ID   ATG1_NEOFI              Reviewed;         950 AA.
AC   A1CX69;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   16-JUN-2009, entry version 18.
DE   RecName: Full=Serine/threonine-protein kinase atg1;
DE            EC=2.7.11.1;
DE   AltName: Full=Autophagy-related protein 1;
GN   Name=atg1; ORFNames=NFIA_107120;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL
OS   181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Neosartorya.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P.,
RA   Anderson M.J., Crabtree J., Silva J.C., Badger J.H., Albarraq A.,
RA   Angiuoli S., Bussey H., Bowyer P., Cotty P.J., Dyer P.S., Egan A.,
RA   Galens K., Fraser-Liggett C.M., Haas B.J., Inman J.M., Kent R.,
RA   Lemieux S., Malavazi I., Orvis J., Roemer T., Ronning C.M.,
RA   Sundaram J.P., Sutton G., Turner G., Venter J.C., White O.R.,
RA   Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H., Wortman J.R.,
RA   Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Serine/threonine protein kinase probably involved in the
CC       cytoplasm to vacuole transport (Cvt) and in autophagy, where it
CC       may be required for the formation of autophagosomes (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr
CC       protein kinase family. APG1/unc-51/ULK1 subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
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DR   EMBL; DS027685; EAW25221.1; -; Genomic_DNA.
DR   RefSeq; XP_001267118.1; -.
DR   GeneID; 4593469; -.
DR   KEGG; nfi:NFIA_107120; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0006468; P:protein amino acid phosphorylation; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR000719; Prot_kinase_core.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_pkinase-rel.
DR   InterPro; IPR008271; Ser_thr_pkin_AS.
DR   InterPro; IPR002290; Ser_thr_pkinase.
DR   Pfam; PF00069; Pkinase; 1.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Autophagy; Complete proteome; Cytoplasm; Kinase;
KW   Nucleotide-binding; Protein transport;
KW   Serine/threonine-protein kinase; Transferase; Transport.
FT   CHAIN         1    950       Serine/threonine-protein kinase atg1.
FT                                /FTId=PRO_0000317794.
FT   DOMAIN        6    311       Protein kinase.
FT   NP_BIND      12     20       ATP (By similarity).
FT   ACT_SITE    149    149       Proton acceptor (By similarity).
FT   BINDING      35     35       ATP (By similarity).
SQ   SEQUENCE   950 AA;  103646 MW;  19BA220961266A8D CRC64;
     MSIGRYTRLD EIGRGSFATV YQGVHTKTRT YVAIKSVNLS KLNKKLKDNL SSEIHILKGL
     YHPHIVALID CHETTSHIHL VMEYCALGDL SLFIKRRDTL GDHRYTRDMI AKYPNPPGGA
     LNEVVVRHFL KQLASALKFL RDRNLIHRDI KPQNLLLCPS PSSYRSGVTQ VVPFKGSEDS
     FNPATGLESL PLLKIADFGF ARSLPATSLA ETLCGSPLYM APEILRYEKY DAKADLWSVG
     TVLYEMVVGK PPFRATNHVE LLRKIEKGED RIKFPEENPA SDEIKALIRA LLKRNPVERL
     NFPDFFENGV ITSPIPGLVA DDQPSIPRDP PADPETAEST PRPDSRSGAI VPGGTERERE
     VSYLPKGDTG LTQRPPSQNQ RFGTPPTTTH MRRIGSGDRP PSTPKELTPP MTYPQRPSAV
     SHATAPGRQE LVDRNAAFTA MERQRGRNTF SEGSPQTDRQ ADKLREERER AAQDVAFERD
     YVVVEKRAVE VNAFADELAH SPRIQGGISR GAQTGALSRR STVHGPTPLN PSPPQATVGK
     AMQVLSGRSR ADSMHNRQSS YERRYGQSPT SATSAISKAL NMASGRLFGM GFSPPLAITK
     GGRSPPLAYN PFPAYPAHGS LMIGDGAKNN VALDEDTKTV QILEECATRS DVVYGFAEVK
     YKQLVPLAPS VQTDPSSKGN LAGERENPDS ADGGLTVDAI VTLSEEALVL YVKALSLLAK
     SMDIAGAWWA RKNRGDGFGD SAMSRADGAS TLAGTRINNV VQWVRNRFNE VLEKGEFVRL
     KLIEAQKRLP PDHPSHPDNH SVGSSLGSGA SVDVVVSPGV SAEKLMYDRA LEMSRTAAIN
     ELTGEDLSGC EIAYVTAIRM LEAVLENGEV PRFGQGKDDT SKDSDKIVLD AVQAEERQVV
     IKLVSSIRSR LAALRKKLAI LAKRAPTPSA NVPSKMAPLN PVSVGATPPK
//