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Protein

Histone-lysine N-methyltransferase

Gene

NFIA_014540

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation

GO - Molecular functioni

  1. double-stranded DNA binding Source: EnsemblFungi
  2. histone methyltransferase activity (H3-K9 specific) Source: EnsemblFungi
  3. single-stranded DNA binding Source: EnsemblFungi
  4. single-stranded RNA binding Source: EnsemblFungi
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. attachment of mitotic spindle microtubules to kinetochore Source: EnsemblFungi
  2. chromatin silencing at rDNA Source: EnsemblFungi
  3. chromatin silencing at silent mating-type cassette Source: EnsemblFungi
  4. chromatin silencing by small RNA Source: EnsemblFungi
  5. donor selection Source: EnsemblFungi
  6. heterochromatin maintenance involved in chromatin silencing at centromere outer repeat region Source: EnsemblFungi
  7. meiotic telomere clustering Source: EnsemblFungi
  8. negative regulation of transcription from RNA polymerase II promoter Source: EnsemblFungi
  9. regulation of production of siRNA involved in RNA interference Source: EnsemblFungi
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferaseSAAS annotation (EC:2.1.1.43SAAS annotation)
Gene namesi
ORF Names:NFIA_014540Imported
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)Imported
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
ProteomesiUP000006702 Componenti: Unassembled WGS sequence

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. CLRC ubiquitin ligase complex Source: EnsemblFungi
  3. mitotic spindle pole body Source: EnsemblFungi
Complete GO annotation...

Keywords - Cellular componenti

ChromosomeSAAS annotation, NucleusUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi36630.CADNFIAP00001748.

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains 1 post-SET domain.UniRule annotation
Contains 1 pre-SET domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000207341.
KOiK11419.
OMAiFIDCYLG.
OrthoDBiEOG7MD509.

Family and domain databases

InterProiIPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
[Graphical view]
PfamiPF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1D2X0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVIDLTLDS DSEDQRRLAV SVMSTSAKPR SALGLGNHNN PITFNSSTAN
60 70 80 90 100
NAIANANTPN SNHVFIPKIQ NPSTPSPSPS SQQEAIGVVI PSPSRQLRKE
110 120 130 140 150
IEKSGWVKAP PVTPEKTALS TEYYPIDAHE KRALKGAYPS ARKVKRSEIP
160 170 180 190 200
FSIGTPGPIL ADRIPVQRQL HETLQRKLSK INGPPVTFAP GEEGLLADFA
210 220 230 240 250
SNFEFVNSYI LRNGVSHIPV DFIAGCDCKK ICDPARCGCL EQDEESKEII
260 270 280 290 300
VPYQRAQDNA RLLVLTPDFL KRTDIIIECS SKCTCDEQKC WNRVVQHGRT
310 320 330 340 350
IRLEIFHTGN RGFGLRSPDW IRAGQFIDCY LGEVITKQEA DVREEVATSQ
360 370 380 390 400
HGHSYLFELD FFHNDDEIYV VDGQKFGSPT RFMNHSCNPN CKLFPVTRTY
410 420 430 440 450
GDERLYDLAF FSLHNIPPNT ELTFDYNPNW EEGKKVDPNA VRCLCGEKNC
460
RGQLWPNQRK GTK
Length:463
Mass (Da):51,934
Last modified:January 23, 2007 - v1
Checksum:i14F0EFF55C8568C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027688 Genomic DNA. Translation: EAW22763.1.
RefSeqiXP_001264660.1. XM_001264659.1.

Genome annotation databases

EnsemblFungiiCADNFIAT00001787; CADNFIAP00001748; CADNFIAG00001787.
GeneIDi4591776.
KEGGinfi:NFIA_014540.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027688 Genomic DNA. Translation: EAW22763.1.
RefSeqiXP_001264660.1. XM_001264659.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi36630.CADNFIAP00001748.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADNFIAT00001787; CADNFIAP00001748; CADNFIAG00001787.
GeneIDi4591776.
KEGGinfi:NFIA_014540.

Phylogenomic databases

HOGENOMiHOG000207341.
KOiK11419.
OMAiFIDCYLG.
OrthoDBiEOG7MD509.

Family and domain databases

InterProiIPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
[Graphical view]
PfamiPF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181Imported.

Entry informationi

Entry nameiA1D2X0_NEOFI
AccessioniPrimary (citable) accession number: A1D2X0
Entry historyi
Integrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: April 1, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.