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A1CYS1 (ATG26_NEOFI) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Sterol 3-beta-glucosyltransferase
EC=2.4.1.173
Alternative name(s):
Autophagy-related protein 26
Gene names
Name:atg26
ORF Names:NFIA_034590
OrganismNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus) [Complete proteome]
Taxonomic identifier331117 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › Neosartorya

Protein attributes

Sequence length1418 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

May be involved in decane metabolism and autophagy. Involved in the biosynthesis of sterol glucoside By similarity.

Catalytic activity

UDP-glucose + a sterol = UDP + a sterol 3-beta-D-glucoside.

Subcellular location

Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity.

Sequence similarities

Belongs to the glycosyltransferase 28 family.

Contains 2 GRAM domains.

Contains 1 PH domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14181418Sterol 3-beta-glucosyltransferase
PRO_0000318044

Regions

Domain249 – 28840GRAM 1
Domain289 – 38799PH
Domain733 – 79967GRAM 2

Sequences

Sequence LengthMass (Da)Tools
A1CYS1 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 8CC8F82911C7D41D

FASTA1,418158,867
        10         20         30         40         50         60 
MRPFLDDAKR RVDRKLSASR QSLSTSRLLP SALPDRLKDN HDAQVDFTAP PGGSGSREGH 

        70         80         90        100        110        120 
LQYMQQSIFG MIAAVGSRSD FHARFDESSD SDGESEQRPR KESSVRKGTS ASANTSSPLD 

       130        140        150        160        170        180 
SSQRSSSRTD GKSEKESGTR GRRHPRTISD HKLFRPFESN SKHEPQTDPS TGDEMPNISP 

       190        200        210        220        230        240 
PTRPRSATPR AAPILSRMVE AQAQFDLKAS STERSQPSLD ESGEKGPRGA SVSPLSTRLM 

       250        260        270        280        290        300 
DMFGFDKPEK VLVEYACSLL QSILLQGYMY VTEGHICFYA YLPKKSTVAI KSGYLYKRGR 

       310        320        330        340        350        360 
KNPKYSRYWF SLKGDVLSYY ADPSNLYFPS GHVDLRYGIS ASLGEAKEKG REPRDFQVTT 

       370        380        390        400        410        420 
DQRTYYFRAD SSMSAKEWVK ALQKVIFRTH NEGESVKISF PIESIIDIEE SPMVDFAETF 

       430        440        450        460        470        480 
KIRVIEDDDS YAIDEYFFTF FNSGREAFEF LRSLINDQSL KISSQHLSPQ PDRSPRSDPT 

       490        500        510        520        530        540 
RKSRNRWSLT SGTSRVLGNS RAETQRKASA STSHTSLAHD VIKSSPATRH QDSSESILNS 

       550        560        570        580        590        600 
FEQGTESSAA WQSMTDAAES ASQILNRSDV FQSPTIHGLD RRPSGGERRG RRNSDETARS 

       610        620        630        640        650        660 
LSTRANVGTG QQIDELGRRM DGDTSGREAR DSTGESDQYT QDPTKSFSGA PSLNELVKAG 

       670        680        690        700        710        720 
VYPLQRAAGL AEYLRTRSKQ MSNLLASESM GYIEKVSGMW TGGRKHYGEA EDVLPDDQDV 

       730        740        750        760        770        780 
DPEDKEDGCN YGDRFRAHFA LPRTEKLQAT YFAYLHRVLP LYGKIYVSQK KLCFRSLIPG 

       790        800        810        820        830        840 
TRTKMILPLR DIENVEKEKG FRFGYHGLVI IIRGHEELFF EFRTSDARDD CAVTLHQHLE 

       850        860        870        880        890        900 
AVKFMAESGL LAEQEQNDSE AAMTEHRMLQ EARYDDYGEN DLRPLNESSE LHPIFDDPRA 

       910        920        930        940        950        960 
SIVNFKPAES LRITCLTIGS RGDVQPYIAL CKGLLAEGHR PKIATHAEFE PWVRKHGIDF 

       970        980        990       1000       1010       1020 
APVEGDPAEL MRICVENGMF TYSFLKEASQ KFRGWIDDLL SSAWASCQDS DLLIESPSAM 

      1030       1040       1050       1060       1070       1080 
AGIHIAEALR IPYFRAFTMP WSRTRAYPHA FAVPEHRMGG AYNYITYVMF DNVFWKAIAG 

      1090       1100       1110       1120       1130       1140 
QVNRWRKNEL GLKATTLDKM QPNKVPFLYN YSPSVVPPPL DYPDWIRITG YWFLNEGSDW 

      1150       1160       1170       1180       1190       1200 
TPPTALCEFI HRAREDGKKI VYIGFGSIVV SDPSALTKTV IESVRKADVR CILSKGWSDR 

      1210       1220       1230       1240       1250       1260 
LGDPASAKPE VPLPPEIHQI QAAPHDWLFS HIDAAVHHGG AGTTGASLRA GVPTIIKPFF 

      1270       1280       1290       1300       1310       1320 
GDQFFFGSRV EDLGVGICMK KLNVSVFSRA LWEATHSERM IIRAQDLGAR IRSEDGVATA 

      1330       1340       1350       1360       1370       1380 
IQAIYRDLEY AKTLARQRSI ASSTPFSPTP SAKTTAEQDA DDDVEDSEEW TFVGDDTDME 

      1390       1400       1410 
MSRRLRDRAI SDADMLPDRL LANSVPGDSG PGRKLSGR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		DS027686 Genomic DNA. Translation: EAW23891.1.
RefSeqXP_001265788.1. XM_001265787.1.

3D structure databases

ProteinModelPortalA1CYS1.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADNFIAT00003713; CADNFIAP00003624; CADNFIAG00003713.
GeneID4592869.
KEGGnfi:NFIA_034590.

Phylogenomic databases

GeneTreeEFGT00050000002910.
OrthoDBEOG48KVK8.
PhylomeDBA1CYS1.

Family and domain databases

InterProIPR004276. Glyco_trans_28.
IPR004182. GRAM.
IPR011993. PH_type.
IPR001849. Pleckstrin_homology.
IPR002213. UDP_glucos_trans.
[Graphical view]
Gene3DG3DSA:2.30.29.30. PH_type. 1 hit.
KOK05841.
PANTHERPTHR11926. UDP_glucos_trans. 1 hit.
PfamPF03033. Glyco_transf_28. 1 hit.
PF02893. GRAM. 2 hits.
PF00169. PH. 1 hit.
[Graphical view]
SMARTSM00568. GRAM. 2 hits.
SM00233. PH. 1 hit.
[Graphical view]
PROSITEPS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameATG26_NEOFI
AccessionPrimary (citable) accession number: A1CYS1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: January 23, 2007
Last modified: December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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