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A1CWV2

- A1CWV2_NEOFI

UniProt

A1CWV2 - A1CWV2_NEOFI

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Protein

Alpha-amylase

Gene
NFIA_105920
Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi67 – 671Calcium 1 By similarityUniRule annotation
Metal bindingi108 – 1081Calcium 1; via carbonyl oxygen By similarityUniRule annotation
Metal bindingi121 – 1211Calcium 1 By similarityUniRule annotation
Active sitei152 – 1521Nucleophile By similarity
Metal bindingi152 – 1521Calcium 2 By similarityUniRule annotation
Metal bindingi156 – 1561Calcium 1; via carbonyl oxygen By similarityUniRule annotation
Active sitei176 – 1761Proton donor By similarityUniRule annotation
Metal bindingi176 – 1761Calcium 2 By similarityUniRule annotation
Sitei243 – 2431Transition state stabilizer By similarityUniRule annotation

GO - Molecular functioni

  1. alpha-amylase activity Source: InterPro
  2. calcium ion binding Source: InterPro

GO - Biological processi

  1. carbohydrate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotation, Hydrolase

Keywords - Biological processi

Carbohydrate metabolismUniRule annotation

Keywords - Ligandi

CalciumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-amylaseUniRule annotation (EC:3.2.1.1UniRule annotation)
Gene namesi
ORF Names:NFIA_105920Imported
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
ProteomesiUP000006702: Unassembled WGS sequence

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi96 ↔ 110 By similarityUniRule annotation
Disulfide bondi186 ↔ 229 By similarityUniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi36630.CADNFIAP00009673.

Structurei

3D structure databases

ProteinModelPortaliA1CWV2.
SMRiA1CWV2. Positions 1-422.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 13 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000165530.
KOiK01176.
OMAiDGSTICT.
OrthoDBiEOG7RBZJ4.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR013777. A-amylase_fun.
IPR015340. A_amylase_DUF1966_C.
IPR006046. Alpha_amylase.
IPR015902. Glyco_hydro_13.
IPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10357. PTHR10357. 1 hit.
PfamiPF00128. Alpha-amylase. 1 hit.
PF09260. DUF1966. 1 hit.
[Graphical view]
PIRSFiPIRSF001024. Alph-amyl_fung. 1 hit.
PRINTSiPR00110. ALPHAAMYLASE.
SMARTiSM00642. Aamy. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

A1CWV2-1 [UniParc]FASTAAdd to Basket

« Hide

MGFTAIWITP VTEQLPQDTS EGTAYHGYWQ QDIYSVNSNY GTADDLKALA    50
SALHDRGMYL MVDVVANHMG YAGAGDSVDY SVFKPFNSQA YFHPLCFISN 100
YDNQKDVEDC WLGDNVVPLP DLNTTNSDVQ KIWYNWVTSL VSNYSIDGLR 150
IDTVKHVQND FWPGFNDAAG VYCIGEVFDG DPAYTCPYQE VLDGVLNYPI 200
YYPLLKAFQS TSGSMSGLYD MINTVKSQCA DSTLLGTFVE NHDTPRFASY 250
TNDMALAKNA AAFIILSDGI PIIYAGQEQH YSGGTDPANR EAVWLSGYSK 300
TSELYKLIAT ANAIRNHAIS KDPGYMTYKN NPIYKDTSTI AMRKGSDGAQ 350
VITVLSNLGA SGSSYTLSLS GTGYEAGQQL TEVFSCTTVT VGSDGKVPVP 400
MASGLPRVFY PTAGLDGSTI CT 422
Length:422
Mass (Da):45,982
Last modified:January 23, 2007 - v1
Checksum:i46BE39CF05067B0E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027685 Genomic DNA. Translation: EAW25104.1.
RefSeqiXP_001267001.1. XM_001267000.1.

Genome annotation databases

EnsemblFungiiCADNFIAT00009913; CADNFIAP00009673; CADNFIAG00009913.
GeneIDi4593921.
KEGGinfi:NFIA_105920.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027685 Genomic DNA. Translation: EAW25104.1 .
RefSeqi XP_001267001.1. XM_001267000.1.

3D structure databases

ProteinModelPortali A1CWV2.
SMRi A1CWV2. Positions 1-422.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 36630.CADNFIAP00009673.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADNFIAT00009913 ; CADNFIAP00009673 ; CADNFIAG00009913 .
GeneIDi 4593921.
KEGGi nfi:NFIA_105920.

Phylogenomic databases

HOGENOMi HOG000165530.
KOi K01176.
OMAi DGSTICT.
OrthoDBi EOG7RBZJ4.

Family and domain databases

Gene3Di 2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR013777. A-amylase_fun.
IPR015340. A_amylase_DUF1966_C.
IPR006046. Alpha_amylase.
IPR015902. Glyco_hydro_13.
IPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10357. PTHR10357. 1 hit.
Pfami PF00128. Alpha-amylase. 1 hit.
PF09260. DUF1966. 1 hit.
[Graphical view ]
PIRSFi PIRSF001024. Alph-amyl_fung. 1 hit.
PRINTSi PR00110. ALPHAAMYLASE.
SMARTi SM00642. Aamy. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

Entry informationi

Entry nameiA1CWV2_NEOFI
AccessioniPrimary (citable) accession number: A1CWV2
Entry historyi
Integrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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