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Protein

Kynurenine 3-monooxygenase

Gene

bna4

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.UniRule annotation

Catalytic activityi

L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Kynurenine 3-monooxygenase (bna4)
  2. Kynureninase 2 (bna5-2), Kynureninase 1 (bna5-1)
  3. 3-hydroxyanthranilate 3,4-dioxygenase 1 (bna1-1), 3-hydroxyanthranilate 3,4-dioxygenase 2 (bna1-2)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

FAD, Flavoprotein, NADP

Enzyme and pathway databases

UniPathwayiUPA00253; UER00328.

Names & Taxonomyi

Protein namesi
Recommended name:
Kynurenine 3-monooxygenaseUniRule annotation (EC:1.14.13.9UniRule annotation)
Alternative name(s):
Biosynthesis of nicotinic acid protein 4UniRule annotation
Kynurenine 3-hydroxylaseUniRule annotation
Gene namesi
Name:bna4
ORF Names:ACLA_081480
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006701 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:ACLA_081480.

Subcellular locationi

  • Mitochondrion outer membrane UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Kynurenine 3-monooxygenasePRO_0000361916Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA1CT23.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000251788.
KOiK00486.
OMAiQPMISVK.
OrthoDBiEOG7QVMC6.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
HAMAPiMF_01971. Kynurenine_monooxygenase.
InterProiIPR002938. FAD-bd.
IPR023753. FAD/NAD-binding_dom.
IPR027545. Kynurenine_monooxygenase.
[Graphical view]
PfamiPF01494. FAD_binding_3. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.

Sequencei

Sequence statusi: Complete.

A1CT23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADTVRKPQK VVIVGAGPVG SLAALYAAAR GDEVEVYELR GDLRDPSTIP
60 70 80 90 100
LNFTKSINLA LSERGINAMK HSNREELTKN VLRDTIPMYG RMIHGKDRGQ
110 120 130 140 150
LWEAAQAYDV HGRAINAVDR STLNNALLDE LEHTPNVKLF FNHKLTGADF
160 170 180 190 200
RANKAWFERR VPGEAPLPNS ANRVPEIEVD FDFMLGADGA HSAVRYHMMK
210 220 230 240 250
FARVDYQQEY IDTLWCEFRI APTENGEFRI SPNHLHIWPG REFMFIALPS
260 270 280 290 300
ADKSFTCTLF APAVHYTYLA SSPQKLLDFF DVHFPGVSPE LIPPADLQEQ
310 320 330 340 350
FATNPHLPLI SLKCKPHHFG SSVAIVGDAA HAVLPFYGQG LNAGLEDIRV
360 370 380 390 400
LFEVLDKHSV YDLDASHEAR REAREKAFQA YTDQRCADTH AINDLSKENY
410 420 430 440 450
VEMRWGVKTP LYKLRKSIEE ILDRYVPSLG WQTQYSRVSF SNQRYSDVIK
460 470 480 490 500
LARRQGTVLG LGLGSTFITA VGVAGYMMWK NPKQYSPLCF MRYCLRHVSH
510
IWVKFFRNTA YA
Length:512
Mass (Da):58,083
Last modified:January 23, 2007 - v1
Checksum:i5B1C7AC98065CD1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027060 Genomic DNA. Translation: EAW06460.1.
RefSeqiXP_001267886.1. XM_001267885.1.

Genome annotation databases

EnsemblFungiiCADACLAT00007583; CADACLAP00007392; CADACLAG00007583.
GeneIDi4700205.
KEGGiact:ACLA_081480.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027060 Genomic DNA. Translation: EAW06460.1.
RefSeqiXP_001267886.1. XM_001267885.1.

3D structure databases

ProteinModelPortaliA1CT23.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADACLAT00007583; CADACLAP00007392; CADACLAG00007583.
GeneIDi4700205.
KEGGiact:ACLA_081480.

Organism-specific databases

EuPathDBiFungiDB:ACLA_081480.

Phylogenomic databases

HOGENOMiHOG000251788.
KOiK00486.
OMAiQPMISVK.
OrthoDBiEOG7QVMC6.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00328.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
HAMAPiMF_01971. Kynurenine_monooxygenase.
InterProiIPR002938. FAD-bd.
IPR023753. FAD/NAD-binding_dom.
IPR027545. Kynurenine_monooxygenase.
[Graphical view]
PfamiPF01494. FAD_binding_3. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiKMO_ASPCL
AccessioniPrimary (citable) accession number: A1CT23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: January 23, 2007
Last modified: November 11, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.