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A1CQL5

- KEX1_ASPCL

UniProt

A1CQL5 - KEX1_ASPCL

Protein

Pheromone-processing carboxypeptidase kex1

Gene

kex1

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.By similarity

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei173 – 1731PROSITE-ProRule annotation
    Active sitei373 – 3731PROSITE-ProRule annotation
    Active sitei435 – 4351PROSITE-ProRule annotation

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Apoptosis

    Protein family/group databases

    MEROPSiS10.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pheromone-processing carboxypeptidase kex1 (EC:3.4.16.6)
    Alternative name(s):
    Carboxypeptidase D
    Gene namesi
    Name:kex1
    ORF Names:ACLA_026530
    OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
    Taxonomic identifieri344612 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000006701: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 613594Pheromone-processing carboxypeptidase kex1PRO_0000411902Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi424 – 4241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi432 – 4321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi484 – 4841N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi5057.CADACLAP00001892.

    Structurei

    3D structure databases

    ProteinModelPortaliA1CQL5.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 506487LumenalSequence AnalysisAdd
    BLAST
    Topological domaini528 – 61386CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei507 – 52721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000208879.
    KOiK01288.
    OMAiHTLEYNN.
    OrthoDBiEOG7TJ3SJ.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A1CQL5-1 [UniParc]FASTAAdd to Basket

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    MTMSFCALLF FLIISPTLAA TKSAADYYVR SLPGAPEGPL LKMHAGHIEV    50
    DAPNNGNLFF WHYQNRHIAN RQRTVIWLNG GPGCSSMDGA LMEIGPYRLK 100
    DNHTLEYNNG SWDEFANLLF VDQPVGTGFS YVNTNSYLHE LDEMAAQFII 150
    FLEKWFQLFP EYERDDIYIA GESYAGQHIP YIAKAIQERN KKVDDKNSAR 200
    WNLRGLVIGN GWISPAQQYP SYLNFAYTEG LVKEGSSLAK DLDVYQSVCE 250
    SKISAAPNAV NIKDCESVLQ QILSRTMDSE RKCYNMYDVR LRDVYPSCGM 300
    NWPSDLVSVK PYLQSRDVVR ALNINPDKKS GWEECSGAVG STFTAANSVP 350
    SVQLLPELLE SGVRILLFSG DKDLICNHIG TEQLINNMKW NGGIGFETSP 400
    GVWAPRRHWT FEGEPAGIYQ YARNLTYVLF YNASHMVPYD LPRQSRDMLD 450
    RFMRVDIANI GGQPADSRID GEKLPQTSVG GHPNSTAAEQ QAKEKIKETE 500
    WKAYAKSGEA ALIVVIIGVT VWGFFIWRSR RRNRGYEGVY QKELGSGSIL 550
    ERFQNKRSGA GDVEAGDFDE SELDTLHSPG LERENYAVGD DSDEDDPNHP 600
    RPTASSREDG THP 613
    Length:613
    Mass (Da):68,819
    Last modified:January 23, 2007 - v1
    Checksum:i88C8D6FD7AB273B9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027059 Genomic DNA. Translation: EAW07936.1.
    RefSeqiXP_001269362.1. XM_001269361.1.

    Genome annotation databases

    EnsemblFungiiCADACLAT00001939; CADACLAP00001892; CADACLAG00001939.
    GeneIDi4700961.
    KEGGiact:ACLA_026530.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027059 Genomic DNA. Translation: EAW07936.1 .
    RefSeqi XP_001269362.1. XM_001269361.1.

    3D structure databases

    ProteinModelPortali A1CQL5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5057.CADACLAP00001892.

    Protein family/group databases

    MEROPSi S10.007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADACLAT00001939 ; CADACLAP00001892 ; CADACLAG00001939 .
    GeneIDi 4700961.
    KEGGi act:ACLA_026530.

    Phylogenomic databases

    HOGENOMi HOG000208879.
    KOi K01288.
    OMAi HTLEYNN.
    OrthoDBi EOG7TJ3SJ.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

    Entry informationi

    Entry nameiKEX1_ASPCL
    AccessioniPrimary (citable) accession number: A1CQL5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3