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A1CP08

- MNS1B_ASPCL

UniProt

A1CP08 - MNS1B_ASPCL

Protein

Probable mannosyl-oligosaccharide alpha-1,2-mannosidase 1B

Gene

mns1B

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Involved in the maturation of Asn-linked oligosaccharides. Progressively trims alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 By similarity.By similarity

    Catalytic activityi

    Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2.

    Cofactori

    Ca2+. Can also use Mg2+, but with lower efficiency By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei370 – 3701Proton donorBy similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. mannosyl-oligosaccharide 1,2-alpha-mannosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protein glycosylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00378.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable mannosyl-oligosaccharide alpha-1,2-mannosidase 1B (EC:3.2.1.113)
    Alternative name(s):
    Class I alpha-mannosidase 1B
    Man(9)-alpha-mannosidase 1B
    Gene namesi
    Name:mns1B
    Synonyms:msdS
    ORF Names:ACLA_020870
    OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
    Taxonomic identifieri344612 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000006701: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle lumen Source: UniProtKB-SubCell
    2. membrane Source: InterPro

    Keywords - Cellular componenti

    Cytoplasmic vesicle

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 511493Probable mannosyl-oligosaccharide alpha-1,2-mannosidase 1BPRO_0000394816Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi327 ↔ 356By similarity
    Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi5057.CADACLAP00002234.

    Structurei

    3D structure databases

    ProteinModelPortaliA1CP08.
    SMRiA1CP08. Positions 34-508.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 47 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG300315.
    HOGENOMiHOG000181987.
    KOiK01230.
    OMAiGPESFGW.
    OrthoDBiEOG7BP8BH.

    Family and domain databases

    Gene3Di1.50.10.50. 1 hit.
    InterProiIPR001382. Glyco_hydro_47.
    [Graphical view]
    PANTHERiPTHR11742. PTHR11742. 1 hit.
    PfamiPF01532. Glyco_hydro_47. 1 hit.
    [Graphical view]
    PRINTSiPR00747. GLYHDRLASE47.
    SUPFAMiSSF48225. SSF48225. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A1CP08-1 [UniParc]FASTAAdd to Basket

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    MHLPSLSLAW ALAGSSLALP QAEQPVLQDD RASSRAAAVK EAFSHAWDGY    50
    KKYAFPHDEL HPISNGYGNS RNGWGASAVD ALSTAIVMRN ATIVHEILDH 100
    IATIDYSKTS DTVSLFETTI RYLGGMLSGY DLLKGPAADL VKDTSKVDIL 150
    LKQSKNLGDI LKFAFDTPSG VPYNNINITS HGHDGAKTNG LAVTGTLVLE 200
    WTRLSDLTGD PEYAQLSQKA ESYLLHPQPS SAEPFPGLIG SNIDIKTGQF 250
    TDGHVSWNGG DDSYYEYLIK MYVYDPTRFA LYRDRWVAAA ESSIEHLASH 300
    PASRPDLTFL ATYDGGRYGL SSQHLACFDG GNFLLGGTVL DRRDLIDFGL 350
    ALVDACHETY SQTLTGIGPE SFGWDANSVP ADQKELYERA GFYVQNGAYI 400
    LRPEVIESFY YAWRVTGRSE YRDWVWTAFV AINKTCRTGS GYAGLTNVNA 450
    ENGGGRYDNQ ESFLFAEVLK YAYLTHSEEL MAAEDAWQVQ RGDGNQFVFN 500
    TEAHPIRVHH S 511
    Length:511
    Mass (Da):56,325
    Last modified:January 23, 2007 - v1
    Checksum:iF13A052EC4FDD714
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027059 Genomic DNA. Translation: EAW07379.1.
    RefSeqiXP_001268805.1. XM_001268804.1.

    Genome annotation databases

    EnsemblFungiiCADACLAT00002281; CADACLAP00002234; CADACLAG00002281.
    GeneIDi4701674.
    KEGGiact:ACLA_020870.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027059 Genomic DNA. Translation: EAW07379.1 .
    RefSeqi XP_001268805.1. XM_001268804.1.

    3D structure databases

    ProteinModelPortali A1CP08.
    SMRi A1CP08. Positions 34-508.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5057.CADACLAP00002234.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADACLAT00002281 ; CADACLAP00002234 ; CADACLAG00002281 .
    GeneIDi 4701674.
    KEGGi act:ACLA_020870.

    Phylogenomic databases

    eggNOGi NOG300315.
    HOGENOMi HOG000181987.
    KOi K01230.
    OMAi GPESFGW.
    OrthoDBi EOG7BP8BH.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .

    Family and domain databases

    Gene3Di 1.50.10.50. 1 hit.
    InterProi IPR001382. Glyco_hydro_47.
    [Graphical view ]
    PANTHERi PTHR11742. PTHR11742. 1 hit.
    Pfami PF01532. Glyco_hydro_47. 1 hit.
    [Graphical view ]
    PRINTSi PR00747. GLYHDRLASE47.
    SUPFAMi SSF48225. SSF48225. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

    Entry informationi

    Entry nameiMNS1B_ASPCL
    AccessioniPrimary (citable) accession number: A1CP08
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3