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A1D911

- MANBB_NEOFI

UniProt

A1D911 - MANBB_NEOFI

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Protein

Beta-mannosidase B

Gene

mndB

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of beta-mannosidic oligosaccharides of various complexity and length. Prefers manobiose over mannotriose and has no activity against polymeric mannan. Is also severly restricetd by galactosyl substitutions at the +1 subsite (By similarity).By similarity

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei432 – 4321Proton donorBy similarity

GO - Molecular functioni

  1. beta-mannosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. mannan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00280.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-mannosidase B (EC:3.2.1.25)
Alternative name(s):
Mannanase B
Short name:
Mannase B
Gene namesi
Name:mndB
ORF Names:NFIA_114030
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
ProteomesiUP000006702: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 845845Beta-mannosidase BPRO_0000394659Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi252 – 2521N-linked (GlcNAc...)Sequence Analysis
Glycosylationi717 – 7171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi723 – 7231N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi36630.CADNFIAP00010151.

Structurei

3D structure databases

ProteinModelPortaliA1D911.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3250.
HOGENOMiHOG000186861.
KOiK01192.
OMAiSWGLGYY.
OrthoDBiEOG7NSB9Q.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.320. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR008979. Galactose-bd-like.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR028369. Mannanase.
[Graphical view]
PANTHERiPTHR10066:SF12. PTHR10066:SF12. 1 hit.
PfamiPF00703. Glyco_hydro_2. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view]
SUPFAMiSSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

A1D911-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKLQQFPLS KGWSFRDSED TSEDAWMPVP VVPSVVHQDL QANSKLKDPY
60 70 80 90 100
IGFNELEARW VNEKSWTYKT VFQKPAAPAG SCIVLAFDGL DTFAKVKLDG
110 120 130 140 150
NVILENDNMF LARRVDVTKA LEAEGDHVLE IDFDCAFLRA KELRKQDPKH
160 170 180 190 200
NWASFNGDPS RLSVRKAQYH WGWDWGPVLM TAGIWRDVRL EVYSARVADL
210 220 230 240 250
WTEVQLASDH QSAQVTAFAE VESVHSGSHR ACFTLSLHGQ EIAREEIGVT
260 270 280 290 300
ENGTAKATFD VKEPSLWWPH GYGDATLYEV SVSLRKEQEE LHKVSKKFGI
310 320 330 340 350
RTAEVVQRPD KHGKSFFFRV NGVDIFCGGS CWIPADNLLP SITAERYRKW
360 370 380 390 400
IELMVHGRQV MIRVWGGGIY EDNSFYDACD ELGVLVWQDF MFGCGNYPTW
410 420 430 440 450
PNLLESIRKE SVYNVRRLRH HPSIVIWVGN NEDYQVQEQA GLTYNYEDKD
460 470 480 490 500
PESWLKTDFP ARYIYEKLLP EVVQEFSPST FYHPGSPWGD GKTTSDPTVG
510 520 530 540 550
DMHQWNVWHG TQEKYQIFDT LGGRFNSEFG MEAFPHMSTI DYFVENEADK
560 570 580 590 600
YPQSHVLDFH NKADGHERRI ATYLVENLRT ATDLETHIYL TQVVQAETMM
610 620 630 640 650
FGYRGWRRQW GDERHCGGAL LWQLNDCWPT ISWAIVDYFL RPKPAFYAVA
660 670 680 690 700
RVLNPIAVGV RREHHDWSVT HAQPPKTSKF ELWVASSRQQ EVQGTVELRF
710 720 730 740 750
LSVNTGLEVR ERIVHENVSI VPNGTTNLIV DGLIDHRVHS EPHVLAARIW
760 770 780 790 800
VDGQLVARDV DWPQPFKYLD LSDRGLEIKK ISESEDEQTL LISTQKPVKC
810 820 830 840
LVFEEREGVR ISDSAMDIVP GDDQRVTIKG LKPGDAPLKY KFLGQ
Length:845
Mass (Da):96,945
Last modified:January 23, 2007 - v1
Checksum:i278825BC6EFB8733
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027692 Genomic DNA. Translation: EAW20872.1.
RefSeqiXP_001262769.1. XM_001262768.1.

Genome annotation databases

EnsemblFungiiCADNFIAT00010427; CADNFIAP00010151; CADNFIAG00010427.
GeneIDi4589289.
KEGGinfi:NFIA_114030.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027692 Genomic DNA. Translation: EAW20872.1 .
RefSeqi XP_001262769.1. XM_001262768.1.

3D structure databases

ProteinModelPortali A1D911.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 36630.CADNFIAP00010151.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADNFIAT00010427 ; CADNFIAP00010151 ; CADNFIAG00010427 .
GeneIDi 4589289.
KEGGi nfi:NFIA_114030.

Phylogenomic databases

eggNOGi COG3250.
HOGENOMi HOG000186861.
KOi K01192.
OMAi SWGLGYY.
OrthoDBi EOG7NSB9Q.

Enzyme and pathway databases

UniPathwayi UPA00280 .

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
2.60.40.320. 1 hit.
3.20.20.80. 2 hits.
InterProi IPR008979. Galactose-bd-like.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR028369. Mannanase.
[Graphical view ]
PANTHERi PTHR10066:SF12. PTHR10066:SF12. 1 hit.
Pfami PF00703. Glyco_hydro_2. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view ]
SUPFAMi SSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

Entry informationi

Entry nameiMANBB_NEOFI
AccessioniPrimary (citable) accession number: A1D911
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

In contrast to clade A beta-mannosidases, which are likely secreted, clade B proteins appear to be intracellular.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3