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A1CVQ6 (M2DH_NEOFI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mannitol 2-dehydrogenase

Short name=M2DH
Short name=MDH
EC=1.1.1.67
Gene names
ORF Names:NFIA_101920
OrganismNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus) [Complete proteome]
Taxonomic identifier331117 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya

Protein attributes

Sequence length502 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway By similarity.

Catalytic activity

D-mannitol + NAD+ = D-fructose + NADH.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

mannitol 2-dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 502502Mannitol 2-dehydrogenase
PRO_0000371546

Regions

Nucleotide binding37 – 4812NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A1CVQ6 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: DD51019DF6C1F7D1

FASTA50256,355
        10         20         30         40         50         60 
MAPLKLNSKN LSQIAAAGGA LVKIPTYQRG RAVKEGIVHI GVGGFHRAHL AVYIDQLMQK 

        70         80         90        100        110        120 
HGVTDYAICG VGLQPFDSAM RDALASQDHL YTLIERSAKG SFAHVIGSIN SYLFAPDNRE 

       130        140        150        160        170        180 
AVIAKMAHPD TKIVSLTITE SGYYYNENTH ELQSEHPDIQ FDLDPANEKA PRTTFGFLYA 

       190        200        210        220        230        240 
GLTRRYQQGL KPFTVMSCDN MQKNGSITRH MLESFARLRN PEVAEWIAEE GAFPNAMVDR 

       250        260        270        280        290        300 
ITPQTSENDK TALADTFGIV DSWPVVTEPF TQWVIEDQFS NGRPPFEKVG VQVVKDVHAV 

       310        320        330        340        350        360 
EQFEKHKLRL LNGSHSALGY PGQLAGFKYV HEVMENPLFR KFVWQMMQEE VKPLLPEIPG 

       370        380        390        400        410        420 
VNIDEYCNTL IERFTNPTIM DQLPRICLNA SGKIPQFIMP SIAEAIWVTG PFRRLCFVAA 

       430        440        450        460        470        480 
AWFHYVKGVD DSGKPFEVVD PMREELQAKA RAGGNDPFEL LSIKSLFGDD LRSDERFLKE 

       490        500 
ITTAMNDIAR DGIMKTLPKY ID 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS027685 Genomic DNA. Translation: EAW24708.1.
RefSeqXP_001266605.1. XM_001266604.1.

3D structure databases

ProteinModelPortalA1CVQ6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING36630.CADNFIAP00009659.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADNFIAT00009899; CADNFIAP00009659; CADNFIAG00009899.
GeneID4593956.
KEGGnfi:NFIA_101920.

Phylogenomic databases

eggNOGCOG0246.
HOGENOMHOG000202982.
KOK00045.
OMAWLHFVRR.
OrthoDBEOG7PCJRT.

Enzyme and pathway databases

BioCycRETL1328306-WGS:GSTH-3753-MONOMER.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSPR00084. MTLDHDRGNASE.
SUPFAMSSF48179. SSF48179. 1 hit.
ProtoNetSearch...

Entry information

Entry nameM2DH_NEOFI
AccessionPrimary (citable) accession number: A1CVQ6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families