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A1CWV2

- A1CWV2_NEOFI

UniProt

A1CWV2 - A1CWV2_NEOFI

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Protein

Alpha-amylase

Gene

NFIA_105920

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi67 – 671Calcium 1
Metal bindingi108 – 1081Calcium 1; via carbonyl oxygen
Metal bindingi121 – 1211Calcium 1
Active sitei152 – 1521NucleophileUniRule annotation
Metal bindingi152 – 1521Calcium 2
Metal bindingi156 – 1561Calcium 1; via carbonyl oxygen
Active sitei176 – 1761Proton donorUniRule annotation
Metal bindingi176 – 1761Calcium 2
Sitei243 – 2431Transition state stabilizerUniRule annotation

GO - Molecular functioni

  1. alpha-amylase activity Source: UniProtKB-EC
  2. calcium ion binding Source: InterPro

GO - Biological processi

  1. carbohydrate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotation, Hydrolase

Keywords - Biological processi

Carbohydrate metabolismUniRule annotation

Keywords - Ligandi

CalciumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-amylaseUniRule annotation (EC:3.2.1.1UniRule annotation)
Gene namesi
ORF Names:NFIA_105920Imported
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)Imported
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
ProteomesiUP000006702: Unassembled WGS sequence

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi96 ↔ 110UniRule annotation
Disulfide bondi186 ↔ 229UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi36630.CADNFIAP00009673.

Structurei

3D structure databases

ProteinModelPortaliA1CWV2.
SMRiA1CWV2. Positions 1-422.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 13 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000165530.
KOiK01176.
OMAiDGSTICT.
OrthoDBiEOG7RBZJ4.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR013777. A-amylase_fun.
IPR015340. A_amylase_DUF1966_C.
IPR006046. Alpha_amylase.
IPR015902. Glyco_hydro_13.
IPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10357. PTHR10357. 1 hit.
PfamiPF00128. Alpha-amylase. 1 hit.
PF09260. DUF1966. 1 hit.
[Graphical view]
PIRSFiPIRSF001024. Alph-amyl_fung. 1 hit.
PRINTSiPR00110. ALPHAAMYLASE.
SMARTiSM00642. Aamy. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

A1CWV2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGFTAIWITP VTEQLPQDTS EGTAYHGYWQ QDIYSVNSNY GTADDLKALA
60 70 80 90 100
SALHDRGMYL MVDVVANHMG YAGAGDSVDY SVFKPFNSQA YFHPLCFISN
110 120 130 140 150
YDNQKDVEDC WLGDNVVPLP DLNTTNSDVQ KIWYNWVTSL VSNYSIDGLR
160 170 180 190 200
IDTVKHVQND FWPGFNDAAG VYCIGEVFDG DPAYTCPYQE VLDGVLNYPI
210 220 230 240 250
YYPLLKAFQS TSGSMSGLYD MINTVKSQCA DSTLLGTFVE NHDTPRFASY
260 270 280 290 300
TNDMALAKNA AAFIILSDGI PIIYAGQEQH YSGGTDPANR EAVWLSGYSK
310 320 330 340 350
TSELYKLIAT ANAIRNHAIS KDPGYMTYKN NPIYKDTSTI AMRKGSDGAQ
360 370 380 390 400
VITVLSNLGA SGSSYTLSLS GTGYEAGQQL TEVFSCTTVT VGSDGKVPVP
410 420
MASGLPRVFY PTAGLDGSTI CT
Length:422
Mass (Da):45,982
Last modified:January 23, 2007 - v1
Checksum:i46BE39CF05067B0E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027685 Genomic DNA. Translation: EAW25104.1.
RefSeqiXP_001267001.1. XM_001267000.1.

Genome annotation databases

EnsemblFungiiCADNFIAT00009913; CADNFIAP00009673; CADNFIAG00009913.
GeneIDi4593921.
KEGGinfi:NFIA_105920.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027685 Genomic DNA. Translation: EAW25104.1 .
RefSeqi XP_001267001.1. XM_001267000.1.

3D structure databases

ProteinModelPortali A1CWV2.
SMRi A1CWV2. Positions 1-422.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 36630.CADNFIAP00009673.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADNFIAT00009913 ; CADNFIAP00009673 ; CADNFIAG00009913 .
GeneIDi 4593921.
KEGGi nfi:NFIA_105920.

Phylogenomic databases

HOGENOMi HOG000165530.
KOi K01176.
OMAi DGSTICT.
OrthoDBi EOG7RBZJ4.

Family and domain databases

Gene3Di 2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR013777. A-amylase_fun.
IPR015340. A_amylase_DUF1966_C.
IPR006046. Alpha_amylase.
IPR015902. Glyco_hydro_13.
IPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10357. PTHR10357. 1 hit.
Pfami PF00128. Alpha-amylase. 1 hit.
PF09260. DUF1966. 1 hit.
[Graphical view ]
PIRSFi PIRSF001024. Alph-amyl_fung. 1 hit.
PRINTSi PR00110. ALPHAAMYLASE.
SMARTi SM00642. Aamy. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181Imported.

Entry informationi

Entry nameiA1CWV2_NEOFI
AccessioniPrimary (citable) accession number: A1CWV2
Entry historyi
Integrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3