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A1CX29

- DPP4_NEOFI

UniProt

A1CX29 - DPP4_NEOFI

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Protein

Probable dipeptidyl peptidase 4

Gene
dpp4, NFIA_106690
Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei613 – 6131Charge relay system By similarity
Active sitei690 – 6901Charge relay system By similarity
Active sitei725 – 7251Charge relay system By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.008.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl peptidase 4 (EC:3.4.14.5)
Alternative name(s):
Dipeptidyl peptidase IV
Short name:
DPP IV
Short name:
DppIV
Gene namesi
Name:dpp4
ORF Names:NFIA_106690
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
ProteomesiUP000006702: Unassembled WGS sequence

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1414 Reviewed predictionAdd
BLAST
Chaini15 – 765751Probable dipeptidyl peptidase 4PRO_0000397814Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi35 – 351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi78 – 781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi101 – 1011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi110 – 1101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi169 – 1691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi218 – 2181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi465 – 4651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi490 – 4901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi665 – 6651N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi36630.CADNFIAP00010057.

Structurei

3D structure databases

ProteinModelPortaliA1CX29.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1506.
HOGENOMiHOG000189891.
KOiK01278.
OMAiWAVNYTK.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1CX29-1 [UniParc]FASTAAdd to Basket

« Hide

MKWSILLLVG CAAAIDVPRQ PYAPTGSGKK RLTFNETVVK RAISPSAISV    50
EWISTSEDGD YVYQDQDGSL KIQSIVTNNT QTLVPADKVP EDAYSYWIHP 100
NLSSVLWATN YTKQYRHSYF ADYFIQDVQS MNLRPLAPDQ SGDIQYAQWS 150
PTGDAIAFVR GNDVFVWTNA STSQITNDGG PDLFNGVPDW IYEEEILGDR 200
FALWFSPDGA YLAFLRFNET GVPTFTVPYY MDNEEIAPPY PRELELRYPK 250
VSQTNPTVEL NLLELRTGER TPVPIDAFDA KELIIGEVAW LTEKHDVVAV 300
KAFNRVQDRQ KVVAVDVASL RTKTINERDG TDGWLDNLLS MAYIGPIGES 350
KEEYYIDISD QSGWAHLWLF PVAGGEPIAL TKGEWEVTAI LSIDKPRQLV 400
YFLSTKHHST ERHLYSVSWK TMEITPLVDD TVPAVWSASF SSQGGYYILS 450
YRGPDVPYQD LYAINSTAPL RTITSNAAVL DGLKEYTLPN ITYFELALPS 500
GETLNVMQRL PVKFSSKKKY PVLFTPYGGP GAQEVSKAWQ ALDFKAYIAS 550
DPELEYITWT VDNRGTGYKG RAFRCQVTSR LGELEAADQV FAAQQAAKLP 600
YVDADHIAIW GWSYGGYLTG KVIETDSGAF SLGVQTAPVS DWRFYDSMYT 650
ERYMKTLESN AAGYNASAIR KVAGYKNVRG GVLIQHGTGD DNVHFQNAAA 700
LVDTLVGAGV TPEKLQVQWF TDSDHGIRYH GGNVFLYRQL SKRLYEEKKR 750
KEKGEAHQWS KKSVL 765
Length:765
Mass (Da):85,823
Last modified:January 23, 2007 - v1
Checksum:i490FAB631D986EA1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027685 Genomic DNA. Translation: EAW25181.1.
RefSeqiXP_001267078.1. XM_001267077.1.

Genome annotation databases

EnsemblFungiiCADNFIAT00010297; CADNFIAP00010057; CADNFIAG00010297.
GeneIDi4593808.
KEGGinfi:NFIA_106690.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027685 Genomic DNA. Translation: EAW25181.1 .
RefSeqi XP_001267078.1. XM_001267077.1.

3D structure databases

ProteinModelPortali A1CX29.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 36630.CADNFIAP00010057.

Protein family/group databases

MEROPSi S09.008.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADNFIAT00010297 ; CADNFIAP00010057 ; CADNFIAG00010297 .
GeneIDi 4593808.
KEGGi nfi:NFIA_106690.

Phylogenomic databases

eggNOGi COG1506.
HOGENOMi HOG000189891.
KOi K01278.
OMAi WAVNYTK.
OrthoDBi EOG72VHFG.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

Entry informationi

Entry nameiDPP4_NEOFI
AccessioniPrimary (citable) accession number: A1CX29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi