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A1D8Y6 (MANA_NEOFI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable mannan endo-1,4-beta-mannosidase A

EC=3.2.1.78
Alternative name(s):
Endo-beta-1,4-mannanase A
Gene names
Name:manA
Synonyms:man1
ORF Names:NFIA_113780
OrganismNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus) [Complete proteome]
Taxonomic identifier331117 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya

Protein attributes

Sequence length373 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Endo-1,4-mannanase, a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans By similarity.

Catalytic activity

Random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 5 (cellulase A) family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
   Cellular componentSecreted
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmannan endo-1,4-beta-mannosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 373354Probable mannan endo-1,4-beta-mannosidase A
PRO_0000393707

Sites

Active site1921Proton donor By similarity
Active site3001Nucleophile By similarity

Amino acid modifications

Glycosylation2491N-linked (GlcNAc...) Potential
Glycosylation3201N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
A1D8Y6 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 752634795B064B08

FASTA37341,498
        10         20         30         40         50         60 
MKFSFLTVAS FLIGQVALAA LSAKKFASAS DLQFTIDGKT GYFAGSNSYW IGFLTNNADV 

        70         80         90        100        110        120 
DLVFDHMKES GLKILRVWGF NDVNTVPGQG TVYYQVHANG KSTINTGADG LQRLDYVVHS 

       130        140        150        160        170        180 
AEKRGIKLII NFVNNWDDYG GMNAYVKAYG ETDHNAFYSN KNIQNAYRRY VKAVVSRYTN 

       190        200        210        220        230        240 
SPAVFAWELA NEPRCKGCDT EVLYEWIKST SEYIKKLDKR HMVCIGDEGF GLDLLSDGSY 

       250        260        270        280        290        300 
PYTYVEGSNF TRNLAIPTID FGTFHLYPDS WGTTHEWGNG WAQSHGAACK AAGKPCLFEE 

       310        320        330        340        350        360 
YGVTSNHCAL ETPWQKTSLN TTGVSGDLYW QYGDTLSTGQ SPNDGNTIYY GTDEFKCIVK 

       370 
DHVAAIKAKQ GWV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS027692 Genomic DNA. Translation: EAW20847.1.
RefSeqXP_001262744.1. XM_001262743.1.

3D structure databases

ProteinModelPortalA1D8Y6.
SMRA1D8Y6. Positions 24-366.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADNFIAT00010693; CADNFIAP00010417; CADNFIAG00010693.
GeneID4589380.
KEGGnfi:NFIA_113780.

Phylogenomic databases

eggNOGCOG3934.
HOGENOMHOG000169951.
OMADYGGMAA.
OrthoDBEOG7M3J90.

Family and domain databases

Gene3D3.20.20.80. 1 hit.
InterProIPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMANA_NEOFI
AccessionPrimary (citable) accession number: A1D8Y6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: January 23, 2007
Last modified: February 19, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries