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A1D9Z6

- DCL2_NEOFI

UniProt

A1D9Z6 - DCL2_NEOFI

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Protein
Dicer-like protein 2
Gene
dcl2, NFIA_030600
Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons By similarity.

Cofactori

Magnesium or manganese By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi1137 – 11371Magnesium or manganese By similarity
Sitei1263 – 12631Important for activity By similarity
Metal bindingi1267 – 12671Magnesium or manganese By similarity
Metal bindingi1270 – 12701Magnesium or manganese By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi36 – 438ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. RNA binding Source: UniProtKB-KW
  3. helicase activity Source: UniProtKB-KW
  4. metal ion binding Source: UniProtKB-KW
  5. ribonuclease III activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. RNA processing Source: InterPro
  2. defense response to virus Source: UniProtKB-KW
  3. regulation of defense response to virus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antiviral protein, Helicase, Hydrolase

Keywords - Biological processi

Antiviral defense

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dicer-like protein 2
Including the following 2 domains:
Endoribonuclease dcl2 (EC:3.1.26.-)
ATP-dependent helicase dcl2 (EC:3.6.4.-)
Gene namesi
Name:dcl2
ORF Names:NFIA_030600
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
ProteomesiUP000006702: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13881388Dicer-like protein 2
PRO_0000306795Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi36630.CADNFIAP00002683.

Structurei

3D structure databases

ProteinModelPortaliA1D9Z6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 203181Helicase ATP-binding
Add
BLAST
Domaini371 – 537167Helicase C-terminal
Add
BLAST
Domaini564 – 65895Dicer dsRNA-binding fold
Add
BLAST
Domaini919 – 1059141RNase III 1
Add
BLAST
Domaini1098 – 1281184RNase III 2
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi144 – 1474DEAH box

Sequence similaritiesi

Contains 2 RNase III domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1111.
HOGENOMiHOG000048683.
OMAiELECAPF.
OrthoDBiEOG76QFRP.

Family and domain databases

Gene3Di1.10.1520.10. 2 hits.
3.40.50.300. 2 hits.
InterProiIPR005034. Dicer_dimerisation_dom.
IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000999. RNase_III_dom.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF03368. Dicer_dimer. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00636. Ribonuclease_3. 2 hits.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00535. RIBOc. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF69065. SSF69065. 3 hits.
PROSITEiPS51327. DICER_DSRBF. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1D9Z6-1 [UniParc]FASTAAdd to Basket

« Hide

MASSVTACQG ASPYQPRNYQ LEMLEASMKE NIIVAMDTGS GKTHIAVLRI     50
KAELDICPPD KLVWFLAPTV ALCIQQHEVI ASNLPAVRTR TLTGLDKVEL 100
WTEQSIWDAV LNGYRVIVST HAVLADALSH GFVKMSRLAL LIFDEAHHCT 150
RRHAANKIMR DFYHPTLTKS GPGAVPRIMG LTASPVVRSN HQELLTVESN 200
LDAVCRTPRV HRQELVKFTH RPHLQQIWYT PTDPAGFKSA SQTLGALYHA 250
WETLDIGDDP YIQRLRKSPL DDTALKKALL TGKTYCREQL RRFVDRSRHI 300
FEELGEWAAE YYIYASIKQL GDRVRNSYMS GDWDEAEKAY LVDFLSKIPA 350
SEIQLALNDP GSFRISPKFE SLLNFLDSLD EREFSGLIFV KQRATVSAMT 400
SLLSVHPCTR ERFRCAAYVG WSNGSASKDI LGDLLNMQLQ RDTLDDFRSG 450
RKNLIIATDV LEEGIDISAC SVVVCYDKPP NLKSFVQRRG RARRKQSTFA 500
IMFPTDDASA DVSKWQDLEQ AMIEAYQDDE RQLQSVSALE SLDEEVMERL 550
TVESTSAVLT ADMAMAHLHH FCAVLPPQPY ADMRPVFSFE TNEDGLLKGT 600
VILPSCVHPK VRRTEGRRWW RTERAAMKET AFQAYKALYE FGLVNDHLLP 650
LTKRPELKSH DLGAMPSILE TSEQYDPWIE WAYSWSSPDI HQSRIVVRMN 700
EGRGDELCMR LMGPTYLPPL SPMTLFWNNS TTFTVTFEAA ERVPLVPLSS 750
VEDMRAITAL YLKATNSRVC SSERDFTALF APDLHHTELK GWLNAYEGCD 800
PAMEVYSRGH NPLLMGVVRD HSRYGEPFLF RKWLVSDQNP SCSVVELECA 850
PFPHRRNLLH RQRLANSQVD VDEETPESAA KNPIVAADAC TIDRLPFTMA 900
IFGLFISAIV ERLETELIAT RLRETILRDV GFKSTDHIIT AISTPFAHAL 950
TNYQRYEFLG DSILKFSVSC QLFFQHPNWH EGYLSEGRAM IVQNPRLAKA 1000
ALDTGLDAYI VTKRIASRKW SAPLISEKLE RVPAKRQMST KVLADVVEAL 1050
IGAAYMDGGH ATAQACIRRL LPEINLHAVD TRTATRSVAP ESARHMMNER 1100
LKDHIGYTFE DESLLVEALT HPSCDYDSTT QSYQRLEYLG DAVLDMVIVS 1150
AIFNHPIQRP QGDMTKIKHA VVNANLLAFL CMESATSEEK LDVAQTSKDS 1200
FAVTTSQESV ELWRFMRYRG QNLNAARDAS LARHRALRDE IASSLLHAPH 1250
YPWHALSRLN ADKFFSDIVE SVLGAIFVDS GGDLAPCEVF VERIGLMAYL 1300
RRILDQEIDV RHPRSVAQQL AKTNIQFVLQ RVPNEEGGAS YQCSVRIEQA 1350
ELFVVTGCLT AEEAEVTAAV EAIKFLTRDE GSTPLNTS 1388
Length:1,388
Mass (Da):156,430
Last modified:January 23, 2007 - v1
Checksum:iC30E206A2EB2D3DB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027693 Genomic DNA. Translation: EAW20627.1.
RefSeqiXP_001262524.1. XM_001262523.1.

Genome annotation databases

EnsemblFungiiCADNFIAT00002760; CADNFIAP00002683; CADNFIAG00002760.
GeneIDi4589127.
KEGGinfi:NFIA_030600.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027693 Genomic DNA. Translation: EAW20627.1 .
RefSeqi XP_001262524.1. XM_001262523.1.

3D structure databases

ProteinModelPortali A1D9Z6.
ModBasei Search...

Protein-protein interaction databases

STRINGi 36630.CADNFIAP00002683.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADNFIAT00002760 ; CADNFIAP00002683 ; CADNFIAG00002760 .
GeneIDi 4589127.
KEGGi nfi:NFIA_030600.

Phylogenomic databases

eggNOGi COG1111.
HOGENOMi HOG000048683.
OMAi ELECAPF.
OrthoDBi EOG76QFRP.

Family and domain databases

Gene3Di 1.10.1520.10. 2 hits.
3.40.50.300. 2 hits.
InterProi IPR005034. Dicer_dimerisation_dom.
IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000999. RNase_III_dom.
[Graphical view ]
Pfami PF00270. DEAD. 1 hit.
PF03368. Dicer_dimer. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00636. Ribonuclease_3. 2 hits.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00535. RIBOc. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF69065. SSF69065. 3 hits.
PROSITEi PS51327. DICER_DSRBF. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

Entry informationi

Entry nameiDCL2_NEOFI
AccessioniPrimary (citable) accession number: A1D9Z6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi