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A1D9Y2

- NTE1_NEOFI

UniProt

A1D9Y2 - NTE1_NEOFI

Protein

Lysophospholipase nte1

Gene

nte1

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 2 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.By similarity

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

    Enzyme regulationi

    Inhibited by organophosphorus esters.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei1253 – 12531By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi681 – 800120cNMP 1Add
    BLAST
    Nucleotide bindingi841 – 961121cNMP 2Add
    BLAST

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid catabolic process Source: UniProtKB-KW
    2. phosphatidylcholine metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysophospholipase nte1 (EC:3.1.1.5)
    Alternative name(s):
    Intracellular phospholipase B
    Neuropathy target esterase homolog
    Gene namesi
    Name:nte1
    ORF Names:NFIA_030460
    OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
    Taxonomic identifieri331117 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
    ProteomesiUP000006702: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15231523Lysophospholipase nte1PRO_0000295325Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi36630.CADNFIAP00002640.

    Structurei

    3D structure databases

    ProteinModelPortaliA1D9Y2.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6666CytoplasmicBy similarityAdd
    BLAST
    Topological domaini88 – 10922LumenalBy similarityAdd
    BLAST
    Topological domaini131 – 15231393CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei67 – 8721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei110 – 13021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1220 – 1384165PatatinAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1251 – 12555GXSXG

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi15 – 5036Ser-richAdd
    BLAST
    Compositional biasi53 – 619Poly-Pro
    Compositional biasi294 – 3018Poly-Ser

    Sequence similaritiesi

    Belongs to the NTE family.Curated
    Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
    Contains 1 patatin domain.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0664.
    HOGENOMiHOG000048680.
    KOiK14676.
    OrthoDBiEOG70W3NS.

    Family and domain databases

    Gene3Di2.60.120.10. 5 hits.
    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 5 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1D9Y2-1 [UniParc]FASTAAdd to Basket

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    MADGVTLVDS TGLHSFSSSP SLSTSSSSLT AVALSLATSA SAVTASYSIS     50
    HLPPPPLPPV PTTMAGWIGW VFSFFFQVIP SVLYWVITFS TITLPTWLFT 100
    LFSMSLTFTM NFTTLLLIVL AMVSTISWFI RYRFLNMYSR LPPEPQRKEP 150
    QVDLFPDVQE GDSKPGLANY LDEFLSAIKV FGYLERPVFH ELTRTMQTRK 200
    LIAGETLMLE EEKGFCLVVD GLVQIFVKSM RDGKSDTDEE LHHLGAESSD 250
    EEHHIDGKQG YQLLTEVKNG ASMSSLFSIL SLFTEDIQLR ENESSGSSSS 300
    SIALRAARVP NSIPTSPRGV MDSPSLGFQD HSDDTSNMIT NGDLPSVPPL 350
    HLGESHTPPS GDQHHQQHHE SRKHSSRKRR KSVHPDIVAR AMVDTTIAII 400
    PASAFRRLTR VYPRATAHIV QVILTRLQRV TFATAHSYLG LSNEVLGIEK 450
    QMTKFTTYDL PNNMRGAALD RLKDKFIKER DRLGSEEVTK GIALHNPSAG 500
    RRRRSSSFLR KDAALQVKMM TPRRAATVVT PESAPAEHDT YGVSPGDLLS 550
    TIQSSRFGPR YEQPPAKLQS PLAEKENTHF RLPAMQARHT FRRQDTMDED 600
    ALFRECILDC IMKGIGLTSS TRDALRKSSH SGDASPKLLS YDSRRQKAIF 650
    TNNAFGFIDP YEGSGDGETE SLMSMSVTSA GGTSPVINLR EELRNDIEIV 700
    YFPKGSVLVE QGERHPGLYY VIDGFLDVGV PIVEKGEDLV GVSKPAASKE 750
    SFPTLKRTTT ANSIGAGGTA ANDSRRRKQS RKSLYLIKPG GIQGYVGAVA 800
    SYRSYTDVVA KTDVYVGFLP RASLERIAER YPIALLTLAK RLTSILPRLL 850
    LHIDFALEWL QVNAGQVIYH QGDESDAIYL VLNGRLRSVL ESPGNKLAVI 900
    GEYGQGESVG ELEVMTESTR PATLHAIRDT ELAKFPRSLF NSLAQEHPGI 950
    TIQVSKLIAQ RMRDLVERPV TEKGVERSNA GGVQTATSTV NLRTVGILPV 1000
    TAGVPVVEFG NRLLHALHQV GVTNGVTSLN QAAILNHLGR HAFSKMGKLK 1050
    LSQYLADLEE KYGMVLYIAD TNVSSPWTQT CITQADCILL VGLAESSPSI 1100
    GEYERFLLGM KTTARKELVL LHSERYCPPG LTRRWLKNRV WINGGHHHIQ 1150
    MAFRLTAEPS HPETKRFGTV LKQRVQVLQA EIQKYTSRRI RQTPLYSAQS 1200
    PFKGDFHRLA RRLCGRAVGL VLGGGGARGI AHVGVIKALE EAGIPVDIIG 1250
    GTSIGSFIGA LYARDADVVP MYGRAKKFAG RMGSMWRFAL DLTYPTVSYT 1300
    TGHEFNRGIF KTFGDSQIED FWLEFYCNTT NISKSRPEYH SSGYVWRYVR 1350
    ASMSLAGLIP PICDEGSMLL DGGYIDNLTV DHMKGLGADV IFAVDVGSID 1400
    DNTPQVYGDS LSGFWSVFNR WNPFSSCPNP PTLSEIQARL AYVSSIDNLE 1450
    RAKNIPGCLY MRPPIDGYGT LEFGKFDEIY QVGYAFGKQF LEKLKTEGSL 1500
    PLPEETEEKK KLQRTMAPRR ASI 1523
    Length:1,523
    Mass (Da):168,447
    Last modified:July 24, 2007 - v2
    Checksum:i95665818D567EF4B
    GO

    Sequence cautioni

    The sequence EAW20613.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027693 Genomic DNA. Translation: EAW20613.1. Different initiation.
    RefSeqiXP_001262510.1. XM_001262509.1.

    Genome annotation databases

    GeneIDi4588979.
    KEGGinfi:NFIA_030460.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027693 Genomic DNA. Translation: EAW20613.1 . Different initiation.
    RefSeqi XP_001262510.1. XM_001262509.1.

    3D structure databases

    ProteinModelPortali A1D9Y2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 36630.CADNFIAP00002640.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4588979.
    KEGGi nfi:NFIA_030460.

    Phylogenomic databases

    eggNOGi COG0664.
    HOGENOMi HOG000048680.
    KOi K14676.
    OrthoDBi EOG70W3NS.

    Family and domain databases

    Gene3Di 2.60.120.10. 5 hits.
    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 5 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

    Entry informationi

    Entry nameiNTE1_NEOFI
    AccessioniPrimary (citable) accession number: A1D9Y2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3