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A1CQL5

- KEX1_ASPCL

UniProt

A1CQL5 - KEX1_ASPCL

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Protein

Pheromone-processing carboxypeptidase kex1

Gene

kex1

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei173 – 1731PROSITE-ProRule annotation
Active sitei373 – 3731PROSITE-ProRule annotation
Active sitei435 – 4351PROSITE-ProRule annotation

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase kex1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:kex1
ORF Names:ACLA_026530
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 613594Pheromone-processing carboxypeptidase kex1PRO_0000411902Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence Analysis
Glycosylationi424 – 4241N-linked (GlcNAc...)Sequence Analysis
Glycosylationi432 – 4321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi484 – 4841N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5057.CADACLAP00001892.

Structurei

3D structure databases

ProteinModelPortaliA1CQL5.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 506487LumenalSequence AnalysisAdd
BLAST
Topological domaini528 – 61386CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei507 – 52721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000208879.
KOiK01288.
OMAiHTLEYNN.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1CQL5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTMSFCALLF FLIISPTLAA TKSAADYYVR SLPGAPEGPL LKMHAGHIEV
60 70 80 90 100
DAPNNGNLFF WHYQNRHIAN RQRTVIWLNG GPGCSSMDGA LMEIGPYRLK
110 120 130 140 150
DNHTLEYNNG SWDEFANLLF VDQPVGTGFS YVNTNSYLHE LDEMAAQFII
160 170 180 190 200
FLEKWFQLFP EYERDDIYIA GESYAGQHIP YIAKAIQERN KKVDDKNSAR
210 220 230 240 250
WNLRGLVIGN GWISPAQQYP SYLNFAYTEG LVKEGSSLAK DLDVYQSVCE
260 270 280 290 300
SKISAAPNAV NIKDCESVLQ QILSRTMDSE RKCYNMYDVR LRDVYPSCGM
310 320 330 340 350
NWPSDLVSVK PYLQSRDVVR ALNINPDKKS GWEECSGAVG STFTAANSVP
360 370 380 390 400
SVQLLPELLE SGVRILLFSG DKDLICNHIG TEQLINNMKW NGGIGFETSP
410 420 430 440 450
GVWAPRRHWT FEGEPAGIYQ YARNLTYVLF YNASHMVPYD LPRQSRDMLD
460 470 480 490 500
RFMRVDIANI GGQPADSRID GEKLPQTSVG GHPNSTAAEQ QAKEKIKETE
510 520 530 540 550
WKAYAKSGEA ALIVVIIGVT VWGFFIWRSR RRNRGYEGVY QKELGSGSIL
560 570 580 590 600
ERFQNKRSGA GDVEAGDFDE SELDTLHSPG LERENYAVGD DSDEDDPNHP
610
RPTASSREDG THP
Length:613
Mass (Da):68,819
Last modified:January 23, 2007 - v1
Checksum:i88C8D6FD7AB273B9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027059 Genomic DNA. Translation: EAW07936.1.
RefSeqiXP_001269362.1. XM_001269361.1.

Genome annotation databases

EnsemblFungiiCADACLAT00001939; CADACLAP00001892; CADACLAG00001939.
GeneIDi4700961.
KEGGiact:ACLA_026530.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027059 Genomic DNA. Translation: EAW07936.1 .
RefSeqi XP_001269362.1. XM_001269361.1.

3D structure databases

ProteinModelPortali A1CQL5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5057.CADACLAP00001892.

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADACLAT00001939 ; CADACLAP00001892 ; CADACLAG00001939 .
GeneIDi 4700961.
KEGGi act:ACLA_026530.

Phylogenomic databases

HOGENOMi HOG000208879.
KOi K01288.
OMAi HTLEYNN.
OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiKEX1_ASPCL
AccessioniPrimary (citable) accession number: A1CQL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3