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Protein

Histone-lysine N-methyltransferase

Gene

ACLA_080330

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotation, Transferase
LigandS-adenosyl-L-methioninePROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferasePROSITE-ProRule annotation (EC:2.1.1.43PROSITE-ProRule annotation)
Gene namesi
ORF Names:ACLA_080330Imported
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)Imported
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006701 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:ACLA_080330.

Structurei

3D structure databases

ProteinModelPortaliA1CSR2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini120 – 234SETInterPro annotationAdd BLAST115

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000214006.
KOiK11429.
OMAiFMGPARF.
OrthoDBiEOG092C4LF0.

Family and domain databases

InterProiView protein in InterPro
IPR025783. Hist-Lys_N-MeTrfase_SET9.
IPR001214. SET_dom.
PfamiView protein in Pfam
PF00856. SET. 1 hit.
SMARTiView protein in SMART
SM00317. SET. 1 hit.
PROSITEiView protein in PROSITE
PS51567. SAM_MT43_SUVAR420_1. 1 hit.
PS50280. SET. 1 hit.

Sequencei

Sequence statusi: Complete.

A1CSR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSLKGRSSP AVERRDRLTL AKLASYDDVA TDALVDRAYF WTNTRKNRTK
60 70 80 90 100
YIPIRGIVDD QVARILLHDV IVAKDASKAE RELLAMPGLK KFMGKLRNDR
110 120 130 140 150
EKDWFRRHLR KYIQMYLPDS PFEITTTNRY TITEHEAAVC ARKFIKQGQE
160 170 180 190 200
IKYLSGTLVP MTREEEQDLD LKRKDFSIVM SSRKRTPSFF LGPARFANHD
210 220 230 240 250
CNANGKLVTR GSEGMQVVAT RDIYIGEEIT VSYGDDYFGI DNRECLCLTC
260 270 280 290 300
ERLVRNGWSQ NAASELPGAA LIPAVNEDML TVDSHVSPKK RKSAPDSETE
310 320 330 340 350
LSAPPTPSKR AKFIRQSSKL RSEVSFPEST NSIEQPAEQP SLINNAISNG
360 370 380 390 400
PVAESVKNDP LDSNLDTTTV HTQPPSPDDY KSPSSITADE SQRTSTSTYV
410 420 430 440 450
TSVCDTGLKI KVEQVIETSV EKVSSTIEKN IEFSTTSQPD LERRSTSSER
460 470 480 490 500
DAQSELSDPP STMDLLETLV TETKKSRTSR RKNTIVSSVE VESQLVRVPG
510 520 530 540 550
DYTKTSKLLA QTYDRWVDCH TCNTWFVQQN SYLTRRECPR CERHSMLYGY
560 570 580 590 600
RWPKTDREGP QDEEERVMDH RTVHRFLYPE EESLVSRKAR GVSFGVTPTP
610 620 630
ELSESRTETE GSDGGDDRRT TRASRRRTRS IRMTM
Length:635
Mass (Da):72,094
Last modified:January 23, 2007 - v1
Checksum:iAB50A8B9373C83CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027060 Genomic DNA. Translation: EAW06349.1.
RefSeqiXP_001267775.1. XM_001267774.1.

Genome annotation databases

EnsemblFungiiCADACLAT00007647; CADACLAP00007456; CADACLAG00007647.
GeneIDi4700093.
KEGGiact:ACLA_080330.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027060 Genomic DNA. Translation: EAW06349.1.
RefSeqiXP_001267775.1. XM_001267774.1.

3D structure databases

ProteinModelPortaliA1CSR2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADACLAT00007647; CADACLAP00007456; CADACLAG00007647.
GeneIDi4700093.
KEGGiact:ACLA_080330.

Organism-specific databases

EuPathDBiFungiDB:ACLA_080330.

Phylogenomic databases

HOGENOMiHOG000214006.
KOiK11429.
OMAiFMGPARF.
OrthoDBiEOG092C4LF0.

Family and domain databases

InterProiView protein in InterPro
IPR025783. Hist-Lys_N-MeTrfase_SET9.
IPR001214. SET_dom.
PfamiView protein in Pfam
PF00856. SET. 1 hit.
SMARTiView protein in SMART
SM00317. SET. 1 hit.
PROSITEiView protein in PROSITE
PS51567. SAM_MT43_SUVAR420_1. 1 hit.
PS50280. SET. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA1CSR2_ASPCL
AccessioniPrimary (citable) accession number: A1CSR2
Entry historyiIntegrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: February 15, 2017
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.