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A1CW53

- CREB_NEOFI

UniProt

A1CW53 - CREB_NEOFI

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Protein
Probable ubiquitin carboxyl-terminal hydrolase creB
Gene
creB, NFIA_103430
Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Plays also a role in response to carbon starvation and the control of extracellular proteases activity By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei64 – 641Nucleophile By similarity
Active sitei419 – 4191Proton acceptor By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitin thiolesterase activity Source: UniProtKB

GO - Biological processi

  1. carbon catabolite repression of transcription Source: UniProtKB
  2. ubiquitin-dependent protein catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin carboxyl-terminal hydrolase creB (EC:3.4.19.12)
Alternative name(s):
Carbon catabolite repression protein B
Deubiquitinating enzyme creB
Ubiquitin thioesterase creB
Ubiquitin-hydrolyzing enzyme creB
Ubiquitin-specific-processing protease creB
Gene namesi
Name:creB
ORF Names:NFIA_103430
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
ProteomesiUP000006702: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 761761Probable ubiquitin carboxyl-terminal hydrolase creB
PRO_0000395685Add
BLAST

Interactioni

Subunit structurei

Interacts with creA, creC and qutD By similarity.

Protein-protein interaction databases

STRINGi36630.CADNFIAP00009226.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 468414USP
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili577 – 64064 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi700 – 7078Poly-Gln

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 USP domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5533.
HOGENOMiHOG000192482.
KOiK11872.
OrthoDBiEOG7TF7JV.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1CW53-1 [UniParc]FASTAAdd to Basket

« Hide

MGSFLRSFRH NGGSTAPSVG AVPAKKEPQP PPMTPLEKRL LDMGPIREDG    50
SDKFYGMENY GNTCYCNSIL QCLYYSVPFR EAVINYPTRT PIESLEAALA 100
KSLRYPNPNA QLEAEAQAEK QKAANAQRPG MPPNPQQKPE DKDSPEYKKK 150
MALQTLPLLE TQNNAASYGM SESLFTSLKD IFESVVGSQS RIGIIRPQQF 200
LEVLRRDHEM FRTAMHQDAH EFLNLLLNEV VANVEAEASK QPLMEKSLPA 250
PETADSVDQS SSTGSKTPNT TRWVHELFEG LLTSETQCLT CEKVSQRDEV 300
FLDLSVDLEQ HSSVTSCLRK FSAEEMLCER NKFHCDNCGG LQEAEKRMKI 350
KRLPRILALH LKRFKYTEDL QRLQKLFHRV VYPYHLRLFN TTDDAEDPDR 400
LYELYAVVVH IGGGPYHGHY VAIIKTEDRG WLLFDDEMVE PVDKNYVKNF 450
FGDKPGLACA YVLFYQETTL EAVLKEQEQE NMDSNLAATD ANDTILKQNG 500
FPQSPLAHVH SASQIPSHED NLRPNGLRRA PTAPQLSTHH EHGDPESTPF 550
SPLSPLSPVP PVPPIPERVA TVATPPKNDA LAKREEKERK AAEKEKEKAE 600
KLRRKEQGAR MKENQRREEA ELKAALEMSK ASKAEEDRRL STENGKEKQG 650
GGLSRLKRGS KSLSHRLGKD KETRSVSSDL PPVPIPEHST LSQSGPTSEQ 700
QQQQRQQSPP NHDQPPNSPQ PGKPTIREDE QVNHKDSKHE RTGHGKWRSF 750
SLRKKSFSIL S 761
Length:761
Mass (Da):85,840
Last modified:July 13, 2010 - v2
Checksum:i1FD8CFA3FCDC6666
GO

Sequence cautioni

The sequence EAW24855.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027685 Genomic DNA. Translation: EAW24855.1. Sequence problems.
RefSeqiXP_001266752.1. XM_001266751.1.

Genome annotation databases

GeneIDi4593253.
KEGGinfi:NFIA_103430.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027685 Genomic DNA. Translation: EAW24855.1 . Sequence problems.
RefSeqi XP_001266752.1. XM_001266751.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 36630.CADNFIAP00009226.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4593253.
KEGGi nfi:NFIA_103430.

Phylogenomic databases

eggNOGi COG5533.
HOGENOMi HOG000192482.
KOi K11872.
OrthoDBi EOG7TF7JV.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

Entry informationi

Entry nameiCREB_NEOFI
AccessioniPrimary (citable) accession number: A1CW53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 13, 2010
Last modified: February 19, 2014
This is version 34 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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