Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A1D1W1

- MNS1B_NEOFI

UniProt

A1D1W1 - MNS1B_NEOFI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Probable mannosyl-oligosaccharide alpha-1,2-mannosidase 1B

Gene

mns1B

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the maturation of Asn-linked oligosaccharides. Progressively trims alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (By similarity).By similarity

Catalytic activityi

Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2.

Cofactori

Ca2+. Can also use Mg2+, but with lower efficiency (By similarity).By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei367 – 3671Proton donorBy similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. mannosyl-oligosaccharide 1,2-alpha-mannosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. protein glycosylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism

Enzyme and pathway databases

UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable mannosyl-oligosaccharide alpha-1,2-mannosidase 1B (EC:3.2.1.113)
Alternative name(s):
Class I alpha-mannosidase 1B
Man(9)-alpha-mannosidase 1B
Gene namesi
Name:mns1B
Synonyms:msdS
ORF Names:NFIA_010860
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
ProteomesiUP000006702: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. cytoplasmic vesicle Source: UniProtKB-KW
  2. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 493475Probable mannosyl-oligosaccharide alpha-1,2-mannosidase 1BPRO_0000394824Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi87 – 871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi174 – 1741N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi324 ↔ 353By similarity
Glycosylationi489 – 4891N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi36630.CADNFIAP00001081.

Structurei

3D structure databases

ProteinModelPortaliA1D1W1.
SMRiA1D1W1. Positions 31-474.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 47 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG300315.
HOGENOMiHOG000181987.
KOiK01230.
OMAiGPESFGW.
OrthoDBiEOG7BP8BH.

Family and domain databases

Gene3Di1.50.10.50. 1 hit.
InterProiIPR001382. Glyco_hydro_47.
[Graphical view]
PANTHERiPTHR11742. PTHR11742. 1 hit.
PfamiPF01532. Glyco_hydro_47. 1 hit.
[Graphical view]
PRINTSiPR00747. GLYHDRLASE47.
SUPFAMiSSF48225. SSF48225. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1D1W1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHLPSLSVAL ALVSSSLALP QTVLPESDVS SHAAAVKEAF SHAWDGYMKY
60 70 80 90 100
AFPHDELLPI SNSYGDSRNG WGASAVDALS TAIVMRNATI VNQILDHIAK
110 120 130 140 150
IDYSKTSDTV SLFETTIRYL GGMLSGYDLL KGPAADLVKD STKVDMLLQQ
160 170 180 190 200
SKNLGDVLKF AFDTPSGVPY NNINITSHGN DGATTNGLAV TGTLVLEWTR
210 220 230 240 250
LSDLTGDQEY AKLSQRAESY LLAPQPSSGE PFPGLVGSEI SIQTGQFTNG
260 270 280 290 300
FVSWNGGSDS FYEYLMKMYV YDPKRFATYK DRWVAAAESS IDHLASSPAS
310 320 330 340 350
RPDLTFLATY NKGSLGLSSQ HLACFDGGSY LLGGTVLDRA DLIDFGLKLV
360 370 380 390 400
DGCAETYHQT LTGIGPESFG WDEKSVPADQ KEFYERAGFY VQSGAYILRP
410 420 430 440 450
EVIESFYYAY RVTGKKQYRD WVWNAFVNIN KYCRTGSGFA GLTDVNAVNG
460 470 480 490
GNRYDNQESF LFAEVMKYAY LTHAPGMSPI SIADEDKANE SRG
Length:493
Mass (Da):53,855
Last modified:January 23, 2007 - v1
Checksum:i8E6C4E050EA8E4CB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027688 Genomic DNA. Translation: EAW22404.1.
RefSeqiXP_001264301.1. XM_001264300.1.

Genome annotation databases

EnsemblFungiiCADNFIAT00001120; CADNFIAP00001081; CADNFIAG00001120.
GeneIDi4591109.
KEGGinfi:NFIA_010860.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027688 Genomic DNA. Translation: EAW22404.1 .
RefSeqi XP_001264301.1. XM_001264300.1.

3D structure databases

ProteinModelPortali A1D1W1.
SMRi A1D1W1. Positions 31-474.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 36630.CADNFIAP00001081.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADNFIAT00001120 ; CADNFIAP00001081 ; CADNFIAG00001120 .
GeneIDi 4591109.
KEGGi nfi:NFIA_010860.

Phylogenomic databases

eggNOGi NOG300315.
HOGENOMi HOG000181987.
KOi K01230.
OMAi GPESFGW.
OrthoDBi EOG7BP8BH.

Enzyme and pathway databases

UniPathwayi UPA00378 .

Family and domain databases

Gene3Di 1.50.10.50. 1 hit.
InterProi IPR001382. Glyco_hydro_47.
[Graphical view ]
PANTHERi PTHR11742. PTHR11742. 1 hit.
Pfami PF01532. Glyco_hydro_47. 1 hit.
[Graphical view ]
PRINTSi PR00747. GLYHDRLASE47.
SUPFAMi SSF48225. SSF48225. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

Entry informationi

Entry nameiMNS1B_NEOFI
AccessioniPrimary (citable) accession number: A1D1W1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3