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A1CTM5

- MANBA_ASPCL

UniProt

A1CTM5 - MANBA_ASPCL

Protein

Beta-mannosidase A

Gene

mndA

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of beta-mannosidic oligosaccharides of various complexity and length. Involved in the degradation of polymeric mannan and galactomannan By similarity.By similarity

    Catalytic activityi

    Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei480 – 4801Proton donorBy similarity

    GO - Molecular functioni

    1. beta-mannosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. polysaccharide catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Polysaccharide degradation

    Enzyme and pathway databases

    UniPathwayiUPA00280.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-mannosidase A (EC:3.2.1.25)
    Alternative name(s):
    Mannanase A
    Short name:
    Mannase A
    Gene namesi
    Name:mndA
    ORF Names:ACLA_083570
    OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
    Taxonomic identifieri344612 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000006701: Unassembled WGS sequence

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 932911Beta-mannosidase APRO_0000394643Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi40 – 401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi248 – 2481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi283 – 2831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi317 – 3171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi348 – 3481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi538 – 5381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi609 – 6091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi632 – 6321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi659 – 6591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi739 – 7391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi762 – 7621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi791 – 7911N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi5057.CADACLAP00007511.

    Structurei

    3D structure databases

    ProteinModelPortaliA1CTM5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG3250.
    HOGENOMiHOG000216059.
    KOiK01192.
    OMAiCHATQLF.
    OrthoDBiEOG78D7TH.

    Family and domain databases

    Gene3Di2.60.120.260. 2 hits.
    2.60.40.320. 1 hit.
    3.20.20.80. 2 hits.
    InterProiIPR008979. Galactose-bd-like.
    IPR013812. Glyco_hydro_2/20_Ig-like.
    IPR006102. Glyco_hydro_2_Ig-like.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF00703. Glyco_hydro_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF49303. SSF49303. 1 hit.
    SSF49785. SSF49785. 1 hit.
    SSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A1CTM5-1 [UniParc]FASTAAdd to Basket

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    MRIREQTILA LLSPGLPPVT GQHVLDLSEP GWTVSSKALN RTVPGRLPSQ    50
    VHLDLFEAGV IATMGSMILT FAGLRMPTGR TPATLLLGCE LTDHESTWLV 100
    FDGLDTFTTI TFCDQIIGST YNQFRQYHFD VSQVLKECKQ EGPVLSINFG 150
    SAPNIANAIA NGPSAEEWPA GVQITNEYPN RWYIRKEQSD FGWDWGPAFA 200
    PAGPWKPAYI VQNKNPDRLY VLNTDLDIYR RGQINHLPPD QSQSWVVNAS 250
    IDVLGSVPQW PSMSVEIKDA YSGVVLSSGL LENVTVSGNS VTGVTVVDGR 300
    TPKLWWPNGM GDQSLYNVTI AVHNHRNQVV AEVMKRTGFR TIFLNQRNIT 350
    EEQLAQGVAP GANWHFEING REFYAKGSNI IPPDAFWPRV TPSRMERLFD 400
    AVTAGNQNML RVWASGAYLH DFIYDLADEK GILLWSEFQF SDALYPVDDA 450
    FLENVAAEVV YNVRRVNHHP SLALWAGGNE IESLMLPMVR RADHKGYAKY 500
    VGEYEKLYIS LILPLVYENT RSITYSPSST TEGYLHVNLS APVPMTERYS 550
    NTTPGSYYGD TDYYNYDTSV SFNYHKYPVG RFANEFGFHS MPSLQTWQQA 600
    VDPKDLYFNS SVVVLRNHHY TAGGLFTDNY QNSSRGMGEM TMGVESYYPI 650
    PSKSDPVANF SAWCHATQLF QADMYKAQIQ FYRRGSGMPE RQLGSLYWQL 700
    EDTWQAPTWA GIEYDGRWKM LHYVARDIYE PIIVSPFWNY TTGDLEVYVT 750
    SDLWEPAQGT VNLTWVDLSG KSIAGNAGTP ESIPFSVGAL NATDVYSANV 800
    ADLSPPDLTD SILILSLAGE GYLPNARTRS EFRHENQFTP VFPKDLALRD 850
    PKLELAYNPD TRTFTVEATA GVSLYTWLDY PAGVVGYFEQ NGFVLLPGMK 900
    KEIGFVVQEG SVDEDWMRSV TVTSLWDQKV RE 932
    Length:932
    Mass (Da):104,680
    Last modified:January 23, 2007 - v1
    Checksum:iAFDBB74995D092FD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027060 Genomic DNA. Translation: EAW06662.1.
    RefSeqiXP_001268088.1. XM_001268087.1.

    Genome annotation databases

    EnsemblFungiiCADACLAT00007702; CADACLAP00007511; CADACLAG00007702.
    GeneIDi4700372.
    KEGGiact:ACLA_083570.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027060 Genomic DNA. Translation: EAW06662.1 .
    RefSeqi XP_001268088.1. XM_001268087.1.

    3D structure databases

    ProteinModelPortali A1CTM5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5057.CADACLAP00007511.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADACLAT00007702 ; CADACLAP00007511 ; CADACLAG00007702 .
    GeneIDi 4700372.
    KEGGi act:ACLA_083570.

    Phylogenomic databases

    eggNOGi COG3250.
    HOGENOMi HOG000216059.
    KOi K01192.
    OMAi CHATQLF.
    OrthoDBi EOG78D7TH.

    Enzyme and pathway databases

    UniPathwayi UPA00280 .

    Family and domain databases

    Gene3Di 2.60.120.260. 2 hits.
    2.60.40.320. 1 hit.
    3.20.20.80. 2 hits.
    InterProi IPR008979. Galactose-bd-like.
    IPR013812. Glyco_hydro_2/20_Ig-like.
    IPR006102. Glyco_hydro_2_Ig-like.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF00703. Glyco_hydro_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49303. SSF49303. 1 hit.
    SSF49785. SSF49785. 1 hit.
    SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

    Entry informationi

    Entry nameiMANBA_ASPCL
    AccessioniPrimary (citable) accession number: A1CTM5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3