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Protein

Catalase-peroxidase

Gene

katG

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per monomer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei93Transition state stabilizerUniRule annotation1
Active sitei97Proton acceptorUniRule annotation1
Metal bindingi283Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei3412. NfCP01.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
ORF Names:NFIA_095260
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006702 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:NFIA_095260.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003541071 – 759Catalase-peroxidaseAdd BLAST759

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki96 ↔ 242Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-268)UniRule annotation
Cross-linki242 ↔ 268Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-96)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiA1DAL6.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA1DAL6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiEOG092C0YTX.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1DAL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQDKCPFKE QPSQPNFAGG GTSNKDWWPD RLKLNILRQH TAVSNPLDAD
60 70 80 90 100
FDYAAAFKSL DYEALKKDLR ALMTDSQDWW PADFGHYGGL FIRMAWHSAG
110 120 130 140 150
TYRVFDGRGG AGQGQQRFAP LNSWPDNVSL DKARRLLWPI KQKYGNKISW
160 170 180 190 200
ADLMILTGNV ALESMGFKTF GFAGGRPDTW EADEATYWGR ETTWLGNDAR
210 220 230 240 250
YAKGFSGSDK RGTLIADEDS HKTTHSRELE TPLAAAHMGL IYVNPEGPDG
260 270 280 290 300
NPDPIAAAHD IRDTFGRMAM NDEETVALIA GGHTFGKTHG AAPADNVGKE
310 320 330 340 350
PEAAGLEAQG LGWANKHGSG KGPDTITSGL EVTWTKTPTQ WSNNFLEYLF
360 370 380 390 400
KFEWELTKSP AGAHQWVAKN ADEIIPHAYD ASKKRKPTML TTDLSLRFDP
410 420 430 440 450
AYEKIARRFL EHPDQFADAF ARAWFKLTHR DMGPRARYLG PEVPSEVLIW
460 470 480 490 500
QDPIPAVNHP LVDASDIATL KDEILASGVP FRSFISTAWA AASTFRGSDK
510 520 530 540 550
RGGANGARIR LAPQRDWEAN NQPWLREALS ALEAVQSRFN SRGDGKKVSL
560 570 580 590 600
ADLIVLAGCA AVEKAAQDAG HPIKVPFVPG RMDASQEETD VQSFSHMEPF
610 620 630 640 650
ADGFRNFAKG PARPRAEHYL VDKAQLLNLS APEMTVLVGG LRVLNTNYDG
660 670 680 690 700
SAHGVFTSRP GALSNDFFVH LLDMNTAWKD AGNGELFEGS DRKTGGKKWT
710 720 730 740 750
ATRADLVFGS NAELRAIAEV YASNDGDMKF VKDFVAAWNK VMNLDRFDLK

GKQTIPARL
Length:759
Mass (Da):83,763
Last modified:January 23, 2007 - v1
Checksum:iD24A7E1F599954A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027694 Genomic DNA. Translation: EAW19906.1.
RefSeqiXP_001261803.1. XM_001261802.1.

Genome annotation databases

EnsemblFungiiCADNFIAT00009101; CADNFIAP00008887; CADNFIAG00009101.
GeneIDi4588896.
KEGGinfi:NFIA_095260.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027694 Genomic DNA. Translation: EAW19906.1.
RefSeqiXP_001261803.1. XM_001261802.1.

3D structure databases

ProteinModelPortaliA1DAL6.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

PeroxiBasei3412. NfCP01.

Proteomic databases

PRIDEiA1DAL6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADNFIAT00009101; CADNFIAP00008887; CADNFIAG00009101.
GeneIDi4588896.
KEGGinfi:NFIA_095260.

Organism-specific databases

EuPathDBiFungiDB:NFIA_095260.

Phylogenomic databases

HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiEOG092C0YTX.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_NEOFI
AccessioniPrimary (citable) accession number: A1DAL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: January 23, 2007
Last modified: October 5, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.