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A1DE13

- DCL1_NEOFI

UniProt

A1DE13 - DCL1_NEOFI

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Protein
Dicer-like protein 1
Gene
dcl1, NFIA_075500
Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons By similarity.

Cofactori

Magnesium or manganese By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi1295 – 12951Magnesium or manganese By similarity
Sitei1388 – 13881Important for activity By similarity
Metal bindingi1392 – 13921Magnesium or manganese By similarity
Metal bindingi1395 – 13951Magnesium or manganese By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi147 – 1548ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. RNA binding Source: UniProtKB-KW
  3. helicase activity Source: UniProtKB-KW
  4. metal ion binding Source: UniProtKB-KW
  5. ribonuclease III activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. RNA processing Source: InterPro
  2. defense response to virus Source: UniProtKB-KW
  3. regulation of defense response to virus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antiviral protein, Helicase, Hydrolase

Keywords - Biological processi

Antiviral defense

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dicer-like protein 1
Including the following 2 domains:
Endoribonuclease dcl1 (EC:3.1.26.-)
ATP-dependent helicase dcl1 (EC:3.6.4.-)
Gene namesi
Name:dcl1
ORF Names:NFIA_075500
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
ProteomesiUP000006702: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15381538Dicer-like protein 1
PRO_0000306782Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi36630.CADNFIAP00007382.

Structurei

3D structure databases

ProteinModelPortaliA1DE13.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini134 – 315182Helicase ATP-binding
Add
BLAST
Domaini460 – 619160Helicase C-terminal
Add
BLAST
Domaini652 – 74291Dicer dsRNA-binding fold
Add
BLAST
Domaini1044 – 1203160RNase III 1
Add
BLAST
Domaini1254 – 1406153RNase III 2
Add
BLAST
Domaini1440 – 150869DRBM
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi260 – 2634DEAH box

Sequence similaritiesi

Contains 2 RNase III domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1111.
HOGENOMiHOG000048448.
KOiK11592.
OMAiNERPRIL.
OrthoDBiEOG76QFRP.

Family and domain databases

Gene3Di1.10.1520.10. 2 hits.
3.40.50.300. 2 hits.
InterProiIPR005034. Dicer_dimerisation_dom.
IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR000999. RNase_III_dom.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF03368. Dicer_dimer. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00636. Ribonuclease_3. 2 hits.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00535. RIBOc. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF69065. SSF69065. 3 hits.
PROSITEiPS51327. DICER_DSRBF. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1DE13-1 [UniParc]FASTAAdd to Basket

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MTEQISLVDV SSSVSLKGED SSNVALLRDL FINDVAASDP AESSADVHKD     50
EHSSDNSDND NEAVPKPNDF SQRRRIQNAQ FEALLSKRTD ADSNEAIDRA 100
PIALSDDELS IAHLVEKQDL GNGMLDPREY QIELFERAKT QNTIAVLDTG 150
SGKTLIAVLL LRHTILNELD NRANGKPHRV SFFLVDSVTL AYQQAAVLRN 200
NIDQNVAHFF GAMGTDLWDK RTWDEHLQRN MVIVCTAEIL NQCLLNSYVK 250
MDQINLLIFD EAHHAKKDHP YARIIRDSYF KAQPSQRPRV FGMTASPIDT 300
KGDITEAATR LETLLDSRIA TTSKITLLRE VVSRPIEKVW AYNRLESPFA 350
TELYKLMDTR YGNIKVLEGV YRFAWHASSE LGKWCSDRAW WHALADDVLP 400
KLEGNISKLV ESNTLNAEHG AVFKDIIRIR EASETVKNYS FADPELPGEL 450
SPKVQLLRME LSKHFSDTTG TKCIVFTQKR YTAKILNELF TVLNIPHLRP 500
GVLIGVRPGD IGGMNVTFRQ QFLALVKFRT GEINCLFATS VAEEGLDIPD 550
CNLVVRFDLY RTLIQYVQSR GRARHCTSTY AIMVEKDNAE HEGRLKEIRE 600
AEKIMQRFCE TLPEDRILHG NDHDLDSLLQ EEEGRRTFTV KSTGAKLTYH 650
SAIAILARYA SSLQYEKETV PQVTYVVGHV SNAYVCEVIL PEKSPIRGLT 700
GSPAIRKAVA KQSAAFDTCL LLRKHRLLDD YFNSIYHRRL PAMRNAKLAI 750
TCKRTNEYDM LLKPSIWAKQ RTTPIDKLYG IHISLLPSKP LSRDHRPILL 800
LTREKLPEFP AFSIYLDEDV ETKVLSYPLK HGLQISVDEL QSLTTFTLRI 850
FRDIFHKVYE HEVQKMPYWL APAKALDGPG SGTNPRDWTD WDTVSFVHNN 900
DEIPFTRDLN PDSLVNRFIF DNWDGRFRYF TVAVADTLQP SDPPPPSVPR 950
RRHMNNIMNY TLSLSKNSRA RFFSGCDWNQ PVLQAELVRL RRNLLDKMTT 1000
QEKEMQTECF ICAEPLRISA IPTSIVSTCL AFPAIISRLD SYLIALEACD 1050
ELELVIRPDF ALEAFTKDSD NTEEHRGQQI HFQRGMGKNY ERLEFLGDCF 1100
LKMATSIALY TQNPDDDEFD YHVNRMCLIC NKNLFNTAIK KQIYRYIRSR 1150
GFSRHIWYPD GLTLLHGKDH SKKLLSEGKH ALGEKTIADV CEALIGASLL 1200
SGGPENRFDM ATKAVTALVD SPSHRVSCWK EYITLYTMPK YQTEKPRGSE 1250
DDLARHVEEE LGYHFTYPRL LASAITHPSL PSTWGYRVPC YQRLEFLGDS 1300
LLDMVCVEDL FRRFPDRDPQ WLTEHKMAMV SNKFLGALSV KLGFHRRIMA 1350
FSNPLQAQIT HYVEEIESAQ AESRGAVDYW VVAKDPPKCL PDMVEAYLGA 1400
IFVDSKFDFQ VIEVFFERQI KPFFEDMSIY DTFANKHPTT FLHNKLTNEY 1450
GCTNYCLKAG ELPTIDGAPA GVLAAVIVHG NVISEARSSS SRYAKVKASE 1500
KALAVLDGLL PFEFCQKYHC GCKETQNSSS AVEIGTAI 1538
Length:1,538
Mass (Da):174,902
Last modified:January 23, 2007 - v1
Checksum:i22BFCACC1932BB46
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027696 Genomic DNA. Translation: EAW17620.1.
RefSeqiXP_001259517.1. XM_001259516.1.

Genome annotation databases

EnsemblFungiiCADNFIAT00007549; CADNFIAP00007382; CADNFIAG00007549.
GeneIDi4586299.
KEGGinfi:NFIA_075500.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027696 Genomic DNA. Translation: EAW17620.1 .
RefSeqi XP_001259517.1. XM_001259516.1.

3D structure databases

ProteinModelPortali A1DE13.
ModBasei Search...

Protein-protein interaction databases

STRINGi 36630.CADNFIAP00007382.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADNFIAT00007549 ; CADNFIAP00007382 ; CADNFIAG00007549 .
GeneIDi 4586299.
KEGGi nfi:NFIA_075500.

Phylogenomic databases

eggNOGi COG1111.
HOGENOMi HOG000048448.
KOi K11592.
OMAi NERPRIL.
OrthoDBi EOG76QFRP.

Family and domain databases

Gene3Di 1.10.1520.10. 2 hits.
3.40.50.300. 2 hits.
InterProi IPR005034. Dicer_dimerisation_dom.
IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR000999. RNase_III_dom.
[Graphical view ]
Pfami PF00270. DEAD. 1 hit.
PF03368. Dicer_dimer. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00636. Ribonuclease_3. 2 hits.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00535. RIBOc. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF69065. SSF69065. 3 hits.
PROSITEi PS51327. DICER_DSRBF. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

Entry informationi

Entry nameiDCL1_NEOFI
AccessioniPrimary (citable) accession number: A1DE13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi