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Protein

Probable beta-glucosidase A

Gene

bglA

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).By similarity

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathway:icellulose degradation

This protein is involved in the pathway cellulose degradation, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway cellulose degradation and in Glycan metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei287 – 2871By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00696.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-glucosidase A (EC:3.2.1.21)
Alternative name(s):
Beta-D-glucoside glucohydrolase A
Cellobiase A
Gentiobiase A
Gene namesi
Name:bglA
Synonyms:bgl1
ORF Names:ACLA_028810
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:ACLA_028810.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 867849Probable beta-glucosidase APRO_0000394092Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi259 – 2591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi322 – 3221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi329 – 3291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi361 – 3611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi449 – 4491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi530 – 5301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi549 – 5491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi571 – 5711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi675 – 6751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi719 – 7191N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiA1CR85.

Structurei

3D structure databases

ProteinModelPortaliA1CR85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1472.
HOGENOMiHOG000031215.
KOiK05349.
OMAiAHHSGVG.
OrthoDBiEOG7HMS8F.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
3.40.50.1700. 1 hit.
InterProiIPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR019800. Glyco_hydro_3_AS.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR30620. PTHR30620. 1 hit.
PfamiPF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
[Graphical view]
PRINTSiPR00133. GLHYDRLASE3.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.
PROSITEiPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1CR85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFSWLEVAV TAASLANANV CIPLFPWYVS SPPFYPSPWA NGQGEWAEAH
60 70 80 90 100
QRAVEIVSQM TLTEKVNLTT GTGWMMEECV GQTGSVPRLG INWGLCGQDS
110 120 130 140 150
PLGIRFSDLN SAFPAGINVA ATWDKTLAYL RGKAMGEEFN DKGIDIQLGP
160 170 180 190 200
AAGPLGKYPD GGRIWEGFSP DPALTGVLFA ETIKGIQDAG VIATAKHYIL
210 220 230 240 250
NEQEQFRQVA EAQGYGYNIT ETLSSNVDDK TMHELYLWPF ADAVRAGVGA
260 270 280 290 300
IMCSYNQINN SYGCQNSQTL NKLLKAELGF QGFVMSDWSA HHSGVGAALA
310 320 330 340 350
GLDMSMPGDI SFDDGLSFWG ANMTVGVLNG TIPAWRVDDM AVRIMTAYYK
360 370 380 390 400
VGRDRLRVPP NFSSWTRDEY GYEHAAVSEG AWKKVNDFVN VQRDHAQLIR
410 420 430 440 450
EVGSASTVLL KNVGALPLTG KERKVGIFGE DAGSNPWGPN GCENRGCDNG
460 470 480 490 500
TLAMAWGSGT AEFPYLVTPE QAIQSEVIKN GGNVFPVTHN GALTQMANIA
510 520 530 540 550
SQSSVSLVFV NADAGEGFIS VDGNIGDRKN LTLWKNGEEV IKTVASHSNN
560 570 580 590 600
TVVVIHSVGP ILVDEWHDNP NITAILWAGL PGQESGNSIA DVLYGRVNPS
610 620 630 640 650
AKTPFTWGKT RESYGAPLVT KPNNGNGAPQ DDFSEGVFID YRYFDKRNET
660 670 680 690 700
PVYEFGFGLS YTSFGYSHLR VQPLNGSTYV PATGTTGPAP AYGSIGSAAD
710 720 730 740 750
YLFPEGLKRI TKFIYPWLNS TDLKASSADP NYGWEDSEYI PEAATDGSPQ
760 770 780 790 800
PILKAGGAPG GNPTLYHDLV KVSATITNTG NVAGYEVPQL YVSLGGPNEP
810 820 830 840 850
RVVLRKFDRI HLAPGEQKVW TTTLTRRDLA NWDVEAQDWV ITKYPKRVYV
860
GSSSRKLPLR APLPRVQ
Length:867
Mass (Da):94,053
Last modified:January 23, 2007 - v1
Checksum:i6E9D96C46B830BA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027059 Genomic DNA. Translation: EAW08156.1.
RefSeqiXP_001269582.1. XM_001269581.1.

Genome annotation databases

EnsemblFungiiCADACLAT00002893; CADACLAP00002846; CADACLAG00002893.
GeneIDi4701004.
KEGGiact:ACLA_028810.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027059 Genomic DNA. Translation: EAW08156.1.
RefSeqiXP_001269582.1. XM_001269581.1.

3D structure databases

ProteinModelPortaliA1CR85.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiA1CR85.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADACLAT00002893; CADACLAP00002846; CADACLAG00002893.
GeneIDi4701004.
KEGGiact:ACLA_028810.

Organism-specific databases

EuPathDBiFungiDB:ACLA_028810.

Phylogenomic databases

eggNOGiCOG1472.
HOGENOMiHOG000031215.
KOiK05349.
OMAiAHHSGVG.
OrthoDBiEOG7HMS8F.

Enzyme and pathway databases

UniPathwayiUPA00696.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
3.40.50.1700. 1 hit.
InterProiIPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR019800. Glyco_hydro_3_AS.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR30620. PTHR30620. 1 hit.
PfamiPF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
[Graphical view]
PRINTSiPR00133. GLHYDRLASE3.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.
PROSITEiPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiBGLA_ASPCL
AccessioniPrimary (citable) accession number: A1CR85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: January 23, 2007
Last modified: July 22, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.