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A1CQL5 (KEX1_ASPCL) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pheromone-processing carboxypeptidase kex1

EC=3.4.16.6
Alternative name(s):
Carboxypeptidase D
Gene names
Name:kex1
ORF Names:ACLA_026530
OrganismAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1) [Complete proteome]
Taxonomic identifier344612 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length613 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentGolgi apparatus
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

proteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 613594Pheromone-processing carboxypeptidase kex1
PRO_0000411902

Regions

Topological domain20 – 506487Lumenal Potential
Transmembrane507 – 52721Helical; Potential
Topological domain528 – 61386Cytoplasmic Potential

Sites

Active site1731 By similarity
Active site3731 By similarity
Active site4351 By similarity

Amino acid modifications

Glycosylation1021N-linked (GlcNAc...) Potential
Glycosylation1091N-linked (GlcNAc...) Potential
Glycosylation4241N-linked (GlcNAc...) Potential
Glycosylation4321N-linked (GlcNAc...) Potential
Glycosylation4841N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
A1CQL5 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: 88C8D6FD7AB273B9

FASTA61368,819
        10         20         30         40         50         60 
MTMSFCALLF FLIISPTLAA TKSAADYYVR SLPGAPEGPL LKMHAGHIEV DAPNNGNLFF 

        70         80         90        100        110        120 
WHYQNRHIAN RQRTVIWLNG GPGCSSMDGA LMEIGPYRLK DNHTLEYNNG SWDEFANLLF 

       130        140        150        160        170        180 
VDQPVGTGFS YVNTNSYLHE LDEMAAQFII FLEKWFQLFP EYERDDIYIA GESYAGQHIP 

       190        200        210        220        230        240 
YIAKAIQERN KKVDDKNSAR WNLRGLVIGN GWISPAQQYP SYLNFAYTEG LVKEGSSLAK 

       250        260        270        280        290        300 
DLDVYQSVCE SKISAAPNAV NIKDCESVLQ QILSRTMDSE RKCYNMYDVR LRDVYPSCGM 

       310        320        330        340        350        360 
NWPSDLVSVK PYLQSRDVVR ALNINPDKKS GWEECSGAVG STFTAANSVP SVQLLPELLE 

       370        380        390        400        410        420 
SGVRILLFSG DKDLICNHIG TEQLINNMKW NGGIGFETSP GVWAPRRHWT FEGEPAGIYQ 

       430        440        450        460        470        480 
YARNLTYVLF YNASHMVPYD LPRQSRDMLD RFMRVDIANI GGQPADSRID GEKLPQTSVG 

       490        500        510        520        530        540 
GHPNSTAAEQ QAKEKIKETE WKAYAKSGEA ALIVVIIGVT VWGFFIWRSR RRNRGYEGVY 

       550        560        570        580        590        600 
QKELGSGSIL ERFQNKRSGA GDVEAGDFDE SELDTLHSPG LERENYAVGD DSDEDDPNHP 

       610 
RPTASSREDG THP 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS027059 Genomic DNA. Translation: EAW07936.1.
RefSeqXP_001269362.1. XM_001269361.1.

3D structure databases

ProteinModelPortalA1CQL5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5057.CADACLAP00001892.

Protein family/group databases

MEROPSS10.007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADACLAT00001939; CADACLAP00001892; CADACLAG00001939.
GeneID4700961.
KEGGact:ACLA_026530.

Phylogenomic databases

HOGENOMHOG000208879.
KOK01288.
OMARLKDNHT.
OrthoDBEOG7TJ3SJ.

Family and domain databases

InterProIPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
PROSITEPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKEX1_ASPCL
AccessionPrimary (citable) accession number: A1CQL5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: January 23, 2007
Last modified: March 19, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries