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Protein

Probable beta-glucosidase M

Gene

bglM

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).By similarity

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei290 – 2901By similarity

GO - Molecular functioni

  1. beta-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00696.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-glucosidase M (EC:3.2.1.21)
Alternative name(s):
Beta-D-glucoside glucohydrolase M
Cellobiase M
Gentiobiase M
Gene namesi
Name:bglM
ORF Names:NFIA_007920
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
ProteomesiUP000006702 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:NFIA_007920.

Subcellular locationi

  1. Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 769747Probable beta-glucosidase MPRO_0000394910Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi28 – 281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi262 – 2621N-linked (GlcNAc...)Sequence Analysis
Glycosylationi318 – 3181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi325 – 3251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi437 – 4371N-linked (GlcNAc...)Sequence Analysis
Glycosylationi546 – 5461N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi36630.CADNFIAP00001080.

Structurei

3D structure databases

ProteinModelPortaliA1D122.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1472.
HOGENOMiHOG000031215.
KOiK05349.
OMAiNITPQFE.
OrthoDBiEOG7HMS8F.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
3.40.50.1700. 1 hit.
InterProiIPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR30620. PTHR30620. 1 hit.
PfamiPF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
[Graphical view]
PRINTSiPR00133. GLHYDRLASE3.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1D122-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHSNLGLAGL AGLLATASVC LSAPADQNIT SDTYCYGQSP PVYPSPEGSG
60 70 80 90 100
TGSWAAAYAK AKNFVAQLTP EEKVNLTAGT DANNGCSGNI AAIPRLNFPG
110 120 130 140 150
LCVSDAGNGL RGTDYVSSWP SGLHVGASWS KALAKQRAIH MAKEFRKKGV
160 170 180 190 200
NVILGPVVGP LGRVAEAGRN WEGFSNDPYL SGALVYETVD GAQSVGVATC
210 220 230 240 250
TKHYILNEQE TNRNPGTEDG VDIAAVSSNI DDKTMHELYL WPFQDAVLAG
260 270 280 290 300
SASIMCSYNR VNNSYGCQNS KTLNGLLKTE LGFQGYVMTD WGAQHAGIAG
310 320 330 340 350
ANAGLDMVMP STETWGANLT TAISNGTMDA SRLDDMAIRI IASWYQMNQN
360 370 380 390 400
SDSPSPGVGM PTNMYAPHQR VIGREASSKQ TLLRGAIEGH VLVKNTNSAL
410 420 430 440 450
PLKSPQLLSV FGYDAKGPDA LKQNFNWLSY SPAIQENHTL WVGGGSGANN
460 470 480 490 500
AAYVDAPIDA IKRQAYEDGT SVLYDLSSED PDVDPTTDAC LVFINSYATE
510 520 530 540 550
GWDRPGLADK SSDSLVKNVA GKCANTIVTI HNAGIRVIGD WIDHENVTAV
560 570 580 590 600
IFAHLPGQDS GRALVELLYG RANPSGKLPY TVAKKAEDYG SLLHPSLPET
610 620 630 640 650
PYGLFPQSDF DEGVYIDYRA FDKANITPQF EFGFGLSYTA FEYSGLRISN
660 670 680 690 700
PKKSPQYPPS AAIQQGGNPH LWDKTVTVSA EVKNTGRVAG AEVAQLYIGI
710 720 730 740 750
PNGPVRQLRG FEKVDVSAGE TTQVKFALNR RDLSTWDVEA QQWSLQRGTY
760
RVYVGRSSRD LPLTGSFTL
Length:769
Mass (Da):82,416
Last modified:January 23, 2007 - v1
Checksum:i5E4C6555397E7FB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027688 Genomic DNA. Translation: EAW22115.1.
RefSeqiXP_001264012.1. XM_001264011.1.

Genome annotation databases

EnsemblFungiiCADNFIAT00001119; CADNFIAP00001080; CADNFIAG00001119.
GeneIDi4592105.
KEGGinfi:NFIA_007920.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027688 Genomic DNA. Translation: EAW22115.1.
RefSeqiXP_001264012.1. XM_001264011.1.

3D structure databases

ProteinModelPortaliA1D122.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi36630.CADNFIAP00001080.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADNFIAT00001119; CADNFIAP00001080; CADNFIAG00001119.
GeneIDi4592105.
KEGGinfi:NFIA_007920.

Organism-specific databases

EuPathDBiFungiDB:NFIA_007920.

Phylogenomic databases

eggNOGiCOG1472.
HOGENOMiHOG000031215.
KOiK05349.
OMAiNITPQFE.
OrthoDBiEOG7HMS8F.

Enzyme and pathway databases

UniPathwayiUPA00696.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
3.40.50.1700. 1 hit.
InterProiIPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR30620. PTHR30620. 1 hit.
PfamiPF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
[Graphical view]
PRINTSiPR00133. GLHYDRLASE3.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

Entry informationi

Entry nameiBGLM_NEOFI
AccessioniPrimary (citable) accession number: A1D122
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: January 23, 2007
Last modified: April 29, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.