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A1D7R6

- DAPB_NEOFI

UniProt

A1D7R6 - DAPB_NEOFI

Protein

Probable dipeptidyl-aminopeptidase B

Gene

dapB

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei757 – 7571Charge relay systemBy similarity
    Active sitei834 – 8341Charge relay systemBy similarity
    Active sitei867 – 8671Charge relay systemBy similarity

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. serine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS09.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
    Short name:
    DPAP B
    Gene namesi
    Name:dapB
    ORF Names:NFIA_069310
    OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
    Taxonomic identifieri331117 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
    ProteomesiUP000006702: Unassembled WGS sequence

    Subcellular locationi

    Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
    Note: Lysosome-like vacuoles.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. vacuolar membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 919919Probable dipeptidyl-aminopeptidase BPRO_0000412151Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi352 – 3521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi643 – 6431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi811 – 8111N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi36630.CADNFIAP00005675.

    Structurei

    3D structure databases

    ProteinModelPortaliA1D7R6.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 9292CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini114 – 919806VacuolarSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei93 – 11321Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S9B family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000189891.
    KOiK01282.
    OMAiGEESYPE.
    OrthoDBiEOG72VHFG.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1D7R6-1 [UniParc]FASTAAdd to Basket

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    MRPSDDHGET SEFLPITRSR SVSAASQTST DSSLSTESLF PGEQKPFPNV    50
    NGTMALADDD QYRDLEDGEV EQTEPFLASS KKAATGGGRA RRIFWILVLL 100
    CLGGWLLAFA LFLTGGRANY QTASDALQAH GADSALGSTS TSSGKPVTLQ 150
    QVLAGQWNPR YHAIGWVAGP NNEDGLLVEK GGDEKQGYLR VDDIRSRKGN 200
    DTGRESRVLM WKPIVHVDGK AIVPSNVWPS PDLKKVLLIS EQQKNWRHSF 250
    TGKYWVLDVD SQTAQPLDPS APDGRVQLAL WSPASDAVVF VRDNNLYLRR 300
    LSSDSVVVIT KDGGENLFYG VPDWVYEEEV ISGNSVTWWS NDAKYIAFFR 350
    TNETSVPEFP VQYYISRPSG KKPLPGLENY PDVREIKYPK PGAPNPVVDL 400
    QFYDVDKNEV FSVEVADDFA DDDRIIIEVL WASEGKVLVR STNRESDILK 450
    VYLIDTKSRT GKLVRSEDVA GLDGGWVEPS QSTRFIPADP NNGRPHDGYI 500
    DTVPYNGYDH LAYFSPLDSP NALMLTSGEW EVVDAPAAVD LQRGLVYFVG 550
    TREAPTQRHV YRVQLDGSNL KPLTDTSKPG YYDVSFSHGT GYALLTYKGP 600
    SIPWQAIIKT QGDEITYEDR IEDNAQLTKM VEAYALPTEI YQNVTVDGYT 650
    LQLVERRPPH FNPAKKYPVL FYLYGGPGSQ TVDRKFTVDF QSYVASSLGY 700
    IVVTVDGRGT GFIGRKARCI VRGNLGFYEA HDQIATAKMW AAKSYVDETR 750
    MAIWGWSFGG FMTLKTLEQD AGQTFQYGMA VAPVTDWRFY DSIYTERYMH 800
    TPQHNPSGYD NSTITDMAAL SESVRFLVMH GASDDNVHLQ NTLVLIDKLD 850
    LSNVENYDLQ FYPDSDHSIY FHNAHTMVYD RLSDWLVNAF NGEWHLIAKP 900
    VPDESMWERM KRSLPLLYP 919
    Length:919
    Mass (Da):102,984
    Last modified:January 23, 2007 - v1
    Checksum:iB37965B691918558
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027690 Genomic DNA. Translation: EAW21760.1.
    RefSeqiXP_001263657.1. XM_001263656.1.

    Genome annotation databases

    EnsemblFungiiCADNFIAT00005832; CADNFIAP00005675; CADNFIAG00005832.
    GeneIDi4590303.
    KEGGinfi:NFIA_069310.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027690 Genomic DNA. Translation: EAW21760.1 .
    RefSeqi XP_001263657.1. XM_001263656.1.

    3D structure databases

    ProteinModelPortali A1D7R6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 36630.CADNFIAP00005675.

    Protein family/group databases

    MEROPSi S09.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADNFIAT00005832 ; CADNFIAP00005675 ; CADNFIAG00005832 .
    GeneIDi 4590303.
    KEGGi nfi:NFIA_069310.

    Phylogenomic databases

    HOGENOMi HOG000189891.
    KOi K01282.
    OMAi GEESYPE.
    OrthoDBi EOG72VHFG.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

    Entry informationi

    Entry nameiDAPB_NEOFI
    AccessioniPrimary (citable) accession number: A1D7R6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3