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A1D911

- MANBB_NEOFI

UniProt

A1D911 - MANBB_NEOFI

Protein

Beta-mannosidase B

Gene

mndB

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of beta-mannosidic oligosaccharides of various complexity and length. Prefers manobiose over mannotriose and has no activity against polymeric mannan. Is also severly restricetd by galactosyl substitutions at the +1 subsite By similarity.By similarity

    Catalytic activityi

    Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei432 – 4321Proton donorBy similarity

    GO - Molecular functioni

    1. beta-mannosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. mannan catabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Polysaccharide degradation

    Enzyme and pathway databases

    UniPathwayiUPA00280.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-mannosidase B (EC:3.2.1.25)
    Alternative name(s):
    Mannanase B
    Short name:
    Mannase B
    Gene namesi
    Name:mndB
    ORF Names:NFIA_114030
    OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
    Taxonomic identifieri331117 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
    ProteomesiUP000006702: Unassembled WGS sequence

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 845845Beta-mannosidase BPRO_0000394659Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi252 – 2521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi717 – 7171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi723 – 7231N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi36630.CADNFIAP00010151.

    Structurei

    3D structure databases

    ProteinModelPortaliA1D911.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG3250.
    HOGENOMiHOG000186861.
    KOiK01192.
    OMAiSWGLGYY.
    OrthoDBiEOG7NSB9Q.

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    2.60.40.320. 1 hit.
    3.20.20.80. 2 hits.
    InterProiIPR008979. Galactose-bd-like.
    IPR013812. Glyco_hydro_2/20_Ig-like.
    IPR006102. Glyco_hydro_2_Ig-like.
    IPR006104. Glyco_hydro_2_N.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR028369. Mannanase.
    [Graphical view]
    PANTHERiPTHR10066:SF12. PTHR10066:SF12. 1 hit.
    PfamiPF00703. Glyco_hydro_2. 1 hit.
    PF02837. Glyco_hydro_2_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF49303. SSF49303. 2 hits.
    SSF49785. SSF49785. 1 hit.
    SSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1D911-1 [UniParc]FASTAAdd to Basket

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    MSKLQQFPLS KGWSFRDSED TSEDAWMPVP VVPSVVHQDL QANSKLKDPY    50
    IGFNELEARW VNEKSWTYKT VFQKPAAPAG SCIVLAFDGL DTFAKVKLDG 100
    NVILENDNMF LARRVDVTKA LEAEGDHVLE IDFDCAFLRA KELRKQDPKH 150
    NWASFNGDPS RLSVRKAQYH WGWDWGPVLM TAGIWRDVRL EVYSARVADL 200
    WTEVQLASDH QSAQVTAFAE VESVHSGSHR ACFTLSLHGQ EIAREEIGVT 250
    ENGTAKATFD VKEPSLWWPH GYGDATLYEV SVSLRKEQEE LHKVSKKFGI 300
    RTAEVVQRPD KHGKSFFFRV NGVDIFCGGS CWIPADNLLP SITAERYRKW 350
    IELMVHGRQV MIRVWGGGIY EDNSFYDACD ELGVLVWQDF MFGCGNYPTW 400
    PNLLESIRKE SVYNVRRLRH HPSIVIWVGN NEDYQVQEQA GLTYNYEDKD 450
    PESWLKTDFP ARYIYEKLLP EVVQEFSPST FYHPGSPWGD GKTTSDPTVG 500
    DMHQWNVWHG TQEKYQIFDT LGGRFNSEFG MEAFPHMSTI DYFVENEADK 550
    YPQSHVLDFH NKADGHERRI ATYLVENLRT ATDLETHIYL TQVVQAETMM 600
    FGYRGWRRQW GDERHCGGAL LWQLNDCWPT ISWAIVDYFL RPKPAFYAVA 650
    RVLNPIAVGV RREHHDWSVT HAQPPKTSKF ELWVASSRQQ EVQGTVELRF 700
    LSVNTGLEVR ERIVHENVSI VPNGTTNLIV DGLIDHRVHS EPHVLAARIW 750
    VDGQLVARDV DWPQPFKYLD LSDRGLEIKK ISESEDEQTL LISTQKPVKC 800
    LVFEEREGVR ISDSAMDIVP GDDQRVTIKG LKPGDAPLKY KFLGQ 845
    Length:845
    Mass (Da):96,945
    Last modified:January 23, 2007 - v1
    Checksum:i278825BC6EFB8733
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027692 Genomic DNA. Translation: EAW20872.1.
    RefSeqiXP_001262769.1. XM_001262768.1.

    Genome annotation databases

    EnsemblFungiiCADNFIAT00010427; CADNFIAP00010151; CADNFIAG00010427.
    GeneIDi4589289.
    KEGGinfi:NFIA_114030.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027692 Genomic DNA. Translation: EAW20872.1 .
    RefSeqi XP_001262769.1. XM_001262768.1.

    3D structure databases

    ProteinModelPortali A1D911.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 36630.CADNFIAP00010151.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADNFIAT00010427 ; CADNFIAP00010151 ; CADNFIAG00010427 .
    GeneIDi 4589289.
    KEGGi nfi:NFIA_114030.

    Phylogenomic databases

    eggNOGi COG3250.
    HOGENOMi HOG000186861.
    KOi K01192.
    OMAi SWGLGYY.
    OrthoDBi EOG7NSB9Q.

    Enzyme and pathway databases

    UniPathwayi UPA00280 .

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    2.60.40.320. 1 hit.
    3.20.20.80. 2 hits.
    InterProi IPR008979. Galactose-bd-like.
    IPR013812. Glyco_hydro_2/20_Ig-like.
    IPR006102. Glyco_hydro_2_Ig-like.
    IPR006104. Glyco_hydro_2_N.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR028369. Mannanase.
    [Graphical view ]
    PANTHERi PTHR10066:SF12. PTHR10066:SF12. 1 hit.
    Pfami PF00703. Glyco_hydro_2. 1 hit.
    PF02837. Glyco_hydro_2_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49303. SSF49303. 2 hits.
    SSF49785. SSF49785. 1 hit.
    SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

    Entry informationi

    Entry nameiMANBB_NEOFI
    AccessioniPrimary (citable) accession number: A1D911
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    In contrast to clade A beta-mannosidases, which are likely secreted, clade B proteins appear to be intracellular.By similarity

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3