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Protein

Probable alpha/beta-glucosidase agdC

Gene

agdC

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Glucosidase involved in the degradation of cellulosic biomass. Has both alpha- and beta-glucosidase activity (By similarity).By similarity

Catalytic activityi

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.
Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei422 – 4221NucleophilePROSITE-ProRule annotation
Active sitei425 – 4251By similarity
Active sitei571 – 5711Proton donorBy similarity

GO - Molecular functioni

  1. alpha-1,4-glucosidase activity Source: UniProtKB-EC
  2. beta-glucosidase activity Source: UniProtKB-EC
  3. carbohydrate binding Source: InterPro
  4. maltose alpha-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable alpha/beta-glucosidase agdC (EC:3.2.1.20, EC:3.2.1.21)
Gene namesi
Name:agdC
ORF Names:NFIA_009180
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
ProteomesiUP000006702: Unassembled WGS sequence

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1414Sequence AnalysisAdd
BLAST
Chaini15 – 881867Probable alpha/beta-glucosidase agdCPRO_0000394920Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi171 – 1711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi373 – 3731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi506 – 5061N-linked (GlcNAc...)Sequence Analysis
Glycosylationi572 – 5721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi608 – 6081N-linked (GlcNAc...)Sequence Analysis
Glycosylationi742 – 7421N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi36630.CADNFIAP00000699.

Structurei

3D structure databases

ProteinModelPortaliA1D1E6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 31 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1501.
HOGENOMiHOG000041175.
KOiK01187.
OMAiDAYFPDD.
OrthoDBiEOG77T1CZ.

Family and domain databases

InterProiIPR011013. Gal_mutarotase_SF_dom.
IPR000322. Glyco_hydro_31.
IPR025887. Glyco_hydro_31_N_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF13802. Gal_mutarotas_2. 1 hit.
PF01055. Glyco_hydro_31. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 2 hits.
SSF74650. SSF74650. 1 hit.
PROSITEiPS00129. GLYCOSYL_HYDROL_F31_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1D1E6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRSLLLLAP LVGAAVLGVR DNSQECPGYK ATNIREGRNS LTADLTLAGT
60 70 80 90 100
PCNTYGTDLK NLKLLVEYQT DKRLHVKIYD ADEEVYQVPE SVLPRVDGKG
110 120 130 140 150
GSGKKSALKF DYQANPFSFK VKRGGEVLFD TSGSNLIFQS QYLNLRTWLP
160 170 180 190 200
EDPNLYGLGE HTDSLRLETT NYTRTLWNRD AYAIPEKTNL YGTHPVYYDH
210 220 230 240 250
RGQDGTHGVF LLNSNGMDIK IDKTEDGKQY LEYNTLGGVF DFYFFTGATP
260 270 280 290 300
KDASIEYAKV VGLPAMQSYW TFGFHQCRYG YRDVFEVAEV VYNYTQAKIP
310 320 330 340 350
LETMWTDIDY MDRRRVFTLD PERFPLEKLR ELVTYLHNHN QRYIVMVDPA
360 370 380 390 400
VSVSDNVGYN DGMEQGIFLQ TQNGSLYKGA VWPGVTAYPD WFHPDIQKYW
410 420 430 440 450
NDQFAKFFDR KTGVDIDGLW IDMNEAANFC PYPCSDPEGY SRDNDLPPAA
460 470 480 490 500
PPVRPSNPRP LPGFPGDFQP SSSSKRSTKG SKVGLPNRDL INPPYMIRNE
510 520 530 540 550
AGSLSNKTIN TDIIHAGEGY AEYDTHNLYG TMMSSASRNA MQHRRPEVRP
560 570 580 590 600
LVITRSTYAG AGAHVGHWLG DNISEWSKYR VSIAQMLAFA SMFQVPMIGS
610 620 630 640 650
DVCGFGGNTT EELCARWARL GAFYTFFRNH NEITGIPQEF YRWPTVAESA
660 670 680 690 700
RKAIDIRYRL LDYIYTAFHR QTQTGEPFLQ PMFYLYPKDK NTFSNQLQFF
710 720 730 740 750
YGDAILVSPV TDGSQTSVDA YFPDDIFYDW HTGAALRGRG ANVTLGNIDV
760 770 780 790 800
TEIPIHIRGG SIIPIRSESA MTTTELRKKG FELIIAPGLD GTASGSLYLD
810 820 830 840 850
DGDSIEQRAT LELEFTYRKG RLRVKGKFGF RTDVKINAVT LLGQSAPASK
860 870 880
SGSVASFDSG RQAVTIKTSL DLTGPSEIDL N
Length:881
Mass (Da):99,054
Last modified:January 23, 2007 - v1
Checksum:i8311042A49FCA1D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027688 Genomic DNA. Translation: EAW22239.1.
RefSeqiXP_001264136.1. XM_001264135.1.

Genome annotation databases

EnsemblFungiiCADNFIAT00000738; CADNFIAP00000699; CADNFIAG00000738.
GeneIDi4591952.
KEGGinfi:NFIA_009180.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027688 Genomic DNA. Translation: EAW22239.1.
RefSeqiXP_001264136.1. XM_001264135.1.

3D structure databases

ProteinModelPortaliA1D1E6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi36630.CADNFIAP00000699.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADNFIAT00000738; CADNFIAP00000699; CADNFIAG00000738.
GeneIDi4591952.
KEGGinfi:NFIA_009180.

Phylogenomic databases

eggNOGiCOG1501.
HOGENOMiHOG000041175.
KOiK01187.
OMAiDAYFPDD.
OrthoDBiEOG77T1CZ.

Family and domain databases

InterProiIPR011013. Gal_mutarotase_SF_dom.
IPR000322. Glyco_hydro_31.
IPR025887. Glyco_hydro_31_N_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF13802. Gal_mutarotas_2. 1 hit.
PF01055. Glyco_hydro_31. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 2 hits.
SSF74650. SSF74650. 1 hit.
PROSITEiPS00129. GLYCOSYL_HYDROL_F31_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

Entry informationi

Entry nameiAGDC_NEOFI
AccessioniPrimary (citable) accession number: A1D1E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: January 23, 2007
Last modified: January 7, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.