Reviewed, UniProtKB/Swiss-Prot A1CT57 (MCES_ASPCL)

Names and origin

Protein names

Recommended name:
    mRNA cap guanine-N7 methyltransferase
    EC=2.1.1.56
Alternative name(s):
    mRNA (guanine-N(7)-)-methyltransferase
    mRNA cap methyltransferase

Gene names

Name:	abd1
ORF Names:	ACLA_081840

Organism

Aspergillus clavatus [Complete proteome]

Taxonomic identifier

5057 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	551 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Responsible for methylating the 5'-cap structure of mRNAs By similarity.
Catalytic activity	S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the methyltransferase superfamily. mRNA cap methyltransferase family.

Ontologies

Keywords
Biological process	mRNA capping mRNA processing
Cellular component	Nucleus
Ligand	RNA-binding S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mRNA capping Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW mRNA (guanine-N7-)-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 551	551	mRNA cap guanine-N7 methyltransferase		PRO_0000303901
Regions
	Compositional bias	64 – 190	127	Arg-rich

Sequences

	Sequence		Length	Mass (Da)
	A1CT57-1 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: 63E6D0D00ABE4934	FASTA	551	62,163
	10 20 30 40 50 60 MENRSSSGTP RPSAGSPDAA KRPSETSPAA GRIPAGQNGS SGDKKRKVTE EGEASEKSEP 70 80 90 100 110 120 PADRPMSKRK RMEERHQKLR KRGRTPPSAY SRRDAEAAPV PNRNRDDPAN RSLSPLPHRS 130 140 150 160 170 180 PTPEEQPRQR KRPGGGARMG LVDRETLRRR QEERERALVE EAMRTSQGRG VTDVVRQHYN 190 200 210 220 230 240 AVPQRGREWR KTESKIKGLR SFNNWIKSTL IQKFSPDEEF LARLNDGRDW ADDSGPPPAE 250 260 270 280 290 300 EKRLLVVDLG CGKGGDLGKW QLAPQPVELY VGLDPAEVSI VQARERYNSM KSGRGNRGRR 310 320 330 340 350 360 NPLFHGEFAP KDCFGEWLGD IGIVQQVGID PNAGPGGSVM SSRWGGGGFD VVASMFAIHY 370 380 390 400 410 420 AFESEEKARQ MLRNVAGCLK KGGRFLGVCP NSDIISARVV ELNAKRKARE EQEKKEKSDE 430 440 450 460 470 480 APEDGEVEED TKLEWGNSIY RVQFPGKTPE DGIFRPPFGW KYSYFMEEAV EEVPEYVVPW 490 500 510 520 530 540 EAFRALTEDY NLELQYRKPF LGIWGDEKDD RELGPLSERM GVRDRNTGEL LMTEEEKEAA 550 NFYHAFCFYK V

References

[1]

"Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus." Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J., Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H., Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M. , Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J., Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C., White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H., Wortman J.R., Jiang B., Denning D.W., Nierman W.C. PLoS Genet. 4:E1000046-E1000046(2008) [PubMed: 18404212] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS027060 Genomic DNA. Translation: EAW06494.1.
RefSeq	XP_001267920.1.
3D structure databases
SMR	A1CT57. Positions 195-551.
ModBase	Search...
Genome annotation databases
GeneID	4700241.
Phylogenomic databases
OrthoDB	EOG9GMWD7.
PhylomeDB	A1CT57.
Enzyme and pathway databases
BRENDA	2.1.1.56. 18580.
Family and domain databases
InterPro	IPR016899. mRNA_G-N7_MeTrfase. IPR004971. Pox_MCEL. [Graphical view]
Pfam	PF03291. Pox_MCEL. 3 hits. [Graphical view]
PIRSF	PIRSF028762. ABD1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MCES_ASPCL

Accession

Primary (citable) accession number: A1CT57

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	January 23, 2007
Last modified:	January 19, 2010
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)