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Protein

Probable glucan 1,3-beta-glucosidase A

Gene

exgA

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. It could also function biosynthetically as a transglycosylase (By similarity).By similarity

Catalytic activityi

Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.

Cofactori

Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei211Proton donorBy similarity1
Active sitei308NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glucan 1,3-beta-glucosidase A (EC:3.2.1.58)
Alternative name(s):
Exo-1,3-beta-glucanase 1
Exo-1,3-beta-glucanase A
Gene namesi
Name:exgA
Synonyms:exg1
ORF Names:NFIA_021060
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006702 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:NFIA_021060

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000039353323 – 416Probable glucan 1,3-beta-glucosidase AAdd BLAST394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi291 ↔ 415By similarity
Disulfide bondi316 ↔ 342By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi36630.CADNFIAP00000871

Structurei

3D structure databases

ProteinModelPortaliA1D4Q5
SMRiA1D4Q5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000114462
KOiK01210
OMAiEGAPGWD
OrthoDBiEOG092C22A6

Family and domain databases

InterProiView protein in InterPro
IPR001547 Glyco_hydro_5
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF00150 Cellulase, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1D4Q5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIFKFSQKAL VALCLVVGLA EAVPSKSRVV SRASTFDYNG IVRGVNIGGW
60 70 80 90 100
LVLEPWITPS IFDNAGDAAV DEWTLTATLG QDQAKAVLSQ HWSTFITQGD
110 120 130 140 150
FHRIAQAGMN HVRIPIGYWA VSSLPDEPYV DGQLEYLDNA ISWARDAGLK
160 170 180 190 200
VVIDLHGAPG SQNGFDNSGR KGPIAWQQGN TVSQTVDAFR ALAERYLPQS
210 220 230 240 250
DVVAAIEALN EPNIPGGVSE AGLRDYYDQI ADVVRQINPD TSVFLSDGFL
260 270 280 290 300
STASWNGFKT GEDVVMDTHH YEMFDNYLIS LDIHGHVKSA CDFGKQIKGS
310 320 330 340 350
DKPVVVGEWS GAVTDCTKYL NGKGVPTRYQ GEYANNPKYG DCGDKTQGSV
360 370 380 390 400
ADLSDQERAD TRRFIEAQLD AYEGKNGWLF WTWKTEGAPG WDMQDLLANG
410
VFPSPLTDRQ FPNQCA
Length:416
Mass (Da):45,600
Last modified:January 23, 2007 - v1
Checksum:iDB485EFFE29A47F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027688 Genomic DNA Translation: EAW23398.1
RefSeqiXP_001265295.1, XM_001265294.1

Genome annotation databases

EnsemblFungiiCADNFIAT00000910; CADNFIAP00000871; CADNFIAG00000910
GeneIDi4591258
KEGGinfi:NFIA_021060

Similar proteinsi

Entry informationi

Entry nameiEXGA_NEOFI
AccessioniPrimary (citable) accession number: A1D4Q5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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