ID   MCES_ASPCL              Reviewed;         551 AA.
AC   A1CT57;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   16-JUN-2009, entry version 16.
DE   RecName: Full=mRNA cap guanine-N7 methyltransferase;
DE            EC=2.1.1.56;
DE   AltName: Full=mRNA (guanine-N(7)-)-methyltransferase;
DE   AltName: Full=mRNA cap methyltransferase;
GN   Name=abd1; ORFNames=ACLA_081840;
OS   Aspergillus clavatus.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae;
OC   mitosporic Trichocomaceae; Aspergillus.
OX   NCBI_TaxID=5057;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P.,
RA   Anderson M.J., Crabtree J., Silva J.C., Badger J.H., Albarraq A.,
RA   Angiuoli S., Bussey H., Bowyer P., Cotty P.J., Dyer P.S., Egan A.,
RA   Galens K., Fraser-Liggett C.M., Haas B.J., Inman J.M., Kent R.,
RA   Lemieux S., Malavazi I., Orvis J., Roemer T., Ronning C.M.,
RA   Sundaram J.P., Sutton G., Turner G., Venter J.C., White O.R.,
RA   Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H., Wortman J.R.,
RA   Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Responsible for methylating the 5'-cap structure of
CC       mRNAs (By similarity).
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + G(5')pppR-RNA = S-
CC       adenosyl-L-homocysteine + m(7)G(5')pppR-RNA.
CC   -!- SUBCELLULAR LOCATION: Nucleus (By similarity).
CC   -!- SIMILARITY: Belongs to the mRNA cap methyltransferase family.
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DR   EMBL; DS027060; EAW06494.1; -; Genomic_DNA.
DR   RefSeq; XP_001267920.1; -.
DR   GeneID; 4700241; -.
DR   BRENDA; 2.1.1.56; 18580.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004482; F:mRNA (guanine-N7-)-methyltransferase activity; IEA:EC.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006370; P:mRNA capping; IEA:UniProtKB-KW.
DR   InterPro; IPR016899; mRNA_G-N7_MeTrfase.
DR   InterPro; IPR004971; Pox_MCEL.
DR   Pfam; PF03291; Pox_MCEL; 1.
DR   PIRSF; PIRSF028762; ABD1; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Methyltransferase; mRNA capping; mRNA processing;
KW   Nucleus; RNA-binding; S-adenosyl-L-methionine; Transferase.
FT   CHAIN         1    551       mRNA cap guanine-N7 methyltransferase.
FT                                /FTId=PRO_0000303901.
FT   COMPBIAS     64    190       Arg-rich.
SQ   SEQUENCE   551 AA;  62163 MW;  63E6D0D00ABE4934 CRC64;
     MENRSSSGTP RPSAGSPDAA KRPSETSPAA GRIPAGQNGS SGDKKRKVTE EGEASEKSEP
     PADRPMSKRK RMEERHQKLR KRGRTPPSAY SRRDAEAAPV PNRNRDDPAN RSLSPLPHRS
     PTPEEQPRQR KRPGGGARMG LVDRETLRRR QEERERALVE EAMRTSQGRG VTDVVRQHYN
     AVPQRGREWR KTESKIKGLR SFNNWIKSTL IQKFSPDEEF LARLNDGRDW ADDSGPPPAE
     EKRLLVVDLG CGKGGDLGKW QLAPQPVELY VGLDPAEVSI VQARERYNSM KSGRGNRGRR
     NPLFHGEFAP KDCFGEWLGD IGIVQQVGID PNAGPGGSVM SSRWGGGGFD VVASMFAIHY
     AFESEEKARQ MLRNVAGCLK KGGRFLGVCP NSDIISARVV ELNAKRKARE EQEKKEKSDE
     APEDGEVEED TKLEWGNSIY RVQFPGKTPE DGIFRPPFGW KYSYFMEEAV EEVPEYVVPW
     EAFRALTEDY NLELQYRKPF LGIWGDEKDD RELGPLSERM GVRDRNTGEL LMTEEEKEAA
     NFYHAFCFYK V
//