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A1CNK4

- AGDC_ASPCL

UniProt

A1CNK4 - AGDC_ASPCL

Protein

Probable alpha/beta-glucosidase agdC

Gene

agdC

Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Glucosidase involved in the degradation of cellulosic biomass. Has both alpha- and beta-glucosidase activity By similarity.By similarity

    Catalytic activityi

    Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.
    Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei422 – 4221NucleophilePROSITE-ProRule annotation
    Active sitei425 – 4251By similarity
    Active sitei571 – 5711Proton donorBy similarity

    GO - Molecular functioni

    1. beta-glucosidase activity Source: UniProtKB-EC
    2. carbohydrate binding Source: InterPro
    3. maltose alpha-glucosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. polysaccharide catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable alpha/beta-glucosidase agdC (EC:3.2.1.20, EC:3.2.1.21)
    Gene namesi
    Name:agdC
    ORF Names:ACLA_019300
    OrganismiAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
    Taxonomic identifieri344612 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000006701: Unassembled WGS sequence

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 887870Probable alpha/beta-glucosidase agdCPRO_0000394913Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi171 – 1711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi373 – 3731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi747 – 7471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi879 – 8791N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi5057.CADACLAP00003050.

    Structurei

    3D structure databases

    ProteinModelPortaliA1CNK4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 31 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG1501.
    HOGENOMiHOG000041175.
    KOiK01187.
    OMAiFWAREIS.
    OrthoDBiEOG77T1CZ.

    Family and domain databases

    InterProiIPR011013. Gal_mutarotase_SF_dom.
    IPR000322. Glyco_hydro_31.
    IPR025887. Glyco_hydro_31_N_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF13802. Gal_mutarotas_2. 1 hit.
    PF01055. Glyco_hydro_31. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 2 hits.
    SSF74650. SSF74650. 1 hit.
    PROSITEiPS00129. GLYCOSYL_HYDROL_F31_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A1CNK4-1 [UniParc]FASTAAdd to Basket

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    MLRSLLLLAP MVGAAVAATE PNSPACPGYR ATNVREGHNS LTADLTLAGK    50
    PCNTYGTDLK NLKLLVEYQT DERLHVKIYD ANEQVYQVPE SVVPRVDGKG 100
    GSRKKSVLKF NFKANPFSFQ VKRGREVLFD TSGSNLVFQD QYLNLRTSLP 150
    RDPNLYGLGE HTDPLRLTTT NYTRTLWNRD SYGIPENSNL YGSHPVYYDH 200
    RGEDGTHGVF LLNSNGMDIK IDKTKDGKQF LEYNALGGIF DFYFFNGDTP 250
    KDASIEYAKV AGLPAMQSYW SFGFHQCRYG YRDAFEVAEV VQNYTQAKIP 300
    LETMWTDIDY MDRRRVFTLD PDRFPLEKVR ELVSYLHKHD QKYIVMVDPA 350
    VSVSDNKGFN DGMEQGVFMK HQNGSLYKGA VWPGVTAYPD WFHPDIQKYW 400
    DGQFNDFFSP EKGVDIDGLW IDMNEAANFC TYPCLDPEGY SIENNLPPAA 450
    PPVRPNPRPL PGFPDDFQPP AASKRSVAKG SKVGLPGRDL LNPRYQIRND 500
    AGLISSKTIN TDLIHAGEGY AEYDTHNLYG TMMSSASRQS MAQRRPAVRP 550
    LIITRSTFAG AGTHVGHWLG DNLADWKHYR ISIAQMLSFA SMFQVPMVGS 600
    DICGFGGDTN EELCARWARL GAFYPFFRNH NEITSIPQEF YRWESVAESA 650
    RKAIEVRYKL LDYVYTAFHR QTQTGEPFLQ PMFYMYPEDK NTFSNDMQFF 700
    YGDSILVSPV HDVSQTSVEA YFPKDIFYDW NTGDVLRGRG AKVTLSNISV 750
    TDIPIHIRGG SIVPIRSESA MTTVELRKKG FELLIAPGQD GTASGTLYLD 800
    DGDSLKQSAS LELEFKYRKG NLQIKGKFGM HTDLKINAIT LLGQTSVPRQ 850
    VTLSRAGKAD SKFDPARQSV TIKTDLSLNE SSEIDIN 887
    Length:887
    Mass (Da):99,904
    Last modified:January 23, 2007 - v1
    Checksum:iDAA2C23C3A28E665
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027059 Genomic DNA. Translation: EAW07225.1.
    RefSeqiXP_001268651.1. XM_001268650.1.

    Genome annotation databases

    EnsemblFungiiCADACLAT00003097; CADACLAP00003050; CADACLAG00003097.
    GeneIDi4700931.
    KEGGiact:ACLA_019300.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027059 Genomic DNA. Translation: EAW07225.1 .
    RefSeqi XP_001268651.1. XM_001268650.1.

    3D structure databases

    ProteinModelPortali A1CNK4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5057.CADACLAP00003050.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADACLAT00003097 ; CADACLAP00003050 ; CADACLAG00003097 .
    GeneIDi 4700931.
    KEGGi act:ACLA_019300.

    Phylogenomic databases

    eggNOGi COG1501.
    HOGENOMi HOG000041175.
    KOi K01187.
    OMAi FWAREIS.
    OrthoDBi EOG77T1CZ.

    Family and domain databases

    InterProi IPR011013. Gal_mutarotase_SF_dom.
    IPR000322. Glyco_hydro_31.
    IPR025887. Glyco_hydro_31_N_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF13802. Gal_mutarotas_2. 1 hit.
    PF01055. Glyco_hydro_31. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 2 hits.
    SSF74650. SSF74650. 1 hit.
    PROSITEi PS00129. GLYCOSYL_HYDROL_F31_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1.

    Entry informationi

    Entry nameiAGDC_ASPCL
    AccessioniPrimary (citable) accession number: A1CNK4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3