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A1D199 (BGALB_NEOFI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable beta-galactosidase B

EC=3.2.1.23
Alternative name(s):
Lactase B
Gene names
Name:lacB
ORF Names:NFIA_008690
OrganismNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus) [Complete proteome]
Taxonomic identifier331117 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya

Protein attributes

Sequence length1015 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans By similarity.

Catalytic activity

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 35 family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Polysaccharide degradation
   Cellular componentSecreted
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpolysaccharide catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbeta-galactosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 1015994Probable beta-galactosidase B
PRO_0000395230

Sites

Active site1961Proton donor Potential
Active site3081Nucleophile Potential
Binding site901Substrate By similarity
Binding site1351Substrate By similarity
Binding site1361Substrate; via amide nitrogen By similarity
Binding site1371Substrate By similarity
Binding site1951Substrate By similarity
Binding site2651Substrate By similarity
Binding site3731Substrate By similarity

Amino acid modifications

Glycosylation231N-linked (GlcNAc...) Potential
Glycosylation1001N-linked (GlcNAc...) Potential
Glycosylation1721N-linked (GlcNAc...) Potential
Glycosylation2111N-linked (GlcNAc...) Potential
Glycosylation4111N-linked (GlcNAc...) Potential
Glycosylation4411N-linked (GlcNAc...) Potential
Glycosylation4561N-linked (GlcNAc...) Potential
Glycosylation5541N-linked (GlcNAc...) Potential
Glycosylation6791N-linked (GlcNAc...) Potential
Glycosylation7351N-linked (GlcNAc...) Potential
Glycosylation7751N-linked (GlcNAc...) Potential
Glycosylation8211N-linked (GlcNAc...) Potential
Glycosylation8781N-linked (GlcNAc...) Potential
Disulfide bond271 ↔ 324 By similarity

Sequences

Sequence LengthMass (Da)Tools
A1D199 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 7BDC616E2D3A2DFF

FASTA1,015111,471
        10         20         30         40         50         60 
MAHIYRLLLL LLSNLWFSAA AQNQSETEWP LHDNGLSKVV QWDHYSFQVN GQRIFIFSGE 

        70         80         90        100        110        120 
FHYWRIPVPE LWRDILEKVK ATGFTAFAFY SSWAYHAPNN RTVDFSTGAR DITPIFELAK 

       130        140        150        160        170        180 
ELGMYMIVRP GPYVNAEASA GGFPLWLTTG EYGSLRNDDP RYTAAWTPYF ANMSQITSKY 

       190        200        210        220        230        240 
QVTDGHNTLV YQIENEYGQQ WIGDPKDRNP NKTAVAYMEL LEASALENGI TVPLTSNDPN 

       250        260        270        280        290        300 
MNSKSWGSDW SNAGGNVDVA GLDSYPSCWT CDVSQCTSTN GEYVPYKVID YYDYFQEVQP 

       310        320        330        340        350        360 
TLPSFMPEFQ GGSYNPWAGP EGGCPQDTGA EFANLFYRWN IGQRVTAMSL YMLYGGTNWG 

       370        380        390        400        410        420 
AIAAPVTATS YDYSAPISED RSIGAKYSET KLLALFTRTA KDLTMTEAIG NGTQYTTNTA 

       430        440        450        460        470        480 
VRAFELRNPQ TNAGFYVTFH NDTTVGGNQA FKLHVNTSVG ALTVPKNEGV IQLNGHQSKI 

       490        500        510        520        530        540 
IVTDFTLGKR TLLYSTAEVL TYAVFENRPT LVLWVPTGES GEFAIKGTKS GKVENGDGCS 

       550        560        570        580        590        600 
GINFKREKDY LVVNFSQAKG LSVLRLDNGV RVVLLDKAAA YRFWAPALTD DPIVQETETV 

       610        620        630        640        650        660 
LVHGPYLVRS ASVSKSTLAL RGDSVEKTTL EIFAPHSVRK ITWNGKEVKT SQTPYGSLKA 

       670        680        690        700        710        720 
TLAAPPTIKL PALTSWRSND SLPERLPSYD DSGPAWIEAN HMTTSNPSPP ATLPVLYADE 

       730        740        750        760        770        780 
YGFHNGVRLW RGYFNGSASG VFLNIQGGSA FGWSAWLNGH FLDSHLGTAT TSQANKTLTF 

       790        800        810        820        830        840 
SSSILNPTEN VLLIVHDDTG HDQTTGALNP RGIIEARLLS NDTSSPAPGF TQWRIAGTAG 

       850        860        870        880        890        900 
GESNLDPIRG VFNEDGLFAE RMGWHLPGFD DSAWTPENST TSASSALSFT GATVRFFRTV 

       910        920        930        940        950        960 
VPLDIPAGLD VSISFVLSTP SAAPKGYRAQ LFVNGYQYGR YNPHIGNQVV FPVPPGILDY 

       970        980        990       1000       1010 
QGDNTIGLAV WAQTEEGAGI QVDWKVNYVA DSSLSVAGFG KGLRPGWTEE RLKFA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS027688 Genomic DNA. Translation: EAW22192.1.
RefSeqXP_001264089.1. XM_001264088.1.

3D structure databases

ProteinModelPortalA1D199.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING36630.CADNFIAP00001723.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADNFIAT00001762; CADNFIAP00001723; CADNFIAG00001762.
GeneID4591479.
KEGGnfi:NFIA_008690.

Phylogenomic databases

eggNOGCOG1874.
HOGENOMHOG000181922.
OMANPVLYVD.
OrthoDBEOG7ZGXBD.

Family and domain databases

Gene3D2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERPTHR23421. PTHR23421. 1 hit.
PfamPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSPR00742. GLHYDRLASE35.
SMARTSM01029. BetaGal_dom2. 1 hit.
[Graphical view]
SUPFAMSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Entry information

Entry nameBGALB_NEOFI
AccessionPrimary (citable) accession number: A1D199
Entry history
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries