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A1CTI3

- EXGD_ASPCL

UniProt

A1CTI3 - EXGD_ASPCL

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Protein

Probable glucan 1,3-beta-glucosidase D

Gene

exgD

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan By similarity.By similarity

Catalytic activityi

Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei597 – 5971Proton donorBy similarity
Active sitei701 – 7011NucleophileBy similarity

GO - Molecular functioni

  1. glucan exo-1,3-beta-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glucan 1,3-beta-glucosidase D (EC:3.2.1.58)
Alternative name(s):
Exo-1,3-beta-glucanase D
Gene namesi
Name:exgD
ORF Names:ACLA_083150
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 830830Probable glucan 1,3-beta-glucosidase DPRO_0000395161Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi331 – 3311N-linked (GlcNAc...)Sequence Analysis
Glycosylationi376 – 3761N-linked (GlcNAc...)Sequence Analysis
Glycosylationi381 – 3811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi393 – 3931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi546 – 5461N-linked (GlcNAc...)Sequence Analysis
Glycosylationi558 – 5581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi610 – 6101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi636 – 6361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi669 – 6691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi689 – 6891N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5057.CADACLAP00007666.

Structurei

3D structure databases

ProteinModelPortaliA1CTI3.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 301301CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini323 – 830508ExtracellularSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei302 – 32221Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi25 – 5127Asp-richAdd
BLAST
Compositional biasi55 – 265211Arg-richAdd
BLAST
Compositional biasi255 – 29238Gly-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2730.
HOGENOMiHOG000114462.
KOiK01210.
OMAiTNELVGG.
OrthoDBiEOG7ZPNTV.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

A1CTI3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSQSRSRDR YRGRDTEYTR RRYPDEHDYS HDDHDYDYDD DDDDNDDLEQ
60 70 80 90 100
DVTERRYRRD GYRRPRGESR ARAYYERDAA AAAAHDEELL AEERERRRAG
110 120 130 140 150
ASGSPRKSGQ HRERDRDRER DREAQSRRRT YEDDGRHRTR DGRRERRREG
160 170 180 190 200
GGEGGRRERR RGESRRGEAA RKHQSSDSTN SASHLLSADA LARLGSQYEK
210 220 230 240 250
EDRRERAHAK DAAKAERKRR KKRAVVGEQE RGLRAEKPRD RSRARVASGA
260 270 280 290 300
YMEEGRGPEM EFRRRGGGGP PMDARWPKGG GWGGSVDGGD AGRPFWKQKK
310 320 330 340 350
WLIGIGVVIL ILVIVIPVAV VVSKKHNDKP NATTTQPDGT TPSNSNLDGL
360 370 380 390 400
SPDSIPGYAK GTFLDPWTWY DTNDFNVTFT NETVGGLSLM GLNSTWDDSA
410 420 430 440 450
RPNDNVPPLN KPFPYGKQPI RGVNLGGWLS LEPFITPSFF QSYSALSGVI
460 470 480 490 500
DEYTLTQKLG STAGARLEKH YATFITEQDF ADIRDAGLDH VRIQYSYWAV
510 520 530 540 550
TTYDGDPYVA KTSWRYLLRA IEYCRKYGLR VKLDPHGIPG SQNGWNHSGR
560 570 580 590 600
QGAIGWLNGT DGELNRKRSL EVHDQVSKFF AQDRYKNVVT IYGLVNEPLM
610 620 630 640 650
LSLSVEDVLN WTVEATKLVQ KNGITAYIAL HDGFLNLSKW KSILKTRPDN
660 670 680 690 700
MLLDTHQYTI FNTGQIVLNH TARVNLICND WSAMIKEVNS TSGFGPTICG
710 720 730 740 750
EWSQADTDCA QYLNNVGRGT RWEGTFSLTD STQYCPTADS GPRCSCANAN
760 770 780 790 800
ADPSAYSADY KKFLQTYAEA QMSAFETGQG WFYWTWRTES AAQWSYRTAW
810 820 830
KGGFMPQKAY SPSFKCGDTV PDFGSLPEYY
Length:830
Mass (Da):94,264
Last modified:January 23, 2007 - v1
Checksum:i6B3691C5BBE14B90
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027060 Genomic DNA. Translation: EAW06620.1.
RefSeqiXP_001268046.1. XM_001268045.1.

Genome annotation databases

EnsemblFungiiCADACLAT00007857; CADACLAP00007666; CADACLAG00007857.
GeneIDi4700413.
KEGGiact:ACLA_083150.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027060 Genomic DNA. Translation: EAW06620.1 .
RefSeqi XP_001268046.1. XM_001268045.1.

3D structure databases

ProteinModelPortali A1CTI3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5057.CADACLAP00007666.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADACLAT00007857 ; CADACLAP00007666 ; CADACLAG00007857 .
GeneIDi 4700413.
KEGGi act:ACLA_083150.

Phylogenomic databases

eggNOGi COG2730.
HOGENOMi HOG000114462.
KOi K01210.
OMAi TNELVGG.
OrthoDBi EOG7ZPNTV.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00150. Cellulase. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiEXGD_ASPCL
AccessioniPrimary (citable) accession number: A1CTI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3