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A1DBH2

- MYO1_NEOFI

UniProt

A1DBH2 - MYO1_NEOFI

Protein

Myosin-1

Gene

myoA

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Plays an important role in polarized growth, spore germination, hyphal morphogenesis, and septal wall formation By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi144 – 1518ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. motor activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Motor protein, Myosin

    Keywords - Ligandi

    Actin-binding, ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myosin-1
    Alternative name(s):
    Class I unconventional myosin
    Type I myosin
    Gene namesi
    Name:myoA
    ORF Names:NFIA_098420
    OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
    Taxonomic identifieri331117 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
    ProteomesiUP000006702: Unassembled WGS sequence

    Subcellular locationi

    Cytoplasmcytoskeletonactin patch By similarity
    Note: Localizes to cortical patch-like structures. Enriched at sites of polarized growth, like the growing hyphal tips and sites of septum formation By similarity.By similarity

    GO - Cellular componenti

    1. actin cortical patch Source: UniProtKB-SubCell
    2. myosin complex Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12501250Myosin-1PRO_0000338557Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei372 – 3721PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylation of the TEDS site (Ser-372) is required for the polarization of the actin cytoskeleton. Phosphorylation probably activates the myosin-I ATPase activity By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi36630.CADNFIAP00009077.

    Structurei

    3D structure databases

    ProteinModelPortaliA1DBH2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini51 – 730680Myosin motorAdd
    BLAST
    Domaini734 – 75421IQ 1Add
    BLAST
    Domaini755 – 78026IQ 2Add
    BLAST
    Domaini1076 – 113762SH3PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni419 – 50183Actin-bindingBy similarityAdd
    BLAST
    Regioni781 – 978198Basic, putative membrane-binding regionBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi974 – 1196223Pro-richAdd
    BLAST
    Compositional biasi1015 – 107561Ala-richAdd
    BLAST
    Compositional biasi1150 – 118839Ala-richAdd
    BLAST
    Compositional biasi1245 – 12495Poly-Asp

    Domaini

    The myosin motor domain displays actin-stimulated ATPase activity and generates a mechanochemical force.By similarity
    The tail domain participates in molecular interactions that specify the role of the motor domain By similarity. It is composed of several tail homology (TH) domains, namely a putative phospholipid-binding domain (TH1), an Ala- and Pro-rich domain (TH2), followed by an SH3 domain and a C-terminal acidic domain (TH3).By similarity

    Sequence similaritiesi

    Contains 2 IQ domains.Curated
    Contains 1 myosin motor domain.Curated
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, SH3 domain

    Phylogenomic databases

    eggNOGiCOG5022.
    HOGENOMiHOG000260265.
    KOiK10356.
    OMAiGNVLHQI.
    OrthoDBiEOG7VDXXK.

    Family and domain databases

    InterProiIPR001609. Myosin_head_motor_dom.
    IPR010926. Myosin_tail_2.
    IPR027417. P-loop_NTPase.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00063. Myosin_head. 1 hit.
    PF06017. Myosin_TH1. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    PRINTSiPR00193. MYOSINHEAVY.
    SMARTiSM00242. MYSc. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS51456. MYOSIN_MOTOR. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1DBH2-1 [UniParc]FASTAAdd to Basket

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    MGHSRRPAGG EKKSRGFGRS KAAADVGDGR QTGGKPQVKK ATFESTKKKE     50
    IGVSDLTLLS KISNEAINDN LKLRFEHDEI YTYIGHVLVS VNPFQDLGIY 100
    TDNVLQSYRG KNRLEVPPHV FAVAESAYYN MKSYKDNQCV IISGESGAGK 150
    TEAAKRIMQY IASVSGGTDS SIQHTKEMVL ATNPLLESFG NAKTLRNNNS 200
    SRFGKYLELE FNTNGEPVGA NITNYLLEKS RVVGQITNER NFHIFYQFTK 250
    AAPQKYRDLF GIQQPQSYLY TSRSKCYDVP GVDDSAEFRD TLNAMNVIGM 300
    TEGEQDDVFR MLAAILWIGN VQFAEDDSGN AVITDQSVVD YVAYLLEVDA 350
    AQVNKAFTIR VMETARGGRR GSVYEVPLNT VQALAVRDAL AKAIYFNLFD 400
    WIVQRVNASL TARGEVANSI GILDIYGFEI FEKNSFEQLC INYVNEKLQQ 450
    IFIQLTLKAE QDEYAREQIQ WTPIKYFDNK VVCSLIEDKR PPGVFAALND 500
    ACATAHADSS AADNTFVGRL NFLSQNPNFE NRQGQFIVKH YAGDVSYAVA 550
    GMTDKNKDQL LKDLLNLVGT SGNQFVHTLF PEQVNQDDKR RPPTASDKIK 600
    ASANDLVATL MKAQPSYIRT IKPNDNKAPK EYNVGNVLHQ IKYLGLQENV 650
    RIRRAGFAYR QTFDKFVERF YLLSPKTSYA GDYTWTGDAE SGARQILKDT 700
    SIPAEEYQMG ITKVFVKTPE TLFALEAMRD RYWHNMAIRI QRAWRNYLRY 750
    RTECAIRIQR FWRRTTGGLE FIKLRDQGHQ LLNGRKERRR MSLLGSRRFL 800
    GDYIGVGNKG GPGEMVRNGA GISGSEDILF SCRGEVLVSK FGRSSKPAPR 850
    ILVLTNRHVY IIAQNLVNNQ LVISSERTIP IGAIKAVSAS NLKDDWFSIV 900
    VGSPQEPDPL VNCVFKTEFF THLNNTLHGQ LNLKIADHIE YNKKPGKLAT 950
    VKVVKDPAVA RDDSYKSGTI HTGPGEPANS VSKPTPRPKQ VSARPVTKGK 1000
    LLRPGGPGGG PSKLAARPTP AAQPLPRATP QPAAPQPAAR AVPQPVAAVA 1050
    ASHTRTGSTA SVRAPPPPPP AAAPAPKKPT AKVLYDFNSQ QSNELSIKAG 1100
    EIVQIVSKEG NGWWLCMNMT TSAQGWTPEA YLEEQVAPTP KPAPPPPPPA 1150
    APRSTPAPAT NGAAAAAKAK PAPPAPPAKR PNMAARKAVP TPPPAPRDSA 1200
    VSMNSHDSSG GSGRGTPNSM SNASLAGGLA EALRARQHAM QGKQDDDDDW 1250
    Length:1,250
    Mass (Da):137,301
    Last modified:January 23, 2007 - v1
    Checksum:i1E806FE5DAEF438B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027694 Genomic DNA. Translation: EAW20212.1.
    RefSeqiXP_001262109.1. XM_001262108.1.

    Genome annotation databases

    EnsemblFungiiCADNFIAT00009291; CADNFIAP00009077; CADNFIAG00009291.
    GeneIDi4588724.
    KEGGinfi:NFIA_098420.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027694 Genomic DNA. Translation: EAW20212.1 .
    RefSeqi XP_001262109.1. XM_001262108.1.

    3D structure databases

    ProteinModelPortali A1DBH2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 36630.CADNFIAP00009077.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADNFIAT00009291 ; CADNFIAP00009077 ; CADNFIAG00009291 .
    GeneIDi 4588724.
    KEGGi nfi:NFIA_098420.

    Phylogenomic databases

    eggNOGi COG5022.
    HOGENOMi HOG000260265.
    KOi K10356.
    OMAi GNVLHQI.
    OrthoDBi EOG7VDXXK.

    Family and domain databases

    InterProi IPR001609. Myosin_head_motor_dom.
    IPR010926. Myosin_tail_2.
    IPR027417. P-loop_NTPase.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00063. Myosin_head. 1 hit.
    PF06017. Myosin_TH1. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00193. MYOSINHEAVY.
    SMARTi SM00242. MYSc. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS51456. MYOSIN_MOTOR. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

    Entry informationi

    Entry nameiMYO1_NEOFI
    AccessioniPrimary (citable) accession number: A1DBH2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3