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A1CUJ5

- CBPYA_ASPCL

UniProt

A1CUJ5 - CBPYA_ASPCL

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Protein
Carboxypeptidase Y homolog A
Gene
cpyA, cpy, ACLA_086840
Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei266 – 2661 By similarity
Active sitei458 – 4581 By similarity
Active sitei520 – 5201 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:cpyA
Synonyms:cpy
ORF Names:ACLA_086840
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

Subcellular locationi

Vacuole By similarity

GO - Cellular componenti

  1. vacuole Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed prediction
Add
BLAST
Propeptidei18 – 124107 By similarity
PRO_0000407430Add
BLAST
Chaini125 – 543419Carboxypeptidase Y homolog A
PRO_0000407431Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi179 ↔ 419 By similarity
Glycosylationi210 – 2101N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi313 ↔ 327 By similarity
Disulfide bondi337 ↔ 360 By similarity
Disulfide bondi344 ↔ 353 By similarity
Disulfide bondi382 ↔ 389 By similarity
Glycosylationi509 – 5091N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PRIDEiA1CUJ5.

Interactioni

Protein-protein interaction databases

STRINGi5057.CADACLAP00007909.

Structurei

3D structure databases

ProteinModelPortaliA1CUJ5.
SMRiA1CUJ5. Positions 124-540.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2939.
HOGENOMiHOG000198296.
KOiK13289.
OMAiWPGQKEY.
OrthoDBiEOG7XDBR1.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1CUJ5-1 [UniParc]FASTAAdd to Basket

« Hide

MRVLPATLLV GAATAAVPPF QQILGLPKKG ADTLSKPLHD FQEQLKTLSD    50
DARRLWDEVA KHFPDSMDHN PVFSLPKKHT RRPDSHWDHI VRGADVQSVW 100
VTGANGEKER EVDGKLEAYD LRVKTTDPGA LGIDPGVKQY TGYLDDNEND 150
KHLFYWFFES RNDPKNDPVV LWLNGGPGCS SLTGLFLELG PSSIDSKIKP 200
VYNDFAWNSN ASVIFLDQPV NVGYSYSGSA VSDTVAAGKD VYALLTLFFK 250
QFPEYAKQDF HIAGESYAGH YIPVFASEIL SHKKRNINLK SVLIGNGLTD 300
PLTQYDHYRP MACGDGGYPA VLDEASCQSM DNALPRCKSM IESCYNTESS 350
WVCVPASIYC NNALIGPYQR TGQNVYDVRG KCEDESNLCY KGMGYVSEYL 400
NKREVREAVG AEVDGYDSCN FDINRNFLFH GDWMKPYHRL VPGLLEQIPV 450
LIYAGDADFI CNWLGNKAWS EALEWPGQKE YASAELEDLV IEQNEHQGKK 500
IGQIKSHGNF TFMRLYGGGH MVPMDQPEAS LEFFNRWIGG EWF 543
Length:543
Mass (Da):60,925
Last modified:January 23, 2007 - v1
Checksum:iB3D2EB24E0FB5442
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027060 Genomic DNA. Translation: EAW06982.1.
RefSeqiXP_001268408.1. XM_001268407.1.

Genome annotation databases

EnsemblFungiiCADACLAT00008100; CADACLAP00007909; CADACLAG00008100.
GeneIDi4700272.
KEGGiact:ACLA_086840.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027060 Genomic DNA. Translation: EAW06982.1 .
RefSeqi XP_001268408.1. XM_001268407.1.

3D structure databases

ProteinModelPortali A1CUJ5.
SMRi A1CUJ5. Positions 124-540.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5057.CADACLAP00007909.

Protein family/group databases

MEROPSi S10.001.

Proteomic databases

PRIDEi A1CUJ5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADACLAT00008100 ; CADACLAP00007909 ; CADACLAG00008100 .
GeneIDi 4700272.
KEGGi act:ACLA_086840.

Phylogenomic databases

eggNOGi COG2939.
HOGENOMi HOG000198296.
KOi K13289.
OMAi WPGQKEY.
OrthoDBi EOG7XDBR1.

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiCBPYA_ASPCL
AccessioniPrimary (citable) accession number: A1CUJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi