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A1CX29

- DPP4_NEOFI

UniProt

A1CX29 - DPP4_NEOFI

Protein

Probable dipeptidyl peptidase 4

Gene

dpp4

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei613 – 6131Charge relay systemBy similarity
    Active sitei690 – 6901Charge relay systemBy similarity
    Active sitei725 – 7251Charge relay systemBy similarity

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. serine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS09.008.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dipeptidyl peptidase 4 (EC:3.4.14.5)
    Alternative name(s):
    Dipeptidyl peptidase IV
    Short name:
    DPP IV
    Short name:
    DppIV
    Gene namesi
    Name:dpp4
    ORF Names:NFIA_106690
    OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
    Taxonomic identifieri331117 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
    ProteomesiUP000006702: Unassembled WGS sequence

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. membrane Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1414Sequence AnalysisAdd
    BLAST
    Chaini15 – 765751Probable dipeptidyl peptidase 4PRO_0000397814Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi35 – 351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi78 – 781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi465 – 4651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi490 – 4901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi665 – 6651N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi36630.CADNFIAP00010057.

    Structurei

    3D structure databases

    ProteinModelPortaliA1CX29.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S9B family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG1506.
    HOGENOMiHOG000189891.
    KOiK01278.
    OMAiWAVNYTK.
    OrthoDBiEOG72VHFG.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A1CX29-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKWSILLLVG CAAAIDVPRQ PYAPTGSGKK RLTFNETVVK RAISPSAISV    50
    EWISTSEDGD YVYQDQDGSL KIQSIVTNNT QTLVPADKVP EDAYSYWIHP 100
    NLSSVLWATN YTKQYRHSYF ADYFIQDVQS MNLRPLAPDQ SGDIQYAQWS 150
    PTGDAIAFVR GNDVFVWTNA STSQITNDGG PDLFNGVPDW IYEEEILGDR 200
    FALWFSPDGA YLAFLRFNET GVPTFTVPYY MDNEEIAPPY PRELELRYPK 250
    VSQTNPTVEL NLLELRTGER TPVPIDAFDA KELIIGEVAW LTEKHDVVAV 300
    KAFNRVQDRQ KVVAVDVASL RTKTINERDG TDGWLDNLLS MAYIGPIGES 350
    KEEYYIDISD QSGWAHLWLF PVAGGEPIAL TKGEWEVTAI LSIDKPRQLV 400
    YFLSTKHHST ERHLYSVSWK TMEITPLVDD TVPAVWSASF SSQGGYYILS 450
    YRGPDVPYQD LYAINSTAPL RTITSNAAVL DGLKEYTLPN ITYFELALPS 500
    GETLNVMQRL PVKFSSKKKY PVLFTPYGGP GAQEVSKAWQ ALDFKAYIAS 550
    DPELEYITWT VDNRGTGYKG RAFRCQVTSR LGELEAADQV FAAQQAAKLP 600
    YVDADHIAIW GWSYGGYLTG KVIETDSGAF SLGVQTAPVS DWRFYDSMYT 650
    ERYMKTLESN AAGYNASAIR KVAGYKNVRG GVLIQHGTGD DNVHFQNAAA 700
    LVDTLVGAGV TPEKLQVQWF TDSDHGIRYH GGNVFLYRQL SKRLYEEKKR 750
    KEKGEAHQWS KKSVL 765
    Length:765
    Mass (Da):85,823
    Last modified:January 23, 2007 - v1
    Checksum:i490FAB631D986EA1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027685 Genomic DNA. Translation: EAW25181.1.
    RefSeqiXP_001267078.1. XM_001267077.1.

    Genome annotation databases

    EnsemblFungiiCADNFIAT00010297; CADNFIAP00010057; CADNFIAG00010297.
    GeneIDi4593808.
    KEGGinfi:NFIA_106690.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027685 Genomic DNA. Translation: EAW25181.1 .
    RefSeqi XP_001267078.1. XM_001267077.1.

    3D structure databases

    ProteinModelPortali A1CX29.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 36630.CADNFIAP00010057.

    Protein family/group databases

    MEROPSi S09.008.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADNFIAT00010297 ; CADNFIAP00010057 ; CADNFIAG00010297 .
    GeneIDi 4593808.
    KEGGi nfi:NFIA_106690.

    Phylogenomic databases

    eggNOGi COG1506.
    HOGENOMi HOG000189891.
    KOi K01278.
    OMAi WAVNYTK.
    OrthoDBi EOG72VHFG.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

    Entry informationi

    Entry nameiDPP4_NEOFI
    AccessioniPrimary (citable) accession number: A1CX29
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 5, 2010
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3