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Protein

Mitochondrial glycine transporter

Gene

NFIA_103940

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial glycine transporterUniRule annotation
Alternative name(s):
Solute carrier family 25 member 38 homologUniRule annotation
Gene namesi
ORF Names:NFIA_103940
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006702 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:NFIA_103940

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 50Helical; Name=1UniRule annotationAdd BLAST26
Transmembranei78 – 104Helical; Name=2UniRule annotationAdd BLAST27
Transmembranei138 – 163Helical; Name=3UniRule annotationAdd BLAST26
Transmembranei191 – 214Helical; Name=4UniRule annotationAdd BLAST24
Transmembranei238 – 264Helical; Name=5UniRule annotationAdd BLAST27
Transmembranei293 – 311Helical; Name=6UniRule annotationAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003789391 – 331Mitochondrial glycine transporterAdd BLAST331

Interactioni

Protein-protein interaction databases

STRINGi36630.CADNFIAP00009925

Structurei

3D structure databases

ProteinModelPortaliA1CWA4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati19 – 103Solcar 1UniRule annotationAdd BLAST85
Repeati132 – 216Solcar 2UniRule annotationAdd BLAST85
Repeati234 – 318Solcar 3UniRule annotationAdd BLAST85

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. [View classification]UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000006978
KOiK15118
OMAiTVYEQMM
OrthoDBiEOG092C3NVU

Family and domain databases

Gene3Di1.50.40.10, 1 hit
HAMAPiMF_03064 SLC25A38, 1 hit
InterProiView protein in InterPro
IPR030847 Hem25/SLC25A38
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

A1CWA4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNNAAYAVT PVKTTSTSSR TTFHFAAGLC SGLTSSILLQ PADLLKTRVQ
60 70 80 90 100
QSQKTASLLP TIKTILSSPH PIRGLWRGTL PSALRTGFGS ALYFTSLNAL
110 120 130 140 150
RQGLAQTEAS MAIAASSSDG KSRTSSSALP KLSNWGNLAT GAVARTAAGF
160 170 180 190 200
VMMPVTVLKV RYESDYYAYR SLYSAGRDIV RTEGVRGLFS GFGATAARDA
210 220 230 240 250
PYAGLYVLFY EQLKRRLASV ASSEQSEQPL KSTSSSSINF VSGGLAAGLA
260 270 280 290 300
TAITNPFDAV KTRLQLMPGK YGNMIRAVRL MIREDGVRSL FGGLGLRITR
310 320 330
KALSSALAWT VYEELILRAE AHWAEKDKID L
Length:331
Mass (Da):35,496
Last modified:January 23, 2007 - v1
Checksum:i17F01461E84B1B2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027685 Genomic DNA Translation: EAW24906.1
RefSeqiXP_001266803.1, XM_001266802.1

Genome annotation databases

EnsemblFungiiCADNFIAT00010165; CADNFIAP00009925; CADNFIAG00010165
GeneIDi4594116
KEGGinfi:NFIA_103940

Similar proteinsi

Entry informationi

Entry nameiS2538_NEOFI
AccessioniPrimary (citable) accession number: A1CWA4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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