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A1CTM5

- MANBA_ASPCL

UniProt

A1CTM5 - MANBA_ASPCL

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Protein

Beta-mannosidase A

Gene
mndA, ACLA_083570
Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of beta-mannosidic oligosaccharides of various complexity and length. Involved in the degradation of polymeric mannan and galactomannan By similarity.

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei480 – 4801Proton donor By similarity

GO - Molecular functioni

  1. beta-mannosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00280.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-mannosidase A (EC:3.2.1.25)
Alternative name(s):
Mannanase A
Short name:
Mannase A
Gene namesi
Name:mndA
ORF Names:ACLA_083570
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Chaini22 – 932911Beta-mannosidase APRO_0000394643Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi40 – 401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi248 – 2481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi283 – 2831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi317 – 3171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi348 – 3481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi538 – 5381N-linked (GlcNAc...) Reviewed prediction
Glycosylationi609 – 6091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi632 – 6321N-linked (GlcNAc...) Reviewed prediction
Glycosylationi659 – 6591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi739 – 7391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi762 – 7621N-linked (GlcNAc...) Reviewed prediction
Glycosylationi791 – 7911N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi5057.CADACLAP00007511.

Structurei

3D structure databases

ProteinModelPortaliA1CTM5.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3250.
HOGENOMiHOG000216059.
KOiK01192.
OMAiCHATQLF.
OrthoDBiEOG78D7TH.

Family and domain databases

Gene3Di2.60.120.260. 2 hits.
2.60.40.320. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR008979. Galactose-bd-like.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR006102. Glyco_hydro_2_Ig-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00703. Glyco_hydro_2. 1 hit.
[Graphical view]
SUPFAMiSSF49303. SSF49303. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1CTM5-1 [UniParc]FASTAAdd to Basket

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MRIREQTILA LLSPGLPPVT GQHVLDLSEP GWTVSSKALN RTVPGRLPSQ    50
VHLDLFEAGV IATMGSMILT FAGLRMPTGR TPATLLLGCE LTDHESTWLV 100
FDGLDTFTTI TFCDQIIGST YNQFRQYHFD VSQVLKECKQ EGPVLSINFG 150
SAPNIANAIA NGPSAEEWPA GVQITNEYPN RWYIRKEQSD FGWDWGPAFA 200
PAGPWKPAYI VQNKNPDRLY VLNTDLDIYR RGQINHLPPD QSQSWVVNAS 250
IDVLGSVPQW PSMSVEIKDA YSGVVLSSGL LENVTVSGNS VTGVTVVDGR 300
TPKLWWPNGM GDQSLYNVTI AVHNHRNQVV AEVMKRTGFR TIFLNQRNIT 350
EEQLAQGVAP GANWHFEING REFYAKGSNI IPPDAFWPRV TPSRMERLFD 400
AVTAGNQNML RVWASGAYLH DFIYDLADEK GILLWSEFQF SDALYPVDDA 450
FLENVAAEVV YNVRRVNHHP SLALWAGGNE IESLMLPMVR RADHKGYAKY 500
VGEYEKLYIS LILPLVYENT RSITYSPSST TEGYLHVNLS APVPMTERYS 550
NTTPGSYYGD TDYYNYDTSV SFNYHKYPVG RFANEFGFHS MPSLQTWQQA 600
VDPKDLYFNS SVVVLRNHHY TAGGLFTDNY QNSSRGMGEM TMGVESYYPI 650
PSKSDPVANF SAWCHATQLF QADMYKAQIQ FYRRGSGMPE RQLGSLYWQL 700
EDTWQAPTWA GIEYDGRWKM LHYVARDIYE PIIVSPFWNY TTGDLEVYVT 750
SDLWEPAQGT VNLTWVDLSG KSIAGNAGTP ESIPFSVGAL NATDVYSANV 800
ADLSPPDLTD SILILSLAGE GYLPNARTRS EFRHENQFTP VFPKDLALRD 850
PKLELAYNPD TRTFTVEATA GVSLYTWLDY PAGVVGYFEQ NGFVLLPGMK 900
KEIGFVVQEG SVDEDWMRSV TVTSLWDQKV RE 932
Length:932
Mass (Da):104,680
Last modified:January 23, 2007 - v1
Checksum:iAFDBB74995D092FD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027060 Genomic DNA. Translation: EAW06662.1.
RefSeqiXP_001268088.1. XM_001268087.1.

Genome annotation databases

EnsemblFungiiCADACLAT00007702; CADACLAP00007511; CADACLAG00007702.
GeneIDi4700372.
KEGGiact:ACLA_083570.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027060 Genomic DNA. Translation: EAW06662.1 .
RefSeqi XP_001268088.1. XM_001268087.1.

3D structure databases

ProteinModelPortali A1CTM5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5057.CADACLAP00007511.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADACLAT00007702 ; CADACLAP00007511 ; CADACLAG00007702 .
GeneIDi 4700372.
KEGGi act:ACLA_083570.

Phylogenomic databases

eggNOGi COG3250.
HOGENOMi HOG000216059.
KOi K01192.
OMAi CHATQLF.
OrthoDBi EOG78D7TH.

Enzyme and pathway databases

UniPathwayi UPA00280 .

Family and domain databases

Gene3Di 2.60.120.260. 2 hits.
2.60.40.320. 1 hit.
3.20.20.80. 2 hits.
InterProi IPR008979. Galactose-bd-like.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR006102. Glyco_hydro_2_Ig-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00703. Glyco_hydro_2. 1 hit.
[Graphical view ]
SUPFAMi SSF49303. SSF49303. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiMANBA_ASPCL
AccessioniPrimary (citable) accession number: A1CTM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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