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Protein

Probable dipeptidyl peptidase 4

Gene

dpp4

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei613 – 6131Charge relay systemBy similarity
Active sitei690 – 6901Charge relay systemBy similarity
Active sitei725 – 7251Charge relay systemBy similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.008.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl peptidase 4 (EC:3.4.14.5)
Alternative name(s):
Dipeptidyl peptidase IV
Short name:
DPP IV
Short name:
DppIV
Gene namesi
Name:dpp4
ORF Names:NFIA_106690
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
ProteomesiUP000006702: Unassembled WGS sequence

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1414Sequence AnalysisAdd
BLAST
Chaini15 – 765751Probable dipeptidyl peptidase 4PRO_0000397814Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi35 – 351N-linked (GlcNAc...)Sequence Analysis
Glycosylationi78 – 781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi465 – 4651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi490 – 4901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi665 – 6651N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi36630.CADNFIAP00010057.

Structurei

3D structure databases

ProteinModelPortaliA1CX29.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1506.
HOGENOMiHOG000189891.
KOiK01278.
OMAiVQYFAWA.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1CX29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKWSILLLVG CAAAIDVPRQ PYAPTGSGKK RLTFNETVVK RAISPSAISV
60 70 80 90 100
EWISTSEDGD YVYQDQDGSL KIQSIVTNNT QTLVPADKVP EDAYSYWIHP
110 120 130 140 150
NLSSVLWATN YTKQYRHSYF ADYFIQDVQS MNLRPLAPDQ SGDIQYAQWS
160 170 180 190 200
PTGDAIAFVR GNDVFVWTNA STSQITNDGG PDLFNGVPDW IYEEEILGDR
210 220 230 240 250
FALWFSPDGA YLAFLRFNET GVPTFTVPYY MDNEEIAPPY PRELELRYPK
260 270 280 290 300
VSQTNPTVEL NLLELRTGER TPVPIDAFDA KELIIGEVAW LTEKHDVVAV
310 320 330 340 350
KAFNRVQDRQ KVVAVDVASL RTKTINERDG TDGWLDNLLS MAYIGPIGES
360 370 380 390 400
KEEYYIDISD QSGWAHLWLF PVAGGEPIAL TKGEWEVTAI LSIDKPRQLV
410 420 430 440 450
YFLSTKHHST ERHLYSVSWK TMEITPLVDD TVPAVWSASF SSQGGYYILS
460 470 480 490 500
YRGPDVPYQD LYAINSTAPL RTITSNAAVL DGLKEYTLPN ITYFELALPS
510 520 530 540 550
GETLNVMQRL PVKFSSKKKY PVLFTPYGGP GAQEVSKAWQ ALDFKAYIAS
560 570 580 590 600
DPELEYITWT VDNRGTGYKG RAFRCQVTSR LGELEAADQV FAAQQAAKLP
610 620 630 640 650
YVDADHIAIW GWSYGGYLTG KVIETDSGAF SLGVQTAPVS DWRFYDSMYT
660 670 680 690 700
ERYMKTLESN AAGYNASAIR KVAGYKNVRG GVLIQHGTGD DNVHFQNAAA
710 720 730 740 750
LVDTLVGAGV TPEKLQVQWF TDSDHGIRYH GGNVFLYRQL SKRLYEEKKR
760
KEKGEAHQWS KKSVL
Length:765
Mass (Da):85,823
Last modified:January 23, 2007 - v1
Checksum:i490FAB631D986EA1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027685 Genomic DNA. Translation: EAW25181.1.
RefSeqiXP_001267078.1. XM_001267077.1.

Genome annotation databases

EnsemblFungiiCADNFIAT00010297; CADNFIAP00010057; CADNFIAG00010297.
GeneIDi4593808.
KEGGinfi:NFIA_106690.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027685 Genomic DNA. Translation: EAW25181.1.
RefSeqiXP_001267078.1. XM_001267077.1.

3D structure databases

ProteinModelPortaliA1CX29.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi36630.CADNFIAP00010057.

Protein family/group databases

MEROPSiS09.008.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADNFIAT00010297; CADNFIAP00010057; CADNFIAG00010297.
GeneIDi4593808.
KEGGinfi:NFIA_106690.

Phylogenomic databases

eggNOGiCOG1506.
HOGENOMiHOG000189891.
KOiK01278.
OMAiVQYFAWA.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

Entry informationi

Entry nameiDPP4_NEOFI
AccessioniPrimary (citable) accession number: A1CX29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: January 23, 2007
Last modified: March 4, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.