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A1CTP5

- PMIP_ASPCL

UniProt

A1CTP5 - PMIP_ASPCL

Protein

Mitochondrial intermediate peptidase

Gene

oct1

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.By similarity

    Catalytic activityi

    Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

    Cofactori

    Binds 1 zinc ion.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi565 – 5651Zinc; catalyticPROSITE-ProRule annotation
    Active sitei566 – 5661PROSITE-ProRule annotation
    Metal bindingi569 – 5691Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi572 – 5721Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. metalloendopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM03.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial intermediate peptidase (EC:3.4.24.59)
    Short name:
    MIP
    Alternative name(s):
    Octapeptidyl aminopeptidase
    Gene namesi
    Name:oct1
    ORF Names:ACLA_083770
    OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
    Taxonomic identifieri344612 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000006701: Unassembled WGS sequence

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4141MitochondrionSequence AnalysisAdd
    BLAST
    Chaini42 – 801760Mitochondrial intermediate peptidasePRO_0000338569Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi5057.CADACLAP00007518.

    Structurei

    3D structure databases

    ProteinModelPortaliA1CTP5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M3 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0339.
    HOGENOMiHOG000076521.
    KOiK01410.
    OMAiASERWHE.
    OrthoDBiEOG71GB4R.

    Family and domain databases

    Gene3Di1.10.1370.10. 2 hits.
    1.20.1050.40. 1 hit.
    3.40.390.10. 1 hit.
    InterProiIPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR024080. Neurolysin/TOP_N.
    IPR001567. Pept_M3A_M3B.
    [Graphical view]
    PfamiPF01432. Peptidase_M3. 1 hit.
    [Graphical view]
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A1CTP5-1 [UniParc]FASTAAdd to Basket

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    MKPQLLTPLR RRPWTCRQCL QRLQRLQQQT RRSFETAASP APGHTQVDYI    50
    PADASQSKKV DDETIRRVFD SQHFWREFSQ RRSTQSKPTG LVQNQYLTSP 100
    DGFRTFANVS LQKCQAIVSK VLAASTLEEY RTMARDLDRL SDLLCRVIDL 150
    SDFIRVIHPD PRVQEAATQA YALMFEYMNV LNTTTGLNDQ LKKAVANPEV 200
    ASHWTEEEKI VAQILIKDFS NSAILMPPQE RQRFVNLSND ISQLGSSFVN 250
    SPEPAKSQVV VNANSLRGLD PMLVQQIKRW NRTASVPTTG MIPRLALRSV 300
    HDESVRREVY LASRTSSARQ LHRLEELLLK RAELAKLSGY SSFGHMTLSD 350
    KMAKSPEAVS NFLTSLVDSN RTLVREELLQ LRNMKGSPLQ PWDHAYYVHK 400
    RVMQYSQSRR SRELSAVPEF FSLGTVMQGL SRLFDRLYGV RLVPQEAAPG 450
    ETWNPDVRRL DVVDEADRHI AVIYCDLFSR PNKHPNPAHF TLRCSREISA 500
    TEVAECASLD QSSHPNDGMA TAVDPTTKTL RQLPTIALVC DFAEPAAHGG 550
    RPSLLSEHSV RTLFHEMGHA LHSILGQTRL QSISGTRCAT DFAELPSVLM 600
    EHFATAPSVL SLYARHWETD EPLSERMIQS MERDRTAHGS IYGAVENEAQ 650
    ILMALVDQEY HSRPADGGRI DSTALYHEVA QRHSSLPDPA ETAPPTSWQG 700
    FFGHLYGYGA TYYSYIFDRA IANKLWADVF GAGRAAVDRA AGERYKTEVL 750
    RWGGGRNGWQ CVAGVLGPSN ASNADGRLVE GGDEAMREVG RWGLGRDGVS 800
    G 801
    Length:801
    Mass (Da):89,815
    Last modified:January 23, 2007 - v1
    Checksum:i38B5273FF01FD833
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027060 Genomic DNA. Translation: EAW06682.1.
    RefSeqiXP_001268108.1. XM_001268107.1.

    Genome annotation databases

    EnsemblFungiiCADACLAT00007709; CADACLAP00007518; CADACLAG00007709.
    GeneIDi4700295.
    KEGGiact:ACLA_083770.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027060 Genomic DNA. Translation: EAW06682.1 .
    RefSeqi XP_001268108.1. XM_001268107.1.

    3D structure databases

    ProteinModelPortali A1CTP5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5057.CADACLAP00007518.

    Protein family/group databases

    MEROPSi M03.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADACLAT00007709 ; CADACLAP00007518 ; CADACLAG00007709 .
    GeneIDi 4700295.
    KEGGi act:ACLA_083770.

    Phylogenomic databases

    eggNOGi COG0339.
    HOGENOMi HOG000076521.
    KOi K01410.
    OMAi ASERWHE.
    OrthoDBi EOG71GB4R.

    Family and domain databases

    Gene3Di 1.10.1370.10. 2 hits.
    1.20.1050.40. 1 hit.
    3.40.390.10. 1 hit.
    InterProi IPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR024080. Neurolysin/TOP_N.
    IPR001567. Pept_M3A_M3B.
    [Graphical view ]
    Pfami PF01432. Peptidase_M3. 1 hit.
    [Graphical view ]
    PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

    Entry informationi

    Entry nameiPMIP_ASPCL
    AccessioniPrimary (citable) accession number: A1CTP5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3