ID A1CXW5_NEOFI Unreviewed; 1167 AA. AC A1CXW5; DT 23-JAN-2007, integrated into UniProtKB/TrEMBL. DT 23-JAN-2007, sequence version 1. DT 27-MAR-2024, entry version 104. DE SubName: Full=Ras guanine-nucleotide exchange protein, putative {ECO:0000313|EMBL:EAW25467.1}; GN ORFNames=NFIA_109610 {ECO:0000313|EMBL:EAW25467.1}; OS Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 OS / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus). OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus; OC Aspergillus subgen. Fumigati. OX NCBI_TaxID=331117 {ECO:0000313|EMBL:EAW25467.1, ECO:0000313|Proteomes:UP000006702}; RN [1] {ECO:0000313|Proteomes:UP000006702} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / RC NRRL 181 / WB 181 {ECO:0000313|Proteomes:UP000006702}; RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046; RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J., RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H., RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M., RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J., RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C., RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H., RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.; RT "Genomic islands in the pathogenic filamentous fungus Aspergillus RT fumigatus."; RL PLoS Genet. 4:E1000046-E1000046(2008). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DS027685; EAW25467.1; -; Genomic_DNA. DR RefSeq; XP_001267364.1; XM_001267363.1. DR AlphaFoldDB; A1CXW5; -. DR STRING; 331117.A1CXW5; -. DR EnsemblFungi; EAW25467; EAW25467; NFIA_109610. DR GeneID; 4593459; -. DR KEGG; nfi:NFIA_109610; -. DR VEuPathDB; FungiDB:NFIA_109610; -. DR eggNOG; KOG3417; Eukaryota. DR HOGENOM; CLU_002116_1_0_1; -. DR OMA; EEVWERD; -. DR OrthoDB; 68574at2759; -. DR Proteomes; UP000006702; Unassembled WGS sequence. DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. DR CDD; cd00155; RasGEF; 1. DR CDD; cd06224; REM; 1. DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1. DR Gene3D; 2.30.30.40; SH3 Domains; 1. DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1. DR InterPro; IPR008937; Ras-like_GEF. DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N. DR InterPro; IPR023578; Ras_GEF_dom_sf. DR InterPro; IPR001895; RASGEF_cat_dom. DR InterPro; IPR036964; RASGEF_cat_dom_sf. DR InterPro; IPR036028; SH3-like_dom_sf. DR InterPro; IPR001452; SH3_domain. DR PANTHER; PTHR23113:SF354; BUD SITE SELECTION PROTEIN 5; 1. DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1. DR Pfam; PF00617; RasGEF; 1. DR Pfam; PF00618; RasGEF_N; 1. DR SMART; SM00147; RasGEF; 1. DR SMART; SM00229; RasGEFN; 1. DR SMART; SM00326; SH3; 1. DR SUPFAM; SSF48366; Ras GEF; 1. DR SUPFAM; SSF50044; SH3-domain; 1. DR PROSITE; PS50009; RASGEF_CAT; 1. DR PROSITE; PS50212; RASGEF_NTER; 1. DR PROSITE; PS50002; SH3; 1. PE 4: Predicted; KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658, KW ECO:0000256|PROSITE-ProRule:PRU00168}; KW Reference proteome {ECO:0000313|Proteomes:UP000006702}; KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE- KW ProRule:PRU00192}. FT DOMAIN 71..137 FT /note="SH3" FT /evidence="ECO:0000259|PROSITE:PS50002" FT DOMAIN 701..821 FT /note="N-terminal Ras-GEF" FT /evidence="ECO:0000259|PROSITE:PS50212" FT DOMAIN 881..1124 FT /note="Ras-GEF" FT /evidence="ECO:0000259|PROSITE:PS50009" FT REGION 16..43 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 506..597 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 17..43 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 510..524 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 539..578 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1167 AA; 128966 MW; 76C133C89B4F0C72 CRC64; MEPMKRHIAP LKVEKTITNP CGSTTSESGD PSSNHYYSTQ HSLQMSPPLT PYCATSSKDS SMDRTEAPRA VFHNYLRAFY PFHPPGDVSP DTITLPLDQG DIILVHSVHT NGWADGTLLD TGARGWLPTN YCEAYDQLPM RPLLKALTDF WDIIRGGCGS SLRDFGNQDL VRGLIAGVRF LLEKSECLTR DSFLVRRHEG LRRNRKALLS DLTALVRTTK SFQVIASGNP LQDEVEYMVD EMLLKAFRVV TRGVRFLDIW NEEVGLSRTI AELEQTKDYA SPLTPASETF VMSERAPSEA ETERNESRVL NRSCMSMSRC STRVDMSEQP RPVSVATKRI SISHRVSYSG PAAASRNANL ASERLNATYD AFLGVLGSFI GLHLQSRSST ELVVTTEQAV RSCRGLLTVV EAVCEHDSQG SALLERAKDT MYERLSELVF AARDAFRPAQ SPDDELVFMP DEGKRLVDAA TDCVRAAGNC LAKARLVLEQ VGDFELEALP QDVATPLVGA GPESQSQQQK GDQPGISLRL PPPPLQIPQN ADLDSSPPTP GLTDDTTPSS SFNSRTLSSP TIAATDEASL PSASIPPPSP AKSSFSSSYD ATAGVKILAN RISHPKSEIG ESFGRGVTST GSSFTYHSHL RDSEMSGVSQ TSTRATSPDI GSCYQAPSLK SCVSHSTLAE EGEETEVNIL EKTYAHELIF KDGQVMGGSL RALIEKLTSH GSTPDAMFVS TFYLTFRLFA TPLEFAEALA ERFNYIGDTP HAAGPVRLRV YNVFKGWLES HWRHDCDDSA LDFIVNFANT TLMQSLPSAG KRLLELTNKV STLQGPVVPR LISSMGKTNT ATAQYVHPDT PLPPPILSKK EVNLLKQWKN GEAAISILDF DPLELARQLT IKESRIFCAI LPEELLATEW MKKSASLAVN VRAMSTLSTD LAHLVADSIL QLEEPKKRAA IIKQWVKIAN KCLELNNYDT LMAIICSLNS SMISRLKRTW EVVSQKTKAT LETLRGIVDV SRNYAVLRQR LQTHVPPCLP FVGTYLTDLT FVDHGNQPLR SLPTDDGEMT VINFDKHMKT AKIISELQRF QIPYRLTEVP ELQTWMQNEL VRVRSNGEKS LQTFYRRSLI LEPREITPRP TLQPESSASS IMENAKDKFD LFAWTHPSKA KSVATNS //