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Protein

Probable alpha/beta-glucosidase agdC

Gene

agdC

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Glucosidase involved in the degradation of cellulosic biomass. Has both alpha- and beta-glucosidase activity (By similarity).By similarity

Catalytic activityi

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.
Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei422 – 4221NucleophilePROSITE-ProRule annotation
Active sitei425 – 4251By similarity
Active sitei571 – 5711Proton donorBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable alpha/beta-glucosidase agdC (EC:3.2.1.20, EC:3.2.1.21)
Gene namesi
Name:agdC
ORF Names:ACLA_019300
OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Taxonomic identifieri344612 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006701 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:ACLA_019300.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 887870Probable alpha/beta-glucosidase agdCPRO_0000394913Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi171 – 1711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi373 – 3731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi747 – 7471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi879 – 8791N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliA1CNK4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 31 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1501.
HOGENOMiHOG000041175.
KOiK01187.
OMAiTISIRTM.
OrthoDBiEOG77T1CZ.

Family and domain databases

InterProiIPR011013. Gal_mutarotase_SF_dom.
IPR000322. Glyco_hydro_31.
IPR030458. Glyco_hydro_31_AS.
IPR025887. Glyco_hydro_31_N_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF13802. Gal_mutarotas_2. 1 hit.
PF01055. Glyco_hydro_31. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 2 hits.
SSF74650. SSF74650. 1 hit.
PROSITEiPS00129. GLYCOSYL_HYDROL_F31_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1CNK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRSLLLLAP MVGAAVAATE PNSPACPGYR ATNVREGHNS LTADLTLAGK
60 70 80 90 100
PCNTYGTDLK NLKLLVEYQT DERLHVKIYD ANEQVYQVPE SVVPRVDGKG
110 120 130 140 150
GSRKKSVLKF NFKANPFSFQ VKRGREVLFD TSGSNLVFQD QYLNLRTSLP
160 170 180 190 200
RDPNLYGLGE HTDPLRLTTT NYTRTLWNRD SYGIPENSNL YGSHPVYYDH
210 220 230 240 250
RGEDGTHGVF LLNSNGMDIK IDKTKDGKQF LEYNALGGIF DFYFFNGDTP
260 270 280 290 300
KDASIEYAKV AGLPAMQSYW SFGFHQCRYG YRDAFEVAEV VQNYTQAKIP
310 320 330 340 350
LETMWTDIDY MDRRRVFTLD PDRFPLEKVR ELVSYLHKHD QKYIVMVDPA
360 370 380 390 400
VSVSDNKGFN DGMEQGVFMK HQNGSLYKGA VWPGVTAYPD WFHPDIQKYW
410 420 430 440 450
DGQFNDFFSP EKGVDIDGLW IDMNEAANFC TYPCLDPEGY SIENNLPPAA
460 470 480 490 500
PPVRPNPRPL PGFPDDFQPP AASKRSVAKG SKVGLPGRDL LNPRYQIRND
510 520 530 540 550
AGLISSKTIN TDLIHAGEGY AEYDTHNLYG TMMSSASRQS MAQRRPAVRP
560 570 580 590 600
LIITRSTFAG AGTHVGHWLG DNLADWKHYR ISIAQMLSFA SMFQVPMVGS
610 620 630 640 650
DICGFGGDTN EELCARWARL GAFYPFFRNH NEITSIPQEF YRWESVAESA
660 670 680 690 700
RKAIEVRYKL LDYVYTAFHR QTQTGEPFLQ PMFYMYPEDK NTFSNDMQFF
710 720 730 740 750
YGDSILVSPV HDVSQTSVEA YFPKDIFYDW NTGDVLRGRG AKVTLSNISV
760 770 780 790 800
TDIPIHIRGG SIVPIRSESA MTTVELRKKG FELLIAPGQD GTASGTLYLD
810 820 830 840 850
DGDSLKQSAS LELEFKYRKG NLQIKGKFGM HTDLKINAIT LLGQTSVPRQ
860 870 880
VTLSRAGKAD SKFDPARQSV TIKTDLSLNE SSEIDIN
Length:887
Mass (Da):99,904
Last modified:January 23, 2007 - v1
Checksum:iDAA2C23C3A28E665
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027059 Genomic DNA. Translation: EAW07225.1.
RefSeqiXP_001268651.1. XM_001268650.1.

Genome annotation databases

EnsemblFungiiCADACLAT00003097; CADACLAP00003050; CADACLAG00003097.
GeneIDi4700931.
KEGGiact:ACLA_019300.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027059 Genomic DNA. Translation: EAW07225.1.
RefSeqiXP_001268651.1. XM_001268650.1.

3D structure databases

ProteinModelPortaliA1CNK4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADACLAT00003097; CADACLAP00003050; CADACLAG00003097.
GeneIDi4700931.
KEGGiact:ACLA_019300.

Organism-specific databases

EuPathDBiFungiDB:ACLA_019300.

Phylogenomic databases

eggNOGiCOG1501.
HOGENOMiHOG000041175.
KOiK01187.
OMAiTISIRTM.
OrthoDBiEOG77T1CZ.

Family and domain databases

InterProiIPR011013. Gal_mutarotase_SF_dom.
IPR000322. Glyco_hydro_31.
IPR030458. Glyco_hydro_31_AS.
IPR025887. Glyco_hydro_31_N_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF13802. Gal_mutarotas_2. 1 hit.
PF01055. Glyco_hydro_31. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 2 hits.
SSF74650. SSF74650. 1 hit.
PROSITEiPS00129. GLYCOSYL_HYDROL_F31_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

Entry informationi

Entry nameiAGDC_ASPCL
AccessioniPrimary (citable) accession number: A1CNK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: January 23, 2007
Last modified: July 22, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.