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A1D1Z9

- BGALA_NEOFI

UniProt

A1D1Z9 - BGALA_NEOFI

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Protein
Probable beta-galactosidase A
Gene
lacA, NFIA_011250
Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans By similarity.

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei96 – 961Substrate By similarity
Binding sitei140 – 1401Substrate By similarity
Binding sitei141 – 1411Substrate; via amide nitrogen By similarity
Binding sitei142 – 1421Substrate By similarity
Binding sitei199 – 1991Substrate By similarity
Active sitei200 – 2001Proton donor Reviewed prediction
Binding sitei260 – 2601Substrate By similarity
Active sitei298 – 2981Nucleophile Reviewed prediction
Binding sitei364 – 3641Substrate By similarity

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-galactosidase A (EC:3.2.1.23)
Alternative name(s):
Lactase A
Gene namesi
Name:lacA
ORF Names:NFIA_011250
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
ProteomesiUP000006702: Unassembled WGS sequence

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 1006988Probable beta-galactosidase A
PRO_0000395221Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi156 – 1561N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi205 ↔ 206 By similarity
Glycosylationi207 – 2071N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi266 ↔ 315 By similarity
Glycosylationi373 – 3731N-linked (GlcNAc...) Reviewed prediction
Glycosylationi402 – 4021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi422 – 4221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi622 – 6221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi777 – 7771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi914 – 9141N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi36630.CADNFIAP00001763.

Structurei

3D structure databases

ProteinModelPortaliA1D1Z9.
SMRiA1D1Z9. Positions 41-1006.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1874.
HOGENOMiHOG000181922.
OMAiHNAPGTG.
OrthoDBiEOG7ZGXBD.

Family and domain databases

Gene3Di2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR019801. Glyco_hydro_35_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 1 hit.
PfamiPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSiPR00742. GLHYDRLASE35.
SMARTiSM01029. BetaGal_dom2. 1 hit.
[Graphical view]
SUPFAMiSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
PROSITEiPS01182. GLYCOSYL_HYDROL_F35. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1D1Z9-1 [UniParc]FASTAAdd to Basket

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MKLLSVCAVA LLAAQAAGAS IKHKLNGFTI MEHSDPAKRE LLQKYVTWDE     50
KSLFVNGERI MIFSGEVHPF RLPVPSLWLD VFQKIKALGF NCVSFYVDWA 100
LLEGKPGKYR AEGNFALEPF FDAAKQAGIY LLARPGPYIN AEASGGGFPG 150
WLQRVNGTLR TSDPAYLKAT DNYIAHVAAT VAKGQITNGG PVILYQPENE 200
YSGACCNATF PDGDYMQYVI DQARNAGIVV PLINNDAWTG GHNAPGTGKG 250
EVDIYGHDSY PLGFDCGHPS VWPKGNLPTT FRTDHLRESP TTPYSLIEFQ 300
AGSFDPWGGP GFAACAALVN HEFERVFYKN DLSFGAAILN LYMTFGGTNW 350
GNLGHPGGYT SYDYGSPLTE SRNVTREKYS ELKLIGNFVK ASPSYLLATP 400
GNLTTSGYAD TADLTVTPLL GNGTGSYFVV RHTDYTSQAS TPYKLSLPTS 450
AGRLTVPQLG GTLTLNGRDS KVHVVDYNVA GTNILYSTAE VFTWKKFGDS 500
KVLVLYGGPG EHHELAVSLK SDVQVVEGSN SEFTSKKVED VVVVAWDVSA 550
SRRIVQIGDL KIFLLDRNSA YNYWVPQLDK DDSSTGYSSE KTTASSIIVK 600
AGYLVRTAYT KGSGLYLTAD FNATTPVEVI GAPSNVRNLY INGEKTQFKT 650
DKNGIWSTGV KYSAPKIKLP SMKDLDWKYL DTLPEVQSTY DDSAWPAADL 700
DTTPNTLRPL TMPKSLHSSD YGFHTGYLIY RGHFVADGSE TTFDVRTQGG 750
SAFGSSVWLN EAFLGSWTGL NANADYNSTY RLPQVEKGKN YVLTVVIDTM 800
GLNENWVVGT DEMKNPRGIL SYKLSGRDAS AITWKLTGNL GGEDYQDKIR 850
GPLNEGGLYA ERQGFHQPEP PSKKWKSASP LDGLSKPGIG FYTAQFDLDI 900
PSGWDVPLYF NFGNSTKSAY RVQLYVNGYQ YGKFVSNIGP QTSFPVPQGI 950
LNYQGTNWVA LTLWALESDG AKLDDFELVN TTPVMTALSK IRPSKQPNYR 1000
QRKGAY 1006
Length:1,006
Mass (Da):110,230
Last modified:January 23, 2007 - v1
Checksum:i0F6D74409FAE7B19
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027688 Genomic DNA. Translation: EAW22442.1.
RefSeqiXP_001264339.1. XM_001264338.1.

Genome annotation databases

EnsemblFungiiCADNFIAT00001802; CADNFIAP00001763; CADNFIAG00001802.
GeneIDi4591834.
KEGGinfi:NFIA_011250.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027688 Genomic DNA. Translation: EAW22442.1 .
RefSeqi XP_001264339.1. XM_001264338.1.

3D structure databases

ProteinModelPortali A1D1Z9.
SMRi A1D1Z9. Positions 41-1006.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 36630.CADNFIAP00001763.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADNFIAT00001802 ; CADNFIAP00001763 ; CADNFIAG00001802 .
GeneIDi 4591834.
KEGGi nfi:NFIA_011250.

Phylogenomic databases

eggNOGi COG1874.
HOGENOMi HOG000181922.
OMAi HNAPGTG.
OrthoDBi EOG7ZGXBD.

Family and domain databases

Gene3Di 2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR019801. Glyco_hydro_35_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR23421. PTHR23421. 1 hit.
Pfami PF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view ]
PRINTSi PR00742. GLHYDRLASE35.
SMARTi SM01029. BetaGal_dom2. 1 hit.
[Graphical view ]
SUPFAMi SSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
PROSITEi PS01182. GLYCOSYL_HYDROL_F35. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

Entry informationi

Entry nameiBGALA_NEOFI
AccessioniPrimary (citable) accession number: A1D1Z9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi