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A1D7R6

- DAPB_NEOFI

UniProt

A1D7R6 - DAPB_NEOFI

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Protein
Probable dipeptidyl-aminopeptidase B
Gene
dapB, NFIA_069310
Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei757 – 7571Charge relay system By similarity
Active sitei834 – 8341Charge relay system By similarity
Active sitei867 – 8671Charge relay system By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:dapB
ORF Names:NFIA_069310
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
ProteomesiUP000006702: Unassembled WGS sequence

Subcellular locationi

Vacuole membrane; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9292Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei93 – 11321Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini114 – 919806Vacuolar Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 919919Probable dipeptidyl-aminopeptidase B
PRO_0000412151Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi200 – 2001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi352 – 3521N-linked (GlcNAc...) Reviewed prediction
Glycosylationi643 – 6431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi811 – 8111N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi36630.CADNFIAP00005675.

Structurei

3D structure databases

ProteinModelPortaliA1D7R6.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000189891.
KOiK01282.
OMAiGEESYPE.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

A1D7R6-1 [UniParc]FASTAAdd to Basket

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MRPSDDHGET SEFLPITRSR SVSAASQTST DSSLSTESLF PGEQKPFPNV    50
NGTMALADDD QYRDLEDGEV EQTEPFLASS KKAATGGGRA RRIFWILVLL 100
CLGGWLLAFA LFLTGGRANY QTASDALQAH GADSALGSTS TSSGKPVTLQ 150
QVLAGQWNPR YHAIGWVAGP NNEDGLLVEK GGDEKQGYLR VDDIRSRKGN 200
DTGRESRVLM WKPIVHVDGK AIVPSNVWPS PDLKKVLLIS EQQKNWRHSF 250
TGKYWVLDVD SQTAQPLDPS APDGRVQLAL WSPASDAVVF VRDNNLYLRR 300
LSSDSVVVIT KDGGENLFYG VPDWVYEEEV ISGNSVTWWS NDAKYIAFFR 350
TNETSVPEFP VQYYISRPSG KKPLPGLENY PDVREIKYPK PGAPNPVVDL 400
QFYDVDKNEV FSVEVADDFA DDDRIIIEVL WASEGKVLVR STNRESDILK 450
VYLIDTKSRT GKLVRSEDVA GLDGGWVEPS QSTRFIPADP NNGRPHDGYI 500
DTVPYNGYDH LAYFSPLDSP NALMLTSGEW EVVDAPAAVD LQRGLVYFVG 550
TREAPTQRHV YRVQLDGSNL KPLTDTSKPG YYDVSFSHGT GYALLTYKGP 600
SIPWQAIIKT QGDEITYEDR IEDNAQLTKM VEAYALPTEI YQNVTVDGYT 650
LQLVERRPPH FNPAKKYPVL FYLYGGPGSQ TVDRKFTVDF QSYVASSLGY 700
IVVTVDGRGT GFIGRKARCI VRGNLGFYEA HDQIATAKMW AAKSYVDETR 750
MAIWGWSFGG FMTLKTLEQD AGQTFQYGMA VAPVTDWRFY DSIYTERYMH 800
TPQHNPSGYD NSTITDMAAL SESVRFLVMH GASDDNVHLQ NTLVLIDKLD 850
LSNVENYDLQ FYPDSDHSIY FHNAHTMVYD RLSDWLVNAF NGEWHLIAKP 900
VPDESMWERM KRSLPLLYP 919
Length:919
Mass (Da):102,984
Last modified:January 23, 2007 - v1
Checksum:iB37965B691918558
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027690 Genomic DNA. Translation: EAW21760.1.
RefSeqiXP_001263657.1. XM_001263656.1.

Genome annotation databases

EnsemblFungiiCADNFIAT00005832; CADNFIAP00005675; CADNFIAG00005832.
GeneIDi4590303.
KEGGinfi:NFIA_069310.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027690 Genomic DNA. Translation: EAW21760.1 .
RefSeqi XP_001263657.1. XM_001263656.1.

3D structure databases

ProteinModelPortali A1D7R6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 36630.CADNFIAP00005675.

Protein family/group databases

MEROPSi S09.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADNFIAT00005832 ; CADNFIAP00005675 ; CADNFIAG00005832 .
GeneIDi 4590303.
KEGGi nfi:NFIA_069310.

Phylogenomic databases

HOGENOMi HOG000189891.
KOi K01282.
OMAi GEESYPE.
OrthoDBi EOG72VHFG.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

Entry informationi

Entry nameiDAPB_NEOFI
AccessioniPrimary (citable) accession number: A1D7R6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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