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Protein

Myosin-1

Gene

myoA

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Plays an important role in polarized growth, spore germination, hyphal morphogenesis, and septal wall formation (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi144 – 151ATPSequence analysis8

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Motor protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-1
Alternative name(s):
Class I unconventional myosin
Type I myosin
Gene namesi
Name:myoA
ORF Names:NFIA_098420
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006702 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:NFIA_098420.

Subcellular locationi

  • Cytoplasmcytoskeletonactin patch By similarity

  • Note: Localizes to cortical patch-like structures. Enriched at sites of polarized growth, like the growing hyphal tips and sites of septum formation (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003385571 – 1250Myosin-1Add BLAST1250

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei372PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation of the TEDS site (Ser-372) is required for the polarization of the actin cytoskeleton. Phosphorylation probably activates the myosin-I ATPase activity (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliA1DBH2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 730Myosin motorAdd BLAST680
Domaini734 – 754IQ 1Add BLAST21
Domaini755 – 780IQ 2Add BLAST26
Domaini788 – 978TH1PROSITE-ProRule annotationAdd BLAST191
Domaini1076 – 1137SH3PROSITE-ProRule annotationAdd BLAST62

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni419 – 501Actin-bindingBy similarityAdd BLAST83

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi974 – 1196Pro-richAdd BLAST223
Compositional biasi1015 – 1075Ala-richAdd BLAST61
Compositional biasi1150 – 1188Ala-richAdd BLAST39
Compositional biasi1245 – 1249Poly-Asp5

Domaini

The myosin motor domain displays actin-stimulated ATPase activity and generates a mechanochemical force.By similarity
The tail domain participates in molecular interactions that specify the role of the motor domain (By similarity). It is composed of several tail homology (TH) domains, namely a putative phospholipid-binding myosin tail domain (also named TH1), an Ala- and Pro-rich domain (TH2), followed by an SH3 domain and a C-terminal acidic domain (TH3).By similarity

Sequence similaritiesi

Contains 2 IQ domains.Curated
Contains 1 myosin motor domain.Curated
Contains 1 SH3 domain.PROSITE-ProRule annotation
Contains 1 TH1 (class I myosin tail homology) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

HOGENOMiHOG000260265.
KOiK10356.
OMAiLKLRFEH.
OrthoDBiEOG092C0QJU.

Family and domain databases

InterProiIPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_TH1.
IPR027417. P-loop_NTPase.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00242. MYSc. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51456. MYOSIN_MOTOR. 1 hit.
PS50002. SH3. 1 hit.
PS51757. TH1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1DBH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHSRRPAGG EKKSRGFGRS KAAADVGDGR QTGGKPQVKK ATFESTKKKE
60 70 80 90 100
IGVSDLTLLS KISNEAINDN LKLRFEHDEI YTYIGHVLVS VNPFQDLGIY
110 120 130 140 150
TDNVLQSYRG KNRLEVPPHV FAVAESAYYN MKSYKDNQCV IISGESGAGK
160 170 180 190 200
TEAAKRIMQY IASVSGGTDS SIQHTKEMVL ATNPLLESFG NAKTLRNNNS
210 220 230 240 250
SRFGKYLELE FNTNGEPVGA NITNYLLEKS RVVGQITNER NFHIFYQFTK
260 270 280 290 300
AAPQKYRDLF GIQQPQSYLY TSRSKCYDVP GVDDSAEFRD TLNAMNVIGM
310 320 330 340 350
TEGEQDDVFR MLAAILWIGN VQFAEDDSGN AVITDQSVVD YVAYLLEVDA
360 370 380 390 400
AQVNKAFTIR VMETARGGRR GSVYEVPLNT VQALAVRDAL AKAIYFNLFD
410 420 430 440 450
WIVQRVNASL TARGEVANSI GILDIYGFEI FEKNSFEQLC INYVNEKLQQ
460 470 480 490 500
IFIQLTLKAE QDEYAREQIQ WTPIKYFDNK VVCSLIEDKR PPGVFAALND
510 520 530 540 550
ACATAHADSS AADNTFVGRL NFLSQNPNFE NRQGQFIVKH YAGDVSYAVA
560 570 580 590 600
GMTDKNKDQL LKDLLNLVGT SGNQFVHTLF PEQVNQDDKR RPPTASDKIK
610 620 630 640 650
ASANDLVATL MKAQPSYIRT IKPNDNKAPK EYNVGNVLHQ IKYLGLQENV
660 670 680 690 700
RIRRAGFAYR QTFDKFVERF YLLSPKTSYA GDYTWTGDAE SGARQILKDT
710 720 730 740 750
SIPAEEYQMG ITKVFVKTPE TLFALEAMRD RYWHNMAIRI QRAWRNYLRY
760 770 780 790 800
RTECAIRIQR FWRRTTGGLE FIKLRDQGHQ LLNGRKERRR MSLLGSRRFL
810 820 830 840 850
GDYIGVGNKG GPGEMVRNGA GISGSEDILF SCRGEVLVSK FGRSSKPAPR
860 870 880 890 900
ILVLTNRHVY IIAQNLVNNQ LVISSERTIP IGAIKAVSAS NLKDDWFSIV
910 920 930 940 950
VGSPQEPDPL VNCVFKTEFF THLNNTLHGQ LNLKIADHIE YNKKPGKLAT
960 970 980 990 1000
VKVVKDPAVA RDDSYKSGTI HTGPGEPANS VSKPTPRPKQ VSARPVTKGK
1010 1020 1030 1040 1050
LLRPGGPGGG PSKLAARPTP AAQPLPRATP QPAAPQPAAR AVPQPVAAVA
1060 1070 1080 1090 1100
ASHTRTGSTA SVRAPPPPPP AAAPAPKKPT AKVLYDFNSQ QSNELSIKAG
1110 1120 1130 1140 1150
EIVQIVSKEG NGWWLCMNMT TSAQGWTPEA YLEEQVAPTP KPAPPPPPPA
1160 1170 1180 1190 1200
APRSTPAPAT NGAAAAAKAK PAPPAPPAKR PNMAARKAVP TPPPAPRDSA
1210 1220 1230 1240 1250
VSMNSHDSSG GSGRGTPNSM SNASLAGGLA EALRARQHAM QGKQDDDDDW
Length:1,250
Mass (Da):137,301
Last modified:January 23, 2007 - v1
Checksum:i1E806FE5DAEF438B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027694 Genomic DNA. Translation: EAW20212.1.
RefSeqiXP_001262109.1. XM_001262108.1.

Genome annotation databases

EnsemblFungiiCADNFIAT00009291; CADNFIAP00009077; CADNFIAG00009291.
GeneIDi4588724.
KEGGinfi:NFIA_098420.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027694 Genomic DNA. Translation: EAW20212.1.
RefSeqiXP_001262109.1. XM_001262108.1.

3D structure databases

ProteinModelPortaliA1DBH2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADNFIAT00009291; CADNFIAP00009077; CADNFIAG00009291.
GeneIDi4588724.
KEGGinfi:NFIA_098420.

Organism-specific databases

EuPathDBiFungiDB:NFIA_098420.

Phylogenomic databases

HOGENOMiHOG000260265.
KOiK10356.
OMAiLKLRFEH.
OrthoDBiEOG092C0QJU.

Family and domain databases

InterProiIPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_TH1.
IPR027417. P-loop_NTPase.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00242. MYSc. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51456. MYOSIN_MOTOR. 1 hit.
PS50002. SH3. 1 hit.
PS51757. TH1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYO1_NEOFI
AccessioniPrimary (citable) accession number: A1DBH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.