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A1D7R6

- DAPB_NEOFI

UniProt

A1D7R6 - DAPB_NEOFI

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Protein

Probable dipeptidyl-aminopeptidase B

Gene

dapB

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei757 – 7571Charge relay systemBy similarity
Active sitei834 – 8341Charge relay systemBy similarity
Active sitei867 – 8671Charge relay systemBy similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:dapB
ORF Names:NFIA_069310
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
ProteomesiUP000006702: Unassembled WGS sequence

Subcellular locationi

Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles.By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuole Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 919919Probable dipeptidyl-aminopeptidase BPRO_0000412151Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi352 – 3521N-linked (GlcNAc...)Sequence Analysis
Glycosylationi643 – 6431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi811 – 8111N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi36630.CADNFIAP00005675.

Structurei

3D structure databases

ProteinModelPortaliA1D7R6.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9292CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini114 – 919806VacuolarSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei93 – 11321Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000189891.
KOiK01282.
OMAiGEESYPE.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

A1D7R6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRPSDDHGET SEFLPITRSR SVSAASQTST DSSLSTESLF PGEQKPFPNV
60 70 80 90 100
NGTMALADDD QYRDLEDGEV EQTEPFLASS KKAATGGGRA RRIFWILVLL
110 120 130 140 150
CLGGWLLAFA LFLTGGRANY QTASDALQAH GADSALGSTS TSSGKPVTLQ
160 170 180 190 200
QVLAGQWNPR YHAIGWVAGP NNEDGLLVEK GGDEKQGYLR VDDIRSRKGN
210 220 230 240 250
DTGRESRVLM WKPIVHVDGK AIVPSNVWPS PDLKKVLLIS EQQKNWRHSF
260 270 280 290 300
TGKYWVLDVD SQTAQPLDPS APDGRVQLAL WSPASDAVVF VRDNNLYLRR
310 320 330 340 350
LSSDSVVVIT KDGGENLFYG VPDWVYEEEV ISGNSVTWWS NDAKYIAFFR
360 370 380 390 400
TNETSVPEFP VQYYISRPSG KKPLPGLENY PDVREIKYPK PGAPNPVVDL
410 420 430 440 450
QFYDVDKNEV FSVEVADDFA DDDRIIIEVL WASEGKVLVR STNRESDILK
460 470 480 490 500
VYLIDTKSRT GKLVRSEDVA GLDGGWVEPS QSTRFIPADP NNGRPHDGYI
510 520 530 540 550
DTVPYNGYDH LAYFSPLDSP NALMLTSGEW EVVDAPAAVD LQRGLVYFVG
560 570 580 590 600
TREAPTQRHV YRVQLDGSNL KPLTDTSKPG YYDVSFSHGT GYALLTYKGP
610 620 630 640 650
SIPWQAIIKT QGDEITYEDR IEDNAQLTKM VEAYALPTEI YQNVTVDGYT
660 670 680 690 700
LQLVERRPPH FNPAKKYPVL FYLYGGPGSQ TVDRKFTVDF QSYVASSLGY
710 720 730 740 750
IVVTVDGRGT GFIGRKARCI VRGNLGFYEA HDQIATAKMW AAKSYVDETR
760 770 780 790 800
MAIWGWSFGG FMTLKTLEQD AGQTFQYGMA VAPVTDWRFY DSIYTERYMH
810 820 830 840 850
TPQHNPSGYD NSTITDMAAL SESVRFLVMH GASDDNVHLQ NTLVLIDKLD
860 870 880 890 900
LSNVENYDLQ FYPDSDHSIY FHNAHTMVYD RLSDWLVNAF NGEWHLIAKP
910
VPDESMWERM KRSLPLLYP
Length:919
Mass (Da):102,984
Last modified:January 23, 2007 - v1
Checksum:iB37965B691918558
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027690 Genomic DNA. Translation: EAW21760.1.
RefSeqiXP_001263657.1. XM_001263656.1.

Genome annotation databases

EnsemblFungiiCADNFIAT00005832; CADNFIAP00005675; CADNFIAG00005832.
GeneIDi4590303.
KEGGinfi:NFIA_069310.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027690 Genomic DNA. Translation: EAW21760.1 .
RefSeqi XP_001263657.1. XM_001263656.1.

3D structure databases

ProteinModelPortali A1D7R6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 36630.CADNFIAP00005675.

Protein family/group databases

MEROPSi S09.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADNFIAT00005832 ; CADNFIAP00005675 ; CADNFIAG00005832 .
GeneIDi 4590303.
KEGGi nfi:NFIA_069310.

Phylogenomic databases

HOGENOMi HOG000189891.
KOi K01282.
OMAi GEESYPE.
OrthoDBi EOG72VHFG.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

Entry informationi

Entry nameiDAPB_NEOFI
AccessioniPrimary (citable) accession number: A1D7R6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3