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A1CVK0

- PDSA_NEOFI

UniProt

A1CVK0 - PDSA_NEOFI

Protein

Protostadienol synthase A

Gene

pdsA

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Protostadienol synthase which cyclizes (3S)-oxidosqualene to (17Z)-protosta-17(20),24-dien-3-beta-ol (protostadienol), the biosynthetic precursor of helvolic acid, a secundary metabolite which promotes virulence.By similarity

    Catalytic activityi

    (3S)-2,3-epoxy-2,3-dihydrosqualene = (17Z)-protosta-17(20),24-dien-3-beta-ol.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei240 – 2401Proton acceptorBy similarity
    Active sitei463 – 4631Proton donorBy similarity

    GO - Molecular functioni

    1. intramolecular transferase activity Source: InterPro

    GO - Biological processi

    1. pathogenesis Source: UniProtKB-KW
    2. steroid biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Virulence

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protostadienol synthase A (EC:5.4.99.32)
    Gene namesi
    Name:pdsA
    ORF Names:NFIA_101360
    OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
    Taxonomic identifieri331117 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
    ProteomesiUP000006702: Unassembled WGS sequence

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 738738Protostadienol synthase APRO_0000415497Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi36630.CADNFIAP00009757.

    Structurei

    3D structure databases

    ProteinModelPortaliA1CVK0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati132 – 17342PFTB 1Add
    BLAST
    Repeati490 – 53142PFTB 2Add
    BLAST
    Repeati567 – 60741PFTB 3Add
    BLAST
    Repeati616 – 66348PFTB 4Add
    BLAST

    Sequence similaritiesi

    Belongs to the terpene cyclase/mutase family.Curated
    Contains 4 PFTB repeats.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    HOGENOMiHOG000234317.
    KOiK15811.
    OMAiETRNTHY.
    OrthoDBiEOG70610B.

    Family and domain databases

    Gene3Di1.50.10.20. 2 hits.
    InterProiIPR001330. Prenyltrans.
    IPR018333. Squalene_cyclase.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view]
    PfamiPF00432. Prenyltrans. 1 hit.
    [Graphical view]
    SUPFAMiSSF48239. SSF48239. 2 hits.
    TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1CVK0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTDSSMPAT VIGKAEFSNT KAASEFGTNL SRWRLNVDNG RHMWEYLESE    50
    DEARKRPQSI LEKYWLGLPY ELPARPRATR ALEAVENGWE FFKRLQTADG 100
    HWGCNDDGPL FVTSGMVIAR YIVGIPIDSH MKQEMCRYLL NVVNEDGGWG 150
    LFIQSPSTVF GTVMNYCMLR ILGLGPEHPA MARARNTLHR LGSASATPTW 200
    GKFWLCVLGV YEWEGMIPLP PEPLLVPASL PFNPGKWWVH TRNVYISMSY 250
    LYGHRFSMPP NKLVQALRDE LYDIPYEQIN WPAQRTNVSA ADRLTDPTWI 300
    QRSFTSALTT YETFKIPFLR RRALNEALFQ IETETRNTHY LCIAPVSFAS 350
    NMLALYHAHG RDSHWIRGMR DRFIDPMWLC REGLAASGTN GTSLWDTALT 400
    VQATIDAGLA ARPENQAILR KALEFIDNSQ IREDPLGVHH VYRQPTRGAW 450
    PFSTRDQSYA VSDTTAEAVK VVVLLQQIEG FPSRISDERL QQAIDLILGM 500
    ENAGGGFSAY EPVRGPKFLE LLNITELYEN VMTDNLYPEC TSSVIMSLTT 550
    FAREYPTYRA RDIQACVSRS VDYLLRSQYP NGGWFASWGV CFTYATMFAL 600
    QGLACMGRNE SNCAACQRAC SFLLQHQNPD GGWGESLDTV RFKQYLPHPD 650
    GSQVTNTAYA VIGLLAARCG NHEAIRRGVA YLMKEQQDTG EWLPGALEGV 700
    FAPPGGMRYP NYKFHFTLMA LGRYAAVHGD ECLAAQLV 738
    Length:738
    Mass (Da):83,217
    Last modified:January 23, 2007 - v1
    Checksum:iC36579825E6BA4AC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027685 Genomic DNA. Translation: EAW24652.1.
    RefSeqiXP_001266549.1. XM_001266548.1.

    Genome annotation databases

    EnsemblFungiiCADNFIAT00009997; CADNFIAP00009757; CADNFIAG00009997.
    GeneIDi4594041.
    KEGGinfi:NFIA_101360.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027685 Genomic DNA. Translation: EAW24652.1 .
    RefSeqi XP_001266549.1. XM_001266548.1.

    3D structure databases

    ProteinModelPortali A1CVK0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 36630.CADNFIAP00009757.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADNFIAT00009997 ; CADNFIAP00009757 ; CADNFIAG00009997 .
    GeneIDi 4594041.
    KEGGi nfi:NFIA_101360.

    Phylogenomic databases

    HOGENOMi HOG000234317.
    KOi K15811.
    OMAi ETRNTHY.
    OrthoDBi EOG70610B.

    Family and domain databases

    Gene3Di 1.50.10.20. 2 hits.
    InterProi IPR001330. Prenyltrans.
    IPR018333. Squalene_cyclase.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view ]
    Pfami PF00432. Prenyltrans. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48239. SSF48239. 2 hits.
    TIGRFAMsi TIGR01787. squalene_cyclas. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

    Entry informationi

    Entry nameiPDSA_NEOFI
    AccessioniPrimary (citable) accession number: A1CVK0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 22, 2012
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3