A1CT23 (KMO_ASPCL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kynurenine 3-monooxygenase
EC=1.14.13.9

Alternative name(s):
Biosynthesis of nicotinic acid protein 4
Kynurenine 3-hydroxylase

Gene names

Name:	bna4
ORF Names:	ACLA_081480

Organism

Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1) [Complete proteome]

Taxonomic identifier

344612 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	512 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid By similarity.
Catalytic activity	L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O.
Cofactor	FAD By similarity.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Mitochondrion
Ligand	FAD Flavoprotein NADP
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyridine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	kynurenine 3-monooxygenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 512	512	Kynurenine 3-monooxygenase		PRO_0000361916

Sequences

	Sequence		Length	Mass (Da)
	A1CT23 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: 5B1C7AC98065CD1B	FASTA	512	58,083
	10 20 30 40 50 60 MADTVRKPQK VVIVGAGPVG SLAALYAAAR GDEVEVYELR GDLRDPSTIP LNFTKSINLA 70 80 90 100 110 120 LSERGINAMK HSNREELTKN VLRDTIPMYG RMIHGKDRGQ LWEAAQAYDV HGRAINAVDR 130 140 150 160 170 180 STLNNALLDE LEHTPNVKLF FNHKLTGADF RANKAWFERR VPGEAPLPNS ANRVPEIEVD 190 200 210 220 230 240 FDFMLGADGA HSAVRYHMMK FARVDYQQEY IDTLWCEFRI APTENGEFRI SPNHLHIWPG 250 260 270 280 290 300 REFMFIALPS ADKSFTCTLF APAVHYTYLA SSPQKLLDFF DVHFPGVSPE LIPPADLQEQ 310 320 330 340 350 360 FATNPHLPLI SLKCKPHHFG SSVAIVGDAA HAVLPFYGQG LNAGLEDIRV LFEVLDKHSV 370 380 390 400 410 420 YDLDASHEAR REAREKAFQA YTDQRCADTH AINDLSKENY VEMRWGVKTP LYKLRKSIEE 430 440 450 460 470 480 ILDRYVPSLG WQTQYSRVSF SNQRYSDVIK LARRQGTVLG LGLGSTFITA VGVAGYMMWK 490 500 510 NPKQYSPLCF MRYCLRHVSH IWVKFFRNTA YA

References

[1]

"Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus." Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J., Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H., Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M. , Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J., Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C., White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H., Wortman J.R., Jiang B., Denning D.W., Nierman W.C. PLoS Genet. 4:E1000046-E1000046(2008) [PubMed: 18404212] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS027060 Genomic DNA. Translation: EAW06460.1.
RefSeq	XP_001267886.1. XM_001267885.1.
3D structure databases
ProteinModelPortal	A1CT23.
ModBase	Search...
Protein-protein interaction databases
STRING	A1CT23.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADACLAT00007583; CADACLAP00007392; CADACLAG00007583.
GeneID	4700205.
KEGG	act:ACLA_081480.
Phylogenomic databases
GeneTree	EFGT00050000002229.
OrthoDB	EOG4QG0P2.
Family and domain databases
InterPro	IPR002938. mOase_FAD-bd. IPR003042. Rng_hydrolase-like. [Graphical view]
KO	K00486.
Pfam	PF01494. FAD_binding_3. 1 hit. [Graphical view]
PRINTS	PR00420. RNGMNOXGNASE.
ProtoNet	Search...

Entry information

Entry name

KMO_ASPCL

Accession

Primary (citable) accession number: A1CT23

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	January 23, 2007
Last modified:	December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program