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A1CP08

- MNS1B_ASPCL

UniProt

A1CP08 - MNS1B_ASPCL

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Protein

Probable mannosyl-oligosaccharide alpha-1,2-mannosidase 1B

Gene

mns1B

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the maturation of Asn-linked oligosaccharides. Progressively trims alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (By similarity).By similarity

Catalytic activityi

Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2.

Cofactori

Ca2+. Can also use Mg2+, but with lower efficiency (By similarity).By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei370 – 3701Proton donorBy similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. mannosyl-oligosaccharide 1,2-alpha-mannosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. protein glycosylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism

Enzyme and pathway databases

UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable mannosyl-oligosaccharide alpha-1,2-mannosidase 1B (EC:3.2.1.113)
Alternative name(s):
Class I alpha-mannosidase 1B
Man(9)-alpha-mannosidase 1B
Gene namesi
Name:mns1B
Synonyms:msdS
ORF Names:ACLA_020870
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. cytoplasmic vesicle Source: UniProtKB-KW
  2. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 511493Probable mannosyl-oligosaccharide alpha-1,2-mannosidase 1BPRO_0000394816Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi327 ↔ 356By similarity
Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi5057.CADACLAP00002234.

Structurei

3D structure databases

ProteinModelPortaliA1CP08.
SMRiA1CP08. Positions 34-508.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 47 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG300315.
HOGENOMiHOG000181987.
KOiK01230.
OMAiGPESFGW.
OrthoDBiEOG7BP8BH.

Family and domain databases

Gene3Di1.50.10.50. 1 hit.
InterProiIPR001382. Glyco_hydro_47.
[Graphical view]
PANTHERiPTHR11742. PTHR11742. 1 hit.
PfamiPF01532. Glyco_hydro_47. 1 hit.
[Graphical view]
PRINTSiPR00747. GLYHDRLASE47.
SUPFAMiSSF48225. SSF48225. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1CP08-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHLPSLSLAW ALAGSSLALP QAEQPVLQDD RASSRAAAVK EAFSHAWDGY
60 70 80 90 100
KKYAFPHDEL HPISNGYGNS RNGWGASAVD ALSTAIVMRN ATIVHEILDH
110 120 130 140 150
IATIDYSKTS DTVSLFETTI RYLGGMLSGY DLLKGPAADL VKDTSKVDIL
160 170 180 190 200
LKQSKNLGDI LKFAFDTPSG VPYNNINITS HGHDGAKTNG LAVTGTLVLE
210 220 230 240 250
WTRLSDLTGD PEYAQLSQKA ESYLLHPQPS SAEPFPGLIG SNIDIKTGQF
260 270 280 290 300
TDGHVSWNGG DDSYYEYLIK MYVYDPTRFA LYRDRWVAAA ESSIEHLASH
310 320 330 340 350
PASRPDLTFL ATYDGGRYGL SSQHLACFDG GNFLLGGTVL DRRDLIDFGL
360 370 380 390 400
ALVDACHETY SQTLTGIGPE SFGWDANSVP ADQKELYERA GFYVQNGAYI
410 420 430 440 450
LRPEVIESFY YAWRVTGRSE YRDWVWTAFV AINKTCRTGS GYAGLTNVNA
460 470 480 490 500
ENGGGRYDNQ ESFLFAEVLK YAYLTHSEEL MAAEDAWQVQ RGDGNQFVFN
510
TEAHPIRVHH S
Length:511
Mass (Da):56,325
Last modified:January 23, 2007 - v1
Checksum:iF13A052EC4FDD714
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027059 Genomic DNA. Translation: EAW07379.1.
RefSeqiXP_001268805.1. XM_001268804.1.

Genome annotation databases

EnsemblFungiiCADACLAT00002281; CADACLAP00002234; CADACLAG00002281.
GeneIDi4701674.
KEGGiact:ACLA_020870.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027059 Genomic DNA. Translation: EAW07379.1 .
RefSeqi XP_001268805.1. XM_001268804.1.

3D structure databases

ProteinModelPortali A1CP08.
SMRi A1CP08. Positions 34-508.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5057.CADACLAP00002234.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADACLAT00002281 ; CADACLAP00002234 ; CADACLAG00002281 .
GeneIDi 4701674.
KEGGi act:ACLA_020870.

Phylogenomic databases

eggNOGi NOG300315.
HOGENOMi HOG000181987.
KOi K01230.
OMAi GPESFGW.
OrthoDBi EOG7BP8BH.

Enzyme and pathway databases

UniPathwayi UPA00378 .

Family and domain databases

Gene3Di 1.50.10.50. 1 hit.
InterProi IPR001382. Glyco_hydro_47.
[Graphical view ]
PANTHERi PTHR11742. PTHR11742. 1 hit.
Pfami PF01532. Glyco_hydro_47. 1 hit.
[Graphical view ]
PRINTSi PR00747. GLYHDRLASE47.
SUPFAMi SSF48225. SSF48225. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiMNS1B_ASPCL
AccessioniPrimary (citable) accession number: A1CP08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3