Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A1DBH2

- MYO1_NEOFI

UniProt

A1DBH2 - MYO1_NEOFI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Myosin-1

Gene

myoA

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Plays an important role in polarized growth, spore germination, hyphal morphogenesis, and septal wall formation (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi144 – 1518ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. motor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Motor protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-1
Alternative name(s):
Class I unconventional myosin
Type I myosin
Gene namesi
Name:myoA
ORF Names:NFIA_098420
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
ProteomesiUP000006702: Unassembled WGS sequence

Subcellular locationi

Cytoplasmcytoskeletonactin patch By similarity
Note: Localizes to cortical patch-like structures. Enriched at sites of polarized growth, like the growing hyphal tips and sites of septum formation (By similarity).By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. myosin complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12501250Myosin-1PRO_0000338557Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei372 – 3721PhosphoserineBy similarity

Post-translational modificationi

Phosphorylation of the TEDS site (Ser-372) is required for the polarization of the actin cytoskeleton. Phosphorylation probably activates the myosin-I ATPase activity (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi36630.CADNFIAP00009077.

Structurei

3D structure databases

ProteinModelPortaliA1DBH2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 730680Myosin motorAdd
BLAST
Domaini734 – 75421IQ 1Add
BLAST
Domaini755 – 78026IQ 2Add
BLAST
Domaini774 – 976203Myosin tailSequence AnalysisAdd
BLAST
Domaini1076 – 113762SH3PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni419 – 50183Actin-bindingBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi974 – 1196223Pro-richAdd
BLAST
Compositional biasi1015 – 107561Ala-richAdd
BLAST
Compositional biasi1150 – 118839Ala-richAdd
BLAST
Compositional biasi1245 – 12495Poly-Asp

Domaini

The myosin motor domain displays actin-stimulated ATPase activity and generates a mechanochemical force.By similarity
The tail domain participates in molecular interactions that specify the role of the motor domain (By similarity). It is composed of several tail homology (TH) domains, namely a putative phospholipid-binding myosin tail domain (also named TH1), an Ala- and Pro-rich domain (TH2), followed by an SH3 domain and a C-terminal acidic domain (TH3).By similarity

Sequence similaritiesi

Contains 2 IQ domains.Curated
Contains 1 myosin motor domain.Curated
Contains 1 myosin tail domain.Curated
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiCOG5022.
HOGENOMiHOG000260265.
KOiK10356.
OMAiGNVLHQI.
OrthoDBiEOG7VDXXK.

Family and domain databases

InterProiIPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_tail_2.
IPR027417. P-loop_NTPase.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00242. MYSc. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51456. MYOSIN_MOTOR. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1DBH2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGHSRRPAGG EKKSRGFGRS KAAADVGDGR QTGGKPQVKK ATFESTKKKE
60 70 80 90 100
IGVSDLTLLS KISNEAINDN LKLRFEHDEI YTYIGHVLVS VNPFQDLGIY
110 120 130 140 150
TDNVLQSYRG KNRLEVPPHV FAVAESAYYN MKSYKDNQCV IISGESGAGK
160 170 180 190 200
TEAAKRIMQY IASVSGGTDS SIQHTKEMVL ATNPLLESFG NAKTLRNNNS
210 220 230 240 250
SRFGKYLELE FNTNGEPVGA NITNYLLEKS RVVGQITNER NFHIFYQFTK
260 270 280 290 300
AAPQKYRDLF GIQQPQSYLY TSRSKCYDVP GVDDSAEFRD TLNAMNVIGM
310 320 330 340 350
TEGEQDDVFR MLAAILWIGN VQFAEDDSGN AVITDQSVVD YVAYLLEVDA
360 370 380 390 400
AQVNKAFTIR VMETARGGRR GSVYEVPLNT VQALAVRDAL AKAIYFNLFD
410 420 430 440 450
WIVQRVNASL TARGEVANSI GILDIYGFEI FEKNSFEQLC INYVNEKLQQ
460 470 480 490 500
IFIQLTLKAE QDEYAREQIQ WTPIKYFDNK VVCSLIEDKR PPGVFAALND
510 520 530 540 550
ACATAHADSS AADNTFVGRL NFLSQNPNFE NRQGQFIVKH YAGDVSYAVA
560 570 580 590 600
GMTDKNKDQL LKDLLNLVGT SGNQFVHTLF PEQVNQDDKR RPPTASDKIK
610 620 630 640 650
ASANDLVATL MKAQPSYIRT IKPNDNKAPK EYNVGNVLHQ IKYLGLQENV
660 670 680 690 700
RIRRAGFAYR QTFDKFVERF YLLSPKTSYA GDYTWTGDAE SGARQILKDT
710 720 730 740 750
SIPAEEYQMG ITKVFVKTPE TLFALEAMRD RYWHNMAIRI QRAWRNYLRY
760 770 780 790 800
RTECAIRIQR FWRRTTGGLE FIKLRDQGHQ LLNGRKERRR MSLLGSRRFL
810 820 830 840 850
GDYIGVGNKG GPGEMVRNGA GISGSEDILF SCRGEVLVSK FGRSSKPAPR
860 870 880 890 900
ILVLTNRHVY IIAQNLVNNQ LVISSERTIP IGAIKAVSAS NLKDDWFSIV
910 920 930 940 950
VGSPQEPDPL VNCVFKTEFF THLNNTLHGQ LNLKIADHIE YNKKPGKLAT
960 970 980 990 1000
VKVVKDPAVA RDDSYKSGTI HTGPGEPANS VSKPTPRPKQ VSARPVTKGK
1010 1020 1030 1040 1050
LLRPGGPGGG PSKLAARPTP AAQPLPRATP QPAAPQPAAR AVPQPVAAVA
1060 1070 1080 1090 1100
ASHTRTGSTA SVRAPPPPPP AAAPAPKKPT AKVLYDFNSQ QSNELSIKAG
1110 1120 1130 1140 1150
EIVQIVSKEG NGWWLCMNMT TSAQGWTPEA YLEEQVAPTP KPAPPPPPPA
1160 1170 1180 1190 1200
APRSTPAPAT NGAAAAAKAK PAPPAPPAKR PNMAARKAVP TPPPAPRDSA
1210 1220 1230 1240 1250
VSMNSHDSSG GSGRGTPNSM SNASLAGGLA EALRARQHAM QGKQDDDDDW
Length:1,250
Mass (Da):137,301
Last modified:January 23, 2007 - v1
Checksum:i1E806FE5DAEF438B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027694 Genomic DNA. Translation: EAW20212.1.
RefSeqiXP_001262109.1. XM_001262108.1.

Genome annotation databases

EnsemblFungiiCADNFIAT00009291; CADNFIAP00009077; CADNFIAG00009291.
GeneIDi4588724.
KEGGinfi:NFIA_098420.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027694 Genomic DNA. Translation: EAW20212.1 .
RefSeqi XP_001262109.1. XM_001262108.1.

3D structure databases

ProteinModelPortali A1DBH2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 36630.CADNFIAP00009077.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADNFIAT00009291 ; CADNFIAP00009077 ; CADNFIAG00009291 .
GeneIDi 4588724.
KEGGi nfi:NFIA_098420.

Phylogenomic databases

eggNOGi COG5022.
HOGENOMi HOG000260265.
KOi K10356.
OMAi GNVLHQI.
OrthoDBi EOG7VDXXK.

Family and domain databases

InterProi IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_tail_2.
IPR027417. P-loop_NTPase.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR00193. MYOSINHEAVY.
SMARTi SM00242. MYSc. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEi PS51456. MYOSIN_MOTOR. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

Entry informationi

Entry nameiMYO1_NEOFI
AccessioniPrimary (citable) accession number: A1DBH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3