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A1CWV2

- A1CWV2_NEOFI

UniProt

A1CWV2 - A1CWV2_NEOFI

Protein

Alpha-amylase

Gene

NFIA_105920

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi67 – 671Calcium 1
    Metal bindingi108 – 1081Calcium 1; via carbonyl oxygen
    Metal bindingi121 – 1211Calcium 1
    Active sitei152 – 1521NucleophileUniRule annotation
    Metal bindingi152 – 1521Calcium 2
    Metal bindingi156 – 1561Calcium 1; via carbonyl oxygen
    Active sitei176 – 1761Proton donorUniRule annotation
    Metal bindingi176 – 1761Calcium 2
    Sitei243 – 2431Transition state stabilizerUniRule annotation

    GO - Molecular functioni

    1. alpha-amylase activity Source: UniProtKB-EC
    2. calcium ion binding Source: InterPro

    GO - Biological processi

    1. carbohydrate catabolic process Source: InterPro

    Keywords - Molecular functioni

    GlycosidaseUniRule annotation, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolismUniRule annotation

    Keywords - Ligandi

    CalciumUniRule annotation, Metal-bindingUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-amylaseUniRule annotation (EC:3.2.1.1UniRule annotation)
    Gene namesi
    ORF Names:NFIA_105920Imported
    OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)Imported
    Taxonomic identifieri331117 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
    ProteomesiUP000006702: Unassembled WGS sequence

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi96 ↔ 110UniRule annotation
    Disulfide bondi186 ↔ 229UniRule annotation

    Keywords - PTMi

    Disulfide bondUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi36630.CADNFIAP00009673.

    Structurei

    3D structure databases

    ProteinModelPortaliA1CWV2.
    SMRiA1CWV2. Positions 1-422.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 13 family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000165530.
    KOiK01176.
    OMAiDGSTICT.
    OrthoDBiEOG7RBZJ4.

    Family and domain databases

    Gene3Di2.60.40.1180. 1 hit.
    3.20.20.80. 1 hit.
    InterProiIPR013777. A-amylase_fun.
    IPR015340. A_amylase_DUF1966_C.
    IPR006046. Alpha_amylase.
    IPR015902. Glyco_hydro_13.
    IPR013780. Glyco_hydro_13_b.
    IPR006047. Glyco_hydro_13_cat_dom.
    IPR006589. Glyco_hydro_13_sub_cat_dom.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR10357. PTHR10357. 1 hit.
    PfamiPF00128. Alpha-amylase. 1 hit.
    PF09260. DUF1966. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001024. Alph-amyl_fung. 1 hit.
    PRINTSiPR00110. ALPHAAMYLASE.
    SMARTiSM00642. Aamy. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1CWV2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGFTAIWITP VTEQLPQDTS EGTAYHGYWQ QDIYSVNSNY GTADDLKALA    50
    SALHDRGMYL MVDVVANHMG YAGAGDSVDY SVFKPFNSQA YFHPLCFISN 100
    YDNQKDVEDC WLGDNVVPLP DLNTTNSDVQ KIWYNWVTSL VSNYSIDGLR 150
    IDTVKHVQND FWPGFNDAAG VYCIGEVFDG DPAYTCPYQE VLDGVLNYPI 200
    YYPLLKAFQS TSGSMSGLYD MINTVKSQCA DSTLLGTFVE NHDTPRFASY 250
    TNDMALAKNA AAFIILSDGI PIIYAGQEQH YSGGTDPANR EAVWLSGYSK 300
    TSELYKLIAT ANAIRNHAIS KDPGYMTYKN NPIYKDTSTI AMRKGSDGAQ 350
    VITVLSNLGA SGSSYTLSLS GTGYEAGQQL TEVFSCTTVT VGSDGKVPVP 400
    MASGLPRVFY PTAGLDGSTI CT 422
    Length:422
    Mass (Da):45,982
    Last modified:January 23, 2007 - v1
    Checksum:i46BE39CF05067B0E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027685 Genomic DNA. Translation: EAW25104.1.
    RefSeqiXP_001267001.1. XM_001267000.1.

    Genome annotation databases

    EnsemblFungiiCADNFIAT00009913; CADNFIAP00009673; CADNFIAG00009913.
    GeneIDi4593921.
    KEGGinfi:NFIA_105920.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027685 Genomic DNA. Translation: EAW25104.1 .
    RefSeqi XP_001267001.1. XM_001267000.1.

    3D structure databases

    ProteinModelPortali A1CWV2.
    SMRi A1CWV2. Positions 1-422.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 36630.CADNFIAP00009673.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADNFIAT00009913 ; CADNFIAP00009673 ; CADNFIAG00009913 .
    GeneIDi 4593921.
    KEGGi nfi:NFIA_105920.

    Phylogenomic databases

    HOGENOMi HOG000165530.
    KOi K01176.
    OMAi DGSTICT.
    OrthoDBi EOG7RBZJ4.

    Family and domain databases

    Gene3Di 2.60.40.1180. 1 hit.
    3.20.20.80. 1 hit.
    InterProi IPR013777. A-amylase_fun.
    IPR015340. A_amylase_DUF1966_C.
    IPR006046. Alpha_amylase.
    IPR015902. Glyco_hydro_13.
    IPR013780. Glyco_hydro_13_b.
    IPR006047. Glyco_hydro_13_cat_dom.
    IPR006589. Glyco_hydro_13_sub_cat_dom.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR10357. PTHR10357. 1 hit.
    Pfami PF00128. Alpha-amylase. 1 hit.
    PF09260. DUF1966. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001024. Alph-amyl_fung. 1 hit.
    PRINTSi PR00110. ALPHAAMYLASE.
    SMARTi SM00642. Aamy. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181Imported.

    Entry informationi

    Entry nameiA1CWV2_NEOFI
    AccessioniPrimary (citable) accession number: A1CWV2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 23, 2007
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3