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A1CTP5

- PMIP_ASPCL

UniProt

A1CTP5 - PMIP_ASPCL

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Protein

Mitochondrial intermediate peptidase

Gene
oct1, ACLA_083770
Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Binds 1 zinc ion By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi565 – 5651Zinc; catalytic By similarity
Active sitei566 – 5661 By similarity
Metal bindingi569 – 5691Zinc; catalytic By similarity
Metal bindingi572 – 5721Zinc; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM03.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:oct1
ORF Names:ACLA_083770
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4141Mitochondrion Reviewed predictionAdd
BLAST
Chaini42 – 801760Mitochondrial intermediate peptidasePRO_0000338569Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5057.CADACLAP00007518.

Structurei

3D structure databases

ProteinModelPortaliA1CTP5.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0339.
HOGENOMiHOG000076521.
KOiK01410.
OMAiASERWHE.
OrthoDBiEOG71GB4R.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1CTP5-1 [UniParc]FASTAAdd to Basket

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MKPQLLTPLR RRPWTCRQCL QRLQRLQQQT RRSFETAASP APGHTQVDYI    50
PADASQSKKV DDETIRRVFD SQHFWREFSQ RRSTQSKPTG LVQNQYLTSP 100
DGFRTFANVS LQKCQAIVSK VLAASTLEEY RTMARDLDRL SDLLCRVIDL 150
SDFIRVIHPD PRVQEAATQA YALMFEYMNV LNTTTGLNDQ LKKAVANPEV 200
ASHWTEEEKI VAQILIKDFS NSAILMPPQE RQRFVNLSND ISQLGSSFVN 250
SPEPAKSQVV VNANSLRGLD PMLVQQIKRW NRTASVPTTG MIPRLALRSV 300
HDESVRREVY LASRTSSARQ LHRLEELLLK RAELAKLSGY SSFGHMTLSD 350
KMAKSPEAVS NFLTSLVDSN RTLVREELLQ LRNMKGSPLQ PWDHAYYVHK 400
RVMQYSQSRR SRELSAVPEF FSLGTVMQGL SRLFDRLYGV RLVPQEAAPG 450
ETWNPDVRRL DVVDEADRHI AVIYCDLFSR PNKHPNPAHF TLRCSREISA 500
TEVAECASLD QSSHPNDGMA TAVDPTTKTL RQLPTIALVC DFAEPAAHGG 550
RPSLLSEHSV RTLFHEMGHA LHSILGQTRL QSISGTRCAT DFAELPSVLM 600
EHFATAPSVL SLYARHWETD EPLSERMIQS MERDRTAHGS IYGAVENEAQ 650
ILMALVDQEY HSRPADGGRI DSTALYHEVA QRHSSLPDPA ETAPPTSWQG 700
FFGHLYGYGA TYYSYIFDRA IANKLWADVF GAGRAAVDRA AGERYKTEVL 750
RWGGGRNGWQ CVAGVLGPSN ASNADGRLVE GGDEAMREVG RWGLGRDGVS 800
G 801
Length:801
Mass (Da):89,815
Last modified:January 23, 2007 - v1
Checksum:i38B5273FF01FD833
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027060 Genomic DNA. Translation: EAW06682.1.
RefSeqiXP_001268108.1. XM_001268107.1.

Genome annotation databases

EnsemblFungiiCADACLAT00007709; CADACLAP00007518; CADACLAG00007709.
GeneIDi4700295.
KEGGiact:ACLA_083770.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027060 Genomic DNA. Translation: EAW06682.1 .
RefSeqi XP_001268108.1. XM_001268107.1.

3D structure databases

ProteinModelPortali A1CTP5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5057.CADACLAP00007518.

Protein family/group databases

MEROPSi M03.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADACLAT00007709 ; CADACLAP00007518 ; CADACLAG00007709 .
GeneIDi 4700295.
KEGGi act:ACLA_083770.

Phylogenomic databases

eggNOGi COG0339.
HOGENOMi HOG000076521.
KOi K01410.
OMAi ASERWHE.
OrthoDBi EOG71GB4R.

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 1 hit.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiPMIP_ASPCL
AccessioniPrimary (citable) accession number: A1CTP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi