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Protein

Pheromone-processing carboxypeptidase kex1

Gene

kex1

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei190PROSITE-ProRule annotation1
Active sitei390PROSITE-ProRule annotation1
Active sitei452PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

ESTHERiaspfu-kex1. Carboxypeptidase_S10.
MEROPSiS10.A67.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase kex1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:kex1
ORF Names:NFIA_016700
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006702 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:NFIA_016700.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini39 – 523LumenalSequence analysisAdd BLAST485
Transmembranei524 – 544HelicalSequence analysisAdd BLAST21
Topological domaini545 – 632CytoplasmicSequence analysisAdd BLAST88

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 38Sequence analysisAdd BLAST38
ChainiPRO_000041192939 – 632Pheromone-processing carboxypeptidase kex1Add BLAST594

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi119N-linked (GlcNAc...)Sequence analysis1
Glycosylationi126N-linked (GlcNAc...)Sequence analysis1
Glycosylationi441N-linked (GlcNAc...)Sequence analysis1
Glycosylationi449N-linked (GlcNAc...)Sequence analysis1
Glycosylationi501N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliA1D3I1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000208879.
KOiK01288.
OMAiSVCESKI.
OrthoDBiEOG092C255X.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1D3I1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLTAPSSRG SRTQSGIANV SWWALSLLLL FSPTLVSAKS AADYYVRSLP
60 70 80 90 100
GAPEGPLLKM HAGHIEVDAQ NNGNLFFWHY QNRHIANRQR TVIWLNGGPG
110 120 130 140 150
CSSMDGALME IGPYRLKDNH TLEYNNGSWD EFANLLFVDQ PVGTGFSYVS
160 170 180 190 200
TNSYIHELDE MSAQFITFLE KWFQLFPEYE GDDIYIAGES YAGQHIPYIA
210 220 230 240 250
KAIQERNNKI QNDQSVRWNL RGIVIGNGWI SPAQQYPSYL TFAYEEGLVT
260 270 280 290 300
EGSSLAKDLE VYQSVCESKI SASPNAINIR DCEEILQQIL ARTKDTNRQC
310 320 330 340 350
YNMYDVRLRD TYPSCGMNWP TDLVDVKPYL QRPDVVQALN INPEKKSGWE
360 370 380 390 400
ECSGAVSSTF NAANSLPSVQ LLPELLESGI PILLFSGDKD LICNHVGTEQ
410 420 430 440 450
LINNMKWNGG TGFETSPGVW APRHDWTFEG EPTGIYQYAR NLTYVLFYNA
460 470 480 490 500
SHMVPYDLPR QSRDMLDRFM KVDIANIGGK PADSRIDGEK LPQTSVGGHP
510 520 530 540 550
NSTAAEQQAK EKIKETEWKA YAKSGEAALI VVIIGVTVWG FFIWRSRRRN
560 570 580 590 600
RGYQGVYQRD VGSGSILERF HNKRSGPADV EAGDFDESEL DNLHSPGPEQ
610 620 630
EHYAVGDDSD EEGPNHHPAA PPSSTKPGGA QP
Length:632
Mass (Da):70,581
Last modified:January 23, 2007 - v1
Checksum:iB2816F2B33C3E0C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027688 Genomic DNA. Translation: EAW22974.1.
RefSeqiXP_001264871.1. XM_001264870.1.

Genome annotation databases

EnsemblFungiiCADNFIAT00001413; CADNFIAP00001374; CADNFIAG00001413.
GeneIDi4591422.
KEGGinfi:NFIA_016700.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027688 Genomic DNA. Translation: EAW22974.1.
RefSeqiXP_001264871.1. XM_001264870.1.

3D structure databases

ProteinModelPortaliA1D3I1.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERiaspfu-kex1. Carboxypeptidase_S10.
MEROPSiS10.A67.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADNFIAT00001413; CADNFIAP00001374; CADNFIAG00001413.
GeneIDi4591422.
KEGGinfi:NFIA_016700.

Organism-specific databases

EuPathDBiFungiDB:NFIA_016700.

Phylogenomic databases

HOGENOMiHOG000208879.
KOiK01288.
OMAiSVCESKI.
OrthoDBiEOG092C255X.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKEX1_NEOFI
AccessioniPrimary (citable) accession number: A1D3I1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.