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Protein

Mitogen-activated protein kinase hog1

Gene

hog1

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Enzyme regulationi

Activated by tyrosine and threonine phosphorylation.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei49 – 491ATPPROSITE-ProRule annotation
Active sitei141 – 1411Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi26 – 349ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. chromatin binding Source: EnsemblFungi
  3. MAP kinase activity involved in osmosensory signaling pathway Source: EnsemblFungi

GO - Biological processi

  1. cellular response to cation stress Source: EnsemblFungi
  2. G1 cell cycle arrest in response to nitrogen starvation Source: EnsemblFungi
  3. hyperosmotic response Source: EnsemblFungi
  4. MAPK cascade in response to starvation Source: EnsemblFungi
  5. mitotic cell cycle arrest in response to nitrogen starvation Source: EnsemblFungi
  6. mRNA export from nucleus in response to heat stress Source: EnsemblFungi
  7. positive regulation of G2/M transition of mitotic cell cycle Source: EnsemblFungi
  8. positive regulation of transcription factor import into nucleus in response to oxidative stress Source: EnsemblFungi
  9. positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress Source: EnsemblFungi
  10. positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress Source: EnsemblFungi
  11. regulation of cAMP-mediated signaling by regulation of transcription from RNA polymerase II promoter Source: EnsemblFungi
  12. regulation of cell shape involved in G1 to G0 transition Source: EnsemblFungi
  13. regulation of chromatin assembly Source: EnsemblFungi
  14. regulation of chromatin disassembly Source: EnsemblFungi
  15. regulation of DNA binding Source: EnsemblFungi
  16. regulation of histone acetylation Source: EnsemblFungi
  17. regulation of mRNA stability involved in cellular response to UV Source: EnsemblFungi
  18. regulation of nuclear cell cycle DNA replication Source: EnsemblFungi
  19. regulation of reciprocal meiotic recombination Source: EnsemblFungi
  20. regulation of translation in response to nitrogen starvation Source: EnsemblFungi
  21. regulation of translation in response to osmotic stress Source: EnsemblFungi
  22. regulation of translation in response to oxidative stress Source: EnsemblFungi
  23. response to arsenic-containing substance Source: EnsemblFungi
  24. stress granule assembly Source: EnsemblFungi
  25. stress granule disassembly Source: EnsemblFungi
  26. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase hog1 (EC:2.7.11.24)
Short name:
MAP kinase hog1
Gene namesi
Name:hog1
ORF Names:ACLA_022520
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:ACLA_022520.

Subcellular locationi

  1. Cytoplasm By similarity
  2. Nucleus By similarity

GO - Cellular componenti

  1. cytosol Source: EnsemblFungi
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 365365Mitogen-activated protein kinase hog1PRO_0000289673Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei171 – 1711PhosphothreonineBy similarity
Modified residuei173 – 1731PhosphotyrosineBy similarity

Post-translational modificationi

Dually phosphorylated on Thr-171 and Tyr-173, which activates the enzyme.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi5057.CADACLAP00002800.

Structurei

3D structure databases

ProteinModelPortaliA1CPG7.
SMRiA1CPG7. Positions 3-342.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 299280Protein kinasePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi171 – 1733TXY

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
KOiK04441.
OMAiHTICSEN.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008352. MAPK_p38.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01773. P38MAPKINASE.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1CPG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEFVRAQIF GTTFEITSRY TDLQPVGMGA FGLVCSARDQ LTGQPVAVKK
60 70 80 90 100
IMKPFSTPVL SKRTYRELKL LKHLRHENII SLSDIFISPL EDIYFVTELL
110 120 130 140 150
GTDLHRLLTS RPLEKQFIQY FLYQILRGLK YVHSAGVVHR DLKPSNILIN
160 170 180 190 200
ENCDLKICDF GLARIQDPQM TGYVSTRYYR APEIMLTWQK YDVEVDIWST
210 220 230 240 250
GCIFAEMLEG KPLFPGKDHV NQFSIITELL GTPPDDVIQT ICSENTLRFV
260 270 280 290 300
KSLPKRERQP LANKFKNADP DAVDLLERML VFDPKKRIRA TEALAHEYLS
310 320 330 340 350
PYHDPTDEPE AEEKFDWSFN DADLPVDTWK IMMYSEILDF HNIDQGNDAS
360
QALAEGLGQG QQNFA
Length:365
Mass (Da):41,875
Last modified:January 23, 2007 - v1
Checksum:i8248ADFABF945475
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027059 Genomic DNA. Translation: EAW07538.1.
RefSeqiXP_001268964.1. XM_001268963.1.

Genome annotation databases

EnsemblFungiiCADACLAT00002847; CADACLAP00002800; CADACLAG00002847.
GeneIDi4701107.
KEGGiact:ACLA_022520.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027059 Genomic DNA. Translation: EAW07538.1.
RefSeqiXP_001268964.1. XM_001268963.1.

3D structure databases

ProteinModelPortaliA1CPG7.
SMRiA1CPG7. Positions 3-342.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5057.CADACLAP00002800.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADACLAT00002847; CADACLAP00002800; CADACLAG00002847.
GeneIDi4701107.
KEGGiact:ACLA_022520.

Organism-specific databases

EuPathDBiFungiDB:ACLA_022520.

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
KOiK04441.
OMAiHTICSEN.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008352. MAPK_p38.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01773. P38MAPKINASE.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiHOG1_ASPCL
AccessioniPrimary (citable) accession number: A1CPG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: January 23, 2007
Last modified: April 29, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.