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A1D9Y2 (NTE1_NEOFI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysophospholipase nte1

EC=3.1.1.5
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene names
Name:nte1
ORF Names:NFIA_030460
OrganismNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus) [Complete proteome]
Taxonomic identifier331117 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya

Protein attributes

Sequence length1523 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulation

Inhibited by organophosphorus esters By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the NTE family.

Contains 2 cyclic nucleotide-binding domains.

Contains 1 patatin domain.

Sequence caution

The sequence EAW20613.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15231523Lysophospholipase nte1
PRO_0000295325

Regions

Topological domain1 – 6666Cytoplasmic By similarity
Transmembrane67 – 8721Helical; Potential
Topological domain88 – 10922Lumenal By similarity
Transmembrane110 – 13021Helical; Potential
Topological domain131 – 15231393Cytoplasmic By similarity
Domain1220 – 1384165Patatin
Nucleotide binding681 – 800120cNMP 1
Nucleotide binding841 – 961121cNMP 2
Motif1251 – 12555GXSXG
Compositional bias15 – 5036Ser-rich
Compositional bias53 – 619Poly-Pro
Compositional bias294 – 3018Poly-Ser

Sites

Active site12531 By similarity

Sequences

Sequence LengthMass (Da)Tools
A1D9Y2 [UniParc].

Last modified July 24, 2007. Version 2.
Checksum: 95665818D567EF4B

FASTA1,523168,447
        10         20         30         40         50         60 
MADGVTLVDS TGLHSFSSSP SLSTSSSSLT AVALSLATSA SAVTASYSIS HLPPPPLPPV 

        70         80         90        100        110        120 
PTTMAGWIGW VFSFFFQVIP SVLYWVITFS TITLPTWLFT LFSMSLTFTM NFTTLLLIVL 

       130        140        150        160        170        180 
AMVSTISWFI RYRFLNMYSR LPPEPQRKEP QVDLFPDVQE GDSKPGLANY LDEFLSAIKV 

       190        200        210        220        230        240 
FGYLERPVFH ELTRTMQTRK LIAGETLMLE EEKGFCLVVD GLVQIFVKSM RDGKSDTDEE 

       250        260        270        280        290        300 
LHHLGAESSD EEHHIDGKQG YQLLTEVKNG ASMSSLFSIL SLFTEDIQLR ENESSGSSSS 

       310        320        330        340        350        360 
SIALRAARVP NSIPTSPRGV MDSPSLGFQD HSDDTSNMIT NGDLPSVPPL HLGESHTPPS 

       370        380        390        400        410        420 
GDQHHQQHHE SRKHSSRKRR KSVHPDIVAR AMVDTTIAII PASAFRRLTR VYPRATAHIV 

       430        440        450        460        470        480 
QVILTRLQRV TFATAHSYLG LSNEVLGIEK QMTKFTTYDL PNNMRGAALD RLKDKFIKER 

       490        500        510        520        530        540 
DRLGSEEVTK GIALHNPSAG RRRRSSSFLR KDAALQVKMM TPRRAATVVT PESAPAEHDT 

       550        560        570        580        590        600 
YGVSPGDLLS TIQSSRFGPR YEQPPAKLQS PLAEKENTHF RLPAMQARHT FRRQDTMDED 

       610        620        630        640        650        660 
ALFRECILDC IMKGIGLTSS TRDALRKSSH SGDASPKLLS YDSRRQKAIF TNNAFGFIDP 

       670        680        690        700        710        720 
YEGSGDGETE SLMSMSVTSA GGTSPVINLR EELRNDIEIV YFPKGSVLVE QGERHPGLYY 

       730        740        750        760        770        780 
VIDGFLDVGV PIVEKGEDLV GVSKPAASKE SFPTLKRTTT ANSIGAGGTA ANDSRRRKQS 

       790        800        810        820        830        840 
RKSLYLIKPG GIQGYVGAVA SYRSYTDVVA KTDVYVGFLP RASLERIAER YPIALLTLAK 

       850        860        870        880        890        900 
RLTSILPRLL LHIDFALEWL QVNAGQVIYH QGDESDAIYL VLNGRLRSVL ESPGNKLAVI 

       910        920        930        940        950        960 
GEYGQGESVG ELEVMTESTR PATLHAIRDT ELAKFPRSLF NSLAQEHPGI TIQVSKLIAQ 

       970        980        990       1000       1010       1020 
RMRDLVERPV TEKGVERSNA GGVQTATSTV NLRTVGILPV TAGVPVVEFG NRLLHALHQV 

      1030       1040       1050       1060       1070       1080 
GVTNGVTSLN QAAILNHLGR HAFSKMGKLK LSQYLADLEE KYGMVLYIAD TNVSSPWTQT 

      1090       1100       1110       1120       1130       1140 
CITQADCILL VGLAESSPSI GEYERFLLGM KTTARKELVL LHSERYCPPG LTRRWLKNRV 

      1150       1160       1170       1180       1190       1200 
WINGGHHHIQ MAFRLTAEPS HPETKRFGTV LKQRVQVLQA EIQKYTSRRI RQTPLYSAQS 

      1210       1220       1230       1240       1250       1260 
PFKGDFHRLA RRLCGRAVGL VLGGGGARGI AHVGVIKALE EAGIPVDIIG GTSIGSFIGA 

      1270       1280       1290       1300       1310       1320 
LYARDADVVP MYGRAKKFAG RMGSMWRFAL DLTYPTVSYT TGHEFNRGIF KTFGDSQIED 

      1330       1340       1350       1360       1370       1380 
FWLEFYCNTT NISKSRPEYH SSGYVWRYVR ASMSLAGLIP PICDEGSMLL DGGYIDNLTV 

      1390       1400       1410       1420       1430       1440 
DHMKGLGADV IFAVDVGSID DNTPQVYGDS LSGFWSVFNR WNPFSSCPNP PTLSEIQARL 

      1450       1460       1470       1480       1490       1500 
AYVSSIDNLE RAKNIPGCLY MRPPIDGYGT LEFGKFDEIY QVGYAFGKQF LEKLKTEGSL 

      1510       1520 
PLPEETEEKK KLQRTMAPRR ASI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS027693 Genomic DNA. Translation: EAW20613.1. Different initiation.
RefSeqXP_001262510.1. XM_001262509.1.

3D structure databases

ProteinModelPortalA1D9Y2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING36630.CADNFIAP00002640.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4588979.
KEGGnfi:NFIA_030460.

Phylogenomic databases

eggNOGCOG0664.
HOGENOMHOG000048680.
KOK14676.
OrthoDBEOG70W3NS.

Family and domain databases

Gene3D2.60.120.10. 5 hits.
InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNTE1_NEOFI
AccessionPrimary (citable) accession number: A1D9Y2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: February 19, 2014
This is version 44 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families