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A1D0C1

- H2AZ_NEOFI

UniProt

A1D0C1 - H2AZ_NEOFI

Protein

Histone H2A.Z

Gene

htz1

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received. Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins. Required for the RNA polymerase II and spt15/TBP recruitment to the target genes. Involved in chromosome stability By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. nucleosome assembly Source: InterPro

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone H2A.Z
    Gene namesi
    Name:htz1
    ORF Names:NFIA_040170
    OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
    Taxonomic identifieri331117 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya

    Subcellular locationi

    Nucleus By similarity. Chromosome By similarity

    GO - Cellular componenti

    1. nucleosome Source: UniProtKB-KW
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Chromosome, Nucleosome core, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 138138Histone H2A.ZPRO_0000297726Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei5 – 51N6-acetyllysineBy similarity
    Modified residuei12 – 121N6-acetyllysineBy similarity

    Post-translational modificationi

    Acetylated once deposited into chromatin.By similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiA1D0C1.

    Interactioni

    Subunit structurei

    The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2A.Z forms a heterodimer with H2B. H2A.Z associates with the vps72/swc2 subunit of the SWR1 chromatin remodeling complex. Interacts also with rbp1/DNA-directed RNA polymerase II largest subunit By similarity.By similarity

    Protein-protein interaction databases

    STRINGi36630.CADNFIAP00003064.

    Structurei

    3D structure databases

    ProteinModelPortaliA1D0C1.
    SMRiA1D0C1. Positions 1-120.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histone H2A family.Curated

    Phylogenomic databases

    eggNOGiCOG5262.
    HOGENOMiHOG000234652.
    KOiK11251.
    OMAiDPQRKGN.
    OrthoDBiEOG7GN30N.

    Family and domain databases

    Gene3Di1.10.20.10. 1 hit.
    InterProiIPR009072. Histone-fold.
    IPR007125. Histone_core_D.
    IPR002119. Histone_H2A.
    [Graphical view]
    PfamiPF00125. Histone. 1 hit.
    [Graphical view]
    PRINTSiPR00620. HISTONEH2A.
    SMARTiSM00414. H2A. 1 hit.
    [Graphical view]
    SUPFAMiSSF47113. SSF47113. 1 hit.
    ProtoNetiSearch...

    Sequencei

    Sequence statusi: Complete.

    A1D0C1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPGGKGKSVG GKAGAKDAAG KTQKSHSAKA GLQFPCGRVK RFLKNNTQNK    50
    MRVGAKAAVY VTAVLEYLTA EVLELAGNAA KDLKVKRITP RHLQLAIRGD 100
    EELDTLIRAT IAFGGVLPRI NRALLLKVEQ KKKNKSDA 138
    Length:138
    Mass (Da):14,790
    Last modified:January 23, 2007 - v1
    Checksum:i9B00FC6623D011E2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027686 Genomic DNA. Translation: EAW24441.1.
    RefSeqiXP_001266338.1. XM_001266337.1.

    Genome annotation databases

    EnsemblFungiiCADNFIAT00003153; CADNFIAP00003064; CADNFIAG00003153.
    GeneIDi4592943.
    KEGGinfi:NFIA_040170.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027686 Genomic DNA. Translation: EAW24441.1 .
    RefSeqi XP_001266338.1. XM_001266337.1.

    3D structure databases

    ProteinModelPortali A1D0C1.
    SMRi A1D0C1. Positions 1-120.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 36630.CADNFIAP00003064.

    Proteomic databases

    PRIDEi A1D0C1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADNFIAT00003153 ; CADNFIAP00003064 ; CADNFIAG00003153 .
    GeneIDi 4592943.
    KEGGi nfi:NFIA_040170.

    Phylogenomic databases

    eggNOGi COG5262.
    HOGENOMi HOG000234652.
    KOi K11251.
    OMAi DPQRKGN.
    OrthoDBi EOG7GN30N.

    Family and domain databases

    Gene3Di 1.10.20.10. 1 hit.
    InterProi IPR009072. Histone-fold.
    IPR007125. Histone_core_D.
    IPR002119. Histone_H2A.
    [Graphical view ]
    Pfami PF00125. Histone. 1 hit.
    [Graphical view ]
    PRINTSi PR00620. HISTONEH2A.
    SMARTi SM00414. H2A. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47113. SSF47113. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

    Entry informationi

    Entry nameiH2AZ_NEOFI
    AccessioniPrimary (citable) accession number: A1D0C1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 21, 2007
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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