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Protein

Beta-mannosidase A

Gene

mndA

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of beta-mannosidic oligosaccharides of various complexity and length. Involved in the degradation of polymeric mannan and galactomannan (By similarity).By similarity

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.

Pathwayi: N-glycan degradation

This protein is involved in the pathway N-glycan degradation, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway N-glycan degradation and in Glycan metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei480Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00280

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-mannosidase A (EC:3.2.1.25)
Alternative name(s):
Mannanase A
Short name:
Mannase A
Gene namesi
Name:mndA
ORF Names:ACLA_083570
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:ACLA_083570

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000039464322 – 932Beta-mannosidase AAdd BLAST911

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi40N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi248N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi283N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi317N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi348N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi538N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi609N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi632N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi659N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi739N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi762N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi791N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiA1CTM5

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi5057.CADACLAP00007511

Structurei

3D structure databases

ProteinModelPortaliA1CTM5
SMRiA1CTM5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000216059
KOiK01192
OMAiCHATQLF
OrthoDBiEOG092C0Q54

Family and domain databases

Gene3Di2.60.120.260, 1 hit
2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR036156 Beta-gal/glucu_dom_sf
IPR008979 Galactose-bd-like_sf
IPR006102 Glyco_hydro_2_Ig-like
IPR017853 Glycoside_hydrolase_SF
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF00703 Glyco_hydro_2, 1 hit
SUPFAMiSSF49303 SSF49303, 1 hit
SSF49785 SSF49785, 1 hit
SSF51445 SSF51445, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1CTM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIREQTILA LLSPGLPPVT GQHVLDLSEP GWTVSSKALN RTVPGRLPSQ
60 70 80 90 100
VHLDLFEAGV IATMGSMILT FAGLRMPTGR TPATLLLGCE LTDHESTWLV
110 120 130 140 150
FDGLDTFTTI TFCDQIIGST YNQFRQYHFD VSQVLKECKQ EGPVLSINFG
160 170 180 190 200
SAPNIANAIA NGPSAEEWPA GVQITNEYPN RWYIRKEQSD FGWDWGPAFA
210 220 230 240 250
PAGPWKPAYI VQNKNPDRLY VLNTDLDIYR RGQINHLPPD QSQSWVVNAS
260 270 280 290 300
IDVLGSVPQW PSMSVEIKDA YSGVVLSSGL LENVTVSGNS VTGVTVVDGR
310 320 330 340 350
TPKLWWPNGM GDQSLYNVTI AVHNHRNQVV AEVMKRTGFR TIFLNQRNIT
360 370 380 390 400
EEQLAQGVAP GANWHFEING REFYAKGSNI IPPDAFWPRV TPSRMERLFD
410 420 430 440 450
AVTAGNQNML RVWASGAYLH DFIYDLADEK GILLWSEFQF SDALYPVDDA
460 470 480 490 500
FLENVAAEVV YNVRRVNHHP SLALWAGGNE IESLMLPMVR RADHKGYAKY
510 520 530 540 550
VGEYEKLYIS LILPLVYENT RSITYSPSST TEGYLHVNLS APVPMTERYS
560 570 580 590 600
NTTPGSYYGD TDYYNYDTSV SFNYHKYPVG RFANEFGFHS MPSLQTWQQA
610 620 630 640 650
VDPKDLYFNS SVVVLRNHHY TAGGLFTDNY QNSSRGMGEM TMGVESYYPI
660 670 680 690 700
PSKSDPVANF SAWCHATQLF QADMYKAQIQ FYRRGSGMPE RQLGSLYWQL
710 720 730 740 750
EDTWQAPTWA GIEYDGRWKM LHYVARDIYE PIIVSPFWNY TTGDLEVYVT
760 770 780 790 800
SDLWEPAQGT VNLTWVDLSG KSIAGNAGTP ESIPFSVGAL NATDVYSANV
810 820 830 840 850
ADLSPPDLTD SILILSLAGE GYLPNARTRS EFRHENQFTP VFPKDLALRD
860 870 880 890 900
PKLELAYNPD TRTFTVEATA GVSLYTWLDY PAGVVGYFEQ NGFVLLPGMK
910 920 930
KEIGFVVQEG SVDEDWMRSV TVTSLWDQKV RE
Length:932
Mass (Da):104,680
Last modified:January 23, 2007 - v1
Checksum:iAFDBB74995D092FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027060 Genomic DNA Translation: EAW06662.1
RefSeqiXP_001268088.1, XM_001268087.1

Genome annotation databases

EnsemblFungiiCADACLAT00007702; CADACLAP00007511; CADACLAG00007702
GeneIDi4700372
KEGGiact:ACLA_083570

Similar proteinsi

Entry informationi

Entry nameiMANBA_ASPCL
AccessioniPrimary (citable) accession number: A1CTM5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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