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Protein

Mitochondrial intermediate peptidase

Gene

oct1

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi565Zinc; catalyticPROSITE-ProRule annotation1
Active sitei566PROSITE-ProRule annotation1
Metal bindingi569Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi572Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM03.006

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:oct1
ORF Names:ACLA_083770
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006701 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:ACLA_083770

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 41MitochondrionSequence analysisAdd BLAST41
ChainiPRO_000033856942 – 801Mitochondrial intermediate peptidaseAdd BLAST760

Interactioni

Protein-protein interaction databases

STRINGi5057.CADACLAP00007518

Structurei

3D structure databases

ProteinModelPortaliA1CTP5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000076521
KOiK01410
OMAiVENTAWQ
OrthoDBiEOG092C0JU2

Family and domain databases

CDDicd06457 M3A_MIP, 1 hit
Gene3Di1.10.1370.10, 2 hits
InterProiView protein in InterPro
IPR033851 M3A_MIP
IPR024077 Neurolysin/TOP_dom2
IPR001567 Pept_M3A_M3B
PANTHERiPTHR11804:SF5 PTHR11804:SF5, 1 hit
PfamiView protein in Pfam
PF01432 Peptidase_M3, 1 hit
PROSITEiView protein in PROSITE
PS00142 ZINC_PROTEASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1CTP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPQLLTPLR RRPWTCRQCL QRLQRLQQQT RRSFETAASP APGHTQVDYI
60 70 80 90 100
PADASQSKKV DDETIRRVFD SQHFWREFSQ RRSTQSKPTG LVQNQYLTSP
110 120 130 140 150
DGFRTFANVS LQKCQAIVSK VLAASTLEEY RTMARDLDRL SDLLCRVIDL
160 170 180 190 200
SDFIRVIHPD PRVQEAATQA YALMFEYMNV LNTTTGLNDQ LKKAVANPEV
210 220 230 240 250
ASHWTEEEKI VAQILIKDFS NSAILMPPQE RQRFVNLSND ISQLGSSFVN
260 270 280 290 300
SPEPAKSQVV VNANSLRGLD PMLVQQIKRW NRTASVPTTG MIPRLALRSV
310 320 330 340 350
HDESVRREVY LASRTSSARQ LHRLEELLLK RAELAKLSGY SSFGHMTLSD
360 370 380 390 400
KMAKSPEAVS NFLTSLVDSN RTLVREELLQ LRNMKGSPLQ PWDHAYYVHK
410 420 430 440 450
RVMQYSQSRR SRELSAVPEF FSLGTVMQGL SRLFDRLYGV RLVPQEAAPG
460 470 480 490 500
ETWNPDVRRL DVVDEADRHI AVIYCDLFSR PNKHPNPAHF TLRCSREISA
510 520 530 540 550
TEVAECASLD QSSHPNDGMA TAVDPTTKTL RQLPTIALVC DFAEPAAHGG
560 570 580 590 600
RPSLLSEHSV RTLFHEMGHA LHSILGQTRL QSISGTRCAT DFAELPSVLM
610 620 630 640 650
EHFATAPSVL SLYARHWETD EPLSERMIQS MERDRTAHGS IYGAVENEAQ
660 670 680 690 700
ILMALVDQEY HSRPADGGRI DSTALYHEVA QRHSSLPDPA ETAPPTSWQG
710 720 730 740 750
FFGHLYGYGA TYYSYIFDRA IANKLWADVF GAGRAAVDRA AGERYKTEVL
760 770 780 790 800
RWGGGRNGWQ CVAGVLGPSN ASNADGRLVE GGDEAMREVG RWGLGRDGVS

G
Length:801
Mass (Da):89,815
Last modified:January 23, 2007 - v1
Checksum:i38B5273FF01FD833
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027060 Genomic DNA Translation: EAW06682.1
RefSeqiXP_001268108.1, XM_001268107.1

Genome annotation databases

EnsemblFungiiCADACLAT00007709; CADACLAP00007518; CADACLAG00007709
GeneIDi4700295
KEGGiact:ACLA_083770

Similar proteinsi

Entry informationi

Entry nameiPMIP_ASPCL
AccessioniPrimary (citable) accession number: A1CTP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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