SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A1CVQ6

- M2DH_NEOFI

UniProt

A1CVQ6 - M2DH_NEOFI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Mannitol 2-dehydrogenase
Gene
NFIA_101920
Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway By similarity.

Catalytic activityi

D-mannitol + NAD+ = D-fructose + NADH.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi37 – 4812NAD By similarity
Add
BLAST

GO - Molecular functioni

  1. coenzyme binding Source: InterPro
  2. mannitol 2-dehydrogenase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciRETL1328306-WGS:GSTH-3753-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mannitol 2-dehydrogenase (EC:1.1.1.67)
    Short name:
    M2DH
    Short name:
    MDH
    Gene namesi
    ORF Names:NFIA_101920
    OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
    Taxonomic identifieri331117 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
    ProteomesiUP000006702: Unassembled WGS sequence

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 502502Mannitol 2-dehydrogenase
    PRO_0000371546Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer By similarity.

    Protein-protein interaction databases

    STRINGi36630.CADNFIAP00009659.

    Structurei

    3D structure databases

    ProteinModelPortaliA1CVQ6.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0246.
    HOGENOMiHOG000202982.
    KOiK00045.
    OMAiWLHFVRR.
    OrthoDBiEOG7PCJRT.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR000669. Mannitol_DH.
    IPR013118. Mannitol_DH_C.
    IPR013131. Mannitol_DH_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF01232. Mannitol_dh. 1 hit.
    PF08125. Mannitol_dh_C. 1 hit.
    [Graphical view]
    PRINTSiPR00084. MTLDHDRGNASE.
    SUPFAMiSSF48179. SSF48179. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1CVQ6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPLKLNSKN LSQIAAAGGA LVKIPTYQRG RAVKEGIVHI GVGGFHRAHL    50
    AVYIDQLMQK HGVTDYAICG VGLQPFDSAM RDALASQDHL YTLIERSAKG 100
    SFAHVIGSIN SYLFAPDNRE AVIAKMAHPD TKIVSLTITE SGYYYNENTH 150
    ELQSEHPDIQ FDLDPANEKA PRTTFGFLYA GLTRRYQQGL KPFTVMSCDN 200
    MQKNGSITRH MLESFARLRN PEVAEWIAEE GAFPNAMVDR ITPQTSENDK 250
    TALADTFGIV DSWPVVTEPF TQWVIEDQFS NGRPPFEKVG VQVVKDVHAV 300
    EQFEKHKLRL LNGSHSALGY PGQLAGFKYV HEVMENPLFR KFVWQMMQEE 350
    VKPLLPEIPG VNIDEYCNTL IERFTNPTIM DQLPRICLNA SGKIPQFIMP 400
    SIAEAIWVTG PFRRLCFVAA AWFHYVKGVD DSGKPFEVVD PMREELQAKA 450
    RAGGNDPFEL LSIKSLFGDD LRSDERFLKE ITTAMNDIAR DGIMKTLPKY 500
    ID 502
    Length:502
    Mass (Da):56,355
    Last modified:January 23, 2007 - v1
    Checksum:iDD51019DF6C1F7D1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027685 Genomic DNA. Translation: EAW24708.1.
    RefSeqiXP_001266605.1. XM_001266604.1.

    Genome annotation databases

    EnsemblFungiiCADNFIAT00009899; CADNFIAP00009659; CADNFIAG00009899.
    GeneIDi4593956.
    KEGGinfi:NFIA_101920.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027685 Genomic DNA. Translation: EAW24708.1 .
    RefSeqi XP_001266605.1. XM_001266604.1.

    3D structure databases

    ProteinModelPortali A1CVQ6.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 36630.CADNFIAP00009659.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADNFIAT00009899 ; CADNFIAP00009659 ; CADNFIAG00009899 .
    GeneIDi 4593956.
    KEGGi nfi:NFIA_101920.

    Phylogenomic databases

    eggNOGi COG0246.
    HOGENOMi HOG000202982.
    KOi K00045.
    OMAi WLHFVRR.
    OrthoDBi EOG7PCJRT.

    Enzyme and pathway databases

    BioCyci RETL1328306-WGS:GSTH-3753-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR000669. Mannitol_DH.
    IPR013118. Mannitol_DH_C.
    IPR013131. Mannitol_DH_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF01232. Mannitol_dh. 1 hit.
    PF08125. Mannitol_dh_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00084. MTLDHDRGNASE.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

    Entry informationi

    Entry nameiM2DH_NEOFI
    AccessioniPrimary (citable) accession number: A1CVQ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: January 23, 2007
    Last modified: July 9, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi