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A1D624 (SSN3_NEOFI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase ssn3

EC=2.7.11.22
EC=2.7.11.23
Alternative name(s):
Cyclin-dependent kinase 8
Gene names
Name:ssn3
Synonyms:cdk8
ORF Names:NFIA_063290
OrganismNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus) [Complete proteome]
Taxonomic identifier331117 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya

Protein attributes

Sequence length426 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The srb8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactor

Magnesium By similarity.

Subunit structure

Component of the srb8-11 complex, a regulatory module of the Mediator complex By similarity.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 426426Serine/threonine-protein kinase ssn3
PRO_0000312948

Regions

Domain41 – 368328Protein kinase
Nucleotide binding47 – 559ATP By similarity

Sites

Active site1731Proton acceptor By similarity
Binding site711ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A1D624 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 0A1FFD1B25B87EAF

FASTA42648,039
        10         20         30         40         50         60 
MFGRNFPFFN SIGGFYPRES LDSKRPSGTG YTSKVRVRDK YHIVGFISSG TYGRVYKAIG 

        70         80         90        100        110        120 
KDGRKGEYAI KKFKPDKEGE IIQYTGLSQS AIREMALCSE LDHPNVVQLA EIILEDKCIF 

       130        140        150        160        170        180 
MVFEYTEHDL LQIIHHHTQP QRHAIPAPMI KSILFQLLNG LLYLHTNWVL HRDLKPANIL 

       190        200        210        220        230        240 
VTSSGAVRIG DLGLARLFYK PLNSLYSGDK VVVTIWYRAP ELLMGSRHYT PAVDLWAVGC 

       250        260        270        280        290        300 
IFAELLSLRP IFKGEEAKMD SKKTVPFQRN QMMKIIDIMG LPRKETWPGL VSMPEFSQLQ 

       310        320        330        340        350        360 
SLAMSRGYLN RQCNLEGWYQ SCLKNNGYSP GSAAGTPGAE GFDLLSRLLE YDPTKRISAR 

       370        380        390        400        410        420 
EALEHPYFTT GTPVTANCFA GYEGKYPHRR VTQDDNDIRS GSLPGTKRSG LPDDSLMGRA 


AKRLKE 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS027690 Genomic DNA. Translation: EAW21168.1.
RefSeqXP_001263065.1. XM_001263064.1.

3D structure databases

ProteinModelPortalA1D624.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING36630.CADNFIAP00006280.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADNFIAT00006437; CADNFIAP00006280; CADNFIAG00006437.
GeneID4589549.
KEGGnfi:NFIA_063290.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
KOK02208.
OMAKWPTLAN.
OrthoDBEOG7K3TWD.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSSN3_NEOFI
AccessionPrimary (citable) accession number: A1D624
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families