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Protein

Methionine aminopeptidase 2-3

Gene

NFIA_093940

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).UniRule annotation

Catalytic activityi

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotation

Cofactori

Co2+UniRule annotation, Zn2+UniRule annotation, Mn2+UniRule annotation, Fe2+UniRule annotationNote: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei198SubstrateUniRule annotation1
Metal bindingi218Divalent metal cation 1UniRule annotation1
Metal bindingi229Divalent metal cation 1UniRule annotation1
Metal bindingi229Divalent metal cation 2; catalyticUniRule annotation1
Metal bindingi298Divalent metal cation 2; catalytic; via tele nitrogenUniRule annotation1
Binding sitei306SubstrateUniRule annotation1
Metal bindingi331Divalent metal cation 2; catalyticUniRule annotation1
Metal bindingi426Divalent metal cation 1UniRule annotation1
Metal bindingi426Divalent metal cation 2; catalyticUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionAminopeptidase, Hydrolase, Protease
LigandMetal-binding

Protein family/group databases

MEROPSiM24.002

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine aminopeptidase 2-3UniRule annotation (EC:3.4.11.18UniRule annotation)
Short name:
MAP 2-3UniRule annotation
Short name:
MetAP 2-3UniRule annotation
Alternative name(s):
Peptidase MUniRule annotation
Gene namesi
ORF Names:NFIA_093940
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006702 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:NFIA_093940

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004076091 – 445Methionine aminopeptidase 2-3Add BLAST445

Proteomic databases

PRIDEiA1DA84

Interactioni

Protein-protein interaction databases

STRINGi36630.CADNFIAP00008867

Structurei

3D structure databases

ProteinModelPortaliA1DA84
SMRiA1DA84
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi61 – 73Poly-LysAdd BLAST13

Sequence similaritiesi

Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000226278
KOiK01265
OMAiCEYPPSK
OrthoDBiEOG092C3NQP

Family and domain databases

CDDicd01088 MetAP2, 1 hit
Gene3Di1.10.10.10, 1 hit
HAMAPiMF_03175 MetAP_2_euk, 1 hit
InterProiView protein in InterPro
IPR036005 Creatinase/aminopeptidase-like
IPR000994 Pept_M24
IPR001714 Pept_M24_MAP
IPR002468 Pept_M24A_MAP2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00557 Peptidase_M24, 1 hit
PRINTSiPR00599 MAPEPTIDASE
SUPFAMiSSF46785 SSF46785, 1 hit
SSF55920 SSF55920, 2 hits
TIGRFAMsiTIGR00501 met_pdase_II, 1 hit

Sequencei

Sequence statusi: Complete.

A1DA84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIDAPELLE KLKISDADAN GADIPGSTSA AANGMLKEDD DSDDDVAENT
60 70 80 90 100
PAVAAENGTA KKKKNKKRKP KKKQPKVQTD PPSIPLSQLF PNNTYPKGEE
110 120 130 140 150
VEYKDENRYR TTSEEKRHLD NLNSDFLSDY RQAAEAHRQV RQWAQRNIKP
160 170 180 190 200
GQTLLEIANG IEDSARRLVG HDGLTEGDSL IAGMGFPTGL NIDNIVAHYS
210 220 230 240 250
PNAGCKTVLA QNNVLKVDIG IHVGGRIVDS AFTMAFDPMY DNLLAAVKDA
260 270 280 290 300
TNTGVREAGI DVRVGELGGY IQEAMESYEC EINGKTHPIK AIRNLCGHTI
310 320 330 340 350
LPYSIHGTKS VPFIKSNDMT KMEEGDVFAI ETFGSTGSGR YVEGGEVSHY
360 370 380 390 400
ALRGDANRKD LTLSSARSLL TAIKKNFSTI PFCRRYLDRI GQEKYLLGLN
410 420 430 440
YLVKSGIVED YPPLNEKQGT YTAQFEHTIL LRPTVKEVIS RGDDY
Length:445
Mass (Da):48,998
Last modified:January 23, 2007 - v1
Checksum:i73B615D9FEC8BA46
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027694 Genomic DNA Translation: EAW19774.1
RefSeqiXP_001261671.1, XM_001261670.1

Genome annotation databases

EnsemblFungiiCADNFIAT00009081; CADNFIAP00008867; CADNFIAG00009081
GeneIDi4588868
KEGGinfi:NFIA_093940

Similar proteinsi

Entry informationi

Entry nameiMAP23_NEOFI
AccessioniPrimary (citable) accession number: A1DA84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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