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A1CTI3

- EXGD_ASPCL

UniProt

A1CTI3 - EXGD_ASPCL

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Protein
Probable glucan 1,3-beta-glucosidase D
Gene
exgD, ACLA_083150
Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan By similarity.

Catalytic activityi

Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei597 – 5971Proton donor By similarity
Active sitei701 – 7011Nucleophile By similarity

GO - Molecular functioni

  1. glucan exo-1,3-beta-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glucan 1,3-beta-glucosidase D (EC:3.2.1.58)
Alternative name(s):
Exo-1,3-beta-glucanase D
Gene namesi
Name:exgD
ORF Names:ACLA_083150
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 301301Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei302 – 32221Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini323 – 830508Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 830830Probable glucan 1,3-beta-glucosidase D
PRO_0000395161Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi331 – 3311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi376 – 3761N-linked (GlcNAc...) Reviewed prediction
Glycosylationi381 – 3811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi393 – 3931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi546 – 5461N-linked (GlcNAc...) Reviewed prediction
Glycosylationi558 – 5581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi610 – 6101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi636 – 6361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi669 – 6691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi689 – 6891N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5057.CADACLAP00007666.

Structurei

3D structure databases

ProteinModelPortaliA1CTI3.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi25 – 5127Asp-rich
Add
BLAST
Compositional biasi55 – 265211Arg-rich
Add
BLAST
Compositional biasi255 – 29238Gly-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2730.
HOGENOMiHOG000114462.
KOiK01210.
OMAiTNELVGG.
OrthoDBiEOG7ZPNTV.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

A1CTI3-1 [UniParc]FASTAAdd to Basket

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MPSQSRSRDR YRGRDTEYTR RRYPDEHDYS HDDHDYDYDD DDDDNDDLEQ    50
DVTERRYRRD GYRRPRGESR ARAYYERDAA AAAAHDEELL AEERERRRAG 100
ASGSPRKSGQ HRERDRDRER DREAQSRRRT YEDDGRHRTR DGRRERRREG 150
GGEGGRRERR RGESRRGEAA RKHQSSDSTN SASHLLSADA LARLGSQYEK 200
EDRRERAHAK DAAKAERKRR KKRAVVGEQE RGLRAEKPRD RSRARVASGA 250
YMEEGRGPEM EFRRRGGGGP PMDARWPKGG GWGGSVDGGD AGRPFWKQKK 300
WLIGIGVVIL ILVIVIPVAV VVSKKHNDKP NATTTQPDGT TPSNSNLDGL 350
SPDSIPGYAK GTFLDPWTWY DTNDFNVTFT NETVGGLSLM GLNSTWDDSA 400
RPNDNVPPLN KPFPYGKQPI RGVNLGGWLS LEPFITPSFF QSYSALSGVI 450
DEYTLTQKLG STAGARLEKH YATFITEQDF ADIRDAGLDH VRIQYSYWAV 500
TTYDGDPYVA KTSWRYLLRA IEYCRKYGLR VKLDPHGIPG SQNGWNHSGR 550
QGAIGWLNGT DGELNRKRSL EVHDQVSKFF AQDRYKNVVT IYGLVNEPLM 600
LSLSVEDVLN WTVEATKLVQ KNGITAYIAL HDGFLNLSKW KSILKTRPDN 650
MLLDTHQYTI FNTGQIVLNH TARVNLICND WSAMIKEVNS TSGFGPTICG 700
EWSQADTDCA QYLNNVGRGT RWEGTFSLTD STQYCPTADS GPRCSCANAN 750
ADPSAYSADY KKFLQTYAEA QMSAFETGQG WFYWTWRTES AAQWSYRTAW 800
KGGFMPQKAY SPSFKCGDTV PDFGSLPEYY 830
Length:830
Mass (Da):94,264
Last modified:January 23, 2007 - v1
Checksum:i6B3691C5BBE14B90
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027060 Genomic DNA. Translation: EAW06620.1.
RefSeqiXP_001268046.1. XM_001268045.1.

Genome annotation databases

EnsemblFungiiCADACLAT00007857; CADACLAP00007666; CADACLAG00007857.
GeneIDi4700413.
KEGGiact:ACLA_083150.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027060 Genomic DNA. Translation: EAW06620.1 .
RefSeqi XP_001268046.1. XM_001268045.1.

3D structure databases

ProteinModelPortali A1CTI3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5057.CADACLAP00007666.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADACLAT00007857 ; CADACLAP00007666 ; CADACLAG00007857 .
GeneIDi 4700413.
KEGGi act:ACLA_083150.

Phylogenomic databases

eggNOGi COG2730.
HOGENOMi HOG000114462.
KOi K01210.
OMAi TNELVGG.
OrthoDBi EOG7ZPNTV.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00150. Cellulase. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiEXGD_ASPCL
AccessioniPrimary (citable) accession number: A1CTI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: January 23, 2007
Last modified: February 19, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi