Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A1D3I1 (KEX1_NEOFI) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pheromone-processing carboxypeptidase kex1

EC=3.4.16.6
Alternative name(s):
Carboxypeptidase D
Gene names
Name:kex1
ORF Names:NFIA_016700
OrganismNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus) [Complete proteome]
Taxonomic identifier331117 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya

Protein attributes

Sequence length632 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentGolgi apparatus
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3838 Potential
Chain39 – 632594Pheromone-processing carboxypeptidase kex1
PRO_0000411929

Regions

Topological domain39 – 523485Lumenal Potential
Transmembrane524 – 54421Helical; Potential
Topological domain545 – 63288Cytoplasmic Potential

Sites

Active site1901 By similarity
Active site3901 By similarity
Active site4521 By similarity

Amino acid modifications

Glycosylation1191N-linked (GlcNAc...) Potential
Glycosylation1261N-linked (GlcNAc...) Potential
Glycosylation4411N-linked (GlcNAc...) Potential
Glycosylation4491N-linked (GlcNAc...) Potential
Glycosylation5011N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
A1D3I1 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: B2816F2B33C3E0C3

FASTA63270,581
        10         20         30         40         50         60 
MLLTAPSSRG SRTQSGIANV SWWALSLLLL FSPTLVSAKS AADYYVRSLP GAPEGPLLKM 

        70         80         90        100        110        120 
HAGHIEVDAQ NNGNLFFWHY QNRHIANRQR TVIWLNGGPG CSSMDGALME IGPYRLKDNH 

       130        140        150        160        170        180 
TLEYNNGSWD EFANLLFVDQ PVGTGFSYVS TNSYIHELDE MSAQFITFLE KWFQLFPEYE 

       190        200        210        220        230        240 
GDDIYIAGES YAGQHIPYIA KAIQERNNKI QNDQSVRWNL RGIVIGNGWI SPAQQYPSYL 

       250        260        270        280        290        300 
TFAYEEGLVT EGSSLAKDLE VYQSVCESKI SASPNAINIR DCEEILQQIL ARTKDTNRQC 

       310        320        330        340        350        360 
YNMYDVRLRD TYPSCGMNWP TDLVDVKPYL QRPDVVQALN INPEKKSGWE ECSGAVSSTF 

       370        380        390        400        410        420 
NAANSLPSVQ LLPELLESGI PILLFSGDKD LICNHVGTEQ LINNMKWNGG TGFETSPGVW 

       430        440        450        460        470        480 
APRHDWTFEG EPTGIYQYAR NLTYVLFYNA SHMVPYDLPR QSRDMLDRFM KVDIANIGGK 

       490        500        510        520        530        540 
PADSRIDGEK LPQTSVGGHP NSTAAEQQAK EKIKETEWKA YAKSGEAALI VVIIGVTVWG 

       550        560        570        580        590        600 
FFIWRSRRRN RGYQGVYQRD VGSGSILERF HNKRSGPADV EAGDFDESEL DNLHSPGPEQ 

       610        620        630 
EHYAVGDDSD EEGPNHHPAA PPSSTKPGGA QP 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS027688 Genomic DNA. Translation: EAW22974.1.
RefSeqXP_001264871.1. XM_001264870.1.

3D structure databases

ProteinModelPortalA1D3I1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING36630.CADNFIAP00001374.

Protein family/group databases

MEROPSS10.007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADNFIAT00001413; CADNFIAP00001374; CADNFIAG00001413.
GeneID4591422.
KEGGnfi:NFIA_016700.

Phylogenomic databases

HOGENOMHOG000208879.
KOK01288.
OMAHTLEYNN.
OrthoDBEOG7TJ3SJ.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
SUPFAMSSF53474. SSF53474. 1 hit.
PROSITEPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKEX1_NEOFI
AccessionPrimary (citable) accession number: A1D3I1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries