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A1CR85

- BGLA_ASPCL

UniProt

A1CR85 - BGLA_ASPCL

Protein

Probable beta-glucosidase A

Gene

bglA

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose By similarity.By similarity

    Catalytic activityi

    Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei287 – 2871By similarity

    GO - Molecular functioni

    1. beta-glucosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellulose catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

    Enzyme and pathway databases

    UniPathwayiUPA00696.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable beta-glucosidase A (EC:3.2.1.21)
    Alternative name(s):
    Beta-D-glucoside glucohydrolase A
    Cellobiase A
    Gentiobiase A
    Gene namesi
    Name:bglA
    Synonyms:bgl1
    ORF Names:ACLA_028810
    OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
    Taxonomic identifieri344612 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000006701: Unassembled WGS sequence

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 867849Probable beta-glucosidase APRO_0000394092Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi259 – 2591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi322 – 3221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi329 – 3291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi361 – 3611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi449 – 4491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi530 – 5301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi549 – 5491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi571 – 5711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi675 – 6751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi719 – 7191N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiA1CR85.

    Interactioni

    Protein-protein interaction databases

    STRINGi5057.CADACLAP00002846.

    Structurei

    3D structure databases

    ProteinModelPortaliA1CR85.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 3 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG1472.
    HOGENOMiHOG000031215.
    KOiK05349.
    OMAiAHHSGVG.
    OrthoDBiEOG7HMS8F.

    Family and domain databases

    Gene3Di3.20.20.300. 1 hit.
    3.40.50.1700. 1 hit.
    InterProiIPR026891. Fn3-like.
    IPR026892. Glyco_hydro_3.
    IPR019800. Glyco_hydro_3_AS.
    IPR002772. Glyco_hydro_3_C.
    IPR001764. Glyco_hydro_3_N.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR30620. PTHR30620. 1 hit.
    PfamiPF14310. Fn3-like. 1 hit.
    PF00933. Glyco_hydro_3. 1 hit.
    PF01915. Glyco_hydro_3_C. 1 hit.
    [Graphical view]
    PRINTSiPR00133. GLHYDRLASE3.
    SUPFAMiSSF51445. SSF51445. 1 hit.
    SSF52279. SSF52279. 2 hits.
    PROSITEiPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A1CR85-1 [UniParc]FASTAAdd to Basket

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    MRFSWLEVAV TAASLANANV CIPLFPWYVS SPPFYPSPWA NGQGEWAEAH    50
    QRAVEIVSQM TLTEKVNLTT GTGWMMEECV GQTGSVPRLG INWGLCGQDS 100
    PLGIRFSDLN SAFPAGINVA ATWDKTLAYL RGKAMGEEFN DKGIDIQLGP 150
    AAGPLGKYPD GGRIWEGFSP DPALTGVLFA ETIKGIQDAG VIATAKHYIL 200
    NEQEQFRQVA EAQGYGYNIT ETLSSNVDDK TMHELYLWPF ADAVRAGVGA 250
    IMCSYNQINN SYGCQNSQTL NKLLKAELGF QGFVMSDWSA HHSGVGAALA 300
    GLDMSMPGDI SFDDGLSFWG ANMTVGVLNG TIPAWRVDDM AVRIMTAYYK 350
    VGRDRLRVPP NFSSWTRDEY GYEHAAVSEG AWKKVNDFVN VQRDHAQLIR 400
    EVGSASTVLL KNVGALPLTG KERKVGIFGE DAGSNPWGPN GCENRGCDNG 450
    TLAMAWGSGT AEFPYLVTPE QAIQSEVIKN GGNVFPVTHN GALTQMANIA 500
    SQSSVSLVFV NADAGEGFIS VDGNIGDRKN LTLWKNGEEV IKTVASHSNN 550
    TVVVIHSVGP ILVDEWHDNP NITAILWAGL PGQESGNSIA DVLYGRVNPS 600
    AKTPFTWGKT RESYGAPLVT KPNNGNGAPQ DDFSEGVFID YRYFDKRNET 650
    PVYEFGFGLS YTSFGYSHLR VQPLNGSTYV PATGTTGPAP AYGSIGSAAD 700
    YLFPEGLKRI TKFIYPWLNS TDLKASSADP NYGWEDSEYI PEAATDGSPQ 750
    PILKAGGAPG GNPTLYHDLV KVSATITNTG NVAGYEVPQL YVSLGGPNEP 800
    RVVLRKFDRI HLAPGEQKVW TTTLTRRDLA NWDVEAQDWV ITKYPKRVYV 850
    GSSSRKLPLR APLPRVQ 867
    Length:867
    Mass (Da):94,053
    Last modified:January 23, 2007 - v1
    Checksum:i6E9D96C46B830BA5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027059 Genomic DNA. Translation: EAW08156.1.
    RefSeqiXP_001269582.1. XM_001269581.1.

    Genome annotation databases

    EnsemblFungiiCADACLAT00002893; CADACLAP00002846; CADACLAG00002893.
    GeneIDi4701004.
    KEGGiact:ACLA_028810.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027059 Genomic DNA. Translation: EAW08156.1 .
    RefSeqi XP_001269582.1. XM_001269581.1.

    3D structure databases

    ProteinModelPortali A1CR85.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5057.CADACLAP00002846.

    Proteomic databases

    PRIDEi A1CR85.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADACLAT00002893 ; CADACLAP00002846 ; CADACLAG00002893 .
    GeneIDi 4701004.
    KEGGi act:ACLA_028810.

    Phylogenomic databases

    eggNOGi COG1472.
    HOGENOMi HOG000031215.
    KOi K05349.
    OMAi AHHSGVG.
    OrthoDBi EOG7HMS8F.

    Enzyme and pathway databases

    UniPathwayi UPA00696 .

    Family and domain databases

    Gene3Di 3.20.20.300. 1 hit.
    3.40.50.1700. 1 hit.
    InterProi IPR026891. Fn3-like.
    IPR026892. Glyco_hydro_3.
    IPR019800. Glyco_hydro_3_AS.
    IPR002772. Glyco_hydro_3_C.
    IPR001764. Glyco_hydro_3_N.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR30620. PTHR30620. 1 hit.
    Pfami PF14310. Fn3-like. 1 hit.
    PF00933. Glyco_hydro_3. 1 hit.
    PF01915. Glyco_hydro_3_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00133. GLHYDRLASE3.
    SUPFAMi SSF51445. SSF51445. 1 hit.
    SSF52279. SSF52279. 2 hits.
    PROSITEi PS00775. GLYCOSYL_HYDROL_F3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

    Entry informationi

    Entry nameiBGLA_ASPCL
    AccessioniPrimary (citable) accession number: A1CR85
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 18, 2010
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3