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A1D624

- SSN3_NEOFI

UniProt

A1D624 - SSN3_NEOFI

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Protein

Serine/threonine-protein kinase ssn3

Gene
ssn3, cdk8, NFIA_063290
Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The srb8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactori

Magnesium By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei71 – 711ATP By similarity
Active sitei173 – 1731Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi47 – 559ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW
  4. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Kinase, Repressor, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase ssn3 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
Cyclin-dependent kinase 8
Gene namesi
Name:ssn3
Synonyms:cdk8
ORF Names:NFIA_063290
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
ProteomesiUP000006702: Unassembled WGS sequence

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 426426Serine/threonine-protein kinase ssn3PRO_0000312948Add
BLAST

Interactioni

Subunit structurei

Component of the srb8-11 complex, a regulatory module of the Mediator complex By similarity.

Protein-protein interaction databases

STRINGi36630.CADNFIAP00006280.

Structurei

3D structure databases

ProteinModelPortaliA1D624.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 368328Protein kinaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
KOiK02208.
OMAiKWPTLAN.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1D624-1 [UniParc]FASTAAdd to Basket

« Hide

MFGRNFPFFN SIGGFYPRES LDSKRPSGTG YTSKVRVRDK YHIVGFISSG    50
TYGRVYKAIG KDGRKGEYAI KKFKPDKEGE IIQYTGLSQS AIREMALCSE 100
LDHPNVVQLA EIILEDKCIF MVFEYTEHDL LQIIHHHTQP QRHAIPAPMI 150
KSILFQLLNG LLYLHTNWVL HRDLKPANIL VTSSGAVRIG DLGLARLFYK 200
PLNSLYSGDK VVVTIWYRAP ELLMGSRHYT PAVDLWAVGC IFAELLSLRP 250
IFKGEEAKMD SKKTVPFQRN QMMKIIDIMG LPRKETWPGL VSMPEFSQLQ 300
SLAMSRGYLN RQCNLEGWYQ SCLKNNGYSP GSAAGTPGAE GFDLLSRLLE 350
YDPTKRISAR EALEHPYFTT GTPVTANCFA GYEGKYPHRR VTQDDNDIRS 400
GSLPGTKRSG LPDDSLMGRA AKRLKE 426
Length:426
Mass (Da):48,039
Last modified:January 23, 2007 - v1
Checksum:i0A1FFD1B25B87EAF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027690 Genomic DNA. Translation: EAW21168.1.
RefSeqiXP_001263065.1. XM_001263064.1.

Genome annotation databases

EnsemblFungiiCADNFIAT00006437; CADNFIAP00006280; CADNFIAG00006437.
GeneIDi4589549.
KEGGinfi:NFIA_063290.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027690 Genomic DNA. Translation: EAW21168.1 .
RefSeqi XP_001263065.1. XM_001263064.1.

3D structure databases

ProteinModelPortali A1D624.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 36630.CADNFIAP00006280.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADNFIAT00006437 ; CADNFIAP00006280 ; CADNFIAG00006437 .
GeneIDi 4589549.
KEGGi nfi:NFIA_063290.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233024.
KOi K02208.
OMAi KWPTLAN.
OrthoDBi EOG7K3TWD.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

Entry informationi

Entry nameiSSN3_NEOFI
AccessioniPrimary (citable) accession number: A1D624
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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