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Protein

Lysophospholipase nte1

Gene

nte1

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1253 – 12531By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi681 – 800120cNMP 1Add
BLAST
Nucleotide bindingi841 – 961121cNMP 2Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
  2. phosphatidylcholine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase nte1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:nte1
ORF Names:NFIA_030460
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
ProteomesiUP000006702: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6666CytoplasmicBy similarityAdd
BLAST
Transmembranei67 – 8721HelicalSequence AnalysisAdd
BLAST
Topological domaini88 – 10922LumenalBy similarityAdd
BLAST
Transmembranei110 – 13021HelicalSequence AnalysisAdd
BLAST
Topological domaini131 – 15231393CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15231523Lysophospholipase nte1PRO_0000295325Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi36630.CADNFIAP00002640.

Structurei

3D structure databases

ProteinModelPortaliA1D9Y2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1220 – 1384165PatatinAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1251 – 12555GXSXG

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi15 – 5036Ser-richAdd
BLAST
Compositional biasi53 – 619Poly-Pro
Compositional biasi294 – 3018Poly-Ser

Sequence similaritiesi

Belongs to the NTE family.Curated
Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 patatin domain.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000048680.
KOiK14676.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 5 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1D9Y2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADGVTLVDS TGLHSFSSSP SLSTSSSSLT AVALSLATSA SAVTASYSIS
60 70 80 90 100
HLPPPPLPPV PTTMAGWIGW VFSFFFQVIP SVLYWVITFS TITLPTWLFT
110 120 130 140 150
LFSMSLTFTM NFTTLLLIVL AMVSTISWFI RYRFLNMYSR LPPEPQRKEP
160 170 180 190 200
QVDLFPDVQE GDSKPGLANY LDEFLSAIKV FGYLERPVFH ELTRTMQTRK
210 220 230 240 250
LIAGETLMLE EEKGFCLVVD GLVQIFVKSM RDGKSDTDEE LHHLGAESSD
260 270 280 290 300
EEHHIDGKQG YQLLTEVKNG ASMSSLFSIL SLFTEDIQLR ENESSGSSSS
310 320 330 340 350
SIALRAARVP NSIPTSPRGV MDSPSLGFQD HSDDTSNMIT NGDLPSVPPL
360 370 380 390 400
HLGESHTPPS GDQHHQQHHE SRKHSSRKRR KSVHPDIVAR AMVDTTIAII
410 420 430 440 450
PASAFRRLTR VYPRATAHIV QVILTRLQRV TFATAHSYLG LSNEVLGIEK
460 470 480 490 500
QMTKFTTYDL PNNMRGAALD RLKDKFIKER DRLGSEEVTK GIALHNPSAG
510 520 530 540 550
RRRRSSSFLR KDAALQVKMM TPRRAATVVT PESAPAEHDT YGVSPGDLLS
560 570 580 590 600
TIQSSRFGPR YEQPPAKLQS PLAEKENTHF RLPAMQARHT FRRQDTMDED
610 620 630 640 650
ALFRECILDC IMKGIGLTSS TRDALRKSSH SGDASPKLLS YDSRRQKAIF
660 670 680 690 700
TNNAFGFIDP YEGSGDGETE SLMSMSVTSA GGTSPVINLR EELRNDIEIV
710 720 730 740 750
YFPKGSVLVE QGERHPGLYY VIDGFLDVGV PIVEKGEDLV GVSKPAASKE
760 770 780 790 800
SFPTLKRTTT ANSIGAGGTA ANDSRRRKQS RKSLYLIKPG GIQGYVGAVA
810 820 830 840 850
SYRSYTDVVA KTDVYVGFLP RASLERIAER YPIALLTLAK RLTSILPRLL
860 870 880 890 900
LHIDFALEWL QVNAGQVIYH QGDESDAIYL VLNGRLRSVL ESPGNKLAVI
910 920 930 940 950
GEYGQGESVG ELEVMTESTR PATLHAIRDT ELAKFPRSLF NSLAQEHPGI
960 970 980 990 1000
TIQVSKLIAQ RMRDLVERPV TEKGVERSNA GGVQTATSTV NLRTVGILPV
1010 1020 1030 1040 1050
TAGVPVVEFG NRLLHALHQV GVTNGVTSLN QAAILNHLGR HAFSKMGKLK
1060 1070 1080 1090 1100
LSQYLADLEE KYGMVLYIAD TNVSSPWTQT CITQADCILL VGLAESSPSI
1110 1120 1130 1140 1150
GEYERFLLGM KTTARKELVL LHSERYCPPG LTRRWLKNRV WINGGHHHIQ
1160 1170 1180 1190 1200
MAFRLTAEPS HPETKRFGTV LKQRVQVLQA EIQKYTSRRI RQTPLYSAQS
1210 1220 1230 1240 1250
PFKGDFHRLA RRLCGRAVGL VLGGGGARGI AHVGVIKALE EAGIPVDIIG
1260 1270 1280 1290 1300
GTSIGSFIGA LYARDADVVP MYGRAKKFAG RMGSMWRFAL DLTYPTVSYT
1310 1320 1330 1340 1350
TGHEFNRGIF KTFGDSQIED FWLEFYCNTT NISKSRPEYH SSGYVWRYVR
1360 1370 1380 1390 1400
ASMSLAGLIP PICDEGSMLL DGGYIDNLTV DHMKGLGADV IFAVDVGSID
1410 1420 1430 1440 1450
DNTPQVYGDS LSGFWSVFNR WNPFSSCPNP PTLSEIQARL AYVSSIDNLE
1460 1470 1480 1490 1500
RAKNIPGCLY MRPPIDGYGT LEFGKFDEIY QVGYAFGKQF LEKLKTEGSL
1510 1520
PLPEETEEKK KLQRTMAPRR ASI
Length:1,523
Mass (Da):168,447
Last modified:July 24, 2007 - v2
Checksum:i95665818D567EF4B
GO

Sequence cautioni

The sequence EAW20613.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027693 Genomic DNA. Translation: EAW20613.1. Different initiation.
RefSeqiXP_001262510.1. XM_001262509.1.

Genome annotation databases

GeneIDi4588979.
KEGGinfi:NFIA_030460.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027693 Genomic DNA. Translation: EAW20613.1. Different initiation.
RefSeqiXP_001262510.1. XM_001262509.1.

3D structure databases

ProteinModelPortaliA1D9Y2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi36630.CADNFIAP00002640.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4588979.
KEGGinfi:NFIA_030460.

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000048680.
KOiK14676.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 5 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

Entry informationi

Entry nameiNTE1_NEOFI
AccessioniPrimary (citable) accession number: A1D9Y2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: March 4, 2015
This is version 48 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.