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A1DBH2

- MYO1_NEOFI

UniProt

A1DBH2 - MYO1_NEOFI

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Protein
Myosin-1
Gene
myoA, NFIA_098420
Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Plays an important role in polarized growth, spore germination, hyphal morphogenesis, and septal wall formation By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi144 – 1518ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. motor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Motor protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-1
Alternative name(s):
Class I unconventional myosin
Type I myosin
Gene namesi
Name:myoA
ORF Names:NFIA_098420
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
ProteomesiUP000006702: Unassembled WGS sequence

Subcellular locationi

Cytoplasmcytoskeletonactin patch By similarity
Note: Localizes to cortical patch-like structures. Enriched at sites of polarized growth, like the growing hyphal tips and sites of septum formation By similarity.

GO - Cellular componenti

  1. actin cortical patch Source: UniProtKB-SubCell
  2. myosin complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12501250Myosin-1
PRO_0000338557Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei372 – 3721Phosphoserine By similarity

Post-translational modificationi

Phosphorylation of the TEDS site (Ser-372) is required for the polarization of the actin cytoskeleton. Phosphorylation probably activates the myosin-I ATPase activity By similarity.

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi36630.CADNFIAP00009077.

Structurei

3D structure databases

ProteinModelPortaliA1DBH2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 730680Myosin motor
Add
BLAST
Domaini734 – 75421IQ 1
Add
BLAST
Domaini755 – 78026IQ 2
Add
BLAST
Domaini1076 – 113762SH3
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni419 – 50183Actin-binding By similarity
Add
BLAST
Regioni781 – 978198Basic, putative membrane-binding region By similarity
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi974 – 1196223Pro-rich
Add
BLAST
Compositional biasi1015 – 107561Ala-rich
Add
BLAST
Compositional biasi1150 – 118839Ala-rich
Add
BLAST
Compositional biasi1245 – 12495Poly-Asp

Domaini

The myosin motor domain displays actin-stimulated ATPase activity and generates a mechanochemical force By similarity.
The tail domain participates in molecular interactions that specify the role of the motor domain By similarity. It is composed of several tail homology (TH) domains, namely a putative phospholipid-binding domain (TH1), an Ala- and Pro-rich domain (TH2), followed by an SH3 domain and a C-terminal acidic domain (TH3).

Sequence similaritiesi

Contains 2 IQ domains.
Contains 1 SH3 domain.

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiCOG5022.
HOGENOMiHOG000260265.
KOiK10356.
OMAiGNVLHQI.
OrthoDBiEOG7VDXXK.

Family and domain databases

InterProiIPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_tail_2.
IPR027417. P-loop_NTPase.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00242. MYSc. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51456. MYOSIN_MOTOR. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1DBH2-1 [UniParc]FASTAAdd to Basket

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MGHSRRPAGG EKKSRGFGRS KAAADVGDGR QTGGKPQVKK ATFESTKKKE     50
IGVSDLTLLS KISNEAINDN LKLRFEHDEI YTYIGHVLVS VNPFQDLGIY 100
TDNVLQSYRG KNRLEVPPHV FAVAESAYYN MKSYKDNQCV IISGESGAGK 150
TEAAKRIMQY IASVSGGTDS SIQHTKEMVL ATNPLLESFG NAKTLRNNNS 200
SRFGKYLELE FNTNGEPVGA NITNYLLEKS RVVGQITNER NFHIFYQFTK 250
AAPQKYRDLF GIQQPQSYLY TSRSKCYDVP GVDDSAEFRD TLNAMNVIGM 300
TEGEQDDVFR MLAAILWIGN VQFAEDDSGN AVITDQSVVD YVAYLLEVDA 350
AQVNKAFTIR VMETARGGRR GSVYEVPLNT VQALAVRDAL AKAIYFNLFD 400
WIVQRVNASL TARGEVANSI GILDIYGFEI FEKNSFEQLC INYVNEKLQQ 450
IFIQLTLKAE QDEYAREQIQ WTPIKYFDNK VVCSLIEDKR PPGVFAALND 500
ACATAHADSS AADNTFVGRL NFLSQNPNFE NRQGQFIVKH YAGDVSYAVA 550
GMTDKNKDQL LKDLLNLVGT SGNQFVHTLF PEQVNQDDKR RPPTASDKIK 600
ASANDLVATL MKAQPSYIRT IKPNDNKAPK EYNVGNVLHQ IKYLGLQENV 650
RIRRAGFAYR QTFDKFVERF YLLSPKTSYA GDYTWTGDAE SGARQILKDT 700
SIPAEEYQMG ITKVFVKTPE TLFALEAMRD RYWHNMAIRI QRAWRNYLRY 750
RTECAIRIQR FWRRTTGGLE FIKLRDQGHQ LLNGRKERRR MSLLGSRRFL 800
GDYIGVGNKG GPGEMVRNGA GISGSEDILF SCRGEVLVSK FGRSSKPAPR 850
ILVLTNRHVY IIAQNLVNNQ LVISSERTIP IGAIKAVSAS NLKDDWFSIV 900
VGSPQEPDPL VNCVFKTEFF THLNNTLHGQ LNLKIADHIE YNKKPGKLAT 950
VKVVKDPAVA RDDSYKSGTI HTGPGEPANS VSKPTPRPKQ VSARPVTKGK 1000
LLRPGGPGGG PSKLAARPTP AAQPLPRATP QPAAPQPAAR AVPQPVAAVA 1050
ASHTRTGSTA SVRAPPPPPP AAAPAPKKPT AKVLYDFNSQ QSNELSIKAG 1100
EIVQIVSKEG NGWWLCMNMT TSAQGWTPEA YLEEQVAPTP KPAPPPPPPA 1150
APRSTPAPAT NGAAAAAKAK PAPPAPPAKR PNMAARKAVP TPPPAPRDSA 1200
VSMNSHDSSG GSGRGTPNSM SNASLAGGLA EALRARQHAM QGKQDDDDDW 1250
Length:1,250
Mass (Da):137,301
Last modified:January 23, 2007 - v1
Checksum:i1E806FE5DAEF438B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027694 Genomic DNA. Translation: EAW20212.1.
RefSeqiXP_001262109.1. XM_001262108.1.

Genome annotation databases

EnsemblFungiiCADNFIAT00009291; CADNFIAP00009077; CADNFIAG00009291.
GeneIDi4588724.
KEGGinfi:NFIA_098420.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027694 Genomic DNA. Translation: EAW20212.1 .
RefSeqi XP_001262109.1. XM_001262108.1.

3D structure databases

ProteinModelPortali A1DBH2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 36630.CADNFIAP00009077.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADNFIAT00009291 ; CADNFIAP00009077 ; CADNFIAG00009291 .
GeneIDi 4588724.
KEGGi nfi:NFIA_098420.

Phylogenomic databases

eggNOGi COG5022.
HOGENOMi HOG000260265.
KOi K10356.
OMAi GNVLHQI.
OrthoDBi EOG7VDXXK.

Family and domain databases

InterProi IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_tail_2.
IPR027417. P-loop_NTPase.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR00193. MYOSINHEAVY.
SMARTi SM00242. MYSc. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEi PS51456. MYOSIN_MOTOR. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

Entry informationi

Entry nameiMYO1_NEOFI
AccessioniPrimary (citable) accession number: A1DBH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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