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A1CVQ6

- M2DH_NEOFI

UniProt

A1CVQ6 - M2DH_NEOFI

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Protein

Mannitol 2-dehydrogenase

Gene

NFIA_101920

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway.By similarity

Catalytic activityi

D-mannitol + NAD+ = D-fructose + NADH.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi37 – 4812NADBy similarityAdd
BLAST

GO - Molecular functioni

  1. coenzyme binding Source: InterPro
  2. mannitol 2-dehydrogenase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-3753-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannitol 2-dehydrogenase (EC:1.1.1.67)
Short name:
M2DH
Short name:
MDH
Gene namesi
ORF Names:NFIA_101920
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
ProteomesiUP000006702: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 502502Mannitol 2-dehydrogenasePRO_0000371546Add
BLAST

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi36630.CADNFIAP00009659.

Structurei

3D structure databases

ProteinModelPortaliA1CVQ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mannitol dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG0246.
HOGENOMiHOG000202982.
KOiK00045.
OMAiWLHFVRR.
OrthoDBiEOG7PCJRT.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSiPR00084. MTLDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.

Sequencei

Sequence statusi: Complete.

A1CVQ6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPLKLNSKN LSQIAAAGGA LVKIPTYQRG RAVKEGIVHI GVGGFHRAHL
60 70 80 90 100
AVYIDQLMQK HGVTDYAICG VGLQPFDSAM RDALASQDHL YTLIERSAKG
110 120 130 140 150
SFAHVIGSIN SYLFAPDNRE AVIAKMAHPD TKIVSLTITE SGYYYNENTH
160 170 180 190 200
ELQSEHPDIQ FDLDPANEKA PRTTFGFLYA GLTRRYQQGL KPFTVMSCDN
210 220 230 240 250
MQKNGSITRH MLESFARLRN PEVAEWIAEE GAFPNAMVDR ITPQTSENDK
260 270 280 290 300
TALADTFGIV DSWPVVTEPF TQWVIEDQFS NGRPPFEKVG VQVVKDVHAV
310 320 330 340 350
EQFEKHKLRL LNGSHSALGY PGQLAGFKYV HEVMENPLFR KFVWQMMQEE
360 370 380 390 400
VKPLLPEIPG VNIDEYCNTL IERFTNPTIM DQLPRICLNA SGKIPQFIMP
410 420 430 440 450
SIAEAIWVTG PFRRLCFVAA AWFHYVKGVD DSGKPFEVVD PMREELQAKA
460 470 480 490 500
RAGGNDPFEL LSIKSLFGDD LRSDERFLKE ITTAMNDIAR DGIMKTLPKY

ID
Length:502
Mass (Da):56,355
Last modified:January 23, 2007 - v1
Checksum:iDD51019DF6C1F7D1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027685 Genomic DNA. Translation: EAW24708.1.
RefSeqiXP_001266605.1. XM_001266604.1.

Genome annotation databases

EnsemblFungiiCADNFIAT00009899; CADNFIAP00009659; CADNFIAG00009899.
GeneIDi4593956.
KEGGinfi:NFIA_101920.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027685 Genomic DNA. Translation: EAW24708.1 .
RefSeqi XP_001266605.1. XM_001266604.1.

3D structure databases

ProteinModelPortali A1CVQ6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 36630.CADNFIAP00009659.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADNFIAT00009899 ; CADNFIAP00009659 ; CADNFIAG00009899 .
GeneIDi 4593956.
KEGGi nfi:NFIA_101920.

Phylogenomic databases

eggNOGi COG0246.
HOGENOMi HOG000202982.
KOi K00045.
OMAi WLHFVRR.
OrthoDBi EOG7PCJRT.

Enzyme and pathway databases

BioCyci RETL1328306-WGS:GSTH-3753-MONOMER.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view ]
PRINTSi PR00084. MTLDHDRGNASE.
SUPFAMi SSF48179. SSF48179. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

Entry informationi

Entry nameiM2DH_NEOFI
AccessioniPrimary (citable) accession number: A1CVQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3