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A1CTI3

- EXGD_ASPCL

UniProt

A1CTI3 - EXGD_ASPCL

Protein

Probable glucan 1,3-beta-glucosidase D

Gene

exgD

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan By similarity.By similarity

    Catalytic activityi

    Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei597 – 5971Proton donorBy similarity
    Active sitei701 – 7011NucleophileBy similarity

    GO - Molecular functioni

    1. glucan exo-1,3-beta-glucosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. polysaccharide catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glucan 1,3-beta-glucosidase D (EC:3.2.1.58)
    Alternative name(s):
    Exo-1,3-beta-glucanase D
    Gene namesi
    Name:exgD
    ORF Names:ACLA_083150
    OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
    Taxonomic identifieri344612 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000006701: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 830830Probable glucan 1,3-beta-glucosidase DPRO_0000395161Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi331 – 3311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi376 – 3761N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi381 – 3811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi393 – 3931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi546 – 5461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi558 – 5581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi610 – 6101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi636 – 6361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi669 – 6691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi689 – 6891N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi5057.CADACLAP00007666.

    Structurei

    3D structure databases

    ProteinModelPortaliA1CTI3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 301301CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini323 – 830508ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei302 – 32221Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi25 – 5127Asp-richAdd
    BLAST
    Compositional biasi55 – 265211Arg-richAdd
    BLAST
    Compositional biasi255 – 29238Gly-richAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2730.
    HOGENOMiHOG000114462.
    KOiK01210.
    OMAiTNELVGG.
    OrthoDBiEOG7ZPNTV.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    InterProiIPR001547. Glyco_hydro_5.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF00150. Cellulase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1CTI3-1 [UniParc]FASTAAdd to Basket

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    MPSQSRSRDR YRGRDTEYTR RRYPDEHDYS HDDHDYDYDD DDDDNDDLEQ    50
    DVTERRYRRD GYRRPRGESR ARAYYERDAA AAAAHDEELL AEERERRRAG 100
    ASGSPRKSGQ HRERDRDRER DREAQSRRRT YEDDGRHRTR DGRRERRREG 150
    GGEGGRRERR RGESRRGEAA RKHQSSDSTN SASHLLSADA LARLGSQYEK 200
    EDRRERAHAK DAAKAERKRR KKRAVVGEQE RGLRAEKPRD RSRARVASGA 250
    YMEEGRGPEM EFRRRGGGGP PMDARWPKGG GWGGSVDGGD AGRPFWKQKK 300
    WLIGIGVVIL ILVIVIPVAV VVSKKHNDKP NATTTQPDGT TPSNSNLDGL 350
    SPDSIPGYAK GTFLDPWTWY DTNDFNVTFT NETVGGLSLM GLNSTWDDSA 400
    RPNDNVPPLN KPFPYGKQPI RGVNLGGWLS LEPFITPSFF QSYSALSGVI 450
    DEYTLTQKLG STAGARLEKH YATFITEQDF ADIRDAGLDH VRIQYSYWAV 500
    TTYDGDPYVA KTSWRYLLRA IEYCRKYGLR VKLDPHGIPG SQNGWNHSGR 550
    QGAIGWLNGT DGELNRKRSL EVHDQVSKFF AQDRYKNVVT IYGLVNEPLM 600
    LSLSVEDVLN WTVEATKLVQ KNGITAYIAL HDGFLNLSKW KSILKTRPDN 650
    MLLDTHQYTI FNTGQIVLNH TARVNLICND WSAMIKEVNS TSGFGPTICG 700
    EWSQADTDCA QYLNNVGRGT RWEGTFSLTD STQYCPTADS GPRCSCANAN 750
    ADPSAYSADY KKFLQTYAEA QMSAFETGQG WFYWTWRTES AAQWSYRTAW 800
    KGGFMPQKAY SPSFKCGDTV PDFGSLPEYY 830
    Length:830
    Mass (Da):94,264
    Last modified:January 23, 2007 - v1
    Checksum:i6B3691C5BBE14B90
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027060 Genomic DNA. Translation: EAW06620.1.
    RefSeqiXP_001268046.1. XM_001268045.1.

    Genome annotation databases

    EnsemblFungiiCADACLAT00007857; CADACLAP00007666; CADACLAG00007857.
    GeneIDi4700413.
    KEGGiact:ACLA_083150.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027060 Genomic DNA. Translation: EAW06620.1 .
    RefSeqi XP_001268046.1. XM_001268045.1.

    3D structure databases

    ProteinModelPortali A1CTI3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5057.CADACLAP00007666.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADACLAT00007857 ; CADACLAP00007666 ; CADACLAG00007857 .
    GeneIDi 4700413.
    KEGGi act:ACLA_083150.

    Phylogenomic databases

    eggNOGi COG2730.
    HOGENOMi HOG000114462.
    KOi K01210.
    OMAi TNELVGG.
    OrthoDBi EOG7ZPNTV.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    InterProi IPR001547. Glyco_hydro_5.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF00150. Cellulase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

    Entry informationi

    Entry nameiEXGD_ASPCL
    AccessioniPrimary (citable) accession number: A1CTI3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3