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A1CQL5

- KEX1_ASPCL

UniProt

A1CQL5 - KEX1_ASPCL

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Protein
Pheromone-processing carboxypeptidase kex1
Gene
kex1, ACLA_026530
Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei173 – 1731 By similarity
Active sitei373 – 3731 By similarity
Active sitei435 – 4351 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase kex1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:kex1
ORF Names:ACLA_026530
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 506487Lumenal Reviewed prediction
Add
BLAST
Transmembranei507 – 52721Helical; Reviewed prediction
Add
BLAST
Topological domaini528 – 61386Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 613594Pheromone-processing carboxypeptidase kex1
PRO_0000411902Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi102 – 1021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi109 – 1091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi424 – 4241N-linked (GlcNAc...) Reviewed prediction
Glycosylationi432 – 4321N-linked (GlcNAc...) Reviewed prediction
Glycosylationi484 – 4841N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5057.CADACLAP00001892.

Structurei

3D structure databases

ProteinModelPortaliA1CQL5.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000208879.
KOiK01288.
OMAiHTLEYNN.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1CQL5-1 [UniParc]FASTAAdd to Basket

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MTMSFCALLF FLIISPTLAA TKSAADYYVR SLPGAPEGPL LKMHAGHIEV    50
DAPNNGNLFF WHYQNRHIAN RQRTVIWLNG GPGCSSMDGA LMEIGPYRLK 100
DNHTLEYNNG SWDEFANLLF VDQPVGTGFS YVNTNSYLHE LDEMAAQFII 150
FLEKWFQLFP EYERDDIYIA GESYAGQHIP YIAKAIQERN KKVDDKNSAR 200
WNLRGLVIGN GWISPAQQYP SYLNFAYTEG LVKEGSSLAK DLDVYQSVCE 250
SKISAAPNAV NIKDCESVLQ QILSRTMDSE RKCYNMYDVR LRDVYPSCGM 300
NWPSDLVSVK PYLQSRDVVR ALNINPDKKS GWEECSGAVG STFTAANSVP 350
SVQLLPELLE SGVRILLFSG DKDLICNHIG TEQLINNMKW NGGIGFETSP 400
GVWAPRRHWT FEGEPAGIYQ YARNLTYVLF YNASHMVPYD LPRQSRDMLD 450
RFMRVDIANI GGQPADSRID GEKLPQTSVG GHPNSTAAEQ QAKEKIKETE 500
WKAYAKSGEA ALIVVIIGVT VWGFFIWRSR RRNRGYEGVY QKELGSGSIL 550
ERFQNKRSGA GDVEAGDFDE SELDTLHSPG LERENYAVGD DSDEDDPNHP 600
RPTASSREDG THP 613
Length:613
Mass (Da):68,819
Last modified:January 23, 2007 - v1
Checksum:i88C8D6FD7AB273B9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027059 Genomic DNA. Translation: EAW07936.1.
RefSeqiXP_001269362.1. XM_001269361.1.

Genome annotation databases

EnsemblFungiiCADACLAT00001939; CADACLAP00001892; CADACLAG00001939.
GeneIDi4700961.
KEGGiact:ACLA_026530.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027059 Genomic DNA. Translation: EAW07936.1 .
RefSeqi XP_001269362.1. XM_001269361.1.

3D structure databases

ProteinModelPortali A1CQL5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5057.CADACLAP00001892.

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADACLAT00001939 ; CADACLAP00001892 ; CADACLAG00001939 .
GeneIDi 4700961.
KEGGi act:ACLA_026530.

Phylogenomic databases

HOGENOMi HOG000208879.
KOi K01288.
OMAi HTLEYNN.
OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiKEX1_ASPCL
AccessioniPrimary (citable) accession number: A1CQL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi