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A1D1Z9 (BGALA_NEOFI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable beta-galactosidase A

EC=3.2.1.23
Alternative name(s):
Lactase A
Gene names
Name:lacA
ORF Names:NFIA_011250
OrganismNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus) [Complete proteome]
Taxonomic identifier331117 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya

Protein attributes

Sequence length1006 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans By similarity.

Catalytic activity

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 35 family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Polysaccharide degradation
   Cellular componentSecreted
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpolysaccharide catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbeta-galactosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 1006988Probable beta-galactosidase A
PRO_0000395221

Sites

Active site2001Proton donor Potential
Active site2981Nucleophile Potential
Binding site961Substrate By similarity
Binding site1401Substrate By similarity
Binding site1411Substrate; via amide nitrogen By similarity
Binding site1421Substrate By similarity
Binding site1991Substrate By similarity
Binding site2601Substrate By similarity
Binding site3641Substrate By similarity

Amino acid modifications

Glycosylation1561N-linked (GlcNAc...) Potential
Glycosylation2071N-linked (GlcNAc...) Potential
Glycosylation3731N-linked (GlcNAc...) Potential
Glycosylation4021N-linked (GlcNAc...) Potential
Glycosylation4221N-linked (GlcNAc...) Potential
Glycosylation6221N-linked (GlcNAc...) Potential
Glycosylation7771N-linked (GlcNAc...) Potential
Glycosylation9141N-linked (GlcNAc...) Potential
Disulfide bond205 ↔ 206 By similarity
Disulfide bond266 ↔ 315 By similarity

Sequences

Sequence LengthMass (Da)Tools
A1D1Z9 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 0F6D74409FAE7B19

FASTA1,006110,230
        10         20         30         40         50         60 
MKLLSVCAVA LLAAQAAGAS IKHKLNGFTI MEHSDPAKRE LLQKYVTWDE KSLFVNGERI 

        70         80         90        100        110        120 
MIFSGEVHPF RLPVPSLWLD VFQKIKALGF NCVSFYVDWA LLEGKPGKYR AEGNFALEPF 

       130        140        150        160        170        180 
FDAAKQAGIY LLARPGPYIN AEASGGGFPG WLQRVNGTLR TSDPAYLKAT DNYIAHVAAT 

       190        200        210        220        230        240 
VAKGQITNGG PVILYQPENE YSGACCNATF PDGDYMQYVI DQARNAGIVV PLINNDAWTG 

       250        260        270        280        290        300 
GHNAPGTGKG EVDIYGHDSY PLGFDCGHPS VWPKGNLPTT FRTDHLRESP TTPYSLIEFQ 

       310        320        330        340        350        360 
AGSFDPWGGP GFAACAALVN HEFERVFYKN DLSFGAAILN LYMTFGGTNW GNLGHPGGYT 

       370        380        390        400        410        420 
SYDYGSPLTE SRNVTREKYS ELKLIGNFVK ASPSYLLATP GNLTTSGYAD TADLTVTPLL 

       430        440        450        460        470        480 
GNGTGSYFVV RHTDYTSQAS TPYKLSLPTS AGRLTVPQLG GTLTLNGRDS KVHVVDYNVA 

       490        500        510        520        530        540 
GTNILYSTAE VFTWKKFGDS KVLVLYGGPG EHHELAVSLK SDVQVVEGSN SEFTSKKVED 

       550        560        570        580        590        600 
VVVVAWDVSA SRRIVQIGDL KIFLLDRNSA YNYWVPQLDK DDSSTGYSSE KTTASSIIVK 

       610        620        630        640        650        660 
AGYLVRTAYT KGSGLYLTAD FNATTPVEVI GAPSNVRNLY INGEKTQFKT DKNGIWSTGV 

       670        680        690        700        710        720 
KYSAPKIKLP SMKDLDWKYL DTLPEVQSTY DDSAWPAADL DTTPNTLRPL TMPKSLHSSD 

       730        740        750        760        770        780 
YGFHTGYLIY RGHFVADGSE TTFDVRTQGG SAFGSSVWLN EAFLGSWTGL NANADYNSTY 

       790        800        810        820        830        840 
RLPQVEKGKN YVLTVVIDTM GLNENWVVGT DEMKNPRGIL SYKLSGRDAS AITWKLTGNL 

       850        860        870        880        890        900 
GGEDYQDKIR GPLNEGGLYA ERQGFHQPEP PSKKWKSASP LDGLSKPGIG FYTAQFDLDI 

       910        920        930        940        950        960 
PSGWDVPLYF NFGNSTKSAY RVQLYVNGYQ YGKFVSNIGP QTSFPVPQGI LNYQGTNWVA 

       970        980        990       1000 
LTLWALESDG AKLDDFELVN TTPVMTALSK IRPSKQPNYR QRKGAY 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS027688 Genomic DNA. Translation: EAW22442.1.
RefSeqXP_001264339.1. XM_001264338.1.

3D structure databases

ProteinModelPortalA1D1Z9.
SMRA1D1Z9. Positions 41-1006.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING36630.CADNFIAP00001763.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADNFIAT00001802; CADNFIAP00001763; CADNFIAG00001802.
GeneID4591834.
KEGGnfi:NFIA_011250.

Phylogenomic databases

eggNOGCOG1874.
HOGENOMHOG000181922.
OMAHNAPGTG.
OrthoDBEOG7ZGXBD.

Family and domain databases

Gene3D2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR019801. Glyco_hydro_35_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERPTHR23421. PTHR23421. 1 hit.
PfamPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSPR00742. GLHYDRLASE35.
SMARTSM01029. BetaGal_dom2. 1 hit.
[Graphical view]
SUPFAMSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
PROSITEPS01182. GLYCOSYL_HYDROL_F35. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBGALA_NEOFI
AccessionPrimary (citable) accession number: A1D1Z9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries