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A1CTM5 (MANBA_ASPCL) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-mannosidase A

EC=3.2.1.25
Alternative name(s):
Mannanase A
Short name=Mannase A
Gene names
Name:mndA
ORF Names:ACLA_083570
OrganismAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1) [Complete proteome]
Taxonomic identifier344612 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length932 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of beta-mannosidic oligosaccharides of various complexity and length. Involved in the degradation of polymeric mannan and galactomannan By similarity.

Catalytic activity

Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.

Pathway

Glycan metabolism; N-glycan degradation.

Subunit structure

Homodimer By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase A subfamily.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Polysaccharide degradation
   Cellular componentSecreted
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processmannan catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbeta-mannosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 932911Beta-mannosidase A
PRO_0000394643

Sites

Active site4801Proton donor By similarity

Amino acid modifications

Glycosylation401N-linked (GlcNAc...) Potential
Glycosylation2481N-linked (GlcNAc...) Potential
Glycosylation2831N-linked (GlcNAc...) Potential
Glycosylation3171N-linked (GlcNAc...) Potential
Glycosylation3481N-linked (GlcNAc...) Potential
Glycosylation5381N-linked (GlcNAc...) Potential
Glycosylation6091N-linked (GlcNAc...) Potential
Glycosylation6321N-linked (GlcNAc...) Potential
Glycosylation6591N-linked (GlcNAc...) Potential
Glycosylation7391N-linked (GlcNAc...) Potential
Glycosylation7621N-linked (GlcNAc...) Potential
Glycosylation7911N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
A1CTM5 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: AFDBB74995D092FD

FASTA932104,680
        10         20         30         40         50         60 
MRIREQTILA LLSPGLPPVT GQHVLDLSEP GWTVSSKALN RTVPGRLPSQ VHLDLFEAGV 

        70         80         90        100        110        120 
IATMGSMILT FAGLRMPTGR TPATLLLGCE LTDHESTWLV FDGLDTFTTI TFCDQIIGST 

       130        140        150        160        170        180 
YNQFRQYHFD VSQVLKECKQ EGPVLSINFG SAPNIANAIA NGPSAEEWPA GVQITNEYPN 

       190        200        210        220        230        240 
RWYIRKEQSD FGWDWGPAFA PAGPWKPAYI VQNKNPDRLY VLNTDLDIYR RGQINHLPPD 

       250        260        270        280        290        300 
QSQSWVVNAS IDVLGSVPQW PSMSVEIKDA YSGVVLSSGL LENVTVSGNS VTGVTVVDGR 

       310        320        330        340        350        360 
TPKLWWPNGM GDQSLYNVTI AVHNHRNQVV AEVMKRTGFR TIFLNQRNIT EEQLAQGVAP 

       370        380        390        400        410        420 
GANWHFEING REFYAKGSNI IPPDAFWPRV TPSRMERLFD AVTAGNQNML RVWASGAYLH 

       430        440        450        460        470        480 
DFIYDLADEK GILLWSEFQF SDALYPVDDA FLENVAAEVV YNVRRVNHHP SLALWAGGNE 

       490        500        510        520        530        540 
IESLMLPMVR RADHKGYAKY VGEYEKLYIS LILPLVYENT RSITYSPSST TEGYLHVNLS 

       550        560        570        580        590        600 
APVPMTERYS NTTPGSYYGD TDYYNYDTSV SFNYHKYPVG RFANEFGFHS MPSLQTWQQA 

       610        620        630        640        650        660 
VDPKDLYFNS SVVVLRNHHY TAGGLFTDNY QNSSRGMGEM TMGVESYYPI PSKSDPVANF 

       670        680        690        700        710        720 
SAWCHATQLF QADMYKAQIQ FYRRGSGMPE RQLGSLYWQL EDTWQAPTWA GIEYDGRWKM 

       730        740        750        760        770        780 
LHYVARDIYE PIIVSPFWNY TTGDLEVYVT SDLWEPAQGT VNLTWVDLSG KSIAGNAGTP 

       790        800        810        820        830        840 
ESIPFSVGAL NATDVYSANV ADLSPPDLTD SILILSLAGE GYLPNARTRS EFRHENQFTP 

       850        860        870        880        890        900 
VFPKDLALRD PKLELAYNPD TRTFTVEATA GVSLYTWLDY PAGVVGYFEQ NGFVLLPGMK 

       910        920        930 
KEIGFVVQEG SVDEDWMRSV TVTSLWDQKV RE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS027060 Genomic DNA. Translation: EAW06662.1.
RefSeqXP_001268088.1. XM_001268087.1.

3D structure databases

ProteinModelPortalA1CTM5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5057.CADACLAP00007511.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADACLAT00007702; CADACLAP00007511; CADACLAG00007702.
GeneID4700372.
KEGGact:ACLA_083570.

Phylogenomic databases

eggNOGCOG3250.
HOGENOMHOG000216059.
KOK01192.
OMACHATQLF.
OrthoDBEOG78D7TH.

Enzyme and pathway databases

UniPathwayUPA00280.

Family and domain databases

Gene3D2.60.120.260. 2 hits.
2.60.40.320. 1 hit.
3.20.20.80. 2 hits.
InterProIPR008979. Galactose-bd-like.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR006102. Glyco_hydro_2_Ig-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR028369. Mannanase.
[Graphical view]
PANTHERPTHR10066:SF12. PTHR10066:SF12. 1 hit.
PfamPF00703. Glyco_hydro_2. 1 hit.
[Graphical view]
SUPFAMSSF49303. SSF49303. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMANBA_ASPCL
AccessionPrimary (citable) accession number: A1CTM5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: January 23, 2007
Last modified: March 19, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries