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A1CWA9

- TRMB_NEOFI

UniProt

A1CWA9 - TRMB_NEOFI

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trm8, NFIA_103990
Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei99 – 991S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding sitei229 – 2291S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Active sitei232 – 2321 By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
  2. tRNA binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine, tRNA-binding

Enzyme and pathway databases

UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
Transfer RNA methyltransferase 8
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trm8
ORF Names:NFIA_103990
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
ProteomesiUP000006702: Unassembled WGS sequence

Subcellular locationi

Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 360360tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
PRO_0000370599Add
BLAST

Interactioni

Subunit structurei

Forms a complex with trm82 By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi36630.CADNFIAP00009899.

Structurei

3D structure databases

ProteinModelPortaliA1CWA9.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni122 – 1232S-adenosyl-L-methionine binding By similarity
Regioni209 – 2102S-adenosyl-L-methionine binding By similarity
Regioni332 – 3343S-adenosyl-L-methionine binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000260965.
KOiK03439.
OMAiRAHSNPI.
OrthoDBiEOG708W9T.

Family and domain databases

Gene3Di3.40.50.150. 3 hits.
HAMAPiMF_03055. tRNA_methyltr_TrmB_euk.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR025763. Trm8_euk.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 2 hits.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1CWA9-1 [UniParc]FASTAAdd to Basket

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MTPPPPKRQK RDEYRKATAE AASQPGPSDV AEIKLPKKKY YRQRAHANPF    50
SDHHLNYPLS PAHMDWSSHY PAFVDPDPSH TNLAGARKLL KDVEVVDIGC 100
GFGGLLIGLA PLLPESLIVG MEIRVSVLEY VTTRIQALRA QQLKLRAATA 150
AATAASETPS QQQAQIDGKQ ANANAAADAA SPVLSTDTEH TPTTLVPGSY 200
ENISAIRSNT MKFFPNFFAR HQLSKIFICF PDPHFKARKH KARIISETLN 250
AEYAYALRPG GLLYTITDVE EYHHWILRHF GVESGAEEES EEKSTSANAN 300
ANANAGVREL FERVSEEELE KDECVRVMKE ATEEGKKVAR NKGNKYVAVF 350
RRKTDPEWPA 360
Length:360
Mass (Da):40,001
Last modified:January 23, 2007 - v1
Checksum:i36CA4ABBD9EEDB41
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027685 Genomic DNA. Translation: EAW24911.1.
RefSeqiXP_001266808.1. XM_001266807.1.

Genome annotation databases

EnsemblFungiiCADNFIAT00010139; CADNFIAP00009899; CADNFIAG00010139.
GeneIDi4593789.
KEGGinfi:NFIA_103990.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027685 Genomic DNA. Translation: EAW24911.1 .
RefSeqi XP_001266808.1. XM_001266807.1.

3D structure databases

ProteinModelPortali A1CWA9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 36630.CADNFIAP00009899.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADNFIAT00010139 ; CADNFIAP00009899 ; CADNFIAG00010139 .
GeneIDi 4593789.
KEGGi nfi:NFIA_103990.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000260965.
KOi K03439.
OMAi RAHSNPI.
OrthoDBi EOG708W9T.

Enzyme and pathway databases

UniPathwayi UPA00989 .

Family and domain databases

Gene3Di 3.40.50.150. 3 hits.
HAMAPi MF_03055. tRNA_methyltr_TrmB_euk.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR025763. Trm8_euk.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 2 hits.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 2 hits.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

Entry informationi

Entry nameiTRMB_NEOFI
AccessioniPrimary (citable) accession number: A1CWA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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