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A1CVK0

- PDSA_NEOFI

UniProt

A1CVK0 - PDSA_NEOFI

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Protein
Protostadienol synthase A
Gene
pdsA, NFIA_101360
Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Protostadienol synthase which cyclizes (3S)-oxidosqualene to (17Z)-protosta-17(20),24-dien-3-beta-ol (protostadienol), the biosynthetic precursor of helvolic acid, a secundary metabolite which promotes virulence By similarity.

Catalytic activityi

(3S)-2,3-epoxy-2,3-dihydrosqualene = (17Z)-protosta-17(20),24-dien-3-beta-ol.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei240 – 2401Proton acceptor By similarity
Active sitei463 – 4631Proton donor By similarity

GO - Molecular functioni

  1. intramolecular transferase activity Source: InterPro

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
  2. steroid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Protostadienol synthase A (EC:5.4.99.32)
Gene namesi
Name:pdsA
ORF Names:NFIA_101360
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
ProteomesiUP000006702: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 738738Protostadienol synthase A
PRO_0000415497Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi36630.CADNFIAP00009757.

Structurei

3D structure databases

ProteinModelPortaliA1CVK0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati132 – 17342PFTB 1
Add
BLAST
Repeati490 – 53142PFTB 2
Add
BLAST
Repeati567 – 60741PFTB 3
Add
BLAST
Repeati616 – 66348PFTB 4
Add
BLAST

Sequence similaritiesi

Contains 4 PFTB repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000234317.
KOiK15811.
OMAiETRNTHY.
OrthoDBiEOG70610B.

Family and domain databases

Gene3Di1.50.10.20. 2 hits.
InterProiIPR001330. Prenyltrans.
IPR018333. Squalene_cyclase.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00432. Prenyltrans. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.

Sequencei

Sequence statusi: Complete.

A1CVK0-1 [UniParc]FASTAAdd to Basket

« Hide

MTTDSSMPAT VIGKAEFSNT KAASEFGTNL SRWRLNVDNG RHMWEYLESE    50
DEARKRPQSI LEKYWLGLPY ELPARPRATR ALEAVENGWE FFKRLQTADG 100
HWGCNDDGPL FVTSGMVIAR YIVGIPIDSH MKQEMCRYLL NVVNEDGGWG 150
LFIQSPSTVF GTVMNYCMLR ILGLGPEHPA MARARNTLHR LGSASATPTW 200
GKFWLCVLGV YEWEGMIPLP PEPLLVPASL PFNPGKWWVH TRNVYISMSY 250
LYGHRFSMPP NKLVQALRDE LYDIPYEQIN WPAQRTNVSA ADRLTDPTWI 300
QRSFTSALTT YETFKIPFLR RRALNEALFQ IETETRNTHY LCIAPVSFAS 350
NMLALYHAHG RDSHWIRGMR DRFIDPMWLC REGLAASGTN GTSLWDTALT 400
VQATIDAGLA ARPENQAILR KALEFIDNSQ IREDPLGVHH VYRQPTRGAW 450
PFSTRDQSYA VSDTTAEAVK VVVLLQQIEG FPSRISDERL QQAIDLILGM 500
ENAGGGFSAY EPVRGPKFLE LLNITELYEN VMTDNLYPEC TSSVIMSLTT 550
FAREYPTYRA RDIQACVSRS VDYLLRSQYP NGGWFASWGV CFTYATMFAL 600
QGLACMGRNE SNCAACQRAC SFLLQHQNPD GGWGESLDTV RFKQYLPHPD 650
GSQVTNTAYA VIGLLAARCG NHEAIRRGVA YLMKEQQDTG EWLPGALEGV 700
FAPPGGMRYP NYKFHFTLMA LGRYAAVHGD ECLAAQLV 738
Length:738
Mass (Da):83,217
Last modified:January 23, 2007 - v1
Checksum:iC36579825E6BA4AC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027685 Genomic DNA. Translation: EAW24652.1.
RefSeqiXP_001266549.1. XM_001266548.1.

Genome annotation databases

EnsemblFungiiCADNFIAT00009997; CADNFIAP00009757; CADNFIAG00009997.
GeneIDi4594041.
KEGGinfi:NFIA_101360.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027685 Genomic DNA. Translation: EAW24652.1 .
RefSeqi XP_001266549.1. XM_001266548.1.

3D structure databases

ProteinModelPortali A1CVK0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 36630.CADNFIAP00009757.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADNFIAT00009997 ; CADNFIAP00009757 ; CADNFIAG00009997 .
GeneIDi 4594041.
KEGGi nfi:NFIA_101360.

Phylogenomic databases

HOGENOMi HOG000234317.
KOi K15811.
OMAi ETRNTHY.
OrthoDBi EOG70610B.

Family and domain databases

Gene3Di 1.50.10.20. 2 hits.
InterProi IPR001330. Prenyltrans.
IPR018333. Squalene_cyclase.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view ]
Pfami PF00432. Prenyltrans. 1 hit.
[Graphical view ]
SUPFAMi SSF48239. SSF48239. 2 hits.
TIGRFAMsi TIGR01787. squalene_cyclas. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

Entry informationi

Entry nameiPDSA_NEOFI
AccessioniPrimary (citable) accession number: A1CVK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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