manganese.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi1295 – 12951Magnesium or manganeseBy similarity
Sitei1388 – 13881Important for activityBy similarity
Metal bindingi1392 – 13921Magnesium or manganeseBy similarity
Metal bindingi1395 – 13951Magnesium or manganeseBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi147 – 1548ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. helicase activity Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
  4. ribonuclease III activity Source: InterPro
  5. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. defense response to virus Source: UniProtKB-KW
  2. regulation of defense response to virus Source: UniProtKB-KW
  3. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Antiviral protein, Helicase, Hydrolase

Keywords - Biological processi

Antiviral defense

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dicer-like protein 1
Including the following 2 domains:
Endoribonuclease dcl1 (EC:3.1.26.-)
ATP-dependent helicase dcl1 (EC:3.6.4.-)
Gene namesi
Name:dcl1
ORF Names:NFIA_075500
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
ProteomesiUP000006702: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15381538Dicer-like protein 1PRO_0000306782Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi36630.CADNFIAP00007382.

Structurei

3D structure databases

ProteinModelPortaliA1DE13.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini134 – 315182Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini460 – 619160Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini652 – 74291Dicer dsRNA-binding foldPROSITE-ProRule annotationAdd
BLAST
Domaini1044 – 1203160RNase III 1PROSITE-ProRule annotationAdd
BLAST
Domaini1254 – 1406153RNase III 2PROSITE-ProRule annotationAdd
BLAST
Domaini1440 – 150869DRBMAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi260 – 2634DEAH box

Sequence similaritiesi

Belongs to the helicase family. Dicer subfamily.PROSITE-ProRule annotation
Contains 1 Dicer dsRNA-binding fold domain.PROSITE-ProRule annotation
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation
Contains 2 RNase III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1111.
HOGENOMiHOG000048448.
KOiK11592.
OMAiNERPRIL.
OrthoDBiEOG76QFRP.

Family and domain databases

Gene3Di1.10.1520.10. 2 hits.
3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR005034. Dicer_dimerisation_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR000999. RNase_III_dom.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF03368. Dicer_dimer. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00636. Ribonuclease_3. 2 hits.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00535. RIBOc. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF69065. SSF69065. 3 hits.
PROSITEiPS51327. DICER_DSRBF. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1DE13-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTEQISLVDV SSSVSLKGED SSNVALLRDL FINDVAASDP AESSADVHKD
60 70 80 90 100
EHSSDNSDND NEAVPKPNDF SQRRRIQNAQ FEALLSKRTD ADSNEAIDRA
110 120 130 140 150
PIALSDDELS IAHLVEKQDL GNGMLDPREY QIELFERAKT QNTIAVLDTG
160 170 180 190 200
SGKTLIAVLL LRHTILNELD NRANGKPHRV SFFLVDSVTL AYQQAAVLRN
210 220 230 240 250
NIDQNVAHFF GAMGTDLWDK RTWDEHLQRN MVIVCTAEIL NQCLLNSYVK
260 270 280 290 300
MDQINLLIFD EAHHAKKDHP YARIIRDSYF KAQPSQRPRV FGMTASPIDT
310 320 330 340 350
KGDITEAATR LETLLDSRIA TTSKITLLRE VVSRPIEKVW AYNRLESPFA
360 370 380 390 400
TELYKLMDTR YGNIKVLEGV YRFAWHASSE LGKWCSDRAW WHALADDVLP
410 420 430 440 450
KLEGNISKLV ESNTLNAEHG AVFKDIIRIR EASETVKNYS FADPELPGEL
460 470 480 490 500
SPKVQLLRME LSKHFSDTTG TKCIVFTQKR YTAKILNELF TVLNIPHLRP
510 520 530 540 550
GVLIGVRPGD IGGMNVTFRQ QFLALVKFRT GEINCLFATS VAEEGLDIPD
560 570 580 590 600
CNLVVRFDLY RTLIQYVQSR GRARHCTSTY AIMVEKDNAE HEGRLKEIRE
610 620 630 640 650
AEKIMQRFCE TLPEDRILHG NDHDLDSLLQ EEEGRRTFTV KSTGAKLTYH
660 670 680 690 700
SAIAILARYA SSLQYEKETV PQVTYVVGHV SNAYVCEVIL PEKSPIRGLT
710 720 730 740 750
GSPAIRKAVA KQSAAFDTCL LLRKHRLLDD YFNSIYHRRL PAMRNAKLAI
760 770 780 790 800
TCKRTNEYDM LLKPSIWAKQ RTTPIDKLYG IHISLLPSKP LSRDHRPILL
810 820 830 840 850
LTREKLPEFP AFSIYLDEDV ETKVLSYPLK HGLQISVDEL QSLTTFTLRI
860 870 880 890 900
FRDIFHKVYE HEVQKMPYWL APAKALDGPG SGTNPRDWTD WDTVSFVHNN
910 920 930 940 950
DEIPFTRDLN PDSLVNRFIF DNWDGRFRYF TVAVADTLQP SDPPPPSVPR
960 970 980 990 1000
RRHMNNIMNY TLSLSKNSRA RFFSGCDWNQ PVLQAELVRL RRNLLDKMTT
1010 1020 1030 1040 1050
QEKEMQTECF ICAEPLRISA IPTSIVSTCL AFPAIISRLD SYLIALEACD
1060 1070 1080 1090 1100
ELELVIRPDF ALEAFTKDSD NTEEHRGQQI HFQRGMGKNY ERLEFLGDCF
1110 1120 1130 1140 1150
LKMATSIALY TQNPDDDEFD YHVNRMCLIC NKNLFNTAIK KQIYRYIRSR
1160 1170 1180 1190 1200
GFSRHIWYPD GLTLLHGKDH SKKLLSEGKH ALGEKTIADV CEALIGASLL
1210 1220 1230 1240 1250
SGGPENRFDM ATKAVTALVD SPSHRVSCWK EYITLYTMPK YQTEKPRGSE
1260 1270 1280 1290 1300
DDLARHVEEE LGYHFTYPRL LASAITHPSL PSTWGYRVPC YQRLEFLGDS
1310 1320 1330 1340 1350
LLDMVCVEDL FRRFPDRDPQ WLTEHKMAMV SNKFLGALSV KLGFHRRIMA
1360 1370 1380 1390 1400
FSNPLQAQIT HYVEEIESAQ AESRGAVDYW VVAKDPPKCL PDMVEAYLGA
1410 1420 1430 1440 1450
IFVDSKFDFQ VIEVFFERQI KPFFEDMSIY DTFANKHPTT FLHNKLTNEY
1460 1470 1480 1490 1500
GCTNYCLKAG ELPTIDGAPA GVLAAVIVHG NVISEARSSS SRYAKVKASE
1510 1520 1530
KALAVLDGLL PFEFCQKYHC GCKETQNSSS AVEIGTAI
Length:1,538
Mass (Da):174,902
Last modified:January 23, 2007 - v1
Checksum:i22BFCACC1932BB46
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027696 Genomic DNA. Translation: EAW17620.1.
RefSeqiXP_001259517.1. XM_001259516.1.

Genome annotation databases

EnsemblFungiiCADNFIAT00007549; CADNFIAP00007382; CADNFIAG00007549.
GeneIDi4586299.
KEGGinfi:NFIA_075500.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027696 Genomic DNA. Translation: EAW17620.1 .
RefSeqi XP_001259517.1. XM_001259516.1.

3D structure databases

ProteinModelPortali A1DE13.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 36630.CADNFIAP00007382.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADNFIAT00007549 ; CADNFIAP00007382 ; CADNFIAG00007549 .
GeneIDi 4586299.
KEGGi nfi:NFIA_075500.

Phylogenomic databases

eggNOGi COG1111.
HOGENOMi HOG000048448.
KOi K11592.
OMAi NERPRIL.
OrthoDBi EOG76QFRP.

Family and domain databases

Gene3Di 1.10.1520.10. 2 hits.
3.40.50.300. 2 hits.
InterProi IPR011545. DEAD/DEAH_box_helicase_dom.
IPR005034. Dicer_dimerisation_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR000999. RNase_III_dom.
[Graphical view ]
Pfami PF00270. DEAD. 1 hit.
PF03368. Dicer_dimer. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00636. Ribonuclease_3. 2 hits.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00535. RIBOc. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF69065. SSF69065. 3 hits.
PROSITEi PS51327. DICER_DSRBF. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

Entry informationi

Entry nameiDCL1_NEOFI
AccessioniPrimary (citable) accession number: A1DE13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3