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Protein

Solute carrier family 25 member 38 homolog

Gene

NFIA_103940

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Mitochondrial carrier required for the biosynthesis of heme, possibly by facilitating 5-aminolevulinate (ALA) production. May act by importing glycine into mitochondria or by exchanging glycine for ALA across the mitochondrial inner membrane.UniRule annotation

GO - Molecular functioni

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 38 homologUniRule annotation
Gene namesi
ORF Names:NFIA_103940
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006702 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:NFIA_103940.

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 50Helical; Name=1UniRule annotationAdd BLAST26
Transmembranei78 – 104Helical; Name=2UniRule annotationAdd BLAST27
Transmembranei138 – 163Helical; Name=3UniRule annotationAdd BLAST26
Transmembranei191 – 214Helical; Name=4UniRule annotationAdd BLAST24
Transmembranei238 – 264Helical; Name=5UniRule annotationAdd BLAST27
Transmembranei293 – 311Helical; Name=6UniRule annotationAdd BLAST19

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003789391 – 331Solute carrier family 25 member 38 homologAdd BLAST331

Interactioni

Protein-protein interaction databases

STRINGi36630.CADNFIAP00009925.

Structurei

3D structure databases

ProteinModelPortaliA1CWA4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati19 – 103Solcar 1Add BLAST85
Repeati132 – 216Solcar 2Add BLAST85
Repeati234 – 318Solcar 3Add BLAST85

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. [View classification]UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000006978.
KOiK15118.
OMAiTVYEQMM.
OrthoDBiEOG092C3NVU.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
HAMAPiMF_03064. SLC25A38. 1 hit.
InterProiView protein in InterPro
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
IPR030847. SLC25A38.
PfamiView protein in Pfam
PF00153. Mito_carr. 3 hits.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiView protein in PROSITE
PS50920. SOLCAR. 3 hits.

Sequencei

Sequence statusi: Complete.

A1CWA4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNNAAYAVT PVKTTSTSSR TTFHFAAGLC SGLTSSILLQ PADLLKTRVQ
60 70 80 90 100
QSQKTASLLP TIKTILSSPH PIRGLWRGTL PSALRTGFGS ALYFTSLNAL
110 120 130 140 150
RQGLAQTEAS MAIAASSSDG KSRTSSSALP KLSNWGNLAT GAVARTAAGF
160 170 180 190 200
VMMPVTVLKV RYESDYYAYR SLYSAGRDIV RTEGVRGLFS GFGATAARDA
210 220 230 240 250
PYAGLYVLFY EQLKRRLASV ASSEQSEQPL KSTSSSSINF VSGGLAAGLA
260 270 280 290 300
TAITNPFDAV KTRLQLMPGK YGNMIRAVRL MIREDGVRSL FGGLGLRITR
310 320 330
KALSSALAWT VYEELILRAE AHWAEKDKID L
Length:331
Mass (Da):35,496
Last modified:January 23, 2007 - v1
Checksum:i17F01461E84B1B2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027685 Genomic DNA. Translation: EAW24906.1.
RefSeqiXP_001266803.1. XM_001266802.1.

Genome annotation databases

EnsemblFungiiCADNFIAT00010165; CADNFIAP00009925; CADNFIAG00010165.
GeneIDi4594116.
KEGGinfi:NFIA_103940.

Similar proteinsi

Entry informationi

Entry nameiS2538_NEOFI
AccessioniPrimary (citable) accession number: A1CWA4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: January 23, 2007
Last modified: July 5, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families